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المؤلفون: Ricardo C.T. Aguiar, Heinz Sill, Albert Wölfler, ZhiJun Qiu, Jamie Myers, Avvaru N. Suhasini, Long Wang, Daifeng Jiang, An-Ping Lin, Jeffrey D. Cooney
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cd43f45cc8d3130c73aa45e5d72c570
https://doi.org/10.1158/1078-0432.22464317.v1 -
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المؤلفون: Ricardo C.T. Aguiar, Heinz Sill, Albert Wölfler, ZhiJun Qiu, Jamie Myers, Avvaru N. Suhasini, Long Wang, Daifeng Jiang, An-Ping Lin, Jeffrey D. Cooney
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f4a51cd21d0de0aac7c04b696156adf
https://doi.org/10.1158/1078-0432.c.6525671.v1 -
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المؤلفون: Ricardo C.T. Aguiar, Heinz Sill, Albert Wölfler, ZhiJun Qiu, Jamie Myers, Avvaru N. Suhasini, Long Wang, Daifeng Jiang, An-Ping Lin, Jeffrey D. Cooney
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7dc3580807f540146307278329fd2098
https://doi.org/10.1158/1078-0432.22464299 -
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المؤلفون: Ricardo C.T. Aguiar, Jeffrey D. Cooney
المصدر: Blood. 128:2886-2890
مصطلحات موضوعية: 0301 basic medicine, Adenosine monophosphate, Angiogenesis, Immunology, Syk, Pharmacology, Models, Biological, Biochemistry, 03 medical and health sciences, chemistry.chemical_compound, Neoplasms, Cyclic AMP, Animals, Humans, Cyclic adenosine monophosphate, Phosphatidylinositol, B-Lymphocytes, BLOOD Spotlight, Kinase, breakpoint cluster region, Cell Biology, Hematology, Cyclic Nucleotide Phosphodiesterases, Type 4, Vascular endothelial growth factor A, 030104 developmental biology, chemistry, Phosphodiesterase 4 Inhibitors
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87500762c6e4bf9260f9d6f608f50798
https://doi.org/10.1182/blood-2016-09-737676 -
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المؤلفون: Zhi Jun Qiu, Long Wang, Heinz Sill, Daifeng Jiang, Jamie Myers, Avvaru N. Suhasini, Albert Wölfler, Jeffrey D. Cooney, An Ping Lin, Ricardo C.T. Aguiar
مصطلحات موضوعية: 0301 basic medicine, Cyclopropanes, Cancer Research, Cell Survival, Class I Phosphatidylinositol 3-Kinases, Chronic lymphocytic leukemia, Aminopyridines, Mice, Nude, Receptors, Antigen, B-Cell, Article, 03 medical and health sciences, Mice, hemic and lymphatic diseases, Catalytic Domain, Cell Line, Tumor, Genetic model, Antineoplastic Combined Chemotherapy Protocols, medicine, Bruton's tyrosine kinase, Animals, Humans, Syk Kinase, Protein Kinase Inhibitors, PI3K/AKT/mTOR pathway, Roflumilast, Quinazolinones, B-Lymphocytes, biology, Chemistry, Kinase, Drug Repositioning, Drug Synergism, medicine.disease, Leukemia, Lymphocytic, Chronic, B-Cell, Xenograft Model Antitumor Assays, Cyclic Nucleotide Phosphodiesterases, Type 4, 030104 developmental biology, Oncology, Purines, Benzamides, Cancer research, biology.protein, Lymphoma, Large B-Cell, Diffuse, Phosphodiesterase 4 Inhibitors, Idelalisib, Tyrosine kinase, medicine.drug, Signal Transduction
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::985ffe93ee6be0e28c4658fd62bb103c
https://europepmc.org/articles/PMC5844841/ -
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المؤلفون: Leonard I. Zon, Owen J. Tamplin, Paul F. McBride, Kelli J. Carroll, Dhvanit I. Shah, Diana S. Branco, Ebrahim Shafizadeh, Gordon J. Hildick-Smith, Heidi Anderson, Clara Wong, Trista E. North, Barry H. Paw, Jeffrey D. Cooney, Patrick G. Gallagher, Arthur J. Dalton, George C. Shaw
المصدر: Developmental Biology. 373:431-441
مصطلحات موضوعية: LMO2, Embryo, Nonmammalian, animal structures, Myeloid, Hematopoietic System, Molecular Sequence Data, Biology, Models, Biological, Article, Evolution, Molecular, 03 medical and health sciences, 0302 clinical medicine, medicine, Animals, Erythropoiesis, Amino Acid Sequence, Cloning, Molecular, Primitive and definitive hematopoiesis, Progenitor cell, Molecular Biology, Transcription factor, Zebrafish, Conserved Sequence, 030304 developmental biology, Genetics, 0303 health sciences, fungi, Gene Expression Regulation, Developmental, Epistasis, Genetic, GATA1, Cell Biology, Zebrafish Proteins, Hematopoietic Stem Cells, biology.organism_classification, Lineage commitment, Hematopoiesis, DNA-Binding Proteins, Haematopoiesis, medicine.anatomical_structure, Differentiation, 030220 oncology & carcinogenesis, Stem cell, Developmental Biology
