المؤلفون: Ricardo A García, Debra J Search, John A Lupisella, Jacek Ostrowski, Bo Guan, Jian Chen, Wen-Pin Yang, Amy Truong, Aiqing He, Rongan Zhang, Mujing Yan, Samuel E Hellings, Peter S Gargalovic, Carol S Ryan, Linda M Watson, Robert A Langish, Petia A Shipkova, Nancy L Carson, Joseph R Taylor, Richard Yang, George C Psaltis, Thomas W Harrity, Jeffrey A Robl, David A Gordon

المصدر: PLoS ONE, Vol 8, Iss 2, p e53192 (2013)

مصطلحات موضوعية: Medicine, Science

وصف الملف: electronic resource

Relation: http://europepmc.org/articles/PMC3562192?pdf=render; https://doaj.org/toc/1932-6203

URL الوصول: https://doaj.org/article/6bd68584051f4497b56fefb3bbb8522c

المؤلفون: James Kempson, Xiaoping Hou, Jung-Hui Sun, Michael Wong, Joseph Pawluczyk, Jianqing Li, Subramaniam Krishnananthan, Eric M. Simmons, Yi Hsiao, Yi-Xin Li, Dawn Sun, Dauh-Rurng Wu, Wei Meng, Saleem Ahmad, Lidet Negash, Robert Brigance, Huji Turdi, Jon J. Hangeland, R. Michael Lawrence, Pratik Devasthale, Jeffrey A. Robl, Arvind Mathur

المصدر: Organic Process Research & Development. 26:1327-1335

مصطلحات موضوعية: Organic Chemistry, Physical and Theoretical Chemistry

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::35fda97669790a07bfdfb80a55523b6b
https://doi.org/10.1021/acs.oprd.2c00036

المؤلفون: Yan Shi, Ying Wang, Wei Meng, Robert P. Brigance, Denis E. Ryono, Scott Bolton, Hao Zhang, Sean Chen, Rebecca Smirk, Shiwei Tao, Joseph A. Tino, Kristin N. Williams, Richard Sulsky, Laura Nielsen, Bruce Ellsworth, Michael K. Y. Wong, Jung-Hui Sun, Leslie W. Leith, Dawn Sun, Dauh-Rurng Wu, Anuradha Gupta, Richard Rampulla, Arvind Mathur, Bang-Chi Chen, Aiying Wang, Helen G. Fuentes-Catanio, Lori Kunselman, Michael Cap, Jacob Zalaznick, Xiaohui Ma, Heng Liu, Joseph R. Taylor, Rachel Zebo, Beverly Jones, Stephen Kalinowski, Joann Swartz, Ada Staal, Kevin O’Malley, Lisa Kopcho, Jodi K. Muckelbauer, Stanley R. Krystek, Steven A. Spronk, Jovita Marcinkeviciene, Gerry Everlof, Xue-Qing Chen, Carrie Xu, Yi-Xin Li, Robert A. Langish, Yanou Yang, Qi Wang, Kamelia Behnia, Aberra Fura, Evan B. Janovitz, Nicola Pannacciulli, Steven Griffen, Bradley A. Zinker, John Krupinski, Mark Kirby, Jean Whaley, Robert Zahler, Joel C. Barrish, Jeffrey A. Robl, Peter T. W. Cheng

المصدر: Journal of Medicinal Chemistry. 65:4291-4317

مصطلحات موضوعية: Drug Discovery, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::cc68196d2f5ecc2fc360366195341ffb
https://doi.org/10.1021/acs.jmedchem.1c02110

المؤلفون: Brian J. Murphy, Daniel Smith, Julia Sapuppo, Giridhar S. Tirucherai, Lawrence J. Kennedy, Ching-Hsuen Chu, Anthony V. Azzara, Shiwei Tao, Glenn D. Rosen, Subramaniam Krishnananthan, Jun Li, Victor R. Guarino, Lisa Burns, Joseph R. Taylor, Milinda Ziegler, Lakshmi Sivaraman, Bruce A. Ellsworth, Selvakumar Kumaravel, Hao Zhang, Tao Wang, Jun Shi, Atsu Apedo, Dhanusu Suresh, Kathy Mosure, Gerry Everlof, David A. Gordon, Lisa Zhang, Michael Gill, Chen-Pin Hung, Jianqing Li, Peter T. W. Cheng, Robert F. Kaltenbach, Sutjano Jusuf, Ying Wang, Stephanie Boehm, Mary Ellen Cvijic, Matthew G. Soars, Chi Shing Sum, Yan Shi, Jeffrey A. Robl, Reddigunta Ramesh Babu, Bradley A. Zinker, Yanou Yang, Stephen S. Kalinowski, Carrie Xu, Steven J. Walker, Sarah C. Traeger, Rebekah Heiry, Kimberley A. Lentz, Qian Ruan

