المؤلفون: Jensen VFH; Department of Safety Sciences & Imaging, 1450Novo Nordisk A/S, Måløv, Denmark., Schefe LH; Department of DMPK (Drug Metabolism and Pharmacokinetics) and Non-clinical Project Management, 1450Novo Nordisk A/S, Måløv, Denmark., Jacobsen H; Department of DMPK (Drug Metabolism and Pharmacokinetics) and Non-clinical Project Management, 1450Novo Nordisk A/S, Måløv, Denmark., Mølck AM; Department of Safety Sciences & Imaging, 1450Novo Nordisk A/S, Måløv, Denmark., Almholt K; Department of Safety Sciences & Imaging, 1450Novo Nordisk A/S, Måløv, Denmark., Sjögren I; Department of Safety Sciences & Imaging, 1450Novo Nordisk A/S, Måløv, Denmark., Dalsgaard CM; Department of Safety Sciences & Imaging, 1450Novo Nordisk A/S, Måløv, Denmark., Kirk RK; Department of Safety Sciences & Imaging, 1450Novo Nordisk A/S, Måløv, Denmark., Benie AJ; Department of Biophysics & Formulation 1, 1450Novo Nordisk A/S, Måløv, Denmark., Petersen BO; Department of Biophysics & Formulation 1, 1450Novo Nordisk A/S, Måløv, Denmark., Kyhn MS; Department of Non-clinical and Clinical Assay Sciences, 1450Novo Nordisk A/S, Måløv, Denmark., Overgaard AJ; Department of Non-clinical and Clinical Assay Sciences, 1450Novo Nordisk A/S, Måløv, Denmark., Bjørnsdottir I; Department of DMPK (Drug Metabolism and Pharmacokinetics) and Non-clinical Project Management, 1450Novo Nordisk A/S, Måløv, Denmark., Stannard DR; 63899Labcorp Early Development Laboratories Limited, Eye, UK., Offenberg HK; Department of DMPK (Drug Metabolism and Pharmacokinetics) and Non-clinical Project Management, 1450Novo Nordisk A/S, Måløv, Denmark., Egecioglu E; Department of DMPK (Drug Metabolism and Pharmacokinetics) and Non-clinical Project Management, 1450Novo Nordisk A/S, Måløv, Denmark.

المصدر: International journal of toxicology [Int J Toxicol] 2022 Dec; Vol. 41 (6), pp. 455-475. Date of Electronic Publication: 2022 Aug 27.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Sage Publications Country of Publication: United States NLM ID: 9708436 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1092-874X (Electronic) Linking ISSN: 10915818 NLM ISO Abbreviation: Int J Toxicol Subsets: MEDLINE

مواضيع طبية MeSH: Factor IX*/therapeutic use , Hemophilia B*/drug therapy, Adult ; Animals ; Child ; Fertility ; Humans ; Infant ; Male ; Polyethylene Glycols/toxicity ; Rats ; Recombinant Proteins

المؤلفون: Jensen VFH; Section for Experimental Animal Models, Department of Veterinary and Animal Sciences, University of Copenhagen, Copenhagen, Denmark. vfhj@novonordisk.com.; Department of Safety Sciences & Imaging, Toxicology Development Projects, Novo Nordisk A/S, Novo Nordisk Park, 2760, Måløv, Denmark. vfhj@novonordisk.com., Mølck AM; Department of Safety Sciences & Imaging, Toxicology Development Projects, Novo Nordisk A/S, Novo Nordisk Park, 2760, Måløv, Denmark., Nowak J; Department of Safety Sciences & Imaging, Toxicology Development Projects, Novo Nordisk A/S, Novo Nordisk Park, 2760, Måløv, Denmark., Fels JJ; Department of Research Bioanalysis, Novo Nordisk A/S, Maaloev, Denmark., Lykkesfeldt J; Section for Experimental Animal Models, Department of Veterinary and Animal Sciences, University of Copenhagen, Copenhagen, Denmark., Bøgh IB; Department of Safety Sciences & Imaging, Toxicology Development Projects, Novo Nordisk A/S, Novo Nordisk Park, 2760, Måløv, Denmark.

