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المؤلفون: Dennis C. Koester, Vanessa M. Marx, Sarah Williams, Jan Jiricek, Maxime Dauphinais, Olivier René, Sarah L. Miller, Lei Zhang, Debjani Patra, Yen-Liang Chen, Harry Cheung, Jonathan Gable, Suresh B. Lakshminarayana, Colin Osborne, Jean-Rene Galarneau, Upendra Kulkarni, Wendy Richmond, Angela Bretz, Linda Xiao, Frantisek Supek, Christian Wiesmann, Srinivas Honnappa, Celine Be, Pascal Mäser, Marcel Kaiser, Ryan Ritchie, Michael P. Barrett, Thierry T. Diagana, Christopher Sarko, Srinivasa P. S. Rao
المصدر: Journal of Medicinal Chemistry. 65:11776-11787
مصطلحات موضوعية: Disease Models, Animal, Mice, Trypanosoma, Trypanosomiasis, African, Cryoelectron Microscopy, Drug Discovery, Quinolines, Animals, Humans, Molecular Medicine, Proteasome Inhibitors
وصف الملف: application/pdf
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المؤلفون: Veronica V. Rezelj, Audrey Fischer, Francesca Moretti, Romel Rosales, Olivier Schwartz, Jiankun Lyu, Francois Pognan, Andrew C. Kruse, Kris M. White, Marco Vignuzzi, Heiko Schadt, Ziyang Zhang, Henry R. O’Donnell, Michael Schotsaert, Kevan M. Shokat, Tia A. Tummino, Adolfo García-Sastre, Nevan J. Krogan, Jean-Rene Galarneau, Raveen Rathnasinghe, Blandine Monel, Benoit Fischer, Briana L. McGovern, Assaf Alon, Matthew J. O’Meara, Thomas Vallet, Brian K. Shoichet, Sonia Jangra, Laszlo Urban
المساهمون: University of California [San Francisco] (UC San Francisco), University of California (UC), Populations virales et Pathogenèse - Viral Populations and Pathogenesis, Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), Novartis Institutes for BioMedical Research (NIBR), University of Michigan [Ann Arbor], University of Michigan System, Virus et Immunité - Virus and immunity (CNRS-UMR3569), Icahn School of Medicine at Mount Sinai [New York] (MSSM), Harvard Medical School [Boston] (HMS), This work was supported by grants from the Defense Advanced Research Projects Agency (HR0011-19-2-0020 to B.K.S., N.J.K., A.G.-S., and K.M.S.), NIGMS R35GM122481 (to B.K.S.), National Institutes of Health (P50AI150476, U19AI135990, U19AI135972, R01AI143292, R01AI120694, P01AI063302, and R01AI122747 to N.J.K.), Excellence in Research Award (ERA) from the Laboratory for Genomics Research (LGR) (to N.J.K.), a collaboration between UCSF, UCB, and GSK (no. 133122P to N.J.K.), a Fast Grant for COVID-19 from the Emergent Ventures program at the Mercatus Center of George Mason University (to N.J.K.), funding from the Roddenberry Foundation (to N.J.K.), funding from F. Hoffmann–La Roche and Vir Biotechnology (to N.J.K.), gifts from QCRG philanthropic donors (to N.J.K.), funding from Institut Pasteur (to O.S. and M.V.), Urgence COVID-19 Fundraising Campaign of Institut Pasteur (to O.S. and M.V.), Labex IBEID (ANR-10-LABX-62-IBEID to O.S. and M.V.), ANR/FRM Flash Covid PROTEO-SARS-CoV-2 (to O.S.), IDISCOVR (to O.S.), National Institutes of Health (R01GM119185 to A.C.K.), partly supported by the Center for Research for Influenza Pathogenesis, a Center of Excellence for Influenza Research and Surveillance supported by the National Institute of Allergy and Infectious Diseases (contract no. HHSN272201400008C to A.G.-S.), a supplement to NIAID grant U19AI135972 and to DoD grant W81XWH-20-1-0270 (to A.G.-S.), a Fast Grant from the Mercatus Center (to A.G.-S.), the generous support of the JPB Foundation and the Open Philanthropy Project [research grant 2020-215611 (5384) to A.G.-S.], and anonymous donors (to A.G.-S.). Z.Z. is a Damon Runyon fellow supported by the Damon Runyon Cancer Research Foundation (DRG-2281-17)., We gratefully acknowledge the Région Ile-de-France (program DIM1Health) for the use of the Institut Pasteur imaging facility. We thank N. Aulner for assistance with image requisition and A. Danckaert for assistance with image analysis at Institut Pasteur, Paris. We thank R. Albrecht for support with the BSL3 facility and procedures at the Icahn School of Medicine at Mount Sinai, New York. We thank C. Hayden for the work with the transmission electron microscopy at Novartis. We thank T. R. O’Meara for reading the manuscript. We thank K. Obernier, M. Bouhaddou, and J. M. Fabius for contributions to the overall COVID-19 effort at QCRG., ANR-10-LABX-0062,IBEID,Integrative Biology of Emerging Infectious Diseases(2010), ANR-20-COVI-0059,PROTEO-SARS-CoV-2,Protéomique du SARS-CoV-2(2020)
المصدر: Science (New York, N.Y.)
