المؤلفون: Xiaodi Yu, Olga Plotnikova, Paul D Bonin, Timothy A Subashi, Thomas J McLellan, Darren Dumlao, Ye Che, Yin Yao Dong, Elisabeth P Carpenter, Graham M West, Xiayang Qiu, Jeffrey S Culp, Seungil Han

المصدر: eLife, Vol 8 (2019)

مصطلحات موضوعية: SLC1A5, ASCT2, glutamine transporter, solute carrier, cryo-EM, outward-facing conformation, Medicine, Science, Biology (General), QH301-705.5

وصف الملف: electronic resource

Relation: https://elifesciences.org/articles/48120; https://doaj.org/toc/2050-084X

URL الوصول: https://doaj.org/article/a33c8724acd14c1bb4ac82ee1b35322f

المؤلفون: Xiayang Qiu, Olga Plotnikova, Thomas J. McLellan, Graham M. West, Timothy A. Subashi, Y.Y. Dong, Elisabeth P. Carpenter, Seungil Han, Darren Dumlao, Paul D. Bonin, Xiaodi Yu, Ye Che, Jeffrey S. Culp

المصدر: eLife
eLife, Vol 8 (2019)

مصطلحات موضوعية: 0301 basic medicine, Amino Acid Transport System ASC, glutamine transporter, SLC1A5, QH301-705.5, Cryo-electron microscopy, Protein Conformation, Science, Structural Biology and Molecular Biophysics, solute carrier, Glutamine, Short Report, General Biochemistry, Genetics and Molecular Biology, Domain (software engineering), Minor Histocompatibility Antigens, 03 medical and health sciences, 0302 clinical medicine, Humans, Biology (General), General Immunology and Microbiology, Chemistry, General Neuroscience, Molecular biophysics, Cholesterol binding, Cryoelectron Microscopy, Transporter, General Medicine, ASCT2, 3. Good health, Transport protein, Solute carrier family, outward-facing conformation, 030104 developmental biology, Structural biology, Biophysics, Medicine, cryo-EM, 030217 neurology & neurosurgery, Human, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a466470cadf94e6122c7dcdd5bfcc94
http://europepmc.org/articles/PMC6800002

المؤلفون: John D. Knafels, David Price, Matthew Gorgoglione, Aaron C. Smith, Kevin D. Parris, Jemy A. Gutierrez, Magee Thomas Victor, Erik Alphie Lachapelle, Yan Weng, Edward L. Conn, Jeffrey A. Pfefferkorn, Jane M. Withka, Kim Huard, Matthew S. Dowling, Timothy A. Subashi, Trenton T. Ross, Benjamin A. Thuma, Kris A. Borzilleri, Paul A. Amor, Jeffrey S. Culp, Meihua Tu, Sylvie Perez, Jayvardhan Pandit, Andre Shavnya, Boris A. Chrunyk, Gang Xing, John D. Weaver, Yang Cong, Kay Ahn, David A. Beebe, Brian Raymer, Gregory J. Tesz, Steven B. Coffey

المصدر: Journal of Medicinal Chemistry. 60:7835-7849

مصطلحات موضوعية: Male, 0301 basic medicine, Pyridines, Pharmacology, Crystallography, X-Ray, 01 natural sciences, Fructokinases, Rats, Sprague-Dawley, Small Molecule Libraries, 03 medical and health sciences, Insulin resistance, In vivo, Drug Discovery, medicine, Animals, Humans, Transferase, Protein Kinase Inhibitors, chemistry.chemical_classification, 010405 organic chemistry, Chemistry, Metabolism, medicine.disease, Small molecule, Rats, 0104 chemical sciences, Molecular Docking Simulation, 030104 developmental biology, Fructose metabolism, Enzyme, Biochemistry, Drug Design, Molecular Medicine, Steatosis

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b654213309542f5b2a14a9d23ebc4df8
https://doi.org/10.1021/acs.jmedchem.7b00947

