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المؤلفون: Barbara M. A. van Vugt-Lussenburg, Liliana Capinha, Jelle Reinen, Martijn Rooseboom, Michel Kranendonk, Rob C. A. Onderwater, Paul Jennings
المصدر: Van Vugt-Lussenburg, B M A, Capinha, L, Reinen, J, Rooseboom, M, Kranendonk, M, Onderwater, R C A & Jennings, P 2022, ' "Commandeuring" Xenobiotic Metabolism : Advances in Understanding Xenobiotic Metabolism ', Chemical Research in Toxicology, vol. 35, no. 7, pp. 1184–1201 . https://doi.org/10.1021/acs.chemrestox.2c00067
مصطلحات موضوعية: General Medicine, Toxicology
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المؤلفون: Jelle Reinen, Martijn Smit, Mira Wenker
المصدر: European Journal of Drug Metabolism and Pharmacokinetics. 43:737-750
مصطلحات موضوعية: Furafylline, Cytochrome P-450 CYP1A2 Inhibitors, Pharmacology, urologic and male genital diseases, digestive system, 030226 pharmacology & pharmacy, Troleandomycin, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Theophylline, Cytochrome P-450 CYP2D6 Inhibitors, medicine, Humans, Drug Interactions, heterocyclic compounds, Pharmacology (medical), Dose-Response Relationship, Drug, CYP3A4, biology, Chemistry, CYP1A2, Cytochrome P450, Glutathione, respiratory system, Dihydralazine, Mifepristone, Paroxetine, enzymes and coenzymes (carbohydrates), Verapamil, 030220 oncology & carcinogenesis, Microsomes, Liver, Microsome, biology.protein, Cytochrome P-450 CYP3A Inhibitors, Drug metabolism, medicine.drug
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المؤلفون: Karoline Klaering, Jelle Reinen, Galvin Vredenburg, Jan N. M. Commandeur, J. Chris Vos, Nico P. E. Vermeulen, Maarten Honing
المساهمون: AIMMS, Molecular and Computational Toxicology, BioAnalytical Chemistry
المصدر: Journal of Molecular Catalysis B. Enzymatic, 121:3212, 64-74. Elsevier
Reinen, J, Vredenburg, G, Klaering, K, Vermeulen, N P E, Commandeur, J N M, Honing, M & Vos, J C 2015, ' Selective whole-cell biosynthesis of the designer drug metabolites 15-or 16-betahydroxynorethisterone by engineered Cytochrome P450 BM3 mutants ', Journal of Molecular Catalysis B. Enzymatic, vol. 121, 3212, pp. 64-74 . https://doi.org/10.1016/j.molcatb.2015.08.003مصطلحات موضوعية: Mutant, Saccharomyces cerevisiae, Bioengineering, medicine.disease_cause, Biochemistry, Catalysis, Hydroxylation, chemistry.chemical_compound, Stereo- and regioselectivity, Biotransformation, Biosynthesis, SDG 3 - Good Health and Well-being, Cytochrome P450 BM3, medicine, Escherichia coli, Whole-cell biocatalysis, biology, Process Chemistry and Technology, Cytochrome P450, biology.organism_classification, In vitro, chemistry, biology.protein, Norethisterone, Biotechnology
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المؤلفون: Leticia Rubio, Kevin Scase, Ton van Huygevoort, Jelle Reinen, Pieter van Sas, Mira Wenker
المصدر: International journal of toxicology. 37(4)