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المؤلفون: Anupama Narla, Jeffrey D. Cooney, Nika N. Danial, Carlo Brugnara, Guillaume Vogin, Tamara A. Dailey, Diane M. Ward, Shilpa M. Hattangadi, Barry H. Paw, Slater N. Hurst, Danilo Faccenda, Jessica Wiwczar, Naoko Takahashi-Makise, Caiyong Chen, Dean R. Campagna, Yi Zhou, Amy E. Medlock, Jerry Kaplan, Harry A. Dailey, Benjamin L. Ebert, Liangtao Li, Nathaniel B. Langer, Eric L. Pierce, Dhvanit I. Shah, Iman J. Schultz, Michelangelo Campanella, Mark D. Fleming, Spencer K. Heggers, Wen Chen, Alexandra Seguin
المصدر: Nature
مصطلحات موضوعية: Settore BIO/06, Erythroblasts, Mutant, Sideroblastic, Heme, Biology, Mitochondrion, Article, Mitochondrial Proteins, chemistry.chemical_compound, Mice, Animals, Humans, Erythropoiesis, Zebrafish, chemistry.chemical_classification, Multidisciplinary, Animal, digestive, oral, and skin physiology, Genetic Complementation Test, Proteins, Anemia, Ferrochelatase, Hydrogen-Ion Concentration, biology.organism_classification, Anemia, Sideroblastic, Mitochondria, Disease Models, Animal, Enzyme, Biochemistry, chemistry, Disease Models, biology.protein, Oxidation-Reduction, Homeostasis, Genetic screen
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المؤلفون: Gordon J. Hildick-Smith, Babette Gwynn, Lionel Blanc, Steven L. Ciciotte, Eric L. Pierce, Luanne L. Peters, Barry H. Paw, Jeffrey D. Cooney, Kathleen A. Soltis
المصدر: Proceedings of the National Academy of Sciences. 109:12099-12104
مصطلحات موضوعية: Mutation, Multidisciplinary, biology, GTPase-activating protein, Mutant, Mutation, Missense, Receptors, Cytoplasmic and Nuclear, Biological Sciences, biology.organism_classification, medicine.disease_cause, GTP Phosphohydrolases, Thrombopoiesis, Animals, Genetically Modified, Enzyme Activation, Mice, Haematopoiesis, Cancer research, medicine, Animals, Missense mutation, Erythropoiesis, Zebrafish, Megakaryopoiesis
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c420f637a32d7a88783045e9d8a31363
https://doi.org/10.1073/pnas.1204948109 -
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المؤلفون: Ivan Adzhubei, Kristen Alexa, Barry H. Paw, Peter B. Kelsey, Seungshin Ha, Wolfram Goessling, Rolf W. Stottmann, Iain A. Drummond, Jeffrey D. Cooney, Ignaty Leshchiner, Christina Austin-Tse, Shamil R. Sunyaev, Heidi Anderson, Matthew J. King, David R. Beier, Maija K. Garnaas, Trista E. North
المساهمون: Harvard University--MIT Division of Health Sciences and Technology, Goessling, Wolfram, Sunyaev, Shamil R.
المصدر: Genome Research
مصطلحات موضوعية: Male, Time Factors, DNA Mutational Analysis, Method, Single-nucleotide polymorphism, Genomics, Computational biology, Biology, Polymorphism, Single Nucleotide, Chromosomes, Mice, Gene Frequency, Gene mapping, Genetics, Animals, Hidden Markov model, Alleles, Crosses, Genetic, Zebrafish, Genetics (clinical), Recombination, Genetic, Whole genome sequencing, Homozygote, Chromosome Mapping, DNA sequencing theory, Markov Chains, Mice, Inbred C57BL, Mutation, Mutation (genetic algorithm), Female, Identification (biology), Software
وصف الملف: application/pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48fe83810f7444303a3fd507a564d15d
https://doi.org/10.1101/gr.135541.111 -
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المؤلفون: Wei Du, Xiaoqui Liu, Dean Y. Li, Yuanli Zhen, Sushil Kumar Dubey, Jiamei Dong, Barry H. Paw, Lejin Wang, Fei He, John D. Phillips, Paul F. McBride, Yi Shi, Chen Liang, Jing Li, Wei Li, Jeffrey D. Cooney, Fang Lu, Ying Lin, Zhenglin Yang, Bo Gong, Yanlei Jia, Kathleen A. Soltis, Prasanthi Namburi, Periasamy Sundaresan, Juan Bu
المصدر: The American Journal of Human Genetics. 90(1):40-48
مصطلحات موضوعية: Central Nervous System, Male, Positional cloning, Molecular Sequence Data, Retinal Pigment Epithelium, Transfection, medicine.disease_cause, Microphthalmia, Article, Cell Line, Morpholinos, Asian People, medicine, Genetics, Animals, Humans, Microphthalmos, Genetics(clinical), Eye Abnormalities, Zebrafish, Genetics (clinical), Coloboma, Mutation, Gene knockdown, Base Sequence, biology, Exons, Middle Aged, Zebrafish Proteins, medicine.disease, biology.organism_classification, Molecular biology, Phenotype, eye diseases, Aniridia, ATP-Binding Cassette Transporters, Female, sense organs, Lod Score