المؤلفون: Arno Amann, Marit Zwierzina, Gabriele Gamerith, Mario Bitsche, Julia M Huber, Georg F Vogel, Michael Blumer, Stefan Koeck, Elisabeth J Pechriggl, Jens M Kelm, Wolfgang Hilbe, Heinz Zwierzina

المصدر: PLoS ONE, Vol 9, Iss 3, p e92511 (2014)

مصطلحات موضوعية: Medicine, Science

وصف الملف: electronic resource

Relation: http://europepmc.org/articles/PMC3963897?pdf=render; https://doaj.org/toc/1932-6203

URL الوصول: https://doaj.org/article/b66e4b20cc6b499cb3d8f7a8531ce4e2

المؤلفون: Arno Amann, Marit Zwierzina, Stefan Koeck, Gabriele Gamerith, Elisabeth Pechriggl, Julia M. Huber, Edith Lorenz, Jens M. Kelm, Wolfgang Hilbe, Heinz Zwierzina, Johann Kern

المصدر: Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)

مصطلحات موضوعية: Medicine, Science

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2045-2322

URL الوصول: https://doaj.org/article/1ee938a72b3246ccbd4db879b442a84b

المؤلفون: Ramona Nudischer, Adrian Roth, Vanessa Baier, Lars M. Blank, José V. Castell, Jens M. Kelm, Annika R. P. Schneider, Florian Caiment, Hans Gmuender, Christoph Thiel, Lars Kuepfer, Wolfgang Moritz, Yannick Schrooders, Henrik Cordes, Jos C. S. Kleinjans, Christian Trautwein, Timo Wittenberger, Olivia Clayton, Ulf P. Neumann

المساهمون: RS: GROW - R1 - Prevention, Toxicogenomics, RS: MHeNs - R3 - Neuroscience

المصدر: Clinical pharmacology & therapeutics : CPT 110(5), 1293-1301 (2021). doi:10.1002/cpt.2406
Clinical Pharmacology & Therapeutics, 110(5), 1293-1301. Wiley
CLINICAL PHARMACOLOGY & THERAPEUTICS
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
instname

مصطلحات موضوعية: Male, PHARMACOKINETICS, AZATHIOPRINE, Azathioprine, Bioinformatics, 030226 pharmacology & pharmacy, Workflow, chemistry.chemical_compound, 0302 clinical medicine, PARACETAMOL, Pharmacology (medical), Enterohepatic circulation, media_common, 0303 health sciences, Cholestasis, Bile acid, Middle Aged, 3. Good health, Benchmarking, Liver, Pharmaceutical Preparations, SINGLE, Drug development, Female, VALPROATE, medicine.drug, Adult, Drug, Drug-Related Side Effects and Adverse Reactions, DICLOFENAC SODIUM, medicine.drug_class, media_common.quotation_subject, Models, Biological, Young Adult, 03 medical and health sciences, Pharmacokinetics, Spheroids, Cellular, medicine, Glycochenodeoxycholic acid, Animals, Humans, ddc:610, 030304 developmental biology, Pharmacology, business.industry, medicine.disease, chemistry, ACETAMINOPHEN, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2bb897e70f87a57b55a2225fb471753
https://doi.org/10.1002/cpt.2406

المؤلفون: Jens M. Kelm, S. Messner, T. M. de Kok, Jian Jiang, M.H.M. van Herwijnen, Danyel Jennen, J.C.S. Kleinjans

المساهمون: Experimental in vitro toxicology and dermato-cosmetology, Pharmaceutical and Pharmacological Sciences, Toxicogenomics, RS: GROW - R1 - Prevention, Ondersteunend personeel ODB, CRISP, RS: FSE MaCSBio, RS: FPN MaCSBio, RS: FHML MaCSBio

