-
1دورية أكاديمية
المؤلفون: Rouba Kozak, Tamás Kiss, Keith Dlugolenski, David E. Johnson, Roxanne R. Gorczyca, Kyle Kuszpit, Brian D. Harvey, Polina Stolyar, Stacey J. Sukoff Rizzo, William E. Hoffmann, Dmitri Volfson, Mihaly Hajós, Jennifer E. Davoren, Amanda L. Abbott, Graham V. Williams, Stacy A. Castner, David L. Gray
المصدر: Frontiers in Pharmacology, Vol 11 (2020)
مصطلحات موضوعية: prefrontal cortex, schizophrenia, working memory, pro-cognitive therapeutics, Parkinson’s disease, Therapeutics. Pharmacology, RM1-950
وصف الملف: electronic resource
-
2
المؤلفون: Graham V. Williams, Jennifer E. Davoren, Dmitri Volfson, David Gray, Mihály Hajós, Kyle Kuszpit, Tamás Kiss, William E. Hoffmann, Brian D. Harvey, Roxanne R Gorczyca, Stacey J. Sukoff Rizzo, David E. Johnson, Amanda L. Abbott, Keith Dlugolenski, Stacy A. Castner, Polina Stolyar, Rouba Kozak
المصدر: Frontiers in Pharmacology, Vol 11 (2020)
Frontiers in Pharmacologyمصطلحات موضوعية: 0301 basic medicine, Agonist, medicine.drug_class, Pharmacology, Partial agonist, working memory, 03 medical and health sciences, 0302 clinical medicine, Dopamine receptor D1, Dopamine, Medicine, Pharmacology (medical), Receptor, Original Research, prefrontal cortex, Radial arm maze, business.industry, Dopaminergic, lcsh:RM1-950, schizophrenia, 030104 developmental biology, lcsh:Therapeutics. Pharmacology, 030220 oncology & carcinogenesis, Parkinson’s disease, NMDA receptor, business, pro-cognitive therapeutics, medicine.drug
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f5b478619938cf5d883f9410506abde
https://www.frontiersin.org/article/10.3389/fphar.2020.01005/full -
3
المؤلفون: Anthony R. Harris, Susan M. Lotarski, Michael Aaron Brodney, Michael Popiolek, Catherine A. Thorn, Stephen Jenkinson, Che Wah Lee, Jennifer E. Davoren, Stefanus J. Steyn, Lei Zhang, Terrence Peter Kenakin, Betty Pettersen, Sarah Grimwood, Damien Webb, Michelle R. Garnsey, Simeon Ramsey, John T. Lazzaro, Steven Victor O'neil, Lisa Nottebaum, Jean-Philippe Fortin, Jeremy R. Edgerton
المصدر: Journal of Medicinal Chemistry. 60:6649-6663
مصطلحات موضوعية: 0301 basic medicine, Agonist, Allosteric modulator, medicine.drug_class, Chemistry, Allosteric regulation, Muscarinic acetylcholine receptor M1, Pharmacology, 03 medical and health sciences, 030104 developmental biology, Drug Discovery, Convulsion, medicine, Molecular Medicine, Cholinergic, Structure–activity relationship, medicine.symptom, Receptor
-
4
المؤلفون: Susan M. Lotarski, Sarah Grimwood, Michael Popiolek, Veronica Reinhart, Jeremy R. Edgerton, Jennifer E. Davoren, Stefanus J. Steyn, John F. Harms, David P. Nguyen
المصدر: Biochemistry. 55:7073-7085
مصطلحات موضوعية: 0301 basic medicine, chemistry.chemical_classification, Muscarinic acetylcholine receptor M3, Muscarinic acetylcholine receptor M2, Muscarinic acetylcholine receptor M1, Pharmacology, Biochemistry, 03 medical and health sciences, chemistry.chemical_compound, 030104 developmental biology, 0302 clinical medicine, chemistry, Muscarinic acetylcholine receptor, Muscarinic acetylcholine receptor M5, Muscarinic acetylcholine receptor M4, Inositol, Inositol phosphate, 030217 neurology & neurosurgery
