المؤلفون: Dennis Hernandez, Ramkumar Rajamani, Rongti Li, Jacques Friborg, Fiona McPhee, Nicholas A. Meanwell, Kathy Mosure, Ying-Kai Wang, Jay O. Knipe, Fei Yu, Herbert E. Klei, Bowsher Michael S, Paul Michael Scola, Alan X. Wang, Sheldon Hiebert

المصدر: Bioorganic & Medicinal Chemistry Letters. 28:43-48

مصطلحات موضوعية: 0301 basic medicine, Proteases, Macrocyclic Compounds, Stereochemistry, Clinical Biochemistry, Drug Evaluation, Preclinical, Molecular Conformation, Administration, Oral, Pharmaceutical Science, Hepacivirus, Naphthalenes, Viral Nonstructural Proteins, Antiviral Agents, Biochemistry, 03 medical and health sciences, chemistry.chemical_compound, Pharmacokinetics, Drug Discovery, Animals, Potency, Protease Inhibitors, Molecular Biology, Naphthalene, chemistry.chemical_classification, Organic Chemistry, Heart, Rats, Bioavailability, Sulfonamide, 030104 developmental biology, chemistry, Hcv ns3 protease, Lipophilicity, Microsomes, Liver, Molecular Medicine, Rabbits, Half-Life

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ebf9908b4ab9994153667ba9b390dad
https://doi.org/10.1016/j.bmcl.2017.11.005

المؤلفون: Katherine A. Grant-Young, Andrew Nickel, Rajesh Onkardas Bora, Prakash Anjanappa, Bender John A, Kevin Kish, Kap-Sun Yeung, Dawn D. Parker, Joseph Raybon, Mark R. Witmer, Karen Rigat, Matthew G. Soars, Steven Sheriff, Yue-Zhong Shu, Kenneth S. Santone, Prashantha Gunaga, Kyle Parcella, Nicholas A. Meanwell, Jay O. Knipe, Susan B. Roberts, Alicia Ng, Michael Sinz, Kathy Mosure, Ying-Kai Wang, Brett R. Beno, Mengping Liu, Elizabeth Colston, Dennis M. Grasela, John F. Kadow, Qi Gao, Min Gao, Umesh Hanumegowda, Roy Haskell, Julie A. Lemm, Xiaoliang Zhuo, Changhong Wan, Kumaravel Selvakumar

المصدر: Journal of Medicinal Chemistry. 60:4369-4385

مصطلحات موضوعية: Male, 0301 basic medicine, Hepatitis C virus, Allosteric regulation, RNA-dependent RNA polymerase, Hepacivirus, Viral Nonstructural Proteins, medicine.disease_cause, Antiviral Agents, 01 natural sciences, Rats, Sprague-Dawley, 03 medical and health sciences, chemistry.chemical_compound, Dogs, Allosteric Regulation, Drug Discovery, medicine, Animals, Humans, Benzofuran, NS5B, Benzofurans, Ligand efficiency, 010405 organic chemistry, Chemistry, Drug discovery, Haplorhini, Hepatitis C, Rats, 0104 chemical sciences, Molecular Docking Simulation, 030104 developmental biology, Biochemistry, Benzothiadiazine, Molecular Medicine, Allosteric Site

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43e500f8c2cd73d6873f1280c193d753
https://doi.org/10.1021/acs.jmedchem.7b00328

المؤلفون: Alan Xiangdong Wang, Andrew C. Good, Fei Yu, Peter Hrnciar, Herbert E. Klei, Manjula Paruchuri, Fiona McPhee, Dennis Hernandez, Paul Falk, Jeffrey Tredup, Amy K. Sheaffer, Qi Gao, Barbara Zheng, Kevin Kish, Kathy Mosure, Stanley D'andrea, Ramkumar Rajamani, Alicia Ng, Jay O. Knipe, Yan Chen, Li-Qiang Sun, Jacques Friborg, Paul Michael Scola, Arvind Mathur, Nicholas A. Meanwell, Richard Rampulla

مصطلحات موضوعية: chemistry.chemical_classification, NS3, Protease, 010405 organic chemistry, Chemistry, Stereochemistry, Hydrogen bond, medicine.medical_treatment, Organic Chemistry, 010402 general chemistry, 01 natural sciences, Biochemistry, Cocrystal, 0104 chemical sciences, Amino acid, Enzyme, Drug Discovery, Hydrolase, medicine, Moiety

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::deb2005e8a0764575ac7a4f49607aedd
https://europepmc.org/articles/PMC5807875/

المؤلفون: Hua Fang, Kathy Mosure, Xiaoliang Zhuo, Arvind Mathur, Umesh Hanumegowda, Mengping Liu, Dauh-Rurng Wu, Nicholas A. Meanwell, Barbara Zhizhen Zheng, Chris Poronsky, Pirama Nayagam Arunachalam, Ying-Kai Wang, Arunachalam Arumugam, Jingfang Qian Cutrone, Karen Rigat, Jay O. Knipe, Susan B. Roberts, Stanley D'andrea, Julie A. Lemm, T.J. Balapragalathan, John F. Kadow, Min Gao