Science (New York, N.Y.), vol 373, iss 6554
Science
Science, 2021, 373 (6554), pp.541-547. ⟨10.1126/science.abi4708⟩مصطلحات موضوعية: Drug, General Science & Technology, media_common.quotation_subject, Microbial Sensitivity Tests, Pharmacology, Lipidoses, Virus Replication, Amiodarone, Antiviral Agents, Article, Dose-Response Relationship, Mice, Surface-Active Agents, Cations, Chlorocebus aethiops, Animals, Humans, Medicine, Lung, Vero Cells, Phospholipids, Repurposing, media_common, Phospholipidosis, Multidisciplinary, Dose-Response Relationship, Drug, SARS-CoV-2, Drug discovery, business.industry, Drug Repositioning, COVID-19, Hydroxychloroquine, Molecular Pharmacology, COVID-19 Drug Treatment, Drug repositioning, Infectious Diseases, Good Health and Well Being, 5.1 Pharmaceuticals, A549 Cells, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, Female, Development of treatments and therapeutic interventions, business, medicine.drug
وصف الملف: application/pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e82c7138db547cd2c3c9cdbd9634a67d
https://doi.org/10.1126/science.abi4708 -
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المؤلفون: Sasmita Mishra, Vanessa L. Schumacher, Jean-Rene Galarneau, Chandrassegar Saravanan, Marielle Odin, Danielle L. Brown, Robert W. Dunstan
المصدر: Toxicologic Pathology. 45:983-1003
مصطلحات موضوعية: 040301 veterinary sciences, Computer science, Pathology field, Toxicology, Session (web analytics), Pathology and Forensic Medicine, Machine Learning, 0403 veterinary science, 03 medical and health sciences, Digital image, 0302 clinical medicine, Image Processing, Computer-Assisted, Pathology, Animals, Humans, Molecular Biology, Feature detection (computer vision), Molecular pathology, Digital pathology, 04 agricultural and veterinary sciences, Cell Biology, Data science, Rats, Workflow, Automatic image annotation, Evaluation Studies as Topic, 030220 oncology & carcinogenesis, Algorithms
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec158f041ff98121beb3c535bcf401b5
https://doi.org/10.1177/0192623317737468 -
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المؤلفون: Robert L. Hall, Emily K. Meseck, Jean-Rene Galarneau, Wenkui Li, Margaret Weaver
المصدر: Toxicologic pathology. 44(8)
مصطلحات موضوعية: 0301 basic medicine, Drug, Central Nervous System, Male, Vasculitis, media_common.quotation_subject, 030106 microbiology, Central nervous system, Pharmacology, Toxicology, Beagle, Pathology and Forensic Medicine, 03 medical and health sciences, Antimalarials, Dogs, Medicine, Animals, Molecular Biology, media_common, biology, Dose-Response Relationship, Drug, business.industry, NAPHTHOQUINE, Neurotoxicity, Plasmodium falciparum, Cell Biology, medicine.disease, biology.organism_classification, Immunohistochemistry, Toxicokinetics, medicine.anatomical_structure, 1-Naphthylamine, Liver, Toxicity, Immunology, Aminoquinolines, Female, business, Malaria
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2f5fc8f7524ce04d4616e1998a4248f
https://pubmed.ncbi.nlm.nih.gov/27834287 -
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المؤلفون: Giuseppe Palladino, Judit Markovits, Kathryn E Bowenkamp, Christine A. Shaw, Gene A. Palmer, Jean-Rene Galarneau, Gillis R. Otten, Nicholas Valiante, Philip R. Dormitzer, Kurt Swanson
المصدر: Vaccine. 31:306-312
مصطلحات موضوعية: Lung Diseases, viruses, Respiratory Syncytial Virus Infections, Disease, Antibodies, Virus, Immune system, Antigen, Immunity, Respiratory Syncytial Virus Vaccines, medicine, Animals, Sigmodontinae, Cotton rat, Antigens, Lung, Immunity, Cellular, Vaccines, General Veterinary, General Immunology and Microbiology, biology, business.industry, Respiratory disease, Public Health, Environmental and Occupational Health, virus diseases, respiratory system, biology.organism_classification, medicine.disease, Virology, Rats, Infectious Diseases, Immunization, Immunology, Molecular Medicine, Female, business
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المؤلفون: Keith Mansfield, James Trevaskis, Cheryl Spence, Jean-Rene Galarneau, Xiaosong Wang, Chandrassegar Saravanan, William A. Chutkow
