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1
المؤلفون: Ghotas Evindar, Amy Hutchings, Jeanine Lorusso, Albion D. Wright, Michael Kelley, Sylvie G. Bernier, Keith Halley, Barry A. Morgan, William F. Westlin, Elisabeth Doyle, Nazbeh Taghizadeh, Gerhard Hannig, Alexander L. Satz, Malcolm J. Kavarana, Ashis K. Saha
المصدر: Bioorganic & Medicinal Chemistry Letters. 19:2315-2319
مصطلحات موضوعية: Agonist, medicine.drug_class, Sphingosine-1-phosphate receptor, Clinical Biochemistry, Drug Evaluation, Preclinical, Pharmaceutical Science, Biochemistry, Chemical synthesis, Mice, chemistry.chemical_compound, Sphingosine, In vivo, Drug Discovery, medicine, Animals, Potency, Sphingosine-1-phosphate, Receptor, Molecular Biology, Dose-Response Relationship, Drug, Fingolimod Hydrochloride, Chemistry, Organic Chemistry, Imidazoles, Amides, In vitro, Protein Subunits, Receptors, Lysosphingolipid, Propylene Glycols, Molecular Medicine
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2
المؤلفون: Hongfeng Deng, Jeanine Lorusso, Ghotas Evindar, Barry A. Morgan, William F. Westlin, Sylvie G. Bernier, Elisabeth Doyle
المصدر: ACS medicinal chemistry letters. 4(10)
مصطلحات موضوعية: Agonist, business.industry, medicine.drug_class, Organic Chemistry, Prodrug, Pharmacology, Biochemistry, In vitro, Bioavailability, Pharmacokinetics, In vivo, Pharmacodynamics, Drug Discovery, Medicine, business, ADME
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3
المؤلفون: William F. Westlin, Jeanine Lorusso, Barry A. Morgan, Ghotas Evindar, Elisabeth Doyle, Sylvie G. Bernier, Hongfeng Deng
المصدر: Bioorganicmedicinal chemistry letters. 23(2)
مصطلحات موضوعية: Stereochemistry, Sphingosine-1-phosphate receptor, Clinical Biochemistry, Pharmaceutical Science, Administration, Oral, Biochemistry, chemistry.chemical_compound, Inhibitory Concentration 50, Mice, In vivo, Lymphopenia, Drug Discovery, Moiety, Inhibitory concentration 50, Animals, Carboxylate, Amino Acids, Receptor, Molecular Biology, chemistry.chemical_classification, Molecular Structure, Organic Chemistry, Amino acid, Receptors, Lysosphingolipid, chemistry, Molecular Medicine, Selectivity, Protein Binding
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4
المؤلفون: Elisabeth Doyle, Sylvie G. Bernier, Jeanine Lorusso, Barry A. Morgan, Gerhard Hannig, Ashis K. Saha, Ghotas Evindar, Malcolm J. Kavarana, William F. Westlin, Heather S. Blanchette, Alexander L. Satz
المصدر: Bioorganicmedicinal chemistry letters. 20(8)
مصطلحات موضوعية: Chemistry, Sphingosine-1-phosphate receptor, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, Administration, Oral, Pharmacology, Biochemistry, Amino Alcohols, Mice, Receptors, Lysosphingolipid, Structure-Activity Relationship, In vivo, Oral administration, Drug Discovery, Molecular Medicine, Moiety, Potency, Animals, Pharmacophore, Selectivity, Receptor, Molecular Biology
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5
المؤلفون: Albion D. Wright, Ashis K. Saha, Jeanine Lorusso, Michael Kelley, Ghotas Evindar, Barry A. Morgan, Elisabeth Doyle, Amy Hutchings, Malcolm J. Kavarana, William F. Westlin, Gerhard Hannig, Sylvie G. Bernier, Keith Halley
المصدر: Bioorganicmedicinal chemistry letters. 19(2)