المصدر: Bioorganicmedicinal chemistry letters. 27(15)

مصطلحات موضوعية: Drug, media_common.quotation_subject, Hepatitis C virus, Clinical Biochemistry, Allosteric regulation, Pharmaceutical Science, Hepacivirus, Pharmacology, Viral Nonstructural Proteins, medicine.disease_cause, Biochemistry, Antiviral Agents, Ns5b polymerase, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Dogs, Pharmacokinetics, Drug Discovery, medicine, Animals, Humans, Molecular Biology, Beclabuvir, Polymerase, media_common, biology, Organic Chemistry, virus diseases, Haplorhini, Metabolic stability, Benzazepines, RNA-Dependent RNA Polymerase, Virology, Hepatitis C, digestive system diseases, Rats, chemistry, 030220 oncology & carcinogenesis, biology.protein, Molecular Medicine, 030211 gastroenterology & hepatology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82881c1418cb3ae765272ccd489cd324
https://pubmed.ncbi.nlm.nih.gov/28633899

المؤلفون: Karen Rigat, Voss Stacey A, Min Gao, Min Ding, Bender John A, Robert G. Gentles, Lenore A. Pelosi, John F. Kadow, Mengping Liu, Jay O. Knipe, Susan B. Roberts, Ying-Kai Wang, Julie A. Lemm, Kenneth S. Santone, Nicholas A. Meanwell, Kathleen W. Mosure, Richard J. Colonno

المصدر: Antimicrobial Agents and Chemotherapy

مصطلحات موضوعية: Male, Indoles, Genotype, Cell Survival, viruses, Hepatitis C virus, medicine.medical_treatment, Hepacivirus, Viral Nonstructural Proteins, Biology, medicine.disease_cause, Antiviral Agents, Rats, Sprague-Dawley, chemistry.chemical_compound, Dogs, Allosteric Regulation, Interferon, Cell Line, Tumor, Chlorocebus aethiops, Drug Resistance, Viral, Ribavirin, medicine, Animals, Humans, Pharmacology (medical), NS5A, Vero Cells, NS5B, Pharmacology, NS3, Protease, Nucleoside analogue, virus diseases, Interferon-alpha, Benzazepines, RNA-Dependent RNA Polymerase, Virology, digestive system diseases, Rats, Infectious Diseases, Liver, chemistry, Drug Therapy, Combination, Replicon, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7508943f17da9aa6954c0351821157b9

المؤلفون: Bender John A, Kyle J. Eastman, Jay O. Knipe, Susan B. Roberts, Julie A. Lemm, Nicholas A. Meanwell, Zhong Yang, Kathy Mosure, John F. Kadow

المصدر: Bioorganic & Medicinal Chemistry Letters. 24:1993-1997

مصطلحات موضوعية: Indoles, Molecular Structure, Stereochemistry, Organic Chemistry, Clinical Biochemistry, Heteroatom, Pharmaceutical Science, Hepacivirus, Benzazepines, Viral Nonstructural Proteins, Antiviral Agents, Biochemistry, Rats, chemistry.chemical_compound, Propellane, Piperazine, chemistry, Drug Discovery, Animals, Molecular Medicine, Molecular Biology, NS5B, Pyrrole

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4383921b2a35dcddcc49efb522282478
https://doi.org/10.1016/j.bmcl.2014.02.047

المؤلفون: Danshi Li, Herbert E. Klei, Sing-Yuen Sit, Piyasena Hewawasam, Ny Sin, Brian Lee Venables, Paul Levesque, Qi Gao, Bilder Donna M, Dennis M. Grasela, Dennis Hernandez, Anthony J. Cocuzza, Amy K. Sheaffer, Richard J. Colonno, Jeffrey Tredup, Kathy Mosure, Stanley D'andrea, Jialong Zhu, Lucy Sun, Fei Yu, Paul Falk, Alan Xiangdong Wang, Steven Levine, Fiona McPhee, Andrew C. Good, Huabin Sun, Jay O. Knipe, Barbara Zheng, Richard Schartman, Nicholas A. Meanwell, Jie Chen, Maria Donoso, James Loy, Guangzhi Zhai, Ramkumar Rajamani, Li-Qiang Sun, Stephen P. Adams, Luciano Mueller, Tatyana Zvyaga, Yong Tu, Hong Shi, Paul Michael Scola, Chaoqun Chen, William Warner, Yan Chen, Yong-Hae Han, Diana Barry, Jacques Friborg, Kevin Kish, Michael Sinz

المصدر: Journal of Medicinal Chemistry. 57:1730-1752

مصطلحات موضوعية: Models, Molecular, Hepatitis C virus, Phases of clinical research, Viral Nonstructural Proteins, Biology, Pharmacology, medicine.disease_cause, Antiviral Agents, chemistry.chemical_compound, Dogs, Drug Discovery, medicine, Animals, Humans, Protease Inhibitors, Protease inhibitor (pharmacology), Beclabuvir, Sulfonamides, NS3, Isoquinolines, Hepatitis C, Virology, Rats, Discontinuation, Clinical trial, chemistry, Molecular Medicine, Asunaprevir, Rabbits

