المؤلفون: Maike Bublitz, Karol Nass, Nikolaj D. Drachmann, Anders J. Markvardsen, Matthias J. Gutmann, Thomas R. M. Barends, Daniel Mattle, Robert L. Shoeman, R. Bruce Doak, Sébastien Boutet, Marc Messerschmidt, Marvin M. Seibert, Garth J. Williams, Lutz Foucar, Linda Reinhard, Oleg Sitsel, Jonas L. Gregersen, Johannes D. Clausen, Thomas Boesen, Kamil Gotfryd, Kai-Tuo Wang, Claus Olesen, Jesper V. Møller, Poul Nissen, Ilme Schlichting

المصدر: IUCrJ, Vol 2, Iss 4, Pp 409-420 (2015)

مصطلحات موضوعية: XFEL, P-type ATPases, ligand screening, serial femtosecond crystallography, Crystallography, QD901-999

وصف الملف: electronic resource

Relation: http://scripts.iucr.org/cgi-bin/paper?S2052252515008969; https://doaj.org/toc/2052-2525

URL الوصول: https://doaj.org/article/0eb55fd648bc4163964e04aef172633f

المؤلفون: Nikolai Engedal, Søren Brøgger Christensen, Poul Nissen, Paula Szalai, Jan B. Parys, Jesper V. Møller, Geert Bultynck

المصدر: Szalai, P, Parys, J B, Bultynck, G, Christensen, S B, Nissen, P, Møller, J V & Engedal, N 2018, ' Nonlinear relationship between ER Ca 2+ depletion versus induction of the unfolded protein response, autophagy inhibition, and cell death ', Cell Calcium, vol. 76, pp. 48-61 . https://doi.org/10.1016/j.ceca.2018.09.005

مصطلحات موضوعية: Cell death, 0301 basic medicine, HOMEOSTASIS, Programmed cell death, SERCA, Thapsigargin, Physiology, CALCIUM, Unfolded protein response, 03 medical and health sciences, chemistry.chemical_compound, ENDOPLASMIC-RETICULUM STRESS, MITOCHONDRIA, Autophagy, THAPSIGARGIN-INDUCED APOPTOSIS, Molecular Biology, PERTURBATION, RECEPTOR, 030102 biochemistry & molecular biology, BIP, Cell growth, Endoplasmic reticulum, ER Ca2+ depletion, Cell Biology, Cell biology, EGTA, 030104 developmental biology, chemistry, PERMEABILITY TRANSITION PORE, RESISTANCE

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f4ccffb24376617bd6e924e91c08820
https://doi.org/10.1016/j.ceca.2018.09.005

المؤلفون: Samuel R. Denmeade, Søren Brøgger Christensen, John T. Isaacs, Jesper V. Møller, Henrik Toft Simonsen, Nikolai Engedal, Poul Nissen

المساهمون: Kinghorn, A.D., Falk, H., Gibbons, S., Asakawa, Y., Liu, J.K., Dirsch, V.M.

المصدر: Progress in the Chemistry of Organic Natural Products 115 ISBN: 9783030648527
Christensen, S B, Simonsen, H T, Engedal, N, Nissen, P, Møller, J V, Denmeade, S R & Isaacs, J T 2021, From Plant to Patient : Thapsigargin, a Tool for Understanding Natural Product Chemistry, Total Syntheses, Biosynthesis, Taxonomy, ATPases, Cell Death, and Drug Development . in A D Kinghorn, H Falk, S Gibbons, Y Asakawa, J K Liu & V M Dirsch (eds), Progress in the Chemistry of Organic Natural Products . vol. 115, Springer, Cham, pp. 59-114 . https://doi.org/10.1007/978-3-030-64853-4_2

مصطلحات موضوعية: Sarco-endoplasmic reticulum calcium ATPase, Thapsigargin, SERCA, biology, ATPase, Endoplasmic reticulum, Apoptosis, Drug development, Mipsagargin, chemistry.chemical_compound, Mechanism of action, chemistry, Biochemistry, cardiovascular system, Unfolded protein response, medicine, biology.protein, Targeted prodrugs, medicine.symptom, Secretory pathway, Intracellular

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c82d37d058a4501f7d785e49d7bb59c
https://doi.org/10.1007/978-3-030-64853-4_2

