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1
المؤلفون: Jean-Marc Lapierre, Cathy O. Bull, Ronald E. Savage, Sudharshan Eathiraj, David Vensel, Sapna Makhija, Eugene Kelleher, Neil Westlund, Jeff Szwaya, Yanbin Liu, Steffi Koerner, Magdi Moussa, Susan Cornell-Kennon, Akihisa Matsuda, Darin Kizer, Nivedita Namdev, Hui Wu, Shin Iimura, Brian Schwartz, Erika Volckova
المصدر: Journal of Medicinal Chemistry. 59:6455-6469
مصطلحات موضوعية: 0301 basic medicine, Stereochemistry, Allosteric regulation, Administration, Oral, Aminopyridines, AKT1, Antineoplastic Agents, AKT2, Mice, Structure-Activity Relationship, 03 medical and health sciences, 0302 clinical medicine, Allosteric Regulation, Drug Discovery, Animals, Humans, Moiety, Protein Kinase Inhibitors, Protein kinase B, Cell Proliferation, chemistry.chemical_classification, Dose-Response Relationship, Drug, Molecular Structure, Kinase, Imidazoles, Neoplasms, Experimental, Endometrial Neoplasms, 030104 developmental biology, Enzyme, chemistry, 030220 oncology & carcinogenesis, embryonic structures, Molecular Medicine, Phosphorylation, Female, Drug Screening Assays, Antitumor, Carcinoma, Endometrioid, Proto-Oncogene Proteins c-akt
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2
المؤلفون: Mark A. Ashwell, Jean-Marc Lapierre, Christopher Brassard, Karen Bresciano, Cathy Bull, Susan Cornell-Kennon, Sudharshan Eathiraj, Dennis S. France, Terence Hall, Jason Hill, Eoin Kelleher, Sampada Khanapurkar, Darin Kizer, Steffi Koerner, Jeff Link, Yanbin Liu, Sapna Makhija, Magdi Moussa, Nivedita Namdev, Khanh Nguyen, Robert Nicewonger, Rocio Palma, Jeff Szwaya, Manish Tandon, Uma Uppalapati, David Vensel, Laurie P. Volak, Erika Volckova, Neil Westlund, Hui Wu, Rui-Yang Yang, Thomas C. K. Chan
المصدر: Journal of Medicinal Chemistry. 55:5291-5310
مصطلحات موضوعية: Models, Molecular, Protein Conformation, Pyridines, Administration, Oral, Biological Availability, AKT1, Antineoplastic Agents, Plasma protein binding, Pharmacology, Crystallography, X-Ray, Mice, Structure-Activity Relationship, Adenosine Triphosphate, In vivo, Catalytic Domain, Cell Line, Tumor, Drug Discovery, Animals, Humans, Structure–activity relationship, Phosphorylation, Protein kinase B, Adaptor Proteins, Signal Transducing, Cell Proliferation, Effector, Chemistry, Imidazoles, Ribosomal Protein S6 Kinases, 70-kDa, Small molecule, Biochemistry, Microsomes, Liver, Molecular Medicine, Proto-Oncogene Proteins c-akt, Protein Binding
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3
المؤلفون: Mark Manfredi, Jeff Szwaya, Rachael L. Brake, Xin Guo, Natasha Iartchouk, Michael Fitzgerald, Keisuke Kuida, Robyn Fabrey, F. Zohren
المصدر: Molecular Cancer Therapeutics. 12:C176-C176
مصطلحات موضوعية: Cancer Research, Oncology, Chemistry, Kinase, Ribosomal protein s6, Phosphorylation, P70-S6 Kinase 1, mTORC1, Pharmacology, Signal transduction, Protein kinase B, PI3K/AKT/mTOR pathway
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::c2766230b69afc65d70f05d72fa7a957
https://doi.org/10.1158/1535-7163.targ-13-c176 -
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المؤلفون: Keli Song, Rachael L. Brake, Michael Fitzgerald, Erik Koenig, Natasha Iartchouk, Yueying Cao, Dong Mei Zhang, Pooja Shah, Jeff Szwaya
المصدر: Molecular Cancer Therapeutics. 12:A169-A169
مصطلحات موضوعية: Cancer Research, Point mutation, Mutant, Biology, P110α, Bioinformatics, medicine.disease_cause, Oncology, In vivo, Genotype, Cancer research, biology.protein, medicine, PTEN, KRAS, PI3K/AKT/mTOR pathway
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::bd6fd7a0a2438fca204c6ad193b9e9db
https://doi.org/10.1158/1535-7163.targ-13-a169 -
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المؤلفون: Thomas C.K. Chan, Mark A. Ashwell, Jean-Marc Lapierre, Christopher Brassard, Cathy Bull, Susan Cornell-Kennon, Sudharshan Eathiraj, Dennis S. France, Jason Hill, Steffi Koerner, Eoin Kelleher, Darin Kizer, Yanbin Liu, Jeff Link, Sapna Makhija, Magdi Moussa, Nivedita Namdev, Robert Nicewonger, Uma Uppalapati, Rocio Palma, Jeff Szwaya, Manish Tandon, David Vensel, Laurie Volak, Erika Volckova, Neil Westland, Hui Wu, Rui-Yang Yang
المصدر: Cancer Research. 72:LB-1
مصطلحات موضوعية: Cancer Research, Effector, Chemistry, AKT1, Cancer, Pharmacology, medicine.disease, Small molecule, In vitro, Oncology, In vivo, medicine, Protein kinase B, Intracellular
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::34014a12fe34271da22ab4f26b260726
https://doi.org/10.1158/1538-7445.am2012-lb-1 -
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المؤلفون: Yi Yu, Xiubin Gu, Enkelada Nakuci, Xiaolan Zhao, Edward Chang, Jeff Szwaya, Jenn Castro, Laura Cousens, Cathy Bull, Yunxia Wang, Ron Savage, Carol Waghorne, Chang-Rung Chen, Dennis S. France, Edwin Clark, Thomas C.K. Chan
المصدر: Cancer Research. 71:3571-3571
مصطلحات موضوعية: Cancer Research, Oncology, Clusterin, Fibroblast growth factor receptor, Kinase, Cell culture, Angiogenesis, biology.protein, Biology, Receptor, Tyrosine kinase, Molecular biology, CXCL16
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::7cd58cde33875165c2f7810a126ba127
https://doi.org/10.1158/1538-7445.am2011-3571
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