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المؤلفون: Jennifer M. Johnston, Karen O. Akinsanya, Jason E. Imbriglio, Noel Byrne, Hratch J. Zokian, Sookhee Ha, Scott P. Salowe, Hyewon Youm, George H. Addona, JeanMarie Lisnock, Vijayalakshmi Agnani, Deborah L. Zink, Kake Zhao, Gregory C. Adam, Yusheng Xiong, Brian K. Hubbard, Pravien Abeywickrema, John P. Caldwell, Yongcheng Huang, Jen Baysarowich, Peter Orth, Wonsuk Chang, Juncai Meng, Michael Kavana, James R. Tata, Whitney Lane Petrilli, Rui Liang, Gopal Parthasarathy, Xi Ai, Rachael E. Ford, Zhe Feng, Oksana C. Palyha, Edward DiNunzio, Stephen M. Soisson, Alison M. Strack, Jennifer M. Shipman, Roman S. Erdmann, Zhijian Lu, Sujata Sharma, Jun Lu
مصطلحات موضوعية: Models, Molecular, Thermal shift assay, Serine Proteinase Inhibitors, Clinical Biochemistry, Allosteric regulation, Drug Evaluation, Preclinical, Protein degradation, Ligands, 01 natural sciences, Biochemistry, Small Molecule Libraries, Drug Discovery, Humans, Molecular Biology, Pharmacology, Serine protease, biology, Molecular Structure, 010405 organic chemistry, Chemistry, PCSK9, Proprotein convertase, Ligand (biochemistry), Small molecule, 0104 chemical sciences, Proteolysis, biology.protein, Molecular Medicine, Kexin, Proprotein Convertase 9
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46333ceb2ad6ba949e70430572ed5675
https://doi.org/10.26434/chemrxiv.8800085 -
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المؤلفون: Shirly Pinto, Deodial Guiadeen, David X. Yang, Tianying Jian, Ravi P. Nargund, Donald M. Sperbeck, Tim Cernak, Qingmei Hong, James M. Balkovec, Christine C. Chung, Dong-Ming Shen, Jeffrey T. Kuethe, Sharon Tong, Pauline C. Ting, Judyann Wiltsie, Jack Gibson, Lisa M. Sonatore, Zhicai Wu, Ginger X. Yang, Michael Wolff, Judith N. Gorski, Robert J. DeVita, Yang Yu, Jian Liu, JeanMarie Lisnock, Zhong Lai, Shuwen He, Jianying Xiao, Jinqi Liu, Bindhu V. Karanam, Arto D. Krikorian, Kevin D. Dykstra, Maria Madeira
المصدر: ACS Medicinal Chemistry Letters. 5:1082-1087
مصطلحات موضوعية: Benzimidazole, Stereochemistry, Metabolite, Organic Chemistry, Pharmacology, Cyclohexanecarboxylic acid, Biology, Biochemistry, Ames test, chemistry.chemical_compound, chemistry, Free fraction, Drug Discovery, Moiety, Epimer, Selectivity
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المؤلفون: Yong Zhang, Jeffrey J. Hale, Andreas Verras, Shirly Pinto, Huaibing He, Zhu Shen, Urmi R. Bhatt, Elaine C. Tung, John S. Debenham, Matthew J. Clements, Dunlu Chen, Dong-Ming Shen, Wayne M. Geissler, Thomas H. Graham, JeanMarie Lisnock, Qing Chen, Suoyu Xu, Xiaohua Li, Margarita Garcia-Calvo, Wensheng Liu, Xinchun Tong, Judyann Wiltsie, Christina B. Madsen-Duggan, Jeffrey T. Kuethe
المصدر: Bioorganic & Medicinal Chemistry Letters. 23:6228-6233
مصطلحات موضوعية: Male, Oral dose, Cyclohexane, High-throughput screening, Clinical Biochemistry, Pharmaceutical Science, Carboxypeptidases, Pharmacology, Biochemistry, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Pharmacokinetics, Cyclohexanes, Drug Discovery, Animals, Obesity, Enzyme Inhibitors, Molecular Biology, Binding affinities, Serine protease, Molecular Structure, biology, Organic Chemistry, Mice, Inbred C57BL, Orally active, chemistry, biology.protein, Molecular Medicine, Ex vivo