المصدر: Toxicology Letters, 312, 34-44. Elsevier Ireland Ltd

مصطلحات موضوعية: Lipopolysaccharides, 0301 basic medicine, INTERLEUKIN-8, Receptors, IgG/genetics, COCULTURE, medicine.medical_treatment, Respiratory chain, Gene Expression Regulation/drug effects, Pharmacology, Toxicology, medicine.disease_cause, HEPATOCYTES, Acetaminophen/toxicity, Tissue Culture Techniques, ACTIVATION, 0302 clinical medicine, Analgesics, Non-Narcotic/toxicity, Chemistry, Human primary hepatocytes, Inflammation/metabolism, digestive, oral, and skin physiology, Cytokines/metabolism, General Medicine, Analgesics, Non-Narcotic, 3D co-culture, Cytokine, Transcriptome/drug effects, Toxicity, Cytokines, medicine.symptom, Hepatocytes/drug effects, EXPRESSION, KUPFFER CELLS, Inflammation, Kupffer Cells/drug effects, Acetaminophen-inflammation interaction, PHAGOCYTOSIS, 03 medical and health sciences, medicine, Humans, Interleukin 8, Human Kupffer cells, Transcriptomics, RECEPTOR, MUTATIONS, Receptors, IgG, Hepatotoxicity, Tissue Culture Techniques/methods, Coculture Techniques, Toll-Like Receptor 4, Lipopolysaccharides/toxicity, 030104 developmental biology, Gene Expression Regulation, Hepatic stellate cell, TLR4, Transcriptome, ACETAMINOPHEN, Toll-Like Receptor 4/genetics, 030217 neurology & neurosurgery, Oxidative stress

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36b284f6f67c1475aa6ddc29b7c7a153
https://doi.org/10.1016/j.toxlet.2019.05.004

المؤلفون: Patrick Guye, Henrik Cordes, Madhu Lal-Nag, Jens M. Kelm, Zoe Weydert, Lesley Mathews-Greiner, Christoph Thiel, Marc Ferrer, Lars Küpfer

المصدر: SLAS discovery : advancing life sciences RD. 25(3)

مصطلحات موضوعية: 0301 basic medicine, Cell type, Stromal cell, Cell Survival, Antineoplastic Agents, Biology, Biochemistry, Analytical Chemistry, 03 medical and health sciences, Mice, 0302 clinical medicine, In vivo, Cell Line, Tumor, Neoplasms, Spheroids, Cellular, medicine, Tumor Microenvironment, Cytotoxic T cell, Animals, Humans, Cell Proliferation, Cancer, medicine.disease, In vitro, 030104 developmental biology, Cell culture, 030220 oncology & carcinogenesis, Cancer cell, Cancer research, NIH 3T3 Cells, Molecular Medicine, Drug Screening Assays, Antitumor, Stromal Cells, Biotechnology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b5afda271c428c2d598638f24a05bc1
https://pubmed.ncbi.nlm.nih.gov/31658853

المؤلفون: Lisa Fredriksson, Claudia Escher, Katrin Roessger, Magdalena Bober, Simon Messner, Volker M. Lauschke, Magnus Ingelman-Sundberg, Wolfgang Moritz, Jens M. Kelm

المصدر: Applied in Vitro Toxicology

مصطلحات موضوعية: 0301 basic medicine, cytochrome P450, Health, Toxicology and Mutagenesis, liver, Toxicology, Bone canaliculus, Proteomics, Transcriptome, transcriptomics, 03 medical and health sciences, proteomics, 0302 clinical medicine, Original Research Articles, biology, Multidrug resistance-associated protein 2, Albumin, In vitro toxicology, Cytochrome P450, Bile Salt Export Pump, Molecular biology, Cell biology, Medical Laboratory Technology, 030104 developmental biology, spheroid, 030220 oncology & carcinogenesis, biology.protein

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7625bd5c5d9679b345964f1487434e92
https://doi.org/10.1089/aivt.2017.0022

المؤلفون: Hubert Hackl, Gabriele Gamerith, Zlatko Trajanoski, Julia M. Huber, Jens M. Kelm, Johannes Rainer, Johann Kern, Edith Lorenz, Heinz Zwierzina, Reinhard Kofler, Arno Amann, Stefan Koeck

