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1
المؤلفون: Hidaka, Koushi, Kimura, Tooru, Sankaranarayanan, Rajesh, Wang, Jun, F. McDaniel, Keith, J. Kempf, Dale, Kameoka, Masanori, Adachi, Motoyasu, Kuroki, Ryota, Jeffrey-Tri, Nguyen, Hayashi, Yoshio, Kiso, Yoshiaki
المصدر: Journal of Medicinal Chemistry. 61(12):5138-5153
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2
المؤلفون: Masanori Kameoka, Ryota Kuroki, Dale J. Kempf, Motoyasu Adachi, Rajesh Sankaranarayanan, Jun Wang, Tooru Kimura, Koushi Hidaka, Jeffrey-Tri Nguyen, Yoshiaki Kiso, Yoshio Hayashi, Keith F. McDaniel
المصدر: Journal of medicinal chemistry. 61(12)
مصطلحات موضوعية: 0301 basic medicine, Serum, Peptidomimetic, medicine.medical_treatment, Glycine, 010402 general chemistry, Crystallography, X-Ray, 01 natural sciences, Virus, Lopinavir, 03 medical and health sciences, Structure-Activity Relationship, HIV Protease, Drug Discovery, Drug Resistance, Viral, medicine, Humans, Darunavir, Protease, Chemistry, Wild type, virus diseases, HIV Protease Inhibitors, Virology, Phenylbutyrates, 0104 chemical sciences, Multiple drug resistance, 030104 developmental biology, HIV-1, Molecular Medicine, Ritonavir, Peptidomimetics, medicine.drug
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3
المؤلفون: Harichandra D. Tagad, Takashi Hamada, Youhei Sohma, Yoshiaki Kiso, Yoshio Hamada, Jeffrey-Tri Nguyen, Tooru Kimura, Koushi Hidaka
المصدر: Bioorganic & Medicinal Chemistry. 19:5238-5246
مصطلحات موضوعية: chemistry.chemical_classification, Stereochemistry, Isostere, Chemistry, Carboxylic acid, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, Substrate (chemistry), Biochemistry, Combinatorial chemistry, Pentapeptide repeat, In vitro, Enzyme, mental disorders, Drug Discovery, Molecular Medicine, Potency, Structure–activity relationship, Molecular Biology
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4
المؤلفون: Jeffrey-Tri Nguyen, Henri-Obadja Kumada, Tooru Kimura, Taeko Kakizawa, Yoshiaki Kiso, Koushi Hidaka, Yoshio Hayashi
المصدر: Journal of Peptide Science. 17:569-575
مصطلحات موضوعية: viruses, medicine.medical_treatment, Mutant, Peptide, Biology, medicine.disease_cause, Biochemistry, law.invention, Scissile bond, immune system diseases, Structural Biology, law, hemic and lymphatic diseases, Drug Discovery, medicine, Moiety, Molecular Biology, Escherichia coli, Pharmacology, chemistry.chemical_classification, Protease, Chromogenic, Organic Chemistry, virus diseases, General Medicine, Molecular biology, chemistry, Recombinant DNA, Molecular Medicine
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5
المؤلفون: Jeffrey-Tri Nguyen, Keiko Kato, Henri-Obadja Kumada, Yoshiaki Kiso, Tooru Kimura, Koushi Hidaka
المصدر: Bioorganic & Medicinal Chemistry Letters. 21:2425-2429
مصطلحات موضوعية: viruses, medicine.medical_treatment, Clinical Biochemistry, T-cell leukemia, Pharmaceutical Science, Crystallography, X-Ray, Biochemistry, Virus, Structure-Activity Relationship, HIV Protease, immune system diseases, Catalytic Domain, hemic and lymphatic diseases, Drug Discovery, Tropical spastic paraparesis, medicine, Humans, Protease Inhibitors, Protease inhibitor (pharmacology), Molecular Biology, chemistry.chemical_classification, Human T-lymphotropic virus 1, Binding Sites, Protease, biology, Organic Chemistry, virus diseases, Hydrogen Bonding, medicine.disease, biology.organism_classification, Virology, Deltaretrovirus, Enzyme, chemistry, Enzyme inhibitor, Drug Design, biology.protein, Computer-Aided Design, Molecular Medicine, Peptides, Hydrophobic and Hydrophilic Interactions, Peptide Hydrolases
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6
المؤلفون: Mi Li, Tadashi Satoh, Alexander Wlodawer, Alla Gustchina, Yoshiaki Kiso, Jeffrey-Tri Nguyen
المصدر: Journal of Molecular Biology. 401:626-641