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2de12395392456b92810af925e724113
https://doi.org/10.1021/jm500297k

المؤلفون: Alan Xiangdong Wang, Barbara Zheng, Min S. Lee, Dennis Hernandez, Andrew C. Good, Stanley D'andrea, Amy K. Sheaffer, Fiona McPhee, Christoph Gesenberg, Sing-Yuen Sit, Ny Sin, Paul Falk, Danshi Li, Piyasena Hewawasam, Yan Chen, Yong-Hae Han, Paul Levesque, Brian Lee Venables, Nicholas A. Meanwell, Michael Sinz, Wenying Li, Qi Gao, Li-Qiang Sun, Jay O. Knipe, Chaoqun Chen, Caly Chien, Diana Barry, Guangzhi Zhai, Anthony J. Cocuzza, Tatyana Zvyaga, Stephen P. Adams, Jialong Zhu, Fei Yu, Dennis M. Grasela, Richard J. Colonno, Yong Tu, Ramkumar Rajamani, Herbert E. Klei, Jianqing Li, Min Ding, Jan Willem Thuring, Jie Chen, Susan Jenkins, Keith D. Combrink, Jeffrey Allen Campbell, Kenneth S. Santone, Paul Michael Scola, Eric Hughes, Bilder Donna M

المصدر: Journal of Medicinal Chemistry. 57:1708-1729

مصطلحات موضوعية: Models, Molecular, Stereochemistry, medicine.medical_treatment, Drug Evaluation, Preclinical, Viral Nonstructural Proteins, Pharmacology, Crystallography, X-Ray, Antiviral Agents, chemistry.chemical_compound, Dogs, Pharmacokinetics, Drug Discovery, medicine, Animals, Humans, Moiety, Potency, Protease Inhibitors, Protease inhibitor (pharmacology), Isoquinoline, Sulfonamides, NS3, Protease, Chemistry, Drug discovery, Isoquinolines, Hepatitis C, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bf8154b804898acc5dffe118ba07d84
https://doi.org/10.1021/jm401840s

المؤلفون: Donald R. O'Boyle, Anjaneya Chimalakonda, Benjamin M. Johnson, Lavoie Rico, Alain Martel, James Clint A, Denis R. St. Laurent, Julie A. Lemm, Van N. Nguyen, David R. Langley, Henry S. Wong, Fukang Yang, Robert A. Fridell, Deon Daniel H, Juliang Zhu, Glenn H. Cantor, Lawrence B. Snyder, Jeffrey L. Romine, Makonen Belema, Lopez Omar D, Kenneth S. Santone, Carol Bachand, Goodrich Jason, Ruediger Edward H, Richard J. Colonno, Stephen P. Adams, Nicholas A. Meanwell, Min Gao, Aberra Fura, Lawrence G. Hamann, Dawn D. Parker, Jay O. Knipe

المصدر: Journal of Medicinal Chemistry. 57:2013-2032

مصطلحات موضوعية: Spectrometry, Mass, Electrospray Ionization, Magnetic Resonance Spectroscopy, Pyrrolidines, Daclatasvir, Hepatitis C virus, Hepacivirus, Viral Nonstructural Proteins, Pharmacology, Virus Replication, medicine.disease_cause, Antiviral Agents, Structure-Activity Relationship, Dogs, Pharmacokinetics, Drug Discovery, medicine, Animals, Structure–activity relationship, Replicon, Enzyme Inhibitors, NS5A, EC50, Chemistry, Drug discovery, Imidazoles, Valine, Virology, Rats, Area Under Curve, Molecular Medicine, Carbamates, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccb09c433565e97a1989a67acd31dde3
https://doi.org/10.1021/jm401836p

المؤلفون: A. Jayne Oliver, Min Gao, Goodrich Jason, Andrew C. Good, Hua Fang, Jeffrey L. Romine, Lopez Omar D, Rudolph G. Krause, Van N. Nguyen, Denis R. St. Laurent, Makonen Belema, Lawrence B. Snyder, Robert A. Fridell, Donald R. O'Boyle, Peter T. Nower, Jay O. Knipe, Nicholas A. Meanwell, Ying-Kai Wang, Julie A. Lemm

المصدر: Journal of Medicinal Chemistry. 57:1995-2012

مصطلحات موضوعية: Spectrometry, Mass, Electrospray Ionization, Magnetic Resonance Spectroscopy, Genotype, Hepatitis C virus, Hepacivirus, Viral Nonstructural Proteins, Biology, Pharmacology, Crystallography, X-Ray, medicine.disease_cause, Inhibitory postsynaptic potential, Antiviral Agents, Structure-Activity Relationship, Drug Discovery, medicine, Structure–activity relationship, Potency, Replicon, Enzyme Inhibitors, NS5A, Chemotype, Drug discovery, Imidazoles, RNA-Dependent RNA Polymerase, Virology, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45701a20518e290c6b370d6b615e3ae1
https://doi.org/10.1021/jm4016203