مصطلحات موضوعية: 0301 basic medicine, Drug, Drug-Related Side Effects and Adverse Reactions, media_common.quotation_subject, Pharmacology, Toxicology, Melanin, 030207 dermatology & venereal diseases, 03 medical and health sciences, 0302 clinical medicine, In vivo, Toxicity Tests, medicine, Distribution (pharmacology), Animals, media_common, Skin, Melanins, integumentary system, Chemistry, Pirfenidone, In vitro, Rats, 030104 developmental biology, Sparfloxacin, Pharmaceutical Preparations, Female, Phototoxicity, medicine.drug, Dermatitis, Phototoxic
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5638c4d6ea89a8002a3b90ef0789338a
https://pubmed.ncbi.nlm.nih.gov/29898631 -
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المؤلفون: Jennifer Thomas, Mira Wenker, Jelle Reinen, Martijn Smit
المصدر: Drug Metabolism and Pharmacokinetics. 34:S40-S41
مصطلحات موضوعية: Pharmacology, Cytochrome P450 Inhibitors, Biochemistry, Chemistry, Reactive metabolite, Pharmaceutical Science, Pharmacology (medical)
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المؤلفون: Jelle Reinen, Daan Noort, A. Fidder, Leyla Nematollahi, Nico P. E. Vermeulen, Jan N. M. Commandeur
المساهمون: Molecular and Computational Toxicology, AIMMS
المصدر: Reinen, J, Nematollahi, L, Fidder, A, Vermeulen, N P E, Noort, D & Commandeur, J N M 2015, ' Characterization of human cytochrome P450s involved in the bioactivation of tri-Ortho-Cresyl phosphate (ToCP) ', Chemical Research in Toxicology, vol. 28, no. 4, pp. 711-721 . https://doi.org/10.1021/tx500490v
Chemical Research in Toxicology, 4 (20 April), 28, 711-721
Chemical Research in Toxicology, 28(4), 711-721. American Chemical Societyمصطلحات موضوعية: Cholinesterase inhibition, Unclassified drug, Metabolite, IC50, Pharmacology, Toxicology, Cytochrome P450 3A4, 329736-03-0, Activation, Metabolic, chemistry.chemical_compound, Aerotoxic syndrome, Cytochrome P-450 Enzyme System, Biotransformation, Butyrylcholinesterase, TS - Technical Sciences, Hydrolysis, Enzyme inactivation, Acetylcholinesterase, 9000-81-1, General Medicine, Observation, Weapon & Protection Systems, Acetylcholinesterase, Tritolyl Phosphates, cytochrome P450, 9035-51-2, Biochemistry, Tri ortho cresyl phosphate, 78-30-8, Microsomes, Liver, Liver microsome, Animal cell, Liver microsome metabolism, Cytochrome P450 3A5, 336874-97-6, Cytochrome P450 1A2, Biology, Gas Chromatography-Mass Spectrometry, SDG 3 - Good Health and Well-being, Cytochrome P450 3A4, Cytochrome P450 3A5, Cytochrome P450 2C18, Neurotoxicity, medicine, Animals, Humans, Cholinesterase, 9001-08-5, CYP3A4, human cell, CBRN - CBRN Protection, CYP1A2, In vitro study, Cytochrome P450 2D6, Nonhuman, medicine.disease, Rats, chemistry, Organophosphorus compound, Microsome, Controlled study
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المساهمون: AIMMS, Molecular and Computational Toxicology
المصدر: Journal of Biomolecular Screening, 20(10), 1246-55. SAGE Publications Inc.