المؤلفون: Olga Plotnikova, Jeffrey S. Culp, Thomas J. McLellan, Y.Y. Dong, Darren Dumlao, Xiayang Qiu, Xiaodi Yu, Ye Che, Elisabeth P. Carpenter, Graham M. West, Paul D. Bonin, Timothy A. Subashi, Seungil Han

مصطلحات موضوعية: Glutamine, Cryo-electron microscopy, Chemistry, Biophysics, Transporter

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::d6535cfe5652486f9831ba6924fd7aee
https://doi.org/10.7554/elife.48120.027

المؤلفون: Xiayang Qiu, Jeffrey S. Culp, Yinyao Dong, Darren Dumlao, Xiaodi Yu, Thomas J. McLellan, Ye Che, Paul D. Bonin, Olga Plotnikova, Elisabeth P. Carpenter, Seungil Han, Graham M. West, Timothy A. Subashi

مصطلحات موضوعية: 0303 health sciences, Mechanism (biology), Chemistry, Cholesterol binding, Substrate (chemistry), Transporter, 3. Good health, Domain (software engineering), Glutamine, 03 medical and health sciences, Domain interface, 0302 clinical medicine, 030220 oncology & carcinogenesis, Biophysics, Function (biology), 030304 developmental biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2e375ab389a77edbb643aca03e7e020
https://doi.org/10.1101/622563

المؤلفون: Jeffrey M. Stadel, Henry M. Sarau, Shelagh Wilson, Jeffrey S. Culp, Brian D. Hellmig, James J. Foley, Janet Park, Alison I. Muir, Jon K. Chambers, Robert S. Ames, J. Randall Slemmon, Dean E. McNulty, Derk J. Bergsma

المصدر: G Protein-Coupled Receptors

مصطلحات موضوعية: Biochemistry, Chemistry, Receptor

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::8b48a2934c1ac3991b17c7c9fc6b9365
https://doi.org/10.1201/9780429129377-4

المؤلفون: Lih-Ling Lin, Guoxing Wang, Joseph P. Gardner, Hong Wang, Suman Shanker, Eicke Latz, Jeffrey S. Culp, Bruce Allen Lefker, Frank Lovering, Daniel C. Schmitt, Dana Castro, Ann Aulabaugh, Ryan Nistler, Timothy A. Subashi, Jimson Wong, Ken Dower, Steven J. Hawrylik, Olga Plotnikova, Karen L. Leach, Wen Lin, Fabien Vincent, James F. Smith, Amy Brault, Darren Dumlao, David Hepworth, Justin Hall, Mark Horn, Shawn Weng, Jing Li, Nootaree Niljanskul, William B. Snyder, Edyta Tyminski, Douglas T. Golenbock, David W. Lin, Leslie Anthony Dakin, Dikran Aivazian, Lyn H. Jones, John I. Trujillo, Ming Chen, Betsy Pierce, Peter Jones

المصدر: PLoS ONE
PLoS ONE, Vol 12, Iss 9, p e0184843 (2017)

مصطلحات موضوعية: 0301 basic medicine, Models, Molecular, GTP', Cell Lines, Druggability, lcsh:Medicine, Plasma protein binding, Biochemistry, Mass Spectrometry, 0302 clinical medicine, Spectrum Analysis Techniques, Drug Discovery, Enzyme-Linked Immunoassays, Enzyme Inhibitors, lcsh:Science, Genetic Interference, Multidisciplinary, ATP synthase, biology, Molecular Structure, Chemistry, Drug discovery, Anti-Inflammatory Agents, Non-Steroidal, Nucleotidyltransferases, Enzymes, Bioassays and Physiological Analysis, Spectrophotometry, 030220 oncology & carcinogenesis, Second messenger system, Biological Cultures, Nucleotides, Cyclic, Research Article, Protein Binding, High-throughput screening, Fluorescence Polarization, Enzyme-Linked Immunosorbent Assay, Research and Analysis Methods, Antibodies, 03 medical and health sciences, Genetics, Humans, Immunoassays, Molecular Biology Techniques, Molecular Biology, Enzyme Assays, Molecular Biology Assays and Analysis Techniques, Hybridomas, Fluorimetry, lcsh:R, Biology and Life Sciences, Proteins, Molecular biology, High Throughput Screening, 030104 developmental biology, Pyrimidines, Phosphodiester bond, biology.protein, Immunologic Techniques, Enzymology, Pyrazoles, lcsh:Q, Biochemical Analysis

