-
1
المؤلفون: Hongliang Cai, Mark Tomilo, Sandra P. McCurdy, Jeremy T. Starr, Manjinder S. Lall, Mandy Lockard, Mark R. Rauckhorst, Jeffrey W. Gage, Barbachyn Michael R, Huifen Chen, Robert M. Owen, Michael D. Huband, Debra Hanna, Lisa Mullins, Richard J. Sciotti
المصدر: Bioorganic & Medicinal Chemistry Letters. 19:5302-5306
مصطلحات موضوعية: DNA Topoisomerase IV, Pyridines, Topoisomerase IV, Gram-positive bacteria, Clinical Biochemistry, Pharmaceutical Science, Microbial Sensitivity Tests, Pharmacology, Gram-Positive Bacteria, medicine.disease_cause, Biochemistry, DNA gyrase, Microbiology, Mice, Structure-Activity Relationship, Sepsis, Drug Discovery, medicine, Animals, Lung, Molecular Biology, Antibacterial agent, chemistry.chemical_classification, biology, Topoisomerase, Organic Chemistry, Imidazoles, biochemical phenomena, metabolism, and nutrition, biology.organism_classification, Anti-Bacterial Agents, Rats, Pyrimidines, Enzyme, chemistry, DNA Gyrase, Staphylococcus aureus, Streptococcus pyogenes, biology.protein, Molecular Medicine
-
2
المصدر: Journal of Antimicrobial Chemotherapy. 41:605-614
مصطلحات موضوعية: Microbiology (medical), Micrococcaceae, Gram-positive bacteria, Microbial Sensitivity Tests, Quinolones, Gram-Positive Bacteria, medicine.disease_cause, Microbiology, Mice, chemistry.chemical_compound, Anti-Infective Agents, Ciprofloxacin, In vivo, Gram-Negative Bacteria, medicine, Animals, Pharmacology (medical), Naphthyridines, Antibacterial agent, Pharmacology, Dose-Response Relationship, Drug, biology, Bacterial Infections, biology.organism_classification, Antimicrobial, Disease Models, Animal, Infectious Diseases, chemistry, Staphylococcus aureus, Female, Clinafloxacin, Fluoroquinolones, medicine.drug
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::158eadec9252fd34b048c3415b2903a3
https://doi.org/10.1093/jac/41.6.605 -
3
المؤلفون: Stephen J. Gracheck, John M. Domagala, Robert C. Reynolds, Gregory E. Roland, Julie A. Dever, Martin A. Shapiro, M R Jacobs, Thomas E. Renau, E. T. Joannides, Joseph P. Sanchez, Jeffrey W. Gage
المصدر: Antimicrobial Agents and Chemotherapy. 40:2363-2368
مصطلحات موضوعية: Cell Survival, medicine.drug_class, Stereochemistry, Mice, Inbred Strains, Microbial Sensitivity Tests, Antimycobacterial, Mycobacterium aurum, Mycobacterium, Mycobacterium tuberculosis, Mice, Structure-Activity Relationship, Anti-Infective Agents, medicine, Animals, Pharmacology (medical), Antibacterial agent, Pharmacology, 4-Quinolones, biology, Mycobacterium smegmatis, biology.organism_classification, Quinolone, Infectious Diseases, Mycobacterium fortuitum, Dermatitis, Phototoxic, Research Article
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e9e9c9ee18fab082ca1f24d37eb8490
https://doi.org/10.1128/aac.40.10.2363 -
4
المؤلفون: Martin A. Shapiro, Stephen J. Gracheck, Julie A. Dever, Thomas E. Renau, John M. Domagala, Joseph P. Sanchez, Jeffrey W. Gage
المصدر: Journal of Medicinal Chemistry. 39:729-735
مصطلحات موضوعية: Magnetic Resonance Spectroscopy, Tuberculosis, Spectrophotometry, Infrared, biology, medicine.drug_class, Chemistry, Mycobacterium smegmatis, Microbial Sensitivity Tests, Quinolone, biology.organism_classification, medicine.disease, Antimycobacterial, Anti-Bacterial Agents, Mycobacterium, Microbiology, Mycobacterium tuberculosis, Structure-Activity Relationship, Biochemistry, Drug Discovery, medicine, Molecular Medicine, Mycobacterium fortuitum, Antibacterial activity, Antibacterial agent
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::347e75ca02154daf9ecad9e09912a208
https://doi.org/10.1021/jm9507082 -
5
المؤلفون: Steven L. Yoder, Carl L. Heifetz, Jeffrey W. Gage, Mark A. Meservey, Sara A. Wold, Michael A. Cohen, Gregory E. Roland, Gail B. Mailloux