المصدر: Scientific reports [Sci Rep] 2022 Aug 18; Vol. 12 (1), pp. 14113. Date of Electronic Publication: 2022 Aug 18.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

مواضيع طبية MeSH: Hypoglycemia*/chemically induced , Hypoglycemia*/metabolism , Islets of Langerhans*/metabolism, Animals ; Blood Glucose/metabolism ; C-Peptide/metabolism ; Female ; Glucagon/metabolism ; Humans ; Insulin/metabolism ; Male ; Rats

المؤلفون: Jensen VFH; Department of Safety Sciences, Imaging & Data Management, Novo Nordisk A/S, Maaloev, Denmark., Mølck AM; Department of Safety Sciences, Imaging & Data Management, Novo Nordisk A/S, Maaloev, Denmark., Nowak J; Department of Safety Sciences, Imaging & Data Management, Novo Nordisk A/S, Maaloev, Denmark., Wohlfarth M; Department of Pediatrics, Medical Faculty, University of Cologne, Cologne, Germany., Nüsken E; Department of Pediatrics, Medical Faculty, University of Cologne, Cologne, Germany., Demozay D; Department of Diabetes Pharmacology 1, Novo Nordisk A/S, Maaloev, Denmark., Nüsken KD; Department of Pediatrics, Medical Faculty, University of Cologne, Cologne, Germany., Bøgh IB; Department of Safety Sciences, Imaging & Data Management, Novo Nordisk A/S, Maaloev, Denmark.

المصدر: PloS one [PLoS One] 2022 Mar 28; Vol. 17 (3), pp. e0265988. Date of Electronic Publication: 2022 Mar 28 (Print Publication: 2022).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE

مواضيع طبية MeSH: Hypoglycemia*/metabolism , Placenta*/metabolism, Amino Acid Transport Systems/metabolism ; Animals ; Female ; Glucose/metabolism ; Glucose Transporter Type 1/metabolism ; Glucose Transporter Type 3/metabolism ; Maternal-Fetal Exchange ; Nutrients ; Pregnancy ; Rats

المؤلفون: Jensen VFH; Lund University, Department of Clinical Sciences Malmö and Skåne University Hospital, Department of Orthopedics, Inga Marie Nilssons Gata 22, 205 02 Malmö, Sweden. Electronic address: vivi_flou_hjorth.jensen@med.lu.se., Mølck AM; Novo Nordisk A/S, Department of Safety Sciences, Imaging & Data Management, Novo Nordisk Park 1, 2760 Maaloev, Denmark., Dalgaard M; Novo Nordisk A/S, Department of Safety Sciences, Imaging & Data Management, Novo Nordisk Park 1, 2760 Maaloev, Denmark., McGuigan FE; Lund University, Department of Clinical Sciences Malmö and Skåne University Hospital, Department of Orthopedics, Inga Marie Nilssons Gata 22, 205 02 Malmö, Sweden., Akesson KE; Lund University, Department of Clinical Sciences Malmö and Skåne University Hospital, Department of Orthopedics, Inga Marie Nilssons Gata 22, 205 02 Malmö, Sweden.

المصدر: Bone [Bone] 2021 Apr; Vol. 145, pp. 115781. Date of Electronic Publication: 2020 Dec 04.

نوع المنشور: Journal Article; Review

بيانات الدورية: Publisher: Elsevier Science Country of Publication: United States NLM ID: 8504048 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2763 (Electronic) Linking ISSN: 18732763 NLM ISO Abbreviation: Bone Subsets: MEDLINE

مواضيع طبية MeSH: Bone Density* , Weight Loss*, Animals ; Bone and Bones ; Humans ; Models, Animal ; Obesity

المؤلفون: Jensen VFH; Department of Safety Sciences & Imaging, 1450Novo Nordisk A/S, Maaloev, Denmark., Brinck PR; Department of Safety Sciences & Imaging, 1450Novo Nordisk A/S, Maaloev, Denmark., Nowak J; Department of Safety Sciences & Imaging, 1450Novo Nordisk A/S, Maaloev, Denmark., Thorup I; Department of Safety Sciences & Imaging, 1450Novo Nordisk A/S, Maaloev, Denmark., Sjögren I; Department of Safety Sciences & Imaging, 1450Novo Nordisk A/S, Maaloev, Denmark., Mølck AM; Department of Safety Sciences & Imaging, 1450Novo Nordisk A/S, Maaloev, Denmark.

