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المؤلفون: Jill C. Milne, Angela Tornblom, Jean Bemis, Jeremy S. Disch, George P. Vlasuk, Peter Elliot, Amy V. Lynch, Robert B. Perni, Pui Yee Ng, James L. Ellis, Akanksha Gupta, Christopher Oalmann, Joseph J. Nunes, J. Joshua Smith, Kristina Kriksciukaite, Michael R. Jirousek, Marie Yeager, Vipin Suri, David P. Carney, Meghan Duncan, Jeffrey Song, Siva Lavu, Thomas V. Riera, Chi B. Vu
المصدر: Letters in Drug Design & Discovery. 10:793-797
مصطلحات موضوعية: Chemistry, Activator (genetics), Drug Discovery, Pharmaceutical Science, Molecular Medicine, Computational biology
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::d0097b909e7a83a1c2a6561804d09532
https://doi.org/10.2174/15701808113100990021 -
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المؤلفون: Andrew J. Nichols, Pallavi Lonkar, Jean Bemis, Michael R. Jirousek, Michael Zimmer, Diana Lee, Jill C. Milne, Adam Shoelson, Amal Ting, Dominic Picarella, Maisy Yeager, Ericka L. Benson, Feng Liu, Smith Jesse J, David Carney, Allison Wensley, Chi B. Vu, Richard Fahrner, P. Bista
المصدر: Journal of medicinal chemistry. 59(3)
مصطلحات موضوعية: 0301 basic medicine, ATP citrate lyase, Administration, Oral, Pharmacology, Niacin, Cell Line, Rats, Sprague-Dawley, 03 medical and health sciences, Hydrolysis, chemistry.chemical_compound, Mice, Structure-Activity Relationship, Dogs, Drug Discovery, Animals, Humans, Tissue Distribution, chemistry.chemical_classification, Dose-Response Relationship, Drug, Molecular Structure, Anti-Inflammatory Agents, Non-Steroidal, Fatty Acids, NF-kappa B, Fatty acid, Hep G2 Cells, Sterol regulatory element-binding protein, Rats, 030104 developmental biology, chemistry, Biochemistry, Liver, Molecular Medicine, Sterol Regulatory Element Binding Protein 1, Sterol regulatory element-binding protein 2, Salicylic Acid, Salicylic acid, Sterol Regulatory Element Binding Protein 2
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المؤلفون: David P. Carney, Amy V. Lynch, Robert B. Perni, Pui Yee Ng, Jeremy S. Disch, Roger Xie, Michael R. Jirousek, Jill C. Milne, J. Joshua Smith, Lei Jin, Andre Iffland, Joseph J. Nunes, Jean Bemis, Siva Lavu, Chi B. Vu
المصدر: Bioorganic & Medicinal Chemistry Letters. 19:2350-2353
مصطلحات موضوعية: endocrine system diseases, Pyridines, medicine.medical_treatment, Clinical Biochemistry, Pharmaceutical Science, Mice, Transgenic, Resveratrol, Biochemistry, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Insulin resistance, Sirtuin 1, Drug Discovery, medicine, Animals, Humans, Sirtuins, Oxazoles, Molecular Biology, chemistry.chemical_classification, Insulin, Organic Chemistry, food and beverages, Bridged Bicyclo Compounds, Heterocyclic, medicine.disease, Small molecule, Rats, Rats, Zucker, Enzyme Activation, Enzyme, chemistry, Molecular Medicine, Protein deacetylase, NAD+ kinase, Histone deacetylase, hormones, hormone substitutes, and hormone antagonists
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المؤلفون: Philip D. Lambert, David J. Gagne, Joseph J. Nunes, Jerrold M. Olefsky, Jean Bemis, Chi B. Vu, Jill C. Milne, Amy V. Lynch, J. Joshua Smith, David P. Carney, Michael R. Jirousek, Robert B. Perni, Pui Yee Ng, Jeremy S. Disch, Simon Schenk, Siva Lavu
المصدر: Journal of Medicinal Chemistry. 52:1275-1283