المؤلفون: Jesper V. Møller, Maxwell M. G. Geurts, Poul Nissen, Marc le Maire, Johannes D. Clausen, Maike Bublitz, Jens Peter Andersen, Robin A. Corey, Guillaume Lenoir, Cédric Montigny, Bertrand Arnou, Christine Jaxel

المساهمون: Department of Biochemistry [Oxford], University of Oxford [Oxford], Aarhus University [Aarhus], Institut de Biologie Intégrative de la Cellule (I2BC), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Laboratoire des Protéines et Systèmes Membranaires (LPSM), Département Biochimie, Biophysique et Biologie Structurale (B3S), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Institut de Biologie Intégrative de la Cellule (I2BC), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), University of Oxford, I2BC, Centre National de la Recherche Scientifique (CNRS)

المصدر: Geurts, M M G, Clausen, J D, Arnou, B, Montigny, C, Lenoir, G, Corey, R A, Jaxel, C, Møller, J V, Nissen, P, Andersen, J P, Le Maire, M & Bublitz, M 2020, ' The SERCA residue Glu340 mediates interdomain communication that guides Ca 2+ transport ', Proceedings of the National Academy of Sciences of the United States of America, vol. 117, no. 49, pp. 31114-31122 . https://doi.org/10.1073/pnas.2014896117
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2020, 117 (49), pp.31114-31122. ⟨10.1073/pnas.2014896117⟩
Proceedings of the National Academy of Sciences of the United States of America, 2020, 117 (49), pp.31114-31122. ⟨10.1073/pnas.2014896117⟩
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2020, ⟨10.1073/pnas.2014896117⟩
Proceedings of the National Academy of Sciences of the United States of America, 2020, ⟨10.1073/pnas.2014896117⟩
'Proceedings of the National Academy of Sciences of the USA ', vol: 117, pages: 31114-31122 (2020)

مصطلحات موضوعية: SERCA, [SDV]Life Sciences [q-bio], ATPase, Mutant, tryptophan fluorescence, 01 natural sciences, 03 medical and health sciences, ATP hydrolysis, 0103 physical sciences, P-type ATPase, Tryptophan fluorescence, [SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biochemistry [q-bio.BM], 030304 developmental biology, 0303 health sciences, Multidisciplinary, 010304 chemical physics, biology, [SDV.BBM.BS]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Structural Biology [q-bio.BM], Chemistry, Ca2+ binding, Molecular dynamics simulations, Cabinding, molecular dynamics simulations, Transmembrane domain, Cytosol, Biophysics, biology.protein, cardiovascular system, Phosphorylation

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3867a5f502b30265725229f2fb4e35be
https://pure.au.dk/portal/da/publications/the-serca-residue-glu340-mediates-interdomain-communication-that-guides-ca2transport(5358e6d5-d66c-4063-8a5e-6952008d820f).html

المؤلفون: Maxwell M G, Geurts, Johannes D, Clausen, Bertrand, Arnou, Cédric, Montigny, Guillaume, Lenoir, Robin A, Corey, Christine, Jaxel, Jesper V, Møller, Poul, Nissen, Jens Peter, Andersen, Marc, le Maire, Maike, Bublitz

المصدر: Proceedings of the National Academy of Sciences of the United States of America

مصطلحات موضوعية: Protein Conformation, alpha-Helical, tryptophan fluorescence, Molecular Dynamics Simulation, Crystallography, X-Ray, Biochemistry, Protein Structure, Secondary, Sarcoplasmic Reticulum Calcium-Transporting ATPases, Adenosine Triphosphate, Cytosol, Protein Domains, SERCA, Escherichia coli, P-type ATPase, Humans, Amino Acid Sequence, Calcium Signaling, Phosphorylation, Binding Sites, Ca2+ binding, Calcium-Binding Proteins, Tryptophan, Hydrogen Bonding, molecular dynamics simulations, Biological Sciences, Kinetics, Mutation, Calcium, Asparagine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::f836ff50a1725b1cb1cfe72ca2c225cb
https://pubmed.ncbi.nlm.nih.gov/33229570

المؤلفون: Hok-Sau Kwong, Maike Bublitz, Claus Olesen, Vitaliy Mykhaylyk, Armin Wagner, Jesper V. Møller, Konstantinos Beis, Nada Mohamad, R. Duman, Kiran Bountra, Katja Schlegel, Maria Romano, Kamel El Omari

