يعرض 1 - 10 نتائج من 14 نتيجة بحث عن '"Jeff, Keats"', وقت الاستعلام: 1.25s تنقيح النتائج
  1. 1
    Data from The Potent ALK Inhibitor Brigatinib (AP26113) Overcomes Mechanisms of Resistance to First- and Second-Generation ALK Inhibitors in Preclinical Models

    المؤلفون: Victor M. Rivera, William C. Shakespeare, David Dalgarno, Tim Clackson, Xiaotian Zhu, Juan Miret, Frank Wang, Narayana Narasimhan, Emily Ye, Hyun Gyung Jang, Qurish Mohemmad, Yihan Wang, Dong Zou, Shuangying Liu, Wei-Sheng Huang, Lauren Moran, Lindsey Eichinger, Youngchul Song, David Miller, Scott D. Wardwell, Yaoyu Ning, Jeff Keats, Tianjun Zhou, Sara Nadworny, Rachel Squillace, Rana Anjum, Sen Zhang

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5126f7a2057f9c47635f6496d280ebf0
    https://doi.org/10.1158/1078-0432.c.6525524.v1

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  2. 2
    Supplementary Methods, Supplementary Results, Supplementary Table 1, Supplementary Figures 1-8 from The Potent ALK Inhibitor Brigatinib (AP26113) Overcomes Mechanisms of Resistance to First- and Second-Generation ALK Inhibitors in Preclinical Models

    المؤلفون: Victor M. Rivera, William C. Shakespeare, David Dalgarno, Tim Clackson, Xiaotian Zhu, Juan Miret, Frank Wang, Narayana Narasimhan, Emily Ye, Hyun Gyung Jang, Qurish Mohemmad, Yihan Wang, Dong Zou, Shuangying Liu, Wei-Sheng Huang, Lauren Moran, Lindsey Eichinger, Youngchul Song, David Miller, Scott D. Wardwell, Yaoyu Ning, Jeff Keats, Tianjun Zhou, Sara Nadworny, Rachel Squillace, Rana Anjum, Sen Zhang

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c6bdb6961073a5b3e650ddfb94203a6
    https://doi.org/10.1158/1078-0432.22463789.v1

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  3. 3
    The Potent ALK Inhibitor Brigatinib (AP26113) Overcomes Mechanisms of Resistance to First- and Second-Generation ALK Inhibitors in Preclinical Models

    المؤلفون: Lauren Moran, Wei-Sheng Huang, Yaoyu Ning, Dong Zou, Scott Wardwell, Emily Y. Ye, Frank Wang, Rachel M. Squillace, Lindsey W. Eichinger, Victor M. Rivera, Jeff Keats, Sen Zhang, William C. Shakespeare, Yihan Wang, Sara Nadworny, Shuangying Liu, Tianjun Zhou, Youngchul Song, Xiaotian Zhu, Tim Clackson, David Miller, Hyun Gyung Jang, Narayana I. Narasimhan, Rana Anjum, David C. Dalgarno, Qurish K. Mohemmad, Juan J. Miret

    المصدر: Clinical cancer research : an official journal of the American Association for Cancer Research. 22(22)

    مصطلحات موضوعية: 0301 basic medicine, Alectinib, Cancer Research, Lung Neoplasms, Brigatinib, medicine.drug_class, Pyridines, Antineoplastic Agents, Biology, 03 medical and health sciences, 0302 clinical medicine, Organophosphorus Compounds, Crizotinib, hemic and lymphatic diseases, Carcinoma, Non-Small-Cell Lung, Cell Line, Tumor, medicine, ROS1, Anaplastic lymphoma kinase, Humans, Anaplastic Lymphoma Kinase, Sulfones, Protein Kinase Inhibitors, Ceritinib, ALK Gene Rearrangement, Receptor Protein-Tyrosine Kinases, Hep G2 Cells, U937 Cells, ALK inhibitor, 030104 developmental biology, Pyrimidines, Oncology, Biochemistry, Drug Resistance, Neoplasm, 030220 oncology & carcinogenesis, Mutation, Cancer research, Pyrazoles, medicine.drug

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a954184cf0503cf7aa96ae269a34c3cb
    https://pubmed.ncbi.nlm.nih.gov/27780853

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  4. 4
    Discovery of 5-(arenethynyl) hetero-monocyclic derivatives as potent inhibitors of BCR–ABL including the T315I gatekeeper mutant

    المؤلفون: Xiaotian Zhu, Dong Zou, Chester A. Metcalf, Raji Sundaramoorthi, Frank Wang, Feng Li, Jan Romero, John Iuliucci, Lois Commodore, Shuangying Liu, Wei-Sheng Huang, Lisi Cai, Qihong Xu, Jeff Keats, Tim Clackson, David C. Dalgarno, Joseph Snodgrass, Jiwei Qi, Yihan Wang, Victor M. Rivera, Mathew Thomas, Ingrid Chen, Tianjun Zhou, Yaoyu Ning, David Wen, Tomi K. Sawyer, Karin Russian, William C. Shakespeare, Marc I Broudy, Scott Wardwell