مصطلحات موضوعية: medicine.drug_class, Stereochemistry, Enzyme Activators, Carboxamide, Chemical synthesis, Diabetes Mellitus, Experimental, Mice, Structure-Activity Relationship, Enzyme activator, chemistry.chemical_compound, Sirtuin 1, Quinoxalines, Amide, Drug Discovery, medicine, Animals, Hypoglycemic Agents, Structure–activity relationship, Thiazole, Bicyclic molecule, Imidazoles, Rats, Rats, Zucker, Thiazoles, Diabetes Mellitus, Type 2, chemistry, Molecular Medicine, NAD+ kinase
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المؤلفون: Heidi Galonek, J. Joshua Smith, Kristine Israelian, Yihua Xu, Wendy Choy, Jean Bemis, Christoph H. Westphal, Michael R. Jirousek, Jill C. Milne, Ethan Hoffmann, David A. Sinclair, Xiaohong Wang, Robert B. Perni, Yuecheng Yang, Michael Morrison, Lei Jin, Yu Xia, David P. Carney
المصدر: Protein Science. 18:514-525
مصطلحات موضوعية: Rapid amplification of cDNA ends, Biochemistry, biology, SIRT3, Sirtuin, biology.protein, Sequence alignment, NAD+ kinase, Mitochondrion, Subcellular localization, Molecular Biology, Peptide sequence
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المؤلفون: Kurt Morgenstern, Matthew W. Martin, Faye Hsieh, Stuart C. Chaffee, Susan A. Tomlinson, Susan M. Turci, Joseph J. Nunes, Lilly Chai, Paul E. Rose, Josie H. Lee, Antonio J. Oliveira-dos-Santos, Erin F. DiMauro, Vinod F. Patel, David Powers, Yan Gu, Xin Huang, Jean Bemis, Andrew A. Welcher, David C. Mcgowan, Huilin Zhao, Joseph L. Kim, Xiaotian Zhu, Holly L. Deak, Li Zhu, Yanyan Tudor, Ted Faust, Linda F. Epstein, Christina Boucher, Anu Gore, Deanna Mohn, Stephen Schneider, John Newcomb, Daniela Metz, Brad Henkle, Paul Gallant
المصدر: Journal of Medicinal Chemistry. 51:1681-1694
مصطلحات موضوعية: Lipopolysaccharides, Male, Models, Molecular, T-Lymphocytes, T cell, Lymphocyte, Administration, Oral, Crystallography, X-Ray, Rats, Sprague-Dawley, Mice, Structure-Activity Relationship, Drug Discovery, medicine, Animals, Humans, Structure–activity relationship, Protein Kinase Inhibitors, Cell Proliferation, Mice, Knockout, Mice, Inbred BALB C, Dose-Response Relationship, Drug, Molecular Structure, biology, Kinase, Chemistry, CD28, Stereoisomerism, Amides, Rats, Enzyme Activation, Killer Cells, Natural, Pyrimidines, medicine.anatomical_structure, Biochemistry, Lymphocyte Specific Protein Tyrosine Kinase p56(lck), Enzyme inhibitor, Drug Design, biology.protein, Interleukin-2, Molecular Medicine, Female, Signal transduction, Tyrosine kinase, Signal Transduction
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المؤلفون: Wendy Choy, Kristine Israelian, J. Joshua Smith, Simon Schenk, Siva Lavu, David P. Carney, Olivier Boss, Philip D. Lambert, Lei Jin, David J. Gagne, David A. Sinclair, Michael R. Jirousek, Andre Iffland, Amy V. Lynch, Jean Bemis, Roger Xie, Robert B. Perni, Pui Yee Ng, Hongying Yang, Jill C. Milne, Jeremy S. Disch, Chi B. Vu, Peter J. Elliott, Jerrold M. Olefsky, Christoph H. Westphal, Heidi Galonek, Oliver Medvedik, Joseph J. Nunes
المصدر: Nature. 450:712-716
مصطلحات موضوعية: Blood Glucose, Male, medicine.medical_specialty, medicine.medical_treatment, Calorie restriction, Adipose tissue, Resveratrol, Heterocyclic Compounds, 4 or More Rings, Article, Cell Line, Rats, Sprague-Dawley, Mice, chemistry.chemical_compound, SRT1720, Insulin resistance, Sirtuin 1, Catalytic Domain, Internal medicine, Stilbenes, medicine, Animals, Humans, Insulin, Sirtuins, Glucose homeostasis, Caloric Restriction, Multidisciplinary, biology, Acetylation, medicine.disease, Dietary Fats, Mitochondria, Rats, Rats, Zucker, Disease Models, Animal, Drosophila melanogaster, Endocrinology, Diabetes Mellitus, Type 2, chemistry, biology.protein, Allosteric Site, hormones, hormone substitutes, and hormone antagonists