Reinen, J, van Hemert, D, Vermeulen, N P E & Commandeur, J N M 2015, ' Application of a Continuous-Flow Bioassay to Investigate the Organic Solvent Tolerability of Cytochrome P450 BM3 Mutants ', Journal of Biomolecular Screening, vol. 20, no. 10, pp. 1246-55 . https://doi.org/10.1177/1087057115607183مصطلحات موضوعية: Amitriptyline, Mutant, Biochemistry, Cofactor, Fluorescence, Analytical Chemistry, chemistry.chemical_compound, Bacterial Proteins, Cytochrome P-450 Enzyme System, Journal Article, Bioassay, Acetonitrile, Enzyme Assays, NADPH-Ferrihemoprotein Reductase, Flow injection analysis, biology, Cytochrome P450, Monooxygenase, Enzyme assay, chemistry, Flow Injection Analysis, Mutation, biology.protein, Solvents, Molecular Medicine, Biotechnology
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ec8a98083c645c7ad6a418fdf65d8e2
https://research.vu.nl/en/publications/635b0191-c0a1-40c8-8fd9-bbdb40580c4e -
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المؤلفون: John Saunders, Jan N. M. Commandeur, Peter D. J. Grootenhuis, Nico P. E. Vermeulen, Jelle Reinen, Caroline Decker, Yongmin Li, Jolanda van Leeuwen, Lifang Sun
المصدر: Drug Metabolism and Disposition. 39:1568-1576
مصطلحات موضوعية: Drug, media_common.quotation_subject, Mutant, Pharmaceutical Science, Biology, Mass Spectrometry, Substrate Specificity, Bacterial Proteins, Cytochrome P-450 Enzyme System, Humans, Genomic library, Gene Library, media_common, Pharmacology, Molecular mass, Cytochrome P450, Chemical space, Pharmaceutical Preparations, Biochemistry, Drug development, Inactivation, Metabolic, Microsomes, Liver, Mutagenesis, Site-Directed, biology.protein, Drug metabolism, Chromatography, Liquid
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0984d93607f7640bd35fa142122525a
https://doi.org/10.1124/dmd.111.039461 -
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المؤلفون: Jan N. M. Commandeur, Livia L. Kalma, Jelle Reinen, Ferry Heus, Nico P. E. Vermeulen, Selina Begheijn
المساهمون: Molecular and Computational Toxicology, BioAnalytical Chemistry, AIMMS
المصدر: Xenobiotica, 41(1), 59-70. Informa Healthcare
Reinen, J, Kalma, L, Begheijn, S, Heus, F A H, Commandeur, J N M & Vermeulen, N P E 2011, ' Application of cytochrome P450 BM3 mutants as biocatalysts for the profiling of estrogen receptor binding metabolites of the mycotoxin zearalenone ', Xenobiotica, vol. 41, no. 1, pp. 59-70 . https://doi.org/10.3109/00498254.2010.525762مصطلحات موضوعية: Health, Toxicology and Mutagenesis, Estrogen receptor, Hydroxylation, Toxicology, Biochemistry, Mass Spectrometry, chemistry.chemical_compound, Cytochrome P-450 Enzyme System, Humans, Biotransformation, Pharmacology, Bacteria, biology, Chemistry, Estrogen receptor binding, fungi, Estrogen Receptor alpha, Cytochrome P450, General Medicine, Monooxygenase, Isoenzymes, Xenoestrogen, Biocatalysis, Microsomes, Liver, biology.protein, Microsome, Zearalenone, Zeranol, Mutant Proteins, Drug metabolism
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المؤلفون: Marc J.-F. Suter, Mariana F. Fernández, Rik I.L. Eggen, Nico P. E. Vermeulen, Jelle Reinen, A. C. Vögeli, Hannu Kiviranta
المساهمون: Molecular and Computational Toxicology, AIMMS
المصدر: Environmental Toxicology and Pharmacology, 30, 209-223. Elsevier
Reinen, J, Suter, M J F, Vogeli, A C, Fernandez, M F, Kiviranta, H, Eggen, R I L & Vermeulen, N P E 2010, ' Endocrine disrupting chemicals-linking internal exposure to vitellogenin levels and ovotestis in Abramis brama from Dutch surface waters ', Environmental Toxicology and Pharmacology, vol. 30, pp. 209-223 . https://doi.org/10.1016/j.etap.2010.07.004مصطلحات موضوعية: Pharmacology, medicine.medical_specialty, Ovotestis, biology, medicine.drug_class, Chemistry, Health, Toxicology and Mutagenesis, Polychlorinated dibenzodioxins, General Medicine, Coumestrol, Toxicology, chemistry.chemical_compound, Vitellogenin, Polybrominated diphenyl ethers, Endocrinology, Estrogen, Environmental chemistry, Internal medicine, medicine, biology.protein, Bioassay, SDG 14 - Life Below Water, Polychlorinated dibenzofurans