    المصدر: Bioorganic & Medicinal Chemistry Letters. 21:3743-3748

    مصطلحات موضوعية: Models, Molecular, medicine.drug_class, Stereochemistry, Clinical Biochemistry, Mutant, Fusion Proteins, bcr-abl, Administration, Oral, Pharmaceutical Science, Carboxamide, Biochemistry, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, hemic and lymphatic diseases, Drug Discovery, medicine, Animals, Molecular Biology, Aniline Compounds, Molecular Structure, biology, Chemistry, Organic Chemistry, Ponatinib, Biological activity, medicine.disease, In vitro, Rats, Disease Models, Animal, Cyclization, Enzyme inhibitor, Alkynes, Mutation, biology.protein, Molecular Medicine, Linker, Toluene, Chronic myelogenous leukemia

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66a38549836ca328c6bb343c0b0ec0da
    https://doi.org/10.1016/j.bmcl.2011.04.060

    View record from ScienceDirect
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  5. 5
    Structural Mechanism of the Pan-BCR-ABL Inhibitor Ponatinib (AP24534): Lessons for Overcoming Kinase Inhibitor Resistance

    المؤلفون: Jeff Keats, Xiaotian Zhu, David C. Dalgarno, Tianjun Zhou, Victor M. Rivera, Lois Commodore, Tim Clackson, William C. Shakespeare, Wei-Sheng Huang, Yihan Wang, Qihong Xu, Mathew Thomas

    المصدر: Chemical Biology & Drug Design. 77:1-11

    مصطلحات موضوعية: Pharmacology, Mutation, Drug discovery, Organic Chemistry, Ponatinib, Myeloid leukemia, Imatinib, Biology, Gene mutation, medicine.disease_cause, Biochemistry, chemistry.chemical_compound, Imatinib mesylate, chemistry, Protein kinase domain, hemic and lymphatic diseases, Drug Discovery, medicine, Cancer research, Molecular Medicine, medicine.drug

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::a6904224cb66a2b48d697f235b5445b9
    https://doi.org/10.1111/j.1747-0285.2010.01054.x

    View record at Wiley
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  6. 6
    Discovery of 3-[2-(Imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide (AP24534), a Potent, Orally Active Pan-Inhibitor of Breakpoint Cluster Region-Abelson (BCR-ABL) Kinase Including the T315I Gatekeeper Mutant

    المؤلفون: Yaoyu Ning, Chester A. Metcalf, Lois Commodore, Jan Romero, Scott Wardwell, Tomi K. Sawyer, Yihan Wang, Qurish K. Mohemmad, Scott Paul Lentini, Ingrid Chen, Victor M. Rivera, Karin Russian, Geetha Banda, Sasmita Das, Narayana I. Narasimhan, Xiaotian Zhu, Raji Sundaramoorthi, Lisi Cai, Tianjun Zhou, Jeff Keats, Frank Wang, Tim Clackson, Qihong Xu, Jiwei Qi, David Wen, Joseph Snodgrass, Shuangying Liu, William C. Shakespeare, R. Mathew Thomas, Marc I Broudy, John Iuliucci, Wei-Sheng Huang, David C. Dalgarno, Dong Zou

    المصدر: Journal of Medicinal Chemistry. 53:4701-4719

    مصطلحات موضوعية: Models, Molecular, Mutant, Fusion Proteins, bcr-abl, Administration, Oral, Antineoplastic Agents, Mice, SCID, Pharmacology, Crystallography, X-Ray, Mice, chemistry.chemical_compound, Cell Line, Tumor, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, hemic and lymphatic diseases, Drug Discovery, medicine, Animals, Kinase activity, Benzamide, Protein Kinase Inhibitors, ADME, Kinase, Chemistry, Imidazoles, breakpoint cluster region, Myeloid leukemia, medicine.disease, Rats, Pyridazines, Leukemia, Blood-Brain Barrier, Mutation, Molecular Medicine, Drug Screening Assays, Antitumor

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::757a483ca43d6a44106283733dc26b6a
    https://doi.org/10.1021/jm100395q

    Find this issue from the American Chemical Society
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  7. 7
    9-(Arenethenyl)purines as Dual Src/Abl Kinase Inhibitors Targeting the Inactive Conformation: Design, Synthesis, and Biological Evaluation

    المؤلفون: Jeff Keats, Marc I Broudy, John Iuliucci, Scott Wardwell, Karin Russian, Sasmita Das, Yaoyu Ning, Scott Paul Lentini, Yihan Wang, David Wen, William C. Shakespeare, Joseph Snodgrass, Tomi K. Sawyer, David C. Dalgarno, R. Mathew Thomas, Xiaotian Zhu, Mohammad Azam, Shuangying Liu, George Q. Daley, Wei-Sheng Huang, Raji Sundaramoorthi, Tim Clackson, Geetha Banda, Qihong Xu, Frank Wang