المصدر: Journal of Medicinal Chemistry. 64:15549-15581

مصطلحات موضوعية: Clinical trial, Pharmacokinetics, In vivo, Chemistry, Drug Discovery, Antagonist, Molecular Medicine, Phases of clinical research, Distribution (pharmacology), Pharmacology, In vitro, ADME

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::c00ce908946d21bafba2486eb2e08c90
https://doi.org/10.1021/acs.jmedchem.1c01256

المؤلفون: Shu Chang, Anthony V. Azzara, Yi-Xin Li, Marta Dabros, James Kempson, Reshma Panemangelor, Huji Turdi, Kimberly A. Foster, William J. Keim, Jean M. Whaley, Jeffrey A. Robl, Fang Moore, Luping Chen, Mary Jane Cullen, Xiaoping Hou, Atsu Apedo, R. Michael Lawrence, Arvind Mathur, David G. Harden, Wei Meng, Kevin O'Malley, Mary Ann Pelleymounter, Hannguang Chao, Pratik Devasthale, Jon J. Hangeland, Zhengping Ma, Dauh-Rurng Wu, Robert Paul Brigance, Guohua Zhao, Lynn M. Abell, Qi Gao, Susan Harvey, Lisa M. Kopcho, Dong Cheng, Elizabeth A. Dierks, Ching-Hsuen Chu, Suzanne Rooney, Xiang-Yang Ye, Saleem Ahmad, Wei Wang

المصدر: Journal of Medicinal Chemistry. 64:14773-14792

مصطلحات موضوعية: Metabolism, Metabolic stability, Pharmacology, Crystallography, X-Ray, N-Acetylglucosaminyltransferases, High-Throughput Screening Assays, Structure-Activity Relationship, chemistry.chemical_compound, Metabolic Diseases, chemistry, Pharmacokinetics, Tolerability, In vivo, Drug Discovery, Animals, Humans, Molecular Medicine, Potency, Tetrazole, Enzyme Inhibitors, IC50

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40e90999a2854f1a395c0459b5cd876d
https://doi.org/10.1021/acs.jmedchem.1c01356

المؤلفون: Mary Jane Cullen, Qian Xiang, Jeffrey A. Robl, Philip M. Sher, Brian J. Murphy, Keith J. Miller, Timothy M. Harper, Andrew Alt, Emily Luk, Sarah E. Malmstrom, Dean A. Wacker, Ginger Wu, Kimberly A. Foster, John M. Fevig, Joseph Carpenter, Robert L. Bertekap, Mary F. Grubb, Ying Wang, Karen A. Rossi, Gang Wu, Christian L. Morales, Jianxin Feng, Xiang Yang Ye, Anthony V. Azzara, Matthias Broekema

المصدر: Journal of Medicinal Chemistry. 60:6166-6190

مصطلحات موضوعية: 0301 basic medicine, Agonist, biology, medicine.drug_class, Chemistry, Mutant, HEK 293 cells, Active site, ATP-binding cassette transporter, Pharmacology, 5-HT2C receptor, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Biochemistry, Drug Discovery, biology.protein, medicine, Molecular Medicine, Structure–activity relationship, Receptor, 030217 neurology & neurosurgery

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::9ab408370d6568ec38a8faeab8daced5
https://doi.org/10.1021/acs.jmedchem.7b00385

المؤلفون: Paul E. Morin, Haixia Wang, Lawrence J. Kennedy, Stephen P. O'connor, James J. Li, Akbar Nayeem, Vidhyashankar Ramamurthy, Steven Sheriff, Nathan Morgan, Steven J. Walker, Xiang-Yang Ye, Frederick Moulin, Brad D. Maxwell, Thomas Harrity, Jeffrey A. Robl, Stephanie Y. Chen, Timothy W. Harper, Rachel Zebo, Jun Li, Zhenqiu Hong, Shung Wu, Mengmeng Wang, Randolph P. Ponticiello, David A. Gordon, Rajasree Golla, Ramakrishna Seethala, Daniel M. Camac, Joseph R. Taylor, David S. Yoon

مصطلحات موضوعية: 0301 basic medicine, biology, Chemistry, Organic Chemistry, Adipose tissue, Dehydrogenase, Pharmacology, Biochemistry, Bioavailability, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Pharmacokinetics, 11β-hydroxysteroid dehydrogenase type 1, 030220 oncology & carcinogenesis, Pharmacodynamics, Drug Discovery, biology.protein, IC50, Ex vivo

