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المؤلفون: Jeffrey S. Wiseman, Nathan C. Law, Cara Schildmeyer, Craig S. Nunemaker, Kathryn L. Corbin, Christopher D. Waters, Avery M Bogart, Hannah L. West, Nicholas W. Vann, Nicholas B. Whitticar, Ishrat Jahan
المصدر: Endocrinology. 159:3747-3760
مصطلحات موضوعية: Male, 0301 basic medicine, endocrine system, medicine.medical_specialty, Pulsatile insulin, Mannoheptulose, medicine.medical_treatment, Mice, Inbred Strains, Type 2 diabetes, Islets of Langerhans, Mice, 03 medical and health sciences, Endocrinology, Insulin-Secreting Cells, Diabetes mellitus, Internal medicine, Glucokinase, Insulin Secretion, medicine, Hyperinsulinemia, Animals, Insulin, Research Articles, Calcium metabolism, geography, geography.geographical_feature_category, Chemistry, medicine.disease, Islet, Disease Models, Animal, Glucose, 030104 developmental biology, Diabetes Mellitus, Type 2, Calcium, Female
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12a47565279c572d29ee0ee8ff060be7
https://doi.org/10.1210/en.2018-00589 -
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المؤلفون: Abby Hearne, Anna Monarchino, Haotong Chen, Jeffrey S. Wiseman
المصدر: Toxicology in vitro : an international journal published in association with BIBRA. 67
مصطلحات موضوعية: 0301 basic medicine, Oligomycin, Proton, Toxicology, Cell Line, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Adenosine Triphosphate, Cyclosporin a, Humans, Bongkrekic Acid, ATP synthase, biology, L-Lactate Dehydrogenase, Chemistry, Uncoupling Agents, fungi, General Medicine, ANT, Mitochondria, Oxygen, 030104 developmental biology, Mitochondrial permeability transition pore, 030220 oncology & carcinogenesis, Reagent, biology.protein, Biophysics, Oligomycins, Protons
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المؤلفون: Haotong Chen, Yuehan Yang, Cuilin Cheng, Zhenyu Li, Jeffrey S. Wiseman, Yong Han, Lingying Tong, Shiyong Wu
المصدر: Toxicol Appl Pharmacol
مصطلحات موضوعية: 0301 basic medicine, Cell, Antineoplastic Agents, Toxicology, Article, Mice, Necrosis, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Neoplasms, medicine, Animals, Humans, Cytotoxicity, Phosphocholine, Pharmacology, Phosphatidylethanolamine, Phosphatidylethanolamines, Cell Membrane, Cancer, 3T3 Cells, Hep G2 Cells, medicine.disease, Cell biology, 030104 developmental biology, medicine.anatomical_structure, chemistry, Mechanism of action, A549 Cells, Drug Resistance, Neoplasm, 030220 oncology & carcinogenesis, Phosphoserine, Cancer cell, MCF-7 Cells, medicine.symptom, Energy Metabolism
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المؤلفون: Ishrat Jahan, Shiyong Wu, Haotong Chen, Brian C. Clark, Jeffrey S. Wiseman, Yong Han
المصدر: Journal of Herbal Medicine. :100282
مصطلحات موضوعية: Oligomycin, biology, Chemistry, Glucose uptake, Metabolism, Pharmacology, Insulin receptor, chemistry.chemical_compound, Complementary and alternative medicine, biology.protein, Glucose homeostasis, Phosphorylation, Protein kinase B, PI3K/AKT/mTOR pathway
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المؤلفون: David Bower, Jeffrey S. Wiseman, Michael Schwarz, Brigitte Landesmann, Martin O. Leonard, Marina Goumenou, Silvia Maggioni, Paul Jennings
المصدر: Archives of Toxicology. 88:2099-2133
مصطلحات موضوعية: Phospholipidosis, Alternative methods, Health, Toxicology and Mutagenesis, Drug Evaluation, Preclinical, Mechanism based, General Medicine, Computational biology, In Vitro Techniques, Reference Standards, Biology, Pharmacology, Animal Testing Alternatives, Toxicology, medicine.disease, Human situation, Cell Line, Liver, Animal Testing Alternative, medicine, Animals, Humans, Steatosis, Animal testing, Mode of action
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المؤلفون: Matthew Clark, Jeffrey S. Wiseman, Marlin Linger, Natalia Mast, Irina A. Pikuleva, Yong Li
المصدر: Journal of Biological Chemistry. 289:3529-3538