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المؤلفون: Gaochao Zhou, Judyann Wiltsie, Jason M. Cox, Lisa Contino, Jaume Balsells, Martin Crook, Ling Xu, Joseph Clemas, Hong D. Chu, JeanMarie Lisnock, Jack Gibson, Christine Yang, Thomas Bateman, Zhicai Wu, Peter J. Sinclair, Beata Zamlynny, Hong C. Shen, Margarita Garcia-Calvo, Xinchun Tong, Alejandro Crespo, Patricia Brown
المصدر: Bioorganic & Medicinal Chemistry Letters. 23:4388-4392
مصطلحات موضوعية: Clinical Biochemistry, Drug Evaluation, Preclinical, Pharmaceutical Science, Pharmacology, Biochemistry, Structure-Activity Relationship, chemistry.chemical_compound, Mineralocorticoid receptor, Pharmacokinetics, Microsomes, Drug Discovery, Animals, Humans, Potency, Oxazoles, Molecular Biology, Mineralocorticoid Receptor Antagonists, Oxazolidinedione, Binding Sites, Chemistry, Organic Chemistry, Protein Structure, Tertiary, Rats, Molecular Docking Simulation, Receptors, Mineralocorticoid, Nuclear receptor, Molecular Medicine, Half-Life
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المؤلفون: David Won-Shik Kim, Ravi P. Nargund, Zhicai Wu, Maria Madeira, Jian Liu, JeanMarie Lisnock, Tianying Jian, Jeffrey T. Kuethe, Bindhu V. Karanam, Qingmei Hong, Dong-Ming Shen, Michael Wolff, Sharon Tong, Jack Gibson, Zhong Lai, Shirly Pinto, Deodial Guiadeen, Yang Yu, Donald M. Sperbeck, Beth Ann Murphy, James M. Balkovec, Christine C. Chung, Dunlu Chen, Judyann Wiltsie, Jinqi Liu, Xiaoli Chen, Shuwen He, Arto D. Krikorian, Lisa M. Sonatore, Pauline C. Ting, Judith N. Gorski, Robert J. DeVita, Ginger X. Yang
المصدر: ACS Medicinal Chemistry Letters. 4:773-778
مصطلحات موضوعية: Benzimidazole, Stereochemistry, Metabolite, Organic Chemistry, Cyclohexanecarboxylic acid, Biology, Biochemistry, chemistry.chemical_compound, chemistry, In vivo, Drug Discovery, Moiety, Epimer, Selectivity, Active metabolite
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المؤلفون: Xinchun Tong, Kun Liu, Margarita Garcia-Calvo, Lisa Contino, Joseph Clemas, Ellen K. Vande Bunte, Gaochao Zhou, Judyann Wiltsie, JeanMarie Lisnock, Patricia Brown, Dennis Leung, Peter J. Sinclair, Yi Pan, Xiuying Ma, Jack Gibson, Zhongxiang Sun, Ling Xu, Alejandro Crespo, Thomas Bateman, Anthony Ogawa, Nina Jochnowitz, Martin Crook, Ping Lan, Rudrajit Mal, Beata Zamlynny
المصدر: Bioorganicmedicinal chemistry letters. 26(12)
مصطلحات موضوعية: 0301 basic medicine, Indoles, Clinical Biochemistry, Pharmaceutical Science, Pharmacology, 01 natural sciences, Biochemistry, Non steroidal, Natriuresis, 03 medical and health sciences, chemistry.chemical_compound, Structure-Activity Relationship, Mineralocorticoid receptor, Drug Discovery, medicine, Humans, Molecular Biology, Mineralocorticoid Receptor Antagonists, Indole test, Dose-Response Relationship, Drug, Molecular Structure, 010405 organic chemistry, Organic Chemistry, Rodent model, 0104 chemical sciences, Eplerenone, 030104 developmental biology, Receptors, Mineralocorticoid, chemistry, Spironolactone, Molecular Medicine, medicine.drug