المصدر: International journal of toxicology [Int J Toxicol] 2020 Nov/Dec; Vol. 39 (6), pp. 560-576. Date of Electronic Publication: 2020 Jul 29.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Sage Publications Country of Publication: United States NLM ID: 9708436 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1092-874X (Electronic) Linking ISSN: 10915818 NLM ISO Abbreviation: Int J Toxicol Subsets: MEDLINE

مواضيع طبية MeSH: Carcinogenesis/*drug effects , Cell Proliferation/*drug effects , Insulin Detemir/*pharmacology , Insulin, Long-Acting/*pharmacology, Animals ; Biomarkers/metabolism ; Female ; Hypoglycemic Agents/pharmacology ; Predictive Value of Tests ; Random Allocation ; Rats ; Rats, Sprague-Dawley

المؤلفون: Jensen VFH; Novo Nordisk A/S, Department of Toxicology, Safety Pharmacology and Pathology, Maaloev, Denmark. vfhj@novonordisk.com.; University of Copenhagen, Department of Veterinary and Animal Sciences, Section for Experimental Animal Models, Copenhagen, Denmark. vfhj@novonordisk.com.; Lund University, Department of Clinical Sciences Malmö and Skåne University Hospital, Department of Orthopedics, Malmö, Sweden. vfhj@novonordisk.com., Mølck AM; Novo Nordisk A/S, Department of Toxicology, Safety Pharmacology and Pathology, Maaloev, Denmark., Bøgh IB; Novo Nordisk A/S, Department of Toxicology, Safety Pharmacology and Pathology, Maaloev, Denmark., Nowak J; Novo Nordisk A/S, Department of Toxicology, Safety Pharmacology and Pathology, Maaloev, Denmark., Viuff BM; Novo Nordisk A/S, Department of Toxicology, Safety Pharmacology and Pathology, Maaloev, Denmark., Rasmussen CLM; University of Copenhagen, Department of Veterinary and Animal Sciences, Section for Experimental Animal Models, Copenhagen, Denmark., Pedersen L; University of Copenhagen, Department of Veterinary and Animal Sciences, Section for Experimental Animal Models, Copenhagen, Denmark., Fels JJ; Novo Nordisk A/S, Department of Research Bioanalysis, Maaloev, Denmark., Madsen SH; Novo Nordisk A/S, Department of Research Bioanalysis, Maaloev, Denmark., McGuigan FE; Lund University, Department of Clinical Sciences Malmö and Skåne University Hospital, Department of Orthopedics, Malmö, Sweden., Tveden-Nyborg P; University of Copenhagen, Department of Veterinary and Animal Sciences, Section for Experimental Animal Models, Copenhagen, Denmark., Lykkesfeldt J; University of Copenhagen, Department of Veterinary and Animal Sciences, Section for Experimental Animal Models, Copenhagen, Denmark., Akesson KE; Lund University, Department of Clinical Sciences Malmö and Skåne University Hospital, Department of Orthopedics, Malmö, Sweden.

المصدر: Scientific reports [Sci Rep] 2020 Mar 27; Vol. 10 (1), pp. 5609. Date of Electronic Publication: 2020 Mar 27.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

مواضيع طبية MeSH: Fetal Development/*physiology , Fetus/*pathology , Growth Plate/*pathology , Hypoglycemia/*pathology, Animals ; Cell Differentiation/physiology ; Chondrocytes/metabolism ; Chondrocytes/pathology ; Corticosterone/metabolism ; Female ; Fetus/metabolism ; Growth Plate/metabolism ; Hypoglycemia/metabolism ; Hypoxia/metabolism ; Hypoxia/pathology ; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism ; Neovascularization, Pathologic/metabolism ; Neovascularization, Pathologic/pathology ; Pregnancy ; Prenatal Care/methods ; Rats ; Rats, Sprague-Dawley ; Vascular Endothelial Growth Factor A/metabolism

