المؤلفون: Julia H Shin, Steven A. Gilbert, Vikram R. Rao, Betsy J. Barnes, Lih-Ling Lin, Ken Dower, Virginia Pascual, Bruce A. Jacobson, Iain Kilty, Jean J Beebe, Tatyana Andreyeva, Bruce L. Homer, Joanne Brodfuehrer, Weiyong Sun, Martin Hegen, Simeon Ramsey, M Nusrat Sharif, Margaret Fleming, Mera Tilley, Heng Liu, Aaron Winkler, Aiping Jiao, Saurav De, Shruti Athale, Peter T. Symanowicz, Ju Wang, Spencer I. Danto

المصدر: Arthritis & Rheumatology. 73:2206-2218

مصطلحات موضوعية: Lactams, Immunology, Arthritis, Inflammation, Peripheral blood mononuclear cell, Mice, Rheumatology, In vivo, Rheumatic Diseases, medicine, Animals, Humans, Immunology and Allergy, Kinase activity, skin and connective tissue diseases, Systemic lupus erythematosus, business.industry, Macrophages, Autoantibody, Dendritic Cells, Isoquinolines, medicine.disease, IRAK4, Arthritis, Experimental, Synoviocytes, Rats, Disease Models, Animal, Interleukin-1 Receptor-Associated Kinases, Leukocytes, Mononuclear, medicine.symptom, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cea4d3ef98a73e9f525a4ce2b040208a
https://doi.org/10.1002/art.41953

المؤلفون: Danese S; Gastrointestinal Immunopathology Lab and IBD Unit, Humanitas Clinical and Research Center and Humanitas University, Milan, Italy., Vermeire S; Department of Gastroenterology, University Hospitals Leuven, Leuven, Belgium., Hellstern P; Nature Coast Clinical Research, Inverness, Florida, USA., Panaccione R; Inflammatory Bowel Disease Clinic, University of Calgary, Calgary, Canada., Rogler G; Department of Gastroenterology and Hepatology, University of Zürich, Zürich, Switzerland., Fraser G; Division of Gastroenterology, Rabin Medical Center, University of Tel-Aviv, Petah Tikva, Israel., Kohn A; UOC Gastroenterologia, AO San Camillo Forlanini, Rome, Italy., Desreumaux P; Lille University School of Medicine, University of Lille, Inserm U995, Lille, France., Leong RW; Inflammatory Bowel Diseases Service, Concord Hospital, Sydney, New South Wales, Australia., Comer GM; Formerly of Worldwide Research and Development, Pfizer Inc, Cambridge, Massachusetts, USA., Cataldi F; Formerly of Worldwide Research and Development, Pfizer Inc, Cambridge, Massachusetts, USA., Banerjee A; Worldwide Research and Development, Pfizer Inc, Cambridge, Massachusetts, USA., Maguire MK; Worldwide Research and Development, Pfizer Inc, Collegeville, Pennsylvania, USA., Li C; Worldwide Research and Development, Pfizer Inc, Cambridge, Massachusetts, USA., Rath N; Worldwide Research and Development, Pfizer Inc, Collegeville, Pennsylvania, USA., Beebe J; Worldwide Research and Development, Pfizer Inc, Cambridge, Massachusetts, USA., Schreiber S; Department of Medicine I, Christian-Albrechts-University and University Hospital Schleswig-Holstein, Kiel, Germany.

المصدر: Gut [Gut] 2019 Jan; Vol. 68 (1), pp. 40-48. Date of Electronic Publication: 2017 Dec 15.

نوع المنشور: Clinical Trial, Phase II; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: British Medical Assn Country of Publication: England NLM ID: 2985108R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1468-3288 (Electronic) Linking ISSN: 00175749 NLM ISO Abbreviation: Gut Subsets: MEDLINE

مواضيع طبية MeSH: Antibodies, Monoclonal, Humanized/*therapeutic use , Crohn Disease/*drug therapy, Adolescent ; Adult ; Aged ; Antibodies, Monoclonal, Humanized/administration & dosage ; Antibodies, Monoclonal, Humanized/adverse effects ; Double-Blind Method ; Female ; Humans ; Male ; Middle Aged ; Severity of Illness Index ; Treatment Outcome

المؤلفون: Li C; Clinical Pharmacology/Pharmacometrics, Clinical Research, Pfizer Inc., Cambridge, MA, USA., Shoji S; Pharmacometrics/Clinical Pharmacology, Clinical Research, Pfizer Japan Inc., Yoyogi, Shibuya-ku, Tokyo, Japan., Beebe J; Clinical Research, Pfizer Inc., Cambridge, MA, USA.