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المؤلفون: Liwen Zhang, Steven S. Mundt, Ling Gao, Melba Hernandez, Yuchen Zhou, Amber Ying Zhu, Xiang-qing Li, Edward A. O'Neill, Oscar Puig, Bruce L. Daugherty, JeanMarie Lisnock, Magdalena Alonso-Galicia, Martin S. Springer
المصدر: Transgenic Research. 21:633-644
مصطلحات موضوعية: Male, Transcriptional Activation, Genetically modified mouse, medicine.medical_specialty, Adipose tissue macrophages, Adipose tissue, Blood Pressure, Mice, Transgenic, Inflammation, DNA Fragmentation, Biology, Transfection, Mice, Insulin resistance, 3T3-L1 Cells, Internal medicine, 11-beta-Hydroxysteroid Dehydrogenase Type 1, Genetics, medicine, Animals, Transgenes, Metabolic Syndrome, Gene Expression Profiling, Muscles, Lipid metabolism, Tetracycline, Lipid Metabolism, medicine.disease, Chromosomes, Mammalian, Fatty Liver, Phenotype, Endocrinology, Adipose Tissue, Trans-Activators, Animal Science and Zoology, Insulin Resistance, medicine.symptom, Metabolic syndrome, Steatosis, Agronomy and Crop Science, Biotechnology
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المؤلفون: Vladimir N. Maiorov, Robert J. DeVita, JeanMarie Lisnock, Roger Meurer, Margarita Garcia-Calvo, Daniel R. McMasters, Herbert G. Bull, Margaret E. McCann, Kobporn L. Howell
المصدر: Bioorganic & Medicinal Chemistry Letters. 19:2965-2968
مصطلحات موضوعية: Swine, Stereochemistry, Guinea Pigs, Clinical Biochemistry, Molecular Conformation, Pharmaceutical Science, Computational biology, Imidazolidines, Biochemistry, Molecular conformation, Dogs, Similarity (network science), Cricetinae, Drug Discovery, Animals, Humans, Spiro Compounds, Molecular Biology, Virtual screening, Chemistry, Anticholesteremic Agents, Ligand binding assay, Organic Chemistry, Membrane Proteins, Membrane Transport Proteins, Macaca mulatta, Rats, Models, Chemical, Drug Design, Molecular Medicine, Software, Three dimensional model
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المؤلفون: Beata Zamlynny, Patricia Brown, Sheng Gao, Xiuying Ma, Jaume Balsells, Christine Yang, Gaochao Zhou, Thomas Bateman, Peter J. Sinclair, Ling Xu, Alejandro Crespo, Judyann Wiltsie, Jack Gibson, Martin Crook, Hong C. Shen, Hong D. Chu, Vincent Tong, Joseph Clemas, Margarita Garcia-Calvo, Jason M. Cox, Lisa Contino, JeanMarie Lisnock
المصدر: ACS medicinal chemistry letters. 6(4)
مصطلحات موضوعية: Benzimidazole, Oxazolidinedione, Organic Chemistry, Antagonist, Pharmacology, Biochemistry, Natriuresis, chemistry.chemical_compound, Mineralocorticoid receptor, chemistry, Pharmacokinetics, Drug Discovery, Spironolactone, Microsome
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المصدر: Chemistry & Biology. 10(8):705-712
مصطلحات موضوعية: Pharmacology, Kinase, MAPKAPK2, MAPK7, Clinical Biochemistry, General Medicine, MAP2K2, Biology, Small molecule, Biochemistry, MAP2K7, Drug Discovery, Molecular Medicine, Signal transduction, Molecular Biology, MAPK14