المصدر: El Omari, K, Mohamad, N, Bountra, K, Duman, R, Romano, M, Schlegel, K, Kwong, H S, Mykhaylyk, V, Olesen, C, Moller, J V, Bublitz, M, Beis, K & Wagner, A 2020, ' Experimental phasing with vanadium and application to nucleotide-binding membrane proteins ', IUCrJ, vol. 7, pp. 1092-1101 . https://doi.org/10.1107/S2052252520012312
IUCrJ
IUCrJ, Vol 7, Iss 6, Pp 1092-1101 (2020)

مصطلحات موضوعية: experimental phasing, RNase P, Vanadium, chemistry.chemical_element, membrane proteins, Biochemistry, 03 medical and health sciences, 0302 clinical medicine, Protein structure, General Materials Science, Vanadate, lcsh:Science, Integral membrane protein, 030304 developmental biology, 0303 health sciences, biology, Chemistry, Endoplasmic reticulum, fungi, Active site, food and beverages, General Chemistry, Condensed Matter Physics, Combinatorial chemistry, Research Papers, Membrane protein, biology.protein, vanadium, lcsh:Q, 030217 neurology & neurosurgery

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a28328d9c9902e5aac0e2af9ca97c9b7
https://pure.au.dk/portal/da/publications/experimental-phasing-with-vanadium-and-application-to-nucleotidebinding-membrane-proteins(dcfd4d87-3c0b-48c7-bd03-b434a797e37e).html

المؤلفون: Maike Bublitz, William Dalby-Brown, Franco Aversa, Paolo Sportoletti, Anne-Marie Lund Winther, Marilena Baglione, Giorgia Rastelli, Chiara Rompietti, Rocchina Vilella, Donatella Stilli, Caterina Loiacono, Federica Rizzi, Samuel Kitara, Luca Pagliaro, Giovanni Roti, Andrea Gherli, Claus Olesen, Anna Montanaro, Roberta La Starza, Monia Savi, Matteo Marchesini, Leonardo Bocchi, Cristina Mecucci, Laura Patrizi, Sabine Heit, Claudia Sorrentino, Jesper V. Møller, Kimberly Stegmaier

المصدر: Cell Chem Biol
Marchesini, M, Gherli, A, Montanaro, A, Patrizi, L, Sorrentino, C, Pagliaro, L, Rompietti, C, Kitara, S, Heit, S, Olesen, C E, Møller, J V, Savi, M, Bocchi, L, Vilella, R, Rizzi, F, Baglione, M, Rastelli, G, Loiacono, C, La Starza, R, Mecucci, C, Stegmaier, K, Aversa, F, Stilli, D, Lund Winther, A M, Sportoletti, P, Bublitz, M, Dalby-Brown, W & Roti, G 2020, ' Blockade of Oncogenic NOTCH1 with the SERCA Inhibitor CAD204520 in T Cell Acute Lymphoblastic Leukemia ', Cell Chemical Biology, vol. 27, no. 6, pp. 678-697.e13 . https://doi.org/10.1016/j.chembiol.2020.04.002

مصطلحات موضوعية: Male, CAD204520, Chronic lymphocytic leukemia, Clinical Biochemistry, Mice, SCID, Precursor T-Cell Lymphoblastic Leukemia-Lymphoma, 01 natural sciences, Biochemistry, Enzyme Inhibitors/chemical synthesis, Cell Proliferation/drug effects, chemistry.chemical_compound, Mice, NOTCH1, Mice, Inbred NOD, Signal Transduction/drug effects, hemic and lymphatic diseases, Drug Discovery, NOTCH1 mutation, Enzyme Inhibitors, Receptor, Notch1, Receptor, Notch1/antagonists & inhibitors, Antineoplastic Agents/chemical synthesis, Mice, Inbred BALB C, Mice, Inbred ICR, Molecular Structure, P-type ATPases screening, PEST mutation, SERCA, T cell acute lymphoblastic leukemia (T-ALL), crystal structure, mantle cell lymphoma (MCL), thapsigargin, ER STRESS, RECURRENT MUTATIONS, medicine.anatomical_structure, Toxicity, cardiovascular system, Molecular Medicine, Female, CALCIUM PUMPS, GAMMA-SECRETASE INHIBITORS, Signal Transduction, Thapsigargin, T cell, THAPSIGARGIN ANALOGS, Precursor T-Cell Lymphoblastic Leukemia-Lymphoma/drug therapy, Antineoplastic Agents, Biology, Article, Neoplasms, Experimental/drug therapy, RETICULUM CA2+ ATPASE, Cell Line, Tumor, medicine, Animals, Humans, PROTON PUMP, Molecular Biology, Cell Proliferation, Pharmacology, THERAPEUTIC TARGET, UNFOLDED-PROTEIN-RESPONSE, 010405 organic chemistry, Endoplasmic reticulum, AMINO-ACID 256, Cancer, Neoplasms, Experimental, medicine.disease, 0104 chemical sciences, Calcium ATPase, chemistry, Mutation, Cancer research, Drug Screening Assays, Antitumor