المصدر: Oncotarget. 8:112647-112661

مصطلحات موضوعية: 0301 basic medicine, DNA repair, Cell cycle, Biology, Cell biology, 03 medical and health sciences, 3D cell culture, 030104 developmental biology, 0302 clinical medicine, Oncology, Cell culture, 030220 oncology & carcinogenesis, DNA methylation, Gene expression, DNA microarray, Gene

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::08138eb1575390fe3f668aede7c63d91
https://doi.org/10.18632/oncotarget.22636

المؤلفون: Alberto Mantovani, Tanja Waldmann, Bob van de Water, Cristina Cadenas, Hennicke Kamp, Thomas Braunbeck, Annemarie H. Meijer, Mathieu Vinken, Sylvia Escher, Domenico Gadaleta, Patricio Godoy, Anna Forsby, Stefan Schildknecht, Chris T. Evelo, Stefan Höhme, Rosemarie Marchan, Gerhard F. Ecker, Harry Vrieling, Susanne Hougaard Bennekou, Ciarán Fisher, Alice Limonciel, Enrico Mombelli, Rabea Graepel, Marcel Leist, Ahmed Ghallab, Michael Schwarz, Joost B. Beltman, Jens M. Kelm, Albert Braeuning, Olivier Taboureau, Bart van der Burg, Andrea Terron, Ferran Sanz, Frédéric Y. Bois, Steven Dooley, Dinant Kroese, Jan G. Hengstler, Paul Jennings, Egon Willighagen, Barbara Zdrazil, Barry Hardy, Erik H.J. Danen, Bjørn E. V. Koch, David A. Fluri, Christoph van Thriel, Dirk Drasdo, Ben van Ravenzwaay, Iain Gardner, Franz Oesch, Reham Hassan, Raymond Reif, Marvin Martens, Thomas Hartung

المساهمون: University of Konstanz, Department of Forensic Medicine and Veterinary Toxicology [Qena], Faculty of Veterinary Medicine [Qena], South Valley University [Qena]-South Valley University [Qena], Universiteit Leiden, Leibniz Research Centre for Working Environment and Human Factors [Dortmund] (IFADO), Technische Universität Dortmund [Dortmund] (TU), The Danish Epidemiology Science Centre, Innsbruck Medical University = Medizinische Universität Innsbruck (IMU), Vrije Universiteit Brussel (VUB), BASF [Ludwigshafen], SimCYP Ltd, Institut National de l'Environnement Industriel et des Risques (INERIS), Bundesinstitut für Risikobewertung - Federal Institute for Risk Assessment (BfR), Johannes Gutenberg - Universität Mainz = Johannes Gutenberg University (JGU), Modelling and Analysis for Medical and Biological Applications (MAMBA), Inria de Paris, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Laboratoire Jacques-Louis Lions (LJLL (UMR_7598)), Université Paris Diderot - Paris 7 (UPD7)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Universität Leipzig, Medical University Graz, Johns Hopkins Bloomberg School of Public Health [Baltimore], Johns Hopkins University (JHU), University of Heidelberg, Medical Faculty, Universitat Pompeu Fabra [Barcelona] (UPF), Karolinska Institutet [Stockholm], Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), InSphero [Schlieren], University of Vienna [Vienna], Université Grenoble Alpes - UFR Médecine (UGA UFRM), Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), BioDetection Systems, Universität Mannheim, Maastricht University [Maastricht], Institut National de la Santé et de la Recherche Médicale (INSERM), IT University of Copenhagen (ITU), Istituto Superiore di Sanità (ISS), Douglas Connect GmbH, Fraunhofer Institute for Toxicology and Experimental Medicine (Fraunhofer ITEM), Fraunhofer (Fraunhofer-Gesellschaft), Carl Zeiss SMT AG, Carl Zeiss, Oberkochen, Faculty of Biology, Division of Physiology, Department of Physiology and Medical Physics, Innsbruck Medical University [Austria] (IMU), BASF, DRC/VIVA/METO, Institut National de l'Environnement Industriel et des Risques, Department of Experimental and Clinical Pharmacology andToxicology [Tübingen], Eberhard Karls Universität Tübingen, Interdisciplinary Centre for Bioinformatics [Leipzig] (IZBI), Universität Leipzig [Leipzig], Institute for Health and Consumer Protection, European Commission - Joint Research Centre, Université Grenoble Alpes - UFR Médecine [ ?-2019] (UGA UFRM [ ?-2019]), Molecular Hepatology - Alcohol Associated Diseases, Department of Medicine II, University of Heidelberg, Medical Faculty of Mannheim-University of Heidelberg, Medical Faculty of Mannheim, BigCat - Bioinformatics and Systems Biology Research Group, UMR-S973, MTi, Université Paris Diderot - Paris 7 (UPD7), Department of Immunology and Cell Biology, Mario Negri Institute, Leiden University, Vrije Universiteit [Brussels] (VUB), Universiteit Leiden [Leiden], BASF SE, 67056 Ludwigshafen, Johannes Gutenberg - University of Mainz (JGU), Centre for Alternatives to Animal Testing (CAAT EU), Universitat Pompeu Fabra [Barcelona], European Food Safety Authority = Autorité européenne de sécurité des aliments, Université Grenoble Alpes (UGA), Universität Mannheim [Mannheim], Istituto Superiore di Sanita [Rome], Fraunhofer Institute for Toxicology and Experimental Medicine (ITEM), Johannes Gutenberg - Universität Mainz (JGU), IT University of Copenhagen, Molecular and Computational Toxicology, AIMMS, Bioinformatica, RS: NUTRIM - R1 - Obesity, diabetes and cardiovascular health, RS: NUTRIM - R4 - Gene-environment interaction, Promovendi NTM, RS: FHML MaCSBio, Publica, Pharmaceutical and Pharmacological Sciences, Connexin Signalling Research Group, Liver Connexin and Pannexin Research Group, Experimental in vitro toxicology and dermato-cosmetology