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b467aadfb55b2af9efbce775d0740c57
http://europepmc.org/articles/PMC5608272

المؤلفون: Frank S. Menniti, Alison H. Varghese, Anne M. Ryan, Patricia G Wylie, Christopher J. Schmidt, Larry C. James, Christine A. Strick, David L Krull, Timothy M. Coskran, Seeger Thomas Francis, Jeffrey S. Culp, Jerry Lanfear, Robert D. Williams, Brenda Bartlett

المصدر: Brain Research. 985:113-126

مصطلحات موضوعية: Cyclin-Dependent Kinase Inhibitor p21, Male, medicine.medical_specialty, DNA, Complementary, Insecta, Blotting, Western, Substantia nigra, Striatum, Hippocampal formation, Biology, Transfection, Medium spiny neuron, Cell Line, Oligodeoxyribonucleotides, Antisense, Rats, Sprague-Dawley, Mice, Cyclins, Internal medicine, medicine, Neuropil, Animals, RNA, Messenger, Molecular Biology, In Situ Hybridization, Brain Chemistry, Neurons, Mice, Inbred BALB C, Phosphoric Diester Hydrolases, Reverse Transcriptase Polymerase Chain Reaction, General Neuroscience, Olfactory tubercle, Antibodies, Monoclonal, Brain, Phosphorus Isotopes, Granule cell, Immunohistochemistry, Precipitin Tests, Peptide Fragments, Rats, Cell biology, Endocrinology, Globus pallidus, medicine.anatomical_structure, nervous system, Autoradiography, Neurology (clinical), Developmental Biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::036c693317461cb6168ece634028a7ed
https://doi.org/10.1016/s0006-8993(03)02754-9

المؤلفون: Brian D. Hellmig, Wayne A. Hendrickson, James E. Robinson, Raymond W. Sweet, Peter D. Kwong, Elizabeth Desjardins, Richard T. Wyatt, Jeffrey S. Culp, Joseph Sodroski

المصدر: Journal of Biological Chemistry. 274:4115-4123

مصطلحات موضوعية: Glycosylation, Protein Conformation, medicine.drug_class, medicine.medical_treatment, HIV Envelope Protein gp120, Type (model theory), Monoclonal antibody, Biochemistry, law.invention, chemistry.chemical_compound, law, medicine, Humans, Crystallization, Molecular Biology, Ternary complex, Envelope (waves), chemistry.chemical_classification, Protease, Chemistry, Antibodies, Monoclonal, Cell Biology, Crystallography, CD4 Antigens, HIV-1, Biophysics, Glycoprotein

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c871cc26792ca847ce2fd9a8af1da609
https://doi.org/10.1074/jbc.274.7.4115

المؤلفون: Susan B. Richardson, Sherin S. Abdel-Meguid, Jeffrey S. Culp, Cheryl A. Janson, Ward W. Smith, Xiayang Qiu, Christine Debouck

المصدر: Proceedings of the National Academy of Sciences. 94:2874-2879

مصطلحات موضوعية: Herpesvirus 3, Human, Proteases, Protein Conformation, viruses, medicine.medical_treatment, Molecular Sequence Data, Crystallography, X-Ray, medicine.disease_cause, Catalysis, Virus, Substrate Specificity, Catalytic triad, medicine, Amino Acid Sequence, Serine protease, Multidisciplinary, Protease, Sequence Homology, Amino Acid, integumentary system, biology, Serine Endopeptidases, Varicella zoster virus, virus diseases, Biological Sciences, Virology, NS2-3 protease, biology.protein, MASP1

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efeeec44f7ef6f5124641055dc22240d
https://doi.org/10.1073/pnas.94.7.2874