    المصدر: Journal of Medicinal Chemistry. 52:4743-4756

    مصطلحات موضوعية: Protein Conformation, Pharmacology, Mice, Structure-Activity Relationship, In vivo, hemic and lymphatic diseases, Drug Discovery, Animals, Humans, Proto-Oncogene Proteins c-abl, Protein Kinase Inhibitors, ABL, biology, Kinase, Chemistry, Wild type, Myeloid leukemia, Rats, src-Family Kinases, Purines, Enzyme inhibitor, Drug Design, NIH 3T3 Cells, biology.protein, Molecular Medicine, Female, K562 Cells, Proto-oncogene tyrosine-protein kinase Src, K562 cells

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15c4c8fc144dc20cf0e38dd91c2a9789
    https://doi.org/10.1021/jm900166t

    Find this issue from the American Chemical Society
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  8. 8
    SAR of Carbon-Linked, 2-Substituted Purines: Synthesis and Characterization of AP23451 as a novel Bone-Targeted Inhibitor of Src Tyrosine Kinase With In Vivo Anti-Resorptive Activity

    المؤلفون: Selvi Pradeepan, Chet Metcalf, Brendan F. Boyce, Shuangying Liu, Manfred Weigele, Surinder S. Narula, Regine S. Bohacek, Lianping Xing, Raji Sundaramoorthi, Jeff Keats, Julie Bogus, Jennifer Saltmarsh, Yihan Wang, Scott Wardwell, Mary K. Ram, David C. Dalgarno, John Iuliucci, Susan Adams, Guru Paramanathan, Shuenn Liou, Marie Rose van Schravendijk, Anne Dilauro, Sonya Roeloffzen, T. Keenan, William C. Shakespeare, Tomi K. Sawyer

    المصدر: Chemical Biology & Drug Design. 71:97-105

    مصطلحات موضوعية: Organophosphonates, Crystallography, X-Ray, Biochemistry, Bone resorption, Inhibitory Concentration 50, Structure-Activity Relationship, Drug Delivery Systems, In vivo, Drug Discovery, Humans, Structure–activity relationship, Bone Resorption, Enzyme Inhibitors, Purine metabolism, IC50, Pharmacology, Tyrosine-protein kinase CSK, Molecular Structure, Chemistry, Adenine, Organic Chemistry, Phosphinic Acids, src-Family Kinases, Parathyroid Hormone, Purines, Hypercalcemia, Osteoporosis, Molecular Medicine, Tyrosine kinase, Proto-oncogene tyrosine-protein kinase Src

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dcdeae0a92758c4ad04f2c1f5760a13
    https://doi.org/10.1111/j.1747-0285.2007.00615.x

    View record at Wiley
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  9. 9
    Abstract C12: Identification of biomarkers and pathways associated with response to the DOT1L inhibitor Pinometostat (EPZ-5676) in MLL-r leukemia

    المؤلفون: Brad Patay, Andrew Carson, Ty M. Thomson, Christine Klaus, Jeff Keats, Alejandra Raimondi, Stephen J. Blakemore, David A. Drubin, Guillermo Garcia-Manero, Alice McDonald, Scott R. Daigle, David A. Rizzieri, Jesus G. Berdeja, Blythe Thomson, Raoul Tibes, Michael J. Maria, Eytan M. Stein

    المصدر: Molecular Cancer Therapeutics. 14:C12-C12

    مصطلحات موضوعية: Genetics, Cancer Research, Messenger RNA, Cell growth, Cancer, RNA, Biology, medicine.disease, Peripheral blood mononuclear cell, Molecular biology, In vitro, Leukemia, chemistry.chemical_compound, Oncology, chemistry, medicine, DNA

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::21f67bbb3a78ed9afaeb069fed211a31
    https://doi.org/10.1158/1535-7163.targ-15-c12

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  10. 10
    Structural mechanism of the Pan-BCR-ABL inhibitor ponatinib (AP24534): lessons for overcoming kinase inhibitor resistance

    المؤلفون: Tianjun, Zhou, Lois, Commodore, Wei-Sheng, Huang, Yihan, Wang, Mathew, Thomas, Jeff, Keats, Qihong, Xu, Victor M, Rivera, William C, Shakespeare, Tim, Clackson, David C, Dalgarno, Xiaotian, Zhu

    المصدر: Chemical biologydrug design. 77(1)

    مصطلحات موضوعية: Fluoroimmunoassay, Fusion Proteins, bcr-abl, Imidazoles, Crystallography, X-Ray, Piperazines, Pyridazines, Mice, Structure-Activity Relationship, Pyrimidines, Drug Resistance, Neoplasm, Cell Line, Tumor, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, Benzamides, Mutation, Imatinib Mesylate, Animals, Protein Kinase Inhibitors, Protein Binding

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::739c760a305560829f128dd173833ac1
    https://pubmed.ncbi.nlm.nih.gov/21118377

    View record at Wiley
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