المصدر: Diagnostic Microbiology and Infectious Disease. 18:41-47
مصطلحات موضوعية: Microbiology (medical), Staphylococcus aureus, Haemophilus Infections, medicine.drug_class, Cephalosporin, Administration, Oral, Microbial Sensitivity Tests, medicine.disease_cause, beta-Lactamases, Haemophilus influenzae, Microbiology, Mice, Ampicillin, medicine, Animals, Subcutaneous abscess, Cefdinir, Cefpodoxime Proxetil, business.industry, General Medicine, Staphylococcal Infections, Cephalosporins, Infectious Diseases, Female, business, Cefaclor, medicine.drug
-
6
المؤلفون: Jeffrey W. Gage, Steven VanderRoest, Michael A. Cohen, M D Huband
المصدر: Drugs. 58:151-153
مصطلحات موضوعية: Pharmacotherapy, business.industry, medicine.drug_class, Staphylococcus aureus, Antibiotics, Pharmacology toxicology, Medicine, Pharmacology (medical), Vancomycin intermediate, business, medicine.disease_cause, Microbiology
-
7
المؤلفون: Mark C. Sulavik, Michael A. Cohen, Glenn Gibson, Jeffrey W. Gage, Stephen J. Gracheck, Michael Stier, Edmund L. Ellsworth, Margaret Zurack, Michael D. Huband, Debra Hanna, Laura A. Skerlos
المصدر: Antimicrobial agents and chemotherapy. 51(4)
مصطلحات موضوعية: Fastidious organism, Pyrrolidines, medicine.drug_class, Microbial Sensitivity Tests, Biology, medicine.disease_cause, Gram-Positive Bacteria, DNA gyrase, Microbiology, Levofloxacin, Streptococcus pneumoniae, Drug Resistance, Bacterial, medicine, Topoisomerase II Inhibitors, Pharmacology (medical), Gram-Positive Bacterial Infections, Antibacterial agent, Quinazolinones, Pharmacology, biochemical phenomena, metabolism, and nutrition, Quinolone, Drug Resistance, Multiple, Anti-Bacterial Agents, Ciprofloxacin, Infectious Diseases, Susceptibility, Streptococcus pyogenes, medicine.drug
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3a171e6e91e61e44b45c7550bdd82e2
https://pubmed.ncbi.nlm.nih.gov/17261623 -
8
المؤلفون: Rajeshwar Singh, E. Themis Joannides, Brian M. Watson, H. D. Hollis Showalter, Steve Dunham, Tuan P. Tran, Dai Q. Nguyen, Michael D. Huband, Michael Stier, Stephen J. Gracheck, Jia Yeu Liu, John M. Domagala, Joseph P. Sanchez, Joel C. Bronstein, Debra Hanna, Jeffrey W. Gage, Martin A. Shapiro, Edmund L. Ellsworth
المصدر: Journal of medicinal chemistry. 49(22)
مصطلحات موضوعية: Fastidious organism, DNA Topoisomerase IV, Gram-negative bacteria, Topoisomerase IV, Microbial Sensitivity Tests, Gram-Positive Bacteria, DNA gyrase, Structure-Activity Relationship, In vivo, Drug Resistance, Multiple, Bacterial, Drug Discovery, Gram-Negative Bacteria, Topoisomerase II Inhibitors, Enzyme Inhibitors, Antibacterial agent, Quinazolinones, biology, Bacteria, Chemistry, biology.organism_classification, Anti-Bacterial Agents, Multiple drug resistance, Biochemistry, biology.protein, Molecular Medicine, Methicillin Resistance, Antibacterial activity
-
9
المؤلفون: Gregory E. Roland, Jeffrey W. Gage, Steven L. Yoder, M D Huband, Stephen J. Gracheck, Michael A. Cohen
المصدر: The Journal of antimicrobial chemotherapy. 40(2)
مصطلحات موضوعية: Microbiology (medical), Drug resistance, Microbial Sensitivity Tests, Quinolones, Gram-Positive Bacteria, Enterococcus faecalis, Microbiology, chemistry.chemical_compound, Minimum inhibitory concentration, Anti-Infective Agents, Ciprofloxacin, Gram-Negative Bacteria, medicine, Pharmacology (medical), Naphthyridines, Antibacterial agent, Pharmacology, biology, Drug Resistance, Microbial, biochemical phenomena, metabolism, and nutrition, biology.organism_classification, Trovafloxacin, Infectious Diseases, chemistry, Enterococcus, Clinafloxacin, medicine.drug, Fluoroquinolones
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f649369cc36515a123194dd4d27883b0
https://pubmed.ncbi.nlm.nih.gov/9301985