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المؤلفون: Ryan White, David C. Mcgowan, Xiaotian Zhu, Matthew W. Martin, John Newcomb, John L. Buchanan, Theodore Faust, Faye Hsieh, Xin Huang, Erin F. DiMauro, Susan M. Turci, Christina Boucher, Stephen Schneider, Joseph J. Nunes, Jean Bemis, Josie H. Lee
المصدر: Bioorganic & Medicinal Chemistry Letters. 17:2299-2304
مصطلحات موضوعية: Pyridines, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Biochemistry, Chemical synthesis, Rats, Sprague-Dawley, Inhibitory Concentration 50, Structure-Activity Relationship, Pharmacokinetics, In vivo, Drug Discovery, Animals, Humans, Structure–activity relationship, Inhibitory concentration 50, Transferase, Amines, Protein Kinase Inhibitors, Molecular Biology, chemistry.chemical_classification, Chemistry, Organic Chemistry, In vitro, Rats, Enzyme, Lymphocyte Specific Protein Tyrosine Kinase p56(lck), Molecular Medicine
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المؤلفون: Joseph L. Kim, Xiaotian Zhu, William H. Buckner, Josie H. Lee, Vinod F. Patel, Lilly Chai, Antonio J. Oliveira-dos-Santos, Ryan White, Holly L. Deak, Brian L. Hodous, Joseph J. Nunes, John L. Buchanan, Paul E. Rose, Huilin Zhao, Andrew A. Welcher, Stephanie D. Geuns-Meyer, Linda F. Epstein, David Powers, Yan Gu, Stephen Schneider, Kurt Morgenstern, Anu Gore, Victor J. Cee, Yanyan Tudor, Ted Faust, Susan A. Tomlinson, Xin Huang, Erin F. DiMauro, Jean Bemis, Susan M. Turci, John Newcomb, David C. Mcgowan, Faye Hsieh, Brad Henkle, Deanna Mohn, Christina Boucher, Li Zhu, Matthew W. Martin, Paul Gallant, Craig E. Masse, Daniela Metz
المصدر: Journal of Medicinal Chemistry. 49:5671-5686
مصطلحات موضوعية: Male, Models, Molecular, T-Lymphocytes, T cell, Administration, Oral, Biological Availability, In Vitro Techniques, Pharmacology, Rats, Sprague-Dawley, Mice, Structure-Activity Relationship, Drug Discovery, medicine, Animals, Humans, Structure–activity relationship, Cells, Cultured, Cell Proliferation, Mice, Inbred BALB C, Tyrosine-protein kinase CSK, Tumor Necrosis Factor-alpha, Kinase, Chemistry, ZAP70, Anti-Inflammatory Agents, Non-Steroidal, T-cell receptor, CD28, Rats, medicine.anatomical_structure, Biochemistry, Lymphocyte Specific Protein Tyrosine Kinase p56(lck), Benzamides, Quinazolines, Interleukin-2, Molecular Medicine, Female, Signal transduction
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المؤلفون: Michael R. Jirousek, Robert B. Perni, Christoph H. Westphal, Hao Peng, Wei Wentao, Wendy Choy, Han Dai, Jill C. Milne, Jean Bemis, Chen Mao, Jianhua Cai, Yaobin Jiang, Lei Jin
المصدر: The Journal of biological chemistry. 284(36)
مصطلحات موضوعية: SIRT3, Acetate-CoA Ligase, Peptide, Biology, Biochemistry, Mitochondrial Proteins, Structure-Activity Relationship, Protein structure, Sirtuin 3, Humans, Sirtuins, Protein Structure, Quaternary, Molecular Biology, chemistry.chemical_classification, Substrate (chemistry), Isothermal titration calorimetry, Acetylation, Cell Biology, NAD, Mitochondria, chemistry, Protein Structure and Folding, Protein deacetylase, NAD+ kinase, Peptides, Protein Binding
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7546fd9a80c6df2e4c2a9c7a5a1c1bc
https://pubmed.ncbi.nlm.nih.gov/19535340
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