مصطلحات موضوعية: Human T-lymphotropic virus 1, Protease, biology, viruses, medicine.medical_treatment, Crystal structure, Crystallography, X-Ray, biology.organism_classification, medicine.disease, Virology, Article, Structure-Activity Relationship, Leukemia, Retrovirus, Structural Biology, HTLV-1 protease, Tropical spastic paraparesis, medicine, Aspartic Acid Endopeptidases, Humans, Structure–activity relationship, Protease Inhibitors, Hydrophobic and Hydrophilic Interactions, Molecular Biology
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7
المؤلفون: Koushi Hidaka, Yoshio Hamada, Tooru Kimura, Takashi Hamada, Hayato Ikari, Hamdy M. Abdel-Rahman, Ayaka Nagamine, Yoshiaki Kiso, Naoto Igawa, Harichandra D. Tagad, Abdellah Yamani, Jeffrey-Tri Nguyen, Youhei Sohma
المصدر: Bioorganic & Medicinal Chemistry. 18:3175-3186
مصطلحات موضوعية: chemistry.chemical_classification, Membrane permeability, Hydrogen bond, Isostere, Stereochemistry, Carboxylic acid, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, Substrate (chemistry), Biochemistry, chemistry.chemical_compound, chemistry, mental disorders, Drug Discovery, Molecular Medicine, Tetrazole, Molecular Biology
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8
المؤلفون: Tooru Kimura, Henri-Obadja Kumada, Maosheng Cheng, Jeffrey-Tri Nguyen, Yoshiaki Kiso, Meihui Zhang, Yoshio Hayashi
المصدر: Bioorganic & Medicinal Chemistry. 16:6880-6890
مصطلحات موضوعية: viruses, medicine.medical_treatment, Clinical Biochemistry, Pharmaceutical Science, Biochemistry, Virus, Structure-Activity Relationship, immune system diseases, hemic and lymphatic diseases, Drug Discovery, Tropical spastic paraparesis, medicine, Humans, Protease Inhibitors, Protease inhibitor (pharmacology), Molecular Biology, chemistry.chemical_classification, Human T-lymphotropic virus 1, Protease, biology, Organic Chemistry, virus diseases, biology.organism_classification, medicine.disease, HTLV-I Infections, Virology, Deltaretrovirus, Leukemia, Enzyme, chemistry, Enzyme inhibitor, biology.protein, Molecular Medicine, Peptides
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9
المؤلفون: Henri-Obadja Kumada, Meihui Zhang, Jeffrey-Tri Nguyen, Yoshiaki Kiso, Maosheng Cheng, Yoshio Hayashi, Tooru Kimura
المصدر: Bioorganic & Medicinal Chemistry. 16:5795-5802
مصطلحات موضوعية: Models, Molecular, viruses, medicine.medical_treatment, Clinical Biochemistry, Drug Evaluation, Preclinical, Molecular Conformation, Pharmaceutical Science, Biochemistry, Virus, Microbiology, Inhibitory Concentration 50, Structure-Activity Relationship, HIV Protease, hemic and lymphatic diseases, Drug Discovery, Tropical spastic paraparesis, medicine, Aspartic Acid Endopeptidases, Humans, Protease Inhibitors, Protease inhibitor (pharmacology), Molecular Biology, chemistry.chemical_classification, Binding Sites, Protease, Dose-Response Relationship, Drug, biology, Chemistry, Organic Chemistry, virus diseases, Stereoisomerism, medicine.disease, In vitro, Leukemia, Enzyme, Enzyme inhibitor, biology.protein, Molecular Medicine, Oligopeptides
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10
المؤلفون: Ei'ichi Ami, Yoshio Hayashi, Koushi Hidaka, Nobuyuki Ohnishi, Yoshiaki Kiso, Yasuko Hori, Akinori Nagai, Shingo Nakatani, Yoshio Hamada, Akihiko Sato, Tooru Kimura, Koichiro Nakahara, Jeffrey-Tri Nguyen
المصدر: Journal of Medicinal Chemistry. 51:2992-3004
مصطلحات موضوعية: Models, Molecular, medicine.medical_treatment, Mutant, Serine, Structure-Activity Relationship, HIV Protease, Drug Resistance, Viral, Drug Discovery, medicine, HIV Protease Inhibitor, Protease inhibitor (pharmacology), Amino Acids, chemistry.chemical_classification, Protease, biology, virus diseases, Stereoisomerism, HIV Protease Inhibitors, Phenylbutyrates, In vitro, Thiazoles, Enzyme, Biochemistry, chemistry, Enzyme inhibitor, Mutation, HIV-1, biology.protein, Molecular Medicine