المؤلفون: Barbara M. A. van Vugt-Lussenburg, Liliana Capinha, Jelle Reinen, Martijn Rooseboom, Michel Kranendonk, Rob C. A. Onderwater, Paul Jennings

المصدر: Van Vugt-Lussenburg, B M A, Capinha, L, Reinen, J, Rooseboom, M, Kranendonk, M, Onderwater, R C A & Jennings, P 2022, ' "Commandeuring" Xenobiotic Metabolism : Advances in Understanding Xenobiotic Metabolism ', Chemical Research in Toxicology, vol. 35, no. 7, pp. 1184–1201 . https://doi.org/10.1021/acs.chemrestox.2c00067

مصطلحات موضوعية: General Medicine, Toxicology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df41a96a33afe60a99553de9285d7df4
https://hdl.handle.net/1871.1/eab2130d-7bc3-41bf-88db-8831940315e9

المؤلفون: Jelle Reinen, Martijn Smit, Mira Wenker

المصدر: European Journal of Drug Metabolism and Pharmacokinetics. 43:737-750

مصطلحات موضوعية: Furafylline, Cytochrome P-450 CYP1A2 Inhibitors, Pharmacology, urologic and male genital diseases, digestive system, 030226 pharmacology & pharmacy, Troleandomycin, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Theophylline, Cytochrome P-450 CYP2D6 Inhibitors, medicine, Humans, Drug Interactions, heterocyclic compounds, Pharmacology (medical), Dose-Response Relationship, Drug, CYP3A4, biology, Chemistry, CYP1A2, Cytochrome P450, Glutathione, respiratory system, Dihydralazine, Mifepristone, Paroxetine, enzymes and coenzymes (carbohydrates), Verapamil, 030220 oncology & carcinogenesis, Microsomes, Liver, Microsome, biology.protein, Cytochrome P-450 CYP3A Inhibitors, Drug metabolism, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d63dc44e48aed22a8ed4a2a408f6c03b
https://doi.org/10.1007/s13318-018-0485-7

المؤلفون: Karoline Klaering, Jelle Reinen, Galvin Vredenburg, Jan N. M. Commandeur, J. Chris Vos, Nico P. E. Vermeulen, Maarten Honing

المساهمون: AIMMS, Molecular and Computational Toxicology, BioAnalytical Chemistry

المصدر: Journal of Molecular Catalysis B. Enzymatic, 121:3212, 64-74. Elsevier
Reinen, J, Vredenburg, G, Klaering, K, Vermeulen, N P E, Commandeur, J N M, Honing, M & Vos, J C 2015, ' Selective whole-cell biosynthesis of the designer drug metabolites 15-or 16-betahydroxynorethisterone by engineered Cytochrome P450 BM3 mutants ', Journal of Molecular Catalysis B. Enzymatic, vol. 121, 3212, pp. 64-74 . https://doi.org/10.1016/j.molcatb.2015.08.003

مصطلحات موضوعية: Mutant, Saccharomyces cerevisiae, Bioengineering, medicine.disease_cause, Biochemistry, Catalysis, Hydroxylation, chemistry.chemical_compound, Stereo- and regioselectivity, Biotransformation, Biosynthesis, SDG 3 - Good Health and Well-being, Cytochrome P450 BM3, medicine, Escherichia coli, Whole-cell biocatalysis, biology, Process Chemistry and Technology, Cytochrome P450, biology.organism_classification, In vitro, chemistry, biology.protein, Norethisterone, Biotechnology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6ba67ba67584643d4c97af72261ef3a
https://doi.org/10.1016/j.molcatb.2015.08.003

المؤلفون: Leticia Rubio, Kevin Scase, Ton van Huygevoort, Jelle Reinen, Pieter van Sas, Mira Wenker

المصدر: International journal of toxicology. 37(4)

مصطلحات موضوعية: 0301 basic medicine, Drug, Drug-Related Side Effects and Adverse Reactions, media_common.quotation_subject, Pharmacology, Toxicology, Melanin, 030207 dermatology & venereal diseases, 03 medical and health sciences, 0302 clinical medicine, In vivo, Toxicity Tests, medicine, Distribution (pharmacology), Animals, media_common, Skin, Melanins, integumentary system, Chemistry, Pirfenidone, In vitro, Rats, 030104 developmental biology, Sparfloxacin, Pharmaceutical Preparations, Female, Phototoxicity, medicine.drug, Dermatitis, Phototoxic

