المؤلفون: Jonathan Solomon, Simone Bonazzi, Eva d'Hennezel, Rohan Beckwith, Lei Xu, Aleem Fazal, Anna Magracheva, Radha Ramesh, Artiom Cernijenko, Brandon Antonakos, Hyo-eun Bhang, Roxana Garcia Caro, Jennifer Cobb, Elizabeth Ornelas, Xiaolei Ma, Charles Wartchow, Matt Clifton, Ry Forseth, Bethany Fortnam, Hongbo Lu, Alfredo Csibi, Jennifer Tullai, Seth Carbonneau, Noel Thomsen, Jay Larrow, Barbara Chie-Leon, Dominik Hainzl, Yi Gu, Darlene Lu, Matthew Meyer, Dylan Alexander, Jacqueline Kinyamu-Akunda, Catherine Sabatos-Peyton, Natalie Dales, Frederic Zecri, Rishi Jain, Janine Shulok, Y. Karen Wang, Karin Briner, Jeffrey Porter, John Tallarico, Jeffrey Engelman, Glenn Dranoff, Jay Bradner, Michael Visser

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::e91b1b99fea2c930f908b107802a0e27
https://doi.org/10.21203/rs.3.rs-1531006/v1

المؤلفون: Simone Bonazzi, Eva d’Hennezel, Rohan E.J. Beckwith, Lei Xu, Aleem Fazal, Anna Magracheva, Radha Ramesh, Artiom Cernijenko, Brandon Antonakos, Hyo-eun C. Bhang, Roxana García Caro, Jennifer S. Cobb, Elizabeth Ornelas, Xiaolei Ma, Charles A. Wartchow, Matthew C. Clifton, Ry R. Forseth, Bethany Hughes Fortnam, Hongbo Lu, Alfredo Csibi, Jennifer Tullai, Seth Carbonneau, Noel M. Thomsen, Jay Larrow, Barbara Chie-Leon, Dominik Hainzl, Yi Gu, Darlene Lu, Matthew J. Meyer, Dylan Alexander, Jacqueline Kinyamu-Akunda, Catherine A. Sabatos-Peyton, Natalie A. Dales, Frédéric J. Zécri, Rishi K. Jain, Janine Shulok, Y. Karen Wang, Karin Briner, Jeffery A. Porter, John A. Tallarico, Jeffrey A. Engelman, Glenn Dranoff, James E. Bradner, Michael Visser, Jonathan M. Solomon

المصدر: Cell Chemical Biology. 30:235-247.e12

مصطلحات موضوعية: Pharmacology, Clinical Biochemistry, Drug Discovery, Molecular Medicine, Molecular Biology, Biochemistry

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::aa86b497ea26c675d8f51551ced46e99
https://doi.org/10.1016/j.chembiol.2023.02.005

المؤلفون: Sanchez Carina Cristina, Jay Larrow, Cary Fridrich, Malte S. Mikus

المصدر: Advanced Synthesis & Catalysis. 362:430-436

مصطلحات موضوعية: General interest, 010405 organic chemistry, Drug discovery, Aryl, chemistry.chemical_element, General Chemistry, 010402 general chemistry, 01 natural sciences, Combinatorial chemistry, 0104 chemical sciences, Catalysis, chemistry.chemical_compound, chemistry, Amine gas treating, Pharmacophore, Palladium

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::30fcf4363b75868f6328c6be4c77a78b
https://doi.org/10.1002/adsc.201901302

المؤلفون: Kelly Slocum, Jianmei Fan, Michael Dore, Palermo Mark G, Zhan Deng, Bakary-Barry Toure, Jorge Garcia-Fortanet, Dyuti Majumdar, Martin F. Hentemann, Nick Keen, Suzanne Zhu, Christopher Towler, Michael Shultz, William R. Sellers, Simon Mathieu, Denise Grunenfelder, Robert Koenig, Douglas C. Bauer, Shumei Liu, Jay Larrow, Victoriano Tamez, David Dunstan, Andreea Argintaru, Timothy Michael Ramsey, Zhouliang Chen, Gang Liu, Ying-Nan Chen, Rukundo Ntaganda, Bing Yu, Joanna Slisz, Hongyun Wang, Pascal D. Fortin, Christopher Sean Straub, Ji-Hu Zhang, Ping Wang, Laura R. LaBonte, Mitsunori Kato, Matthew J. Meyer, Fan Yang, Patrick James Sarver, Samuel B. Ho, Brant Firestone, Rajesh Karki, John F. Reilly, Troy Smith, Ho Man Chan, Cary Fridrich, John William Giraldes, Julie Boisclair, Chen Christine Hiu-Tung, Meir Glick, Zhao B. Kang, Morvarid Mohseni, Lawrence Blas Perez, Michael G. Acker, Sarah Williams, Matthew J. LaMarche, Martin Sendzik, Michelle Fodor, Huia-Xiang Hao, Peter Fekkes, Minying Pu, Travis Stams, Stanley Spence, Andriana Jouk