مصطلحات موضوعية: Cyclopropanes, Male, medicine.medical_specialty, Efavirenz, Mirtazapine, HIV Infections, Stimulation, Pharmacology, Biology, Models, Biological, Biochemistry, Mice, chemistry.chemical_compound, Alzheimer Disease, Internal medicine, Cholesterol 24-Hydroxylase, medicine, Galantamine, Animals, Adverse effect, Molecular Biology, Brain Chemistry, Cholesterol, Brain, Cytochrome P450, Cell Biology, Lipids, Benzoxazines, Acetaminophen, Enzyme Activation, Endocrinology, chemistry, Alkynes, Steroid Hydroxylases, biology.protein, Reverse Transcriptase Inhibitors, Cattle, Female, medicine.drug
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::951aa6db0406ece30cd53cde1d97dcf3
https://doi.org/10.1074/jbc.m113.532846 -
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المؤلفون: Natalia Mast, Irina A. Pikuleva, Jeffrey S. Wiseman, Matthew Clark, C. David Stout, Marlin Linger
المصدر: Molecular Pharmacology. 82:824-834
مصطلحات موضوعية: Models, Molecular, Stereochemistry, Entropy, Quantitative Structure-Activity Relationship, Plasma protein binding, In Vitro Techniques, Crystallography, X-Ray, Hydroxylation, chemistry.chemical_compound, In vivo, Microsomes, Cholesterol 24-Hydroxylase, Animals, Humans, Computer Simulation, Protease Inhibitors, Heme, Enzyme Assays, Pharmacology, chemistry.chemical_classification, Molecular Structure, biology, Brain, Water, Cytochrome P450, Active site, Substrate (chemistry), Stereoisomerism, Articles, Antidepressive Agents, Recombinant Proteins, Cholesterol, Enzyme, chemistry, Fluvoxamine, Steroid Hydroxylases, biology.protein, Molecular Medicine, Cattle, Tranylcypromine, Crystallization, Protein Binding
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7438f463769f39f6248007042309e54
https://doi.org/10.1124/mol.112.080424 -
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المصدر: Journal of Chemical Information and Modeling. 51:52-60
مصطلحات موضوعية: Models, Molecular, Protein Conformation, Stereochemistry, General Chemical Engineering, Amino Acid Motifs, Molecular Sequence Data, Allosteric regulation, Crystal structure, Library and Information Sciences, Crystallography, X-Ray, Ligands, p38 Mitogen-Activated Protein Kinases, Insert (molecular biology), Adenosine Triphosphate, Protein structure, Allosteric Regulation, Amino Acid Sequence, Protein Kinase Inhibitors, Peptide sequence, Chemistry, Binding protein, Proteins, General Chemistry, Protein superfamily, Computer Science Applications, Protein kinase domain, Lymphocyte Specific Protein Tyrosine Kinase p56(lck), Protein Kinases
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المؤلفون: Steven J. Freedman, Matthew Clark, Jinming Zou, Jeffrey S. Wiseman, Jennifer L. Ludington, George Talbot, Sia Meshkat, Zenon Konteatis
المصدر: Drug Development Research. 70:279-287
مصطلحات موضوعية: Drug, Flexibility (engineering), Biodefense, Computer science, Drug discovery, media_common.quotation_subject, Nanotechnology, Probability of success, Identification (information), Drug development, Risk analysis (engineering), Drug Discovery, Multiple treatments, media_common
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المؤلفون: Jeffrey S. Wiseman, Siavash Meshkat, Matthew Clark
المصدر: Journal of Chemical Information and Modeling. 49:934-943
مصطلحات موضوعية: Computer science, General Chemical Engineering, Computation, Monte Carlo method, Thermodynamics, Library and Information Sciences, Ligands, Quantitative Biology::Subcellular Processes, Computational chemistry, Bacteriophage T4, Computer Simulation, Binding site, Quantitative Biology::Biomolecules, Binding Sites, Models, Statistical, Solvation, Computational Biology, Proteins, General Chemistry, Ligand (biochemistry), Computer Science Applications, Grand canonical ensemble, Energy Transfer, Mutation, Muramidase, Monte Carlo Method, Algorithms, Energy (signal processing), Protein Binding, Protein ligand