المصدر: The FASEB Journal. 29
مصطلحات موضوعية: Pathology, medicine.medical_specialty, business.industry, Hyperplasia, medicine.disease, digestive system, Biochemistry, digestive system diseases, Cholangiocellular carcinoma, Genetics, medicine, Hepatic fibrosis, business, Molecular Biology, Myofibroblast, Biotechnology
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المؤلفون: Joseph Cruz, Chikwendu Ibebunjo, Michelle Broome, Sophie Brachat, Sabine Gutzwiller, Steven P. Gygi, QiCheng Ma, Christine Li, John K. Eash, Brigitte Fournier, David J. Glass, Tracee L. Kendall, Brian A. Clarke, Yunyu Zhang, Joel M. Chick, Zhidan Wu, Elizabeth Skuba, Judit Markovits, Michelle Steinkrauss, Jun Shi, Jean-Rene Galarneau, Chad Vickers
مصطلحات موضوعية: Male, Proteomics, Aging, Sarcopenia, Proteome, Neuromuscular Junction, Inflammation, Biology, Protein degradation, Mitochondrion, DNA, Mitochondrial, Neuromuscular junction, Rats, Sprague-Dawley, Gene expression, medicine, Animals, Muscle Strength, Muscle, Skeletal, Molecular Biology, Microarray analysis techniques, Reverse Transcriptase Polymerase Chain Reaction, Gene Expression Profiling, Cell Biology, Articles, medicine.disease, musculoskeletal system, Microarray Analysis, Molecular biology, Immunohistochemistry, Cell biology, Mitochondria, Rats, Up-Regulation, Gene expression profiling, medicine.anatomical_structure, Postmortem Changes, Linear Models, medicine.symptom, Energy Metabolism, Transcriptome, human activities, Signal Transduction
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84b22769308ebbe381f2179855585dcd
https://europepmc.org/articles/PMC3554128/ -
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المؤلفون: Katherine W. Calabro, Jean-Rene Galarneau, Irving J. Bigio, Allison Curtis, Thomas Krucker
المصدر: Biomedical Applications of Light Scattering V.
مصطلحات موضوعية: Elastic scattering, Materials science, integumentary system, business.industry, Scattering, Optical Biopsy, Light scattering, Melanin, Optics, In vivo, Mouse skin, sense organs, business, Spectroscopy, Biomedical engineering
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::ebe6456d4f03a13e955e71a5c5556c1e
https://doi.org/10.1117/12.880166 -
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المؤلفون: Jean-Rene Galarneau, Katherine W. Calabro, Thomas Krucker, Irving J. Bigio, Allison Curtis
المصدر: Journal of biomedical optics. 16(1)
مصطلحات موضوعية: Male, Materials science, Light, Biomedical Engineering, Mice, Nude, Absorption (skin), Biomaterials, Mice, Nuclear magnetic resonance, Optics, Sex Factors, Dermis, Species Specificity, Nephelometry and Turbidimetry, Skin Physiological Phenomena, medicine, Animals, Humans, Scattering, Radiation, Spectroscopy, Skin, Elastic scattering, Scattering, business.industry, Atomic and Molecular Physics, and Optics, Electronic, Optical and Magnetic Materials, Mice, Inbred C57BL, medicine.anatomical_structure, Attenuation coefficient, Mouse skin, Models, Animal, Elasticity Imaging Techniques, Female, Epidermis, business
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67f98e5cb846b2904be700ec486fa7cf
https://pubmed.ncbi.nlm.nih.gov/21280895 -
10Temporal variations of skin pigmentation in C57BL/6 mice affect optical bioluminescence quantitation
المؤلفون: Allison Curtis, Irving J. Bigio, Thomas Krucker, Jean-Rene Galarneau, Katherine W. Calabro
المصدر: Molecular Imaging and Biology
مصطلحات موضوعية: Male, Cancer Research, Pathology, medicine.medical_specialty, Optics and Photonics, Time Factors, Reflectance spectroscopy, Skin Pigmentation, Absorption (skin), Biology, Hair Removal, Signal, Optical imaging, Melanin, Mice, Imaging, Three-Dimensional, In vivo, medicine, Bioluminescence, Animals, Radiology, Nuclear Medicine and imaging, Luciferase, Skin, Medicine(all), Sex Characteristics, integumentary system, Phantoms, Imaging, Attenuation, Spectrum Analysis, Depilation, Mice, Inbred C57BL, Oncology, Luminescent Measurements, Biophysics, C57Bl/6 Mice, Female, sense organs, Ex vivo, Research Article