المصدر: British journal of clinical pharmacology [Br J Clin Pharmacol] 2018 Sep; Vol. 84 (9), pp. 2059-2074. Date of Electronic Publication: 2018 Jun 25.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 7503323 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2125 (Electronic) Linking ISSN: 03065251 NLM ISO Abbreviation: Br J Clin Pharmacol Subsets: MEDLINE

مواضيع طبية MeSH: Models, Biological*, Antibodies, Monoclonal, Humanized/*pharmacokinetics , Autoimmune Diseases/*drug therapy , C-Reactive Protein/*analysis , Interleukin-6/*antagonists & inhibitors, Adult ; Aged ; Antibodies, Monoclonal, Humanized/administration & dosage ; Autoimmune Diseases/blood ; Autoimmune Diseases/immunology ; C-Reactive Protein/immunology ; Clinical Trials as Topic ; Dose-Response Relationship, Drug ; Female ; Healthy Volunteers ; Humans ; Interleukin-6/immunology ; Male ; Middle Aged ; Young Adult

المؤلفون: Wallace DJ; Division of Rheumatology, Cedars-Sinai Medical Center, Los Angeles, California, USA., Strand V; Division of Immunology/Rheumatology, Stanford University, Palo Alto, California, USA., Merrill JT; Department of Pharmacology, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA., Popa S; Republican Clinical Hospital, Chisinau, Moldova., Spindler AJ; Centro Medico Privado de Reumatologia, Tucuman, Argentina., Eimon A; CEMIC, Buenos Aires, Argentina., Petri M; Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Smolen JS; Division of Rheumatology, Department of Medicine 3, Medical University of Vienna, Vienna, Austria., Wajdula J; Pfizer Inc, Collegeville, Pennsylvania, USA., Christensen J; Pfizer Inc, Cambridge, Massachusetts, USA., Li C; Pfizer Inc, Cambridge, Massachusetts, USA., Diehl A; Pfizer Inc, Collegeville, Pennsylvania, USA., Vincent MS; Pfizer Inc, Cambridge, Massachusetts, USA., Beebe J; Pfizer Inc, Cambridge, Massachusetts, USA., Healey P; Pfizer Inc, Groton, Connecticut, USA., Sridharan S; PPD Inc, Rockville, Maryland, USA.

المصدر: Annals of the rheumatic diseases [Ann Rheum Dis] 2017 Mar; Vol. 76 (3), pp. 534-542. Date of Electronic Publication: 2016 Sep 26.

نوع المنشور: Clinical Trial, Phase II; Journal Article; Randomized Controlled Trial

بيانات الدورية: Publisher: BMJ Country of Publication: England NLM ID: 0372355 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1468-2060 (Electronic) Linking ISSN: 00034967 NLM ISO Abbreviation: Ann Rheum Dis Subsets: MEDLINE

مواضيع طبية MeSH: Antibodies, Monoclonal/*administration & dosage , Antibodies, Monoclonal/*adverse effects , Antibodies, Monoclonal, Humanized/*administration & dosage , Antibodies, Monoclonal, Humanized/*adverse effects , Interleukin-6/*antagonists & inhibitors , Lupus Erythematosus, Systemic/*drug therapy, Adult ; Diarrhea/chemically induced ; Female ; Headache/chemically induced ; Humans ; Injections, Subcutaneous ; Male ; Middle Aged ; Nausea/chemically induced ; Pulmonary Embolism/chemically induced ; Sepsis/chemically induced ; Severity of Illness Index ; Symptom Flare Up

المؤلفون: Pitha-Rowe I; Department of Pharmacology and Toxicology, Dartmouth Medical School, Hanover, New Hampshire 03755, USA., Petty WJ, Feng Q, Koza-Taylor PH, Dimattia DA, Pinder L, Dragnev KH, Memoli N, Memoli V, Turi T, Beebe J, Kitareewan S, Dmitrovsky E

المصدر: Cancer research [Cancer Res] 2004 Nov 01; Vol. 64 (21), pp. 8109-15.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.

بيانات الدورية: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 2984705R Publication Model: Print Cited Medium: Print ISSN: 0008-5472 (Print) Linking ISSN: 00085472 NLM ISO Abbreviation: Cancer Res Subsets: MEDLINE

مواضيع طبية MeSH: Anticarcinogenic Agents/*therapeutic use , Lung Neoplasms/*prevention & control , Tretinoin/*therapeutic use , Ubiquitin-Activating Enzymes/*genetics, Cell Line, Tumor ; Genes, Tumor Suppressor ; Humans ; Immunohistochemistry ; Lung Neoplasms/genetics ; Oligonucleotide Array Sequence Analysis ; Ubiquitin-Activating Enzymes/analysis ; Ubiquitin-Activating Enzymes/physiology