المؤلفون: Jensen VFH; Department of Toxicology Development Projects, Novo Nordisk A/S Maaloev, Denmark; Department of Veterinary and Animal Sciences, Section for Experimental Animal Models, University of Copenhagen, Copenhagen, Denmark; Department of Clinical Sciences Malmö, Clinical and Molecular Osteoporosis Research Unit, Lund University, Malmö, Sweden; Department of Orthopedics, Skåne University, Malmö, Sweden. Electronic address: vivi_flou_hjorth.jensen@med.lu.se., Mølck AM; Department of Toxicology Development Projects, Novo Nordisk A/S Maaloev, Denmark., Lykkesfeldt J; Department of Veterinary and Animal Sciences, Section for Experimental Animal Models, University of Copenhagen, Copenhagen, Denmark., Fels JJ; Department of Research Bioanalysis, Novo Nordisk A/S, Maaloev, Denmark., Andersen L; Department of Clinical Bioanalysis, Novo Nordisk A/S, Maaloev, Denmark., Renaut R; Division of Toxicology, Envigo, Eye, Suffolk, UK., McGuigan F; Department of Clinical Sciences Malmö, Clinical and Molecular Osteoporosis Research Unit, Lund University, Malmö, Sweden; Department of Orthopedics, Skåne University, Malmö, Sweden., Åkesson KE; Department of Clinical Sciences Malmö, Clinical and Molecular Osteoporosis Research Unit, Lund University, Malmö, Sweden; Department of Orthopedics, Skåne University, Malmö, Sweden., Bøgh IB; Department of Toxicology Development Projects, Novo Nordisk A/S Maaloev, Denmark.

المصدر: Reproductive toxicology (Elmsford, N.Y.) [Reprod Toxicol] 2020 Jan; Vol. 91, pp. 14-26. Date of Electronic Publication: 2019 Oct 20.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Pergamon In Cooperation With The Reproductive Toxicology Center Country of Publication: United States NLM ID: 8803591 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-1708 (Electronic) Linking ISSN: 08906238 NLM ISO Abbreviation: Reprod Toxicol Subsets: MEDLINE

مواضيع طبية MeSH: Embryonic Development* , Eye Abnormalities* , Fetal Development*, Bone and Bones/*abnormalities , Hypoglycemia/*complications, Animals ; Blood Glucose/analysis ; Embryo, Mammalian/abnormalities ; Female ; Hypoglycemia/chemically induced ; Insulin ; Male ; Maternal-Fetal Exchange ; Osteogenesis ; Pregnancy ; Rats, Sprague-Dawley

المؤلفون: Jensen VFH; Toxicology, Safety Pharm and Pathology, Novo Nordisk A/S, Novo Nordisk Park, 2760 Maaloev, Denmark; Department of Veterinary and Animal Sciences, Section for Experimental Animal Models, University of Copenhagen, Denmark. Electronic address: vfhj@novonordisk.com., Mølck AM; Toxicology, Safety Pharm and Pathology, Novo Nordisk A/S, Novo Nordisk Park, 2760 Maaloev, Denmark., Lykkesfeldt J; Department of Veterinary and Animal Sciences, Section for Experimental Animal Models, University of Copenhagen, Denmark., Bøgh IB; Toxicology, Safety Pharm and Pathology, Novo Nordisk A/S, Novo Nordisk Park, 2760 Maaloev, Denmark.

المصدر: Reproductive toxicology (Elmsford, N.Y.) [Reprod Toxicol] 2018 Apr; Vol. 77, pp. 1-24. Date of Electronic Publication: 2018 Feb 03.

نوع المنشور: Journal Article; Review

بيانات الدورية: Publisher: Pergamon In Cooperation With The Reproductive Toxicology Center Country of Publication: United States NLM ID: 8803591 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-1708 (Electronic) Linking ISSN: 08906238 NLM ISO Abbreviation: Reprod Toxicol Subsets: MEDLINE

مواضيع طبية MeSH: Embryonic Development* , Fetal Development*, Hypoglycemia/*metabolism , Placenta/*metabolism , Pregnancy/*metabolism, Animals ; Female ; Glucose/metabolism ; Humans ; Maternal-Fetal Exchange ; Rats

المؤلفون: Jensen VFH; Section for Experimental Animal Models, Department of Veterinary and Animal Sciences, University of Copenhagen, Copenhagen, Denmark.; Department of Toxicology, Safety Pharm and Pathology, Novo Nordisk A/S, Maaloev, Denmark., Molck AM; Department of Toxicology, Safety Pharm and Pathology, Novo Nordisk A/S, Maaloev, Denmark., Soeborg H; Department of Toxicology, Safety Pharm and Pathology, Novo Nordisk A/S, Maaloev, Denmark., Nowak J; Department of Toxicology, Safety Pharm and Pathology, Novo Nordisk A/S, Maaloev, Denmark., Chapman M; Division of Toxicology, Envigo, Eye, Suffolk, UK., Lykkesfeldt J; Section for Experimental Animal Models, Department of Veterinary and Animal Sciences, University of Copenhagen, Copenhagen, Denmark., Bogh IB; Department of Toxicology, Safety Pharm and Pathology, Novo Nordisk A/S, Maaloev, Denmark.