المصدر: Archives of Toxicology
Archives of Toxicology, 2017, 91 (11), pp.3477-3505. ⟨10.1007/s00204-017-2045-3⟩
Archives of Toxicology, Springer Verlag, 2017, 91 (11), pp.3477-3505. ⟨10.1007/s00204-017-2045-3⟩
Archives of Toxicology, 91(11), 3477-3505. Springer Verlag
Archives of Toxicology, 91(11), 3477-3505
Archives of Toxicology, 91(11), 3477-3505. Springer
Archives of Toxicology, 11, 91, 3477-3505
Leist, M, Ghallab, A, Graepel, R, Marchan, R, Hassan, R, Bennekou, S H, Limonciel, A, Vinken, M, Schildknecht, S, Waldmann, T, Danen, E H J, van Ravenzwaay, B, Kamp, H, Gardner, I, Godoy, P, Bois, F Y, Braeuning, A, Reif, R, Oesch, F, Drasdo, D, Höhme, S, Schwarz, M, Hartung, T, Braunbeck, T, Beltman, J, Vrieling, H, Sanz, F, Forsby, A, Gadaleta, D, Fisher, C, Kelm, J, Fluri, D, Ecker, G F, Zdrazil, B, Terron, A, Jennings, P, van der Burg, B, Dooley, S, Meijer, A H, Willighagen, E, Martens, M, Evelo, C T, Mombelli, E, Taboureau, O, Mantovani, A, Hardy, B, Koch, B, Escher, S, van Thriel, C, Cadenas, C, Kroese, D, van de Water, B & Hengstler, J G 2017, ' Adverse outcome pathways : opportunities, limitations and open questions ', Archives of Toxicology, vol. 91, no. 11, pp. 3477-3505 . https://doi.org/10.1007/s00204-017-2045-3