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86e63576c860546d9cf10c8571266edb
https://doi.org/10.1016/j.chembiol.2020.04.002

المؤلفون: Paula Lindner, Nikolai Engedal, Jesper V. Møller, Poul Nissen, Søren Brøgger Christensen

المصدر: Lindner, P, Christensen, S B, Nissen, P, Moller, J V & Engedal, N 2020, ' Cell death induced by the ER stressor thapsigargin involves death receptor 5, a non-autophagic function of MAP1LC3B, and distinct contributions from unfolded protein response components ', Cell Communication and Signaling, vol. 18, 12 . https://doi.org/10.1186/s12964-019-0499-z
Cell Communication and Signaling, Vol 18, Iss 1, Pp 1-23 (2020)
Cell Communication and Signaling : CCS

مصطلحات موضوعية: X-Box Binding Protein 1, 0301 basic medicine, Cell, lcsh:Medicine, Apoptosis, Endoplasmic Reticulum, Biochemistry, Unfolded protein response, 0302 clinical medicine, ATF4, LC3B, Caspase 8, lcsh:Cytology, Chemistry, Endoplasmic Reticulum Stress, Cell biology, Cell killing, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Thapsigargin, Caspase-8, Microtubule-Associated Proteins, PERK, Cell death, Programmed cell death, IRE1, 03 medical and health sciences, Cell Line, Tumor, SERCA, LNCaP, Autophagy, medicine, Humans, DR5, lcsh:QH573-671, Molecular Biology, Research, lcsh:R, JNK Mitogen-Activated Protein Kinases, Cell Biology, Activating Transcription Factor 4, Receptors, TNF-Related Apoptosis-Inducing Ligand, 030104 developmental biology, XBP1s, JNK, CHOP

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4676ca81b21a1aadeee486f6c6ed75be
https://doi.org/10.1186/s12964-019-0499-z

المؤلفون: Søren Brøgger Christensen, Helle A. Praetorius, Jesper V. Møller, Pankaj Sehgal, Paula Szalai, Nikolai Engedal, Poul Nissen, Claus Olesen

المصدر: Sehgal, P, Szalai, P, Olesen, C, Praetorius, H A, Nissen, P, Christensen, S B, Engedal, N & Møller, J V 2017, ' Inhibition of the sarco/endoplasmic reticulum (ER) Ca2+-ATPase by thapsigargin analogs induces cell death via ER Ca2+ depletion and the unfolded protein response ', Journal of Biological Chemistry, vol. 292, pp. 19656-19673 . https://doi.org/10.1074/jbc.M117.796920

مصطلحات موضوعية: 0301 basic medicine, Programmed cell death, Thapsigargin, SERCA, Chemistry, Cell growth, Endoplasmic reticulum, STIM1, Cell Biology, Biochemistry, Cell biology, 03 medical and health sciences, chemistry.chemical_compound, 030104 developmental biology, 0302 clinical medicine, Apoptosis, 030220 oncology & carcinogenesis, Journal Article, Unfolded protein response, Molecular Biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ab344f2ce47b2460055b73b630f6cb1
https://doi.org/10.1074/jbc.m117.796920

المؤلفون: Paula, Szalai, Jan B, Parys, Geert, Bultynck, Søren Brøgger, Christensen, Poul, Nissen, Jesper V, Møller, Nikolai, Engedal

المصدر: Cell calcium. 76

مصطلحات موضوعية: Cell Death, Dose-Response Relationship, Drug, Cell Survival, Molecular Conformation, Endoplasmic Reticulum, Sarcoplasmic Reticulum Calcium-Transporting ATPases, Structure-Activity Relationship, PC-3 Cells, Autophagy, Unfolded Protein Response, Humans, Thapsigargin, Calcium, Cells, Cultured

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::b53ac654648ac76b4c1cb1bbc4cc90f1
https://pubmed.ncbi.nlm.nih.gov/30261424