مصطلحات موضوعية: Stereochemistry, Sphingosine-1-phosphate receptor, Clinical Biochemistry, Pharmaceutical Science, Biochemistry, chemistry.chemical_compound, Mice, Structure-Activity Relationship, In vivo, Drug Discovery, Molecule, Animals, Humans, Sphingosine-1-phosphate, Receptor, Molecular Biology, Dose-Response Relationship, Drug, Chemistry, Organic Chemistry, Imidazoles, Amides, Receptors, Lysosphingolipid, Alkoxy group, Molecular Medicine, Selectivity
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6
المؤلفون: Jennifer G. Hoyt, Beth Doyle, Sylvie G. Bernier, Russell Karp, Edward A. Clark, William F. Westlin, Jeanine Lorusso, Gerhard Hannig
المصدر: Arthritis and rheumatism. 56(3)
مصطلحات موضوعية: Pathology, medicine.medical_specialty, Immunology, Arthritis, Osteoclasts, Inflammation, Peptidoglycan, Pharmacology, Aminopeptidases, Severity of Illness Index, Bone resorption, Arthritis, Rheumatoid, Rheumatology, In vivo, Osteoclast, Polysaccharides, medicine, Immunology and Allergy, Animals, Humans, Pharmacology (medical), Bone Resorption, Enzyme Inhibitors, Cells, Cultured, Glycoproteins, Cartilage oligomeric matrix protein, biology, business.industry, Cartilage, Cell Differentiation, Valine, medicine.disease, Rats, Disease Models, Animal, medicine.anatomical_structure, Rats, Inbred Lew, Rheumatoid arthritis, biology.protein, Epoxy Compounds, Female, Joints, medicine.symptom, business
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7
المؤلفون: Gerhard, Hannig, Douglas D, Lazarus, Sylvie G, Bernier, Russell M, Karp, Jeanine, Lorusso, Daniel, Qiu, Matthew T, Labenski, Jim D, Wakefield, Charles D, Thompson, William F, Westlin
المصدر: International journal of oncology. 28(4)
مصطلحات موضوعية: Cyclin-Dependent Kinase Inhibitor p21, Male, Melanins, Dose-Response Relationship, Drug, Blotting, Western, Melanoma, Experimental, Administration, Oral, Valine, Aminopeptidases, Cell Line, Mice, Inbred C57BL, Mice, Cell Line, Tumor, Animals, Epoxy Compounds, Humans, Methionyl Aminopeptidases, Cell Proliferation, Glycoproteins
URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::212705018d08a4fd526a59fe86fd9986
https://pubmed.ncbi.nlm.nih.gov/16525646 -
8
المؤلفون: Kristan Meetze, Samantha Perino, Alisa C. Bell, William Winston, Heidi Okamura, Jeno Gyuris, Joelle Brodeur, Adrian Cooper, Ronan C. O'hagan, David Keane, Jeanine Lorusso, William M. Rideout
المصدر: Cancer Research. 70:5170-5170
مصطلحات موضوعية: Cancer Research, Angiogenesis, medicine.drug_class, Notch signaling pathway, Cancer, Biology, medicine.disease, medicine.disease_cause, Monoclonal antibody, Oncology, Hes3 signaling axis, Immunology, medicine, Cancer research, Cyclin-dependent kinase 8, Receptor, Carcinogenesis
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::96830de5963bdf6c881987d01c9b4eb6
https://doi.org/10.1158/1538-7445.am10-5170 -
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المؤلفون: Heidi Okamura, Ronan C. O'hagan, Jeno Gyuris, David Keane, Jeanine Lorusso, Alisa C. Bell, Samantha Perino
المصدر: Cancer Research. 69:A73-A73
مصطلحات موضوعية: Cancer Research, Cell type, Cell signaling, Oncology, Notch proteins, Hes3 signaling axis, Notch signaling pathway, Cyclin-dependent kinase 8, Context (language use), Biology, Receptor, Cell biology
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::8ccde097ab70df3b7a1b7b4b33956ac2
https://doi.org/10.1158/0008-5472.fbcr09-a73