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5638c4d6ea89a8002a3b90ef0789338a
https://pubmed.ncbi.nlm.nih.gov/29898631

المؤلفون: Jennifer Thomas, Mira Wenker, Jelle Reinen, Martijn Smit

المصدر: Drug Metabolism and Pharmacokinetics. 34:S40-S41

مصطلحات موضوعية: Pharmacology, Cytochrome P450 Inhibitors, Biochemistry, Chemistry, Reactive metabolite, Pharmaceutical Science, Pharmacology (medical)

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::b9b066b489c0a18c45e4af5a2139e6c1
https://doi.org/10.1016/j.dmpk.2018.09.148

المؤلفون: Jelle Reinen, Daan Noort, A. Fidder, Leyla Nematollahi, Nico P. E. Vermeulen, Jan N. M. Commandeur

المساهمون: Molecular and Computational Toxicology, AIMMS

المصدر: Reinen, J, Nematollahi, L, Fidder, A, Vermeulen, N P E, Noort, D & Commandeur, J N M 2015, ' Characterization of human cytochrome P450s involved in the bioactivation of tri-Ortho-Cresyl phosphate (ToCP) ', Chemical Research in Toxicology, vol. 28, no. 4, pp. 711-721 . https://doi.org/10.1021/tx500490v
Chemical Research in Toxicology, 4 (20 April), 28, 711-721
Chemical Research in Toxicology, 28(4), 711-721. American Chemical Society

مصطلحات موضوعية: Cholinesterase inhibition, Unclassified drug, Metabolite, IC50, Pharmacology, Toxicology, Cytochrome P450 3A4, 329736-03-0, Activation, Metabolic, chemistry.chemical_compound, Aerotoxic syndrome, Cytochrome P-450 Enzyme System, Biotransformation, Butyrylcholinesterase, TS - Technical Sciences, Hydrolysis, Enzyme inactivation, Acetylcholinesterase, 9000-81-1, General Medicine, Observation, Weapon & Protection Systems, Acetylcholinesterase, Tritolyl Phosphates, cytochrome P450, 9035-51-2, Biochemistry, Tri ortho cresyl phosphate, 78-30-8, Microsomes, Liver, Liver microsome, Animal cell, Liver microsome metabolism, Cytochrome P450 3A5, 336874-97-6, Cytochrome P450 1A2, Biology, Gas Chromatography-Mass Spectrometry, SDG 3 - Good Health and Well-being, Cytochrome P450 3A4, Cytochrome P450 3A5, Cytochrome P450 2C18, Neurotoxicity, medicine, Animals, Humans, Cholinesterase, 9001-08-5, CYP3A4, human cell, CBRN - CBRN Protection, CYP1A2, In vitro study, Cytochrome P450 2D6, Nonhuman, medicine.disease, Rats, chemistry, Organophosphorus compound, Microsome, Controlled study

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4eb7a38178e9c163430a723b529b4453
https://doi.org/10.1021/tx500490v

المؤلفون: Jan N. M. Commandeur, Daniel van Hemert, Jelle Reinen, Nico P. E. Vermeulen

المساهمون: AIMMS, Molecular and Computational Toxicology

المصدر: Journal of Biomolecular Screening, 20(10), 1246-55. SAGE Publications Inc.
Reinen, J, van Hemert, D, Vermeulen, N P E & Commandeur, J N M 2015, ' Application of a Continuous-Flow Bioassay to Investigate the Organic Solvent Tolerability of Cytochrome P450 BM3 Mutants ', Journal of Biomolecular Screening, vol. 20, no. 10, pp. 1246-55 . https://doi.org/10.1177/1087057115607183

مصطلحات موضوعية: Amitriptyline, Mutant, Biochemistry, Cofactor, Fluorescence, Analytical Chemistry, chemistry.chemical_compound, Bacterial Proteins, Cytochrome P-450 Enzyme System, Journal Article, Bioassay, Acetonitrile, Enzyme Assays, NADPH-Ferrihemoprotein Reductase, Flow injection analysis, biology, Cytochrome P450, Monooxygenase, Enzyme assay, chemistry, Flow Injection Analysis, Mutation, biology.protein, Solvents, Molecular Medicine, Biotechnology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ec8a98083c645c7ad6a418fdf65d8e2
https://research.vu.nl/en/publications/635b0191-c0a1-40c8-8fd9-bbdb40580c4e