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::537bf023154f9aff48423a9bc7df61b2
https://europepmc.org/articles/PMC6295842/

المؤلفون: Jeffrey A. Robl, Michael Thomas, Mary Ann Pelleymounter, Brian Gemzik, Anthony V. Azzara, Brian J. Murphy, Sharon N. Bisaha, Helen E. Godonis, Daniel Longhi, Neil Flynn, William N. Washburn, Kenneth W. Rohrbach, Khehyong Ngu, Saleem Ahmad, Susan Harvey, Christine Huang, Evan B. Janovitz, Andres S. Hernandez, James Devenny, Hongwei Zhang, Lisa Zhang, Susan Glick, Suzanne Rooney, Wei Wang

المصدر: Journal of Medicinal Chemistry. 59:8848-8858

مصطلحات موضوعية: 010405 organic chemistry, Stereochemistry, Chemistry, Antagonist, Halogenation, Pharmacology, 010402 general chemistry, 01 natural sciences, In vitro, 0104 chemical sciences, Melanin-concentrating hormone receptor, Pharmacokinetics, In vivo, Drug Discovery, Molecular Medicine, Structure–activity relationship, Receptor

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::b952b4585a825fd9a757591676fa67d8
https://doi.org/10.1021/acs.jmedchem.6b00676

المؤلفون: Gary G. Cao, Min Zhou, Ramya Jayaram, Douglas B. Moore, Andres S. Hernandez, Tao Wang, Jean M. Whaley, Yue-Zhong Shu, Carrie Xu, Lori Kunselman, Atsu Apedo, William R. Ewing, Reshma Panemangalore, Qi Gao, Arvind Mathur, Richard Rampulla, Bradley A. Zinker, Lauren Haque, Mary Ellen Cvijic, Marta Dabros, Arun Kumar Gupta, Heng Liu, Jeffrey A. Robl, Bruce A. Ellsworth, Jun Shi, Zhengxiang Gu, Jason J. Wilkes, Akin H. Davulcu, Kristin N. Williams, Elizabeth A. Dierks, John Krupinski, Zhenqiu Hong, Edward J. Brady, Ximao Wu, Qin Sun, Hong Cai, Chunshan Xie, Elizabeth A. Jurica, Kimberly A. Foster

المصدر: Journal of medicinal chemistry. 61(3)

مصطلحات موضوعية: 0301 basic medicine, Agonist, Male, Models, Molecular, endocrine system, Pyrrolidines, medicine.drug_class, medicine.medical_treatment, Molecular Conformation, Incretin, Administration, Oral, Biological Availability, Pharmacology, 01 natural sciences, Receptors, G-Protein-Coupled, 03 medical and health sciences, Mice, In vivo, Free fatty acid receptor 1, Drug Discovery, medicine, Animals, Humans, Secretion, Receptor, 010405 organic chemistry, Chemistry, Drug discovery, Insulin, 0104 chemical sciences, 030104 developmental biology, Molecular Medicine, Pyrazoles

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fbe81ca0de7013eecb9cd7ee4d58d5d
https://pubmed.ncbi.nlm.nih.gov/29316397

المؤلفون: Neil Flynn, Mary Jane Cullen, Hongwei Zhang, Wei Wang, Susan Glick, Lisa Zhang, Jeffrey A. Robl, Pratik Devasthale, Andres S. Hernandez, Christian Caporuscio, Brian J. Murphy, Suzanne Rooney, Ning Huang, Mary Ann Pelleymounter, Kenneth W. Rohrbach, Kishore Renduchintala, Anthony V. Azzara, Helen E. Godonis, Yi-Xin Li, Radhakrishnan Sridhar, Michael Thomas, Susan Harvey, Paul Stetsko, Mary F. Grubb, Chris Freeden, Fang Moore, Christine Huang, James Devenny, Daniel Longhi, William N. Washburn

المصدر: Bioorganic & Medicinal Chemistry Letters. 25:2793-2799

مصطلحات موضوعية: Chemistry, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, Pharmacology, Biochemistry, In vitro, Rats, Rats, Sprague-Dawley, Structure-Activity Relationship, In vivo, Weight Loss, Drug Discovery, Animals, Humans, Pyrazoles, Molecular Medicine, Anti-Obesity Agents, Obesity, Receptors, Somatostatin, Molecular Biology, Incubation, Half-Life, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17121b519c7b9c469d07059362c3d928
https://doi.org/10.1016/j.bmcl.2015.05.008