المصدر: Journal of medicinal chemistry. 63(22)

مصطلحات موضوعية: Drug, Programmed cell death, media_common.quotation_subject, Allosteric regulation, Antineoplastic Agents, Protein Tyrosine Phosphatase, Non-Receptor Type 11, Protein tyrosine phosphatase, Pharmacology, 01 natural sciences, 03 medical and health sciences, Mice, Dogs, Allosteric Regulation, In vivo, Neoplasms, Drug Discovery, medicine, Tumor Cells, Cultured, Animals, Humans, Enzyme Inhibitors, Gene, 030304 developmental biology, media_common, 0303 health sciences, Chemistry, Cancer, medicine.disease, Xenograft Model Antitumor Assays, 0104 chemical sciences, Rats, PTPN11, 010404 medicinal & biomolecular chemistry, Macaca fascicularis, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::345804676325a445ebbb9ef600ced79a
https://pubmed.ncbi.nlm.nih.gov/32910655

المؤلفون: Matthew J. LaMarche, Peter Fekkes, Jorge Garcia Fortanet, Michael Shultz, Denise Grunenfelder, Zhouliang Chen, Gang Liu, Chen Christine Hiu-Tung, Minying Pu, Travis Stams, Pascal D. Fortin, Palermo Mark G, Ping Wang, Samuel B. Ho, Brant Firestone, Matthew J. Meyer, Dyuti Majumdar, Laura R. LaBonte, Francois Lenoir, Rajesh Karki, Nick Keen, Cary Fridrich, Michelle Fodor, Jay Larrow, Sarah Williams, Christopher Towler, Timothy Michael Ramsey, Ji-Hu Zhang, Franco Lombardo, Ying-Nan P. Chen, Zhan Deng, Mitsunori Kato, Zhao B. Kang, Lawrence Blas Perez, Shumei Liu, William R. Sellers

المصدر: Journal of Medicinal Chemistry. 59:7773-7782

مصطلحات موضوعية: Male, Models, Molecular, 0301 basic medicine, Programmed cell death, Allosteric modulator, Protein Conformation, Allosteric regulation, Administration, Oral, Mice, Nude, Antineoplastic Agents, Protein Tyrosine Phosphatase, Non-Receptor Type 11, Protein tyrosine phosphatase, Crystallography, X-Ray, Structure-Activity Relationship, 03 medical and health sciences, 0302 clinical medicine, Protein structure, Allosteric Regulation, Piperidines, Cell Line, Tumor, Drug Discovery, Animals, Humans, Structure–activity relationship, Chemistry, Small molecule, High-Throughput Screening Assays, Mice, Inbred C57BL, PTPN11, Pyrimidines, 030104 developmental biology, Biochemistry, Drug Design, Pyrazines, 030220 oncology & carcinogenesis, Heterografts, Molecular Medicine, Female, Allosteric Site, Neoplasm Transplantation

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dab8364be893583bdc1d3f32d1e22004
https://doi.org/10.1021/acs.jmedchem.6b00680

المؤلفون: Palermo Mark G, Timothy Michael Ramsey, Ping Zhu, Shumei Liu, Jay Larrow, Laura R. La Bonte, Rajesh Karki, Chen Christine Hiu-Tung, Kavitha Venkatesan, Jaison Jacob, Pascal D. Fortin, Francois Lenoir, Hui Gao, Guizhi Yang, Matthew J. Meyer, Ji-Hu Zhang, William R. Sellers, Michael Shultz, Denise Grunenfelder, Edmund Price, Jorge Garcia-Fortanet, Feng Fei, Zhouliang Chen, Gang Liu, Vesselina G. Cooke, Jing Yuan, Michelle Fodor, Ping Wang, Minying Pu, Nicholas Keen, Samuel B. Ho, Kathy Hsiao, Markus Warmuth, Travis Stams, Christopher Quinn, Mitsunori Kato, Subarna Shakya, Sarah Williams, Dyuti Majumdar, Peter Fekkes, Michael G. Acker, Cary Fridrich, Joanna Slisz, Huaixiang Hao, Matthew J. LaMarche, Ying-Nan P. Chen, Brandon Antonakos, Jason R. Dobson, Brant Firestone, Lawrence Blas Perez, Zhao B. Kang, Ho Man Chan, Zhan Deng

المصدر: Nature. 535:148-152

مصطلحات موضوعية: 0301 basic medicine, Multidisciplinary, biology, Cell growth, Protein tyrosine phosphatase, Receptor tyrosine kinase, Immune checkpoint, Cell biology, PTPN11, 03 medical and health sciences, 030104 developmental biology, Growth factor receptor, biology.protein, Signal transduction, Tyrosine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::f58ee0fa5f3f5109027ba2125d369122
https://doi.org/10.1038/nature18621