المؤلفون: John Saunders, Jan N. M. Commandeur, Peter D. J. Grootenhuis, Nico P. E. Vermeulen, Jelle Reinen, Caroline Decker, Yongmin Li, Jolanda van Leeuwen, Lifang Sun

المصدر: Drug Metabolism and Disposition. 39:1568-1576

مصطلحات موضوعية: Drug, media_common.quotation_subject, Mutant, Pharmaceutical Science, Biology, Mass Spectrometry, Substrate Specificity, Bacterial Proteins, Cytochrome P-450 Enzyme System, Humans, Genomic library, Gene Library, media_common, Pharmacology, Molecular mass, Cytochrome P450, Chemical space, Pharmaceutical Preparations, Biochemistry, Drug development, Inactivation, Metabolic, Microsomes, Liver, Mutagenesis, Site-Directed, biology.protein, Drug metabolism, Chromatography, Liquid

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0984d93607f7640bd35fa142122525a
https://doi.org/10.1124/dmd.111.039461

المؤلفون: Jan N. M. Commandeur, Livia L. Kalma, Jelle Reinen, Ferry Heus, Nico P. E. Vermeulen, Selina Begheijn

المساهمون: Molecular and Computational Toxicology, BioAnalytical Chemistry, AIMMS

المصدر: Xenobiotica, 41(1), 59-70. Informa Healthcare
Reinen, J, Kalma, L, Begheijn, S, Heus, F A H, Commandeur, J N M & Vermeulen, N P E 2011, ' Application of cytochrome P450 BM3 mutants as biocatalysts for the profiling of estrogen receptor binding metabolites of the mycotoxin zearalenone ', Xenobiotica, vol. 41, no. 1, pp. 59-70 . https://doi.org/10.3109/00498254.2010.525762

مصطلحات موضوعية: Health, Toxicology and Mutagenesis, Estrogen receptor, Hydroxylation, Toxicology, Biochemistry, Mass Spectrometry, chemistry.chemical_compound, Cytochrome P-450 Enzyme System, Humans, Biotransformation, Pharmacology, Bacteria, biology, Chemistry, Estrogen receptor binding, fungi, Estrogen Receptor alpha, Cytochrome P450, General Medicine, Monooxygenase, Isoenzymes, Xenoestrogen, Biocatalysis, Microsomes, Liver, biology.protein, Microsome, Zearalenone, Zeranol, Mutant Proteins, Drug metabolism

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a69afef89ea7970a96c797ac418dbb7
https://doi.org/10.3109/00498254.2010.525762

المؤلفون: Marc J.-F. Suter, Mariana F. Fernández, Rik I.L. Eggen, Nico P. E. Vermeulen, Jelle Reinen, A. C. Vögeli, Hannu Kiviranta

المساهمون: Molecular and Computational Toxicology, AIMMS

المصدر: Environmental Toxicology and Pharmacology, 30, 209-223. Elsevier
Reinen, J, Suter, M J F, Vogeli, A C, Fernandez, M F, Kiviranta, H, Eggen, R I L & Vermeulen, N P E 2010, ' Endocrine disrupting chemicals-linking internal exposure to vitellogenin levels and ovotestis in Abramis brama from Dutch surface waters ', Environmental Toxicology and Pharmacology, vol. 30, pp. 209-223 . https://doi.org/10.1016/j.etap.2010.07.004

مصطلحات موضوعية: Pharmacology, medicine.medical_specialty, Ovotestis, biology, medicine.drug_class, Chemistry, Health, Toxicology and Mutagenesis, Polychlorinated dibenzodioxins, General Medicine, Coumestrol, Toxicology, chemistry.chemical_compound, Vitellogenin, Polybrominated diphenyl ethers, Endocrinology, Estrogen, Environmental chemistry, Internal medicine, medicine, biology.protein, Bioassay, SDG 14 - Life Below Water, Polychlorinated dibenzofurans

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f58f2268e0ee62a37d24bf588bf6f9e9
https://doi.org/10.1016/j.etap.2010.07.004