المصدر: Basic & clinical pharmacology & toxicology [Basic Clin Pharmacol Toxicol] 2018 Jan; Vol. 122 (1), pp. 165-175. Date of Electronic Publication: 2017 Sep 06.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Blackwell Country of Publication: England NLM ID: 101208422 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1742-7843 (Electronic) Linking ISSN: 17427835 NLM ISO Abbreviation: Basic Clin Pharmacol Toxicol Subsets: MEDLINE

مواضيع طبية MeSH: Diabetes Mellitus/*drug therapy , Hypoglycemia/*physiopathology , Hypoglycemic Agents/*adverse effects , Muscle, Skeletal/*pathology , Peripheral Nervous System Diseases/*physiopathology, Animals ; Atrophy/etiology ; Chronic Disease ; Diabetes Mellitus/blood ; Disease Models, Animal ; Disease Progression ; Female ; Hindlimb/innervation ; Hindlimb/pathology ; Hindlimb/physiopathology ; Humans ; Hypoglycemia/blood ; Hypoglycemia/chemically induced ; Insulin/adverse effects ; Male ; Muscle, Skeletal/innervation ; Muscle, Skeletal/physiopathology ; Peripheral Nervous System Diseases/blood ; Peripheral Nervous System Diseases/etiology ; Rats ; Rats, Sprague-Dawley ; Sciatic Nerve/pathology ; Tibial Nerve/physiopathology

المؤلفون: Jensen VFH; Department of Veterinary and Animal Sciences, Section for Experimental Animal Models, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Department of Toxicology, Safety Pharm and Pathology, Novo Nordisk A/S, Maaloev, Denmark., Mølck AM; Department of Toxicology, Safety Pharm and Pathology, Novo Nordisk A/S, Maaloev, Denmark., Berthelsen LO; Department of Toxicology, Safety Pharm and Pathology, Novo Nordisk A/S, Maaloev, Denmark., Alifrangis L; Department of Development DMPK, Novo Nordisk A/S, Maaloev, Denmark., Andersen L; Department of Diabetes Bioanalysis, Novo Nordisk A/S, Maaloev, Denmark., Chapman M; Division of Toxicology, Envigo, Suffolk, UK., Lykkesfeldt J; Department of Veterinary and Animal Sciences, Section for Experimental Animal Models, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Bøgh IB; Department of Toxicology, Safety Pharm and Pathology, Novo Nordisk A/S, Maaloev, Denmark.

المصدر: Basic & clinical pharmacology & toxicology [Basic Clin Pharmacol Toxicol] 2017 Jul; Vol. 121 (1), pp. 53-66. Date of Electronic Publication: 2017 May 03.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Blackwell Country of Publication: England NLM ID: 101208422 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1742-7843 (Electronic) Linking ISSN: 17427835 NLM ISO Abbreviation: Basic Clin Pharmacol Toxicol Subsets: MEDLINE

مواضيع طبية MeSH: Blood Glucose/*drug effects , Hyperglycemia/*etiology , Hypoglycemia/*chemically induced , Hypoglycemic Agents/*toxicity , Insulin, Long-Acting/*toxicity, Animals ; Axons/drug effects ; Axons/pathology ; Blood Glucose/analysis ; Disease Models, Animal ; Female ; Gluconeogenesis/drug effects ; Hyperglycemia/blood ; Hyperphagia/etiology ; Hypoglycemia/blood ; Hypoglycemia/complications ; Male ; Muscle, Skeletal/drug effects ; Muscle, Skeletal/pathology ; Peripheral Nerves/drug effects ; Peripheral Nerves/pathology ; Rats ; Rats, Sprague-Dawley ; Time Factors ; Weight Loss/drug effects