-
5
المؤلفون: Jotham Wadsworth Coe, Brajesh K. Rai, Sidney Liang, Keith Dlugolenski, Jennifer E. Davoren, Erik Alphie Lachapelle, Rebecca E. O’Connor, Deane M. Nason, Christine C. Orozco, David Gray, Rouba Kozak, Christopher John Helal, Brian Samas, Yue Liu, Michelle A. Salafia, Anthony R. Harris, Wenjian Xu
المصدر: Journal of medicinal chemistry. 61(24)
مصطلحات موضوعية: 0301 basic medicine, Agonist, Male, medicine.drug_class, medicine.medical_treatment, Biological Availability, Mice, Inbred Strains, CHO Cells, Pharmacology, Madin Darby Canine Kidney Cells, 03 medical and health sciences, Structure-Activity Relationship, 0302 clinical medicine, Dopamine receptor D1, Cricetulus, Dogs, Dopamine, Drug Discovery, medicine, Cyclic AMP, Structure–activity relationship, Animals, Humans, Receptor, Desensitization (medicine), Neurons, Atropisomer, Dose-Response Relationship, Drug, Chemistry, Receptors, Dopamine D1, HEK 293 cells, Stereoisomerism, High-Throughput Screening Assays, Rats, 030104 developmental biology, HEK293 Cells, Dopamine Agonists, Molecular Medicine, 030217 neurology & neurosurgery, medicine.drug, Half-Life
-
6
المؤلفون: Deborah L. Smith, Sarah J. Neal, Lei Zhang, Jeremy R. Edgerton, Jennifer E. Davoren, Sarah Grimwood, John T. Lazzaro, Chewah Lee
المصدر: Molecular Pharmacology. 90:177-187
مصطلحات موضوعية: Male, 0301 basic medicine, Carbachol, Allosteric modulator, Pyridines, Stereochemistry, Allosteric regulation, CHO Cells, Isoindoles, Hippocampus, Rats, Sprague-Dawley, Radioligand Assay, 03 medical and health sciences, Cricetulus, 0302 clinical medicine, Allosteric Regulation, Cricetinae, Muscarinic acetylcholine receptor, medicine, Radioligand, Animals, Humans, Fluorometry, Pharmacology, Membranes, Chemistry, Ligand binding assay, Receptor, Muscarinic M1, N-Methylscopolamine, Acetylcholine, Electrophysiological Phenomena, Kinetics, HEK293 Cells, 030104 developmental biology, Positron-Emission Tomography, Autoradiography, Molecular Medicine, 030217 neurology & neurosurgery, medicine.drug
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59a4cbb153c3abcd01cb4427f9543370
https://doi.org/10.1124/mol.116.104737 -
7
المؤلفون: Ludivine Moine, Bruce N. Rogers, Mark L. Weber, Karen Tse, Sheri L. Snow, Susan E. Drozda, Karen Baker, John A. Lowe, Kevin A. Serpa, Katherine Schuyten, Jennifer E. Davoren, Rong Suobao, Ann S. Wright, Shari L. DeNinno, Michelle Marie Claffey, Allen J. Duplantier, Christopher Ryan Butler, Brian P. Boscoe, Alan J. Clark, Polina Stolyar, Robert J. Mather, Lois K. Chenard, Haojing Rong, Gaurav Arora, Matthew R. Reese, Tammy Whisman, Lei Zhang
المصدر: Bioorganic & Medicinal Chemistry Letters. 25:4941-4944