المؤلفون: Lipa Shah, Thierry Mann, Penny Wright, Jennifer Bilotta, Joseph Twomey, Jay Larrow, Christina Capacci-Daniel, Melissa S. Grondine, Christopher Towler, Stephanie Kay Dodd, John Reilly

المصدر: Journal of Liquid Chromatography & Related Technologies. 35:1001-1010

مصطلحات موضوعية: chemistry.chemical_classification, Chromatography, Clinical Biochemistry, Ion chromatography, Pharmaceutical Science, Salt (chemistry), Biochemistry, Analytical Chemistry, Column chromatography, chemistry, Reagent, Instrumentation (computer programming), Counterion, Pre formulation

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::4fde920b97e854c3d6e867c060471725
https://doi.org/10.1080/10826076.2011.615090

المؤلفون: James K. Lee, Pilar Franco, Geoffrey B. Cox, Kenichi Sakai, Jay Larrow, Karl B. Hansen, George A. Moniz, Saab Khattabi, Margaret M. Faul, Jerome Boni, Liane M. Klingensmith, Jason S. Tedrow, Michael J. Martinelli, Larry Miller, Seb Caille

المصدر: Organic Process Research & Development. 14:133-141

مصطلحات موضوعية: Resolution (mass spectrometry), Scale (chemistry), Organic Chemistry, Diastereomer, Combinatorial chemistry, 2-Norbornyl cation, Chiral column chromatography, chemistry.chemical_compound, Thiourea, chemistry, Organic chemistry, Amine gas treating, Physical and Theoretical Chemistry, Salt formation

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::f2cf952ff3741ee14500cd8a4a9f5a87
https://doi.org/10.1021/op9002328

المؤلفون: Steven F. Bellon, Monica Reese, Jay Larrow, Isabelle Dussault, Stephanie Springer, Paula Kaplan-Lefko, Jodi Moriguchi, David Bauer, Yajing Yang, Kavita Shah, Loren Berry, Jean-Christophe Harmange, Christiane Bode, Karen Rex, Brian K. Albrecht, Yihong Zhang, Doug Hoffman, Jasmine Lin, Deborah Choquette, Alessandro Boezio, Alexander M. Long, Roman Shimanovich, Anne B. O’Connor, Aaron C. Siegmund, April Chen, Cary Fridrich, Julia Lohman, Yohannes Teffera, Michele Potashman, Satoko Hirai

المصدر: Journal of Medicinal Chemistry. 51:2879-2882

مصطلحات موضوعية: Models, Molecular, C-Met, In Vitro Techniques, Crystallography, X-Ray, medicine.disease_cause, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Growth factor receptor, Drug Discovery, medicine, Animals, Phosphorylation, Molecular Structure, Oncogene, Hepatocyte Growth Factor, Chemistry, Kinase, Proto-Oncogene Proteins c-met, Triazoles, Rats, Pyridazines, Biochemistry, Microsomes, Liver, Cancer research, Molecular Medicine, Hepatocyte growth factor, Signal transduction, Carcinogenesis, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a031daf87fd230380ea41665042176aa
https://doi.org/10.1021/jm800043g

المؤلفون: Shaun Flynn, James Bready, Shawn Harriman, Vinod F. Patel, Zhiyang Zhao, Alexander M. Long, Anthony Polverino, Jean-Christophe Harmange, Michael Morrison, Jay Larrow, Nicholas Doerr, Daniel S. La, Juan Estrada, Thomas DeMelfi, Julie Belzile, Matthew Weiss, Julie Flynn, Yohannes Teffera, Douglas A. Whittington, Russell Graceffa, Philip Roveto, Matthew W. Martin, Angela Coxon, Ling Wang

المصدر: Journal of Medicinal Chemistry. 51:1695-1705

مصطلحات موضوعية: Male, Models, Molecular, Vascular Endothelial Growth Factor A, Angiogenesis, Injections, Subcutaneous, Administration, Oral, Biological Availability, Mice, Nude, Angiogenesis Inhibitors, Crystallography, X-Ray, Ligands, Cell Line, Rats, Sprague-Dawley, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Growth factor receptor, Neoplasms, Drug Discovery, Animals, Humans, Corneal Neovascularization, Cell Proliferation, Mice, Inbred BALB C, Dose-Response Relationship, Drug, Molecular Structure, Neovascularization, Pathologic, Chemistry, Endothelial Cells, Stereoisomerism, Kinase insert domain receptor, Vascular Endothelial Growth Factor Receptor-2, Benzoxazines, Rats, Endothelial stem cell, Vascular endothelial growth factor, Vascular endothelial growth factor A, Biochemistry, Models, Animal, cardiovascular system, Cancer research, Molecular Medicine, Female, Human umbilical vein endothelial cell, Signal transduction

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64dafc54f7435bfc86e716abcc843b0d
https://doi.org/10.1021/jm701129j