مصطلحات موضوعية: CCl4, 0301 basic medicine, Proof of non-toxicity, Health, Toxicology and Mutagenesis, CCl, RAPID - Risk Analysis for Products in Development, Biomedical Innovation, Signal transduction, Ecotoxicology, Toxicology, NATURAL-KILLER-CELLS, Prioritization of compounds, Life, Adverse Outcome Pathway, ACTIVATED STELLATE CELLS, ComputingMilieux_MISCELLANEOUS, Risk assessment, TUMOR-NECROSIS-FACTOR, Event (computing), EVIDENCE-BASED TOXICOLOGY, ENVIRONMENTAL CHEMICALS, General Medicine, Toxicokinetics, Multiple hit events Proof of non-toxicity, Evidence-based toxicology, Identification (information), Paracetamol, Risk analysis (engineering), Vinyl acetate, RISK-ASSESSMENT, Systems biology, Construct (philosophy), Healthy Living, Human, Quality Control, READ-ACROSS, Vinyl Compounds, Plasticity, Liver fibrosis, Nanotechnology, Harmonization, Multiple hit events, Biology, History, 21st Century, Risk Assessment, Binning of events, Adverse outcome, 03 medical and health sciences, Adverse outcome pathway, SDG 3 - Good Health and Well-being, ddc:570, Tumor promotion, Journal Article, Animals, Humans, Vinyl acetate Tumor promotion, Regulatory toxicology, Set (psychology), Epidemiological data, Adverse Outcome Pathways, Interspecies extrapolation, 030111 toxicology, SYSTEMS TOXICOLOGY, Nonhuman, Toxicity assay, [INFO.INFO-MO]Computer Science [cs]/Modeling and Simulation, Mice, Inbred C57BL, Multi-scale integration, Metabolism, 030104 developmental biology, DEVELOPMENTAL NEUROTOXICITY, Computational toxicology, ELSS - Earth, Life and Social Sciences, Pathway unidirectionality

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da8f557dd7872bdda32c94a20832dbd6
https://doi.org/10.1007/s00204-017-2045-3

المؤلفون: Edith Lorenz, Gabriele Gamerith, Stefan Koeck, Elisabeth J. Pechriggl, Heinz Zwierzina, Johann Kern, Arno Amann, Marit Zwierzina, Wolfgang Hilbe, Julia M. Huber, Jens M. Kelm

المصدر: Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Scientific Reports

مصطلحات موضوعية: 0301 basic medicine, Models, Anatomic, Vascular Endothelial Growth Factor A, Stromal cell, Angiogenesis, Cell Survival, Science, Cell Communication, Biology, Article, Neovascularization, 03 medical and health sciences, chemistry.chemical_compound, Cell Movement, Cell Line, Tumor, Neoplasms, medicine, Human Umbilical Vein Endothelial Cells, Tumor Microenvironment, Humans, Cell Proliferation, Tumor microenvironment, Multidisciplinary, Neovascularization, Pathologic, Cell growth, Endothelial Cells, Immunohistochemistry, Coculture Techniques, Vascular endothelial growth factor, Endothelial stem cell, Oxygen, Platelet Endothelial Cell Adhesion Molecule-1, 030104 developmental biology, Cell Transformation, Neoplastic, chemistry, Cell culture, Immunology, Cancer research, Cytokines, Medicine, medicine.symptom, Stromal Cells

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7aff20f70382008547102d2e7f164be6
https://doaj.org/article/1ee938a72b3246ccbd4db879b442a84b

المؤلفون: Petra Obexer, Jens M. Kelm, Gabriele Gamerith, Arno Amann, Edith Lorenz, Heinz Zwierzina, Julia M. Huber, Stefan Koeck

المصدر: Journal of Cancer Research and Clinical Oncology

مصطلحات موضوعية: 0301 basic medicine, Cancer Research, Lung Neoplasms, Computational biology, Pharmacology, Afatinib, Vinblastine, Efficacy, Tissue Culture Techniques, 03 medical and health sciences, 0302 clinical medicine, Spheroids, Cellular, medicine, Tumor Cells, Cultured, Humans, Lung cancer, Lung, Cell Proliferation, business.industry, In vivo mimicking, Cell Cycle, Hanging-drop, Drug testing, Vinorelbine, General Medicine, respiratory system, medicine.disease, 030104 developmental biology, medicine.anatomical_structure, Oncology, 030220 oncology & carcinogenesis, Quinazolines, Three-dimensional model, Cisplatin, Drug Screening Assays, Antitumor, business, Original Article – Cancer Research, Three dimensional model

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::253c6eb7120fe038f6d265265a5ae8d5
http://europepmc.org/articles/PMC4978763