مصطلحات موضوعية: Clinical Biochemistry, Pharmaceutical Science, Stimulation, Pharmacology, Biochemistry, Cell Line, Tonic (physiology), Structure-Activity Relationship, Epilepsy, Piperidines, In vivo, Microsomes, Drug Discovery, medicine, Animals, Humans, KCNQ2 Potassium Channel, Molecular Biology, ADME, Electroshock, Dose-Response Relationship, Drug, Molecular Structure, Chemistry, Organic Chemistry, medicine.disease, In vitro, Rats, Maximal electroshock, Pyrimidines, Adjunctive treatment, Molecular Medicine, Ion Channel Gating
-
8
المؤلفون: Jennifer E, Davoren, Michelle, Garnsey, Betty, Pettersen, Michael A, Brodney, Jeremy R, Edgerton, Jean-Philippe, Fortin, Sarah, Grimwood, Anthony R, Harris, Stephen, Jenkinson, Terry, Kenakin, John T, Lazzaro, Che-Wah, Lee, Susan M, Lotarski, Lisa, Nottebaum, Steven V, O'Neil, Michael, Popiolek, Simeon, Ramsey, Stefanus J, Steyn, Catherine A, Thorn, Lei, Zhang, Damien, Webb
المصدر: Journal of medicinal chemistry. 60(15)
مصطلحات موضوعية: Diarrhea, Male, Lactams, Vomiting, Scopolamine, Isoindoles, Structure-Activity Relationship, Dogs, Allosteric Regulation, Piperidines, Seizures, Thiadiazoles, Animals, Humans, Donepezil, Rats, Wistar, Oxazoles, Sulfonamides, Receptor, Muscarinic M1, Mice, Inbred C57BL, Amphetamine, Drug Design, Indans, Microsomes, Liver, Ataxia, Female
-
9
المؤلفون: Michael, Popiolek, David P, Nguyen, Veronica, Reinhart, Jeremy R, Edgerton, John, Harms, Susan M, Lotarski, Stefanus J, Steyn, Jennifer E, Davoren, Sarah, Grimwood
المصدر: Biochemistry. 55(51)
مصطلحات موضوعية: Male, Dose-Response Relationship, Drug, Inositol Phosphates, Dopamine Agents, Receptor, Muscarinic M1, Brain, CHO Cells, Motor Activity, Muscarinic Agonists, Hippocampus, Corpus Striatum, Electrophysiological Phenomena, Rats, Sprague-Dawley, Amphetamine, Mice, Cricetulus, Cricetinae, Animals, Humans, Calcium
-
10
المؤلفون: Deane M. Nason, Keith Dlugolenski, Chewah Lee, Betty Pettersen, Gregory W. Kauffman, Lei Zhang, Carrie Northcott, Stephen Jenkinson, Yuxia Mao, Jennifer E. Davoren, Susan M. Lotarski, Veronica Reinhart, Damien Webb, Michelle R. Garnsey, Sarah Grimwood, John T. Lazzaro, Michael Aaron Brodney, Jeremy R. Edgerton, Jason Cordes, Stefanus J. Steyn, Romelia Salomon-Ferrer, Steven Victor O'neil, Terrence Peter Kenakin, Lisa Nottebaum, Michael Popiolek, Christopher John Helal, Anthony R. Harris
المصدر: Journal of medicinal chemistry. 59(13)
مصطلحات موضوعية: 0301 basic medicine, Agonist, Male, Models, Molecular, Allosteric modulator, Stereochemistry, medicine.drug_class, Carboxamide, Pharmacology, 03 medical and health sciences, chemistry.chemical_compound, Mice, Structure-Activity Relationship, 0302 clinical medicine, Muscarinic acetylcholine receptor, Drug Discovery, medicine, Structure–activity relationship, Animals, Picolinic Acids, Dose-Response Relationship, Drug, Molecular Structure, Chemistry, Receptor, Muscarinic M1, Rats, Thiazoles, 030104 developmental biology, Pyran, Molecular Medicine, Cholinergic, Female, Pharmacophore, 030217 neurology & neurosurgery