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المؤلفون: Tyler P. Molitor, Enchi Liu, Alyssa M. A. Toda, Kristin M. Andruska, Molly Murphy, Paul Wren, Jessica M. Bright, Holly J. Carlisle, Carrolee Barlow
المصدر: Movement Disorders
مصطلحات موضوعية: 0301 basic medicine, Heterozygote, Parkinson's disease, Mutant, Regular Issue Articles, Pharmacology, Leucine-Rich Repeat Serine-Threonine Protein Kinase-2, Peripheral blood mononuclear cell, 03 medical and health sciences, 0302 clinical medicine, medicine, Humans, G2019S LRRK2, Kinase activity, Allele, Research Articles, Kinase, business.industry, Parkinson Disease, peripheral blood mononuclear cells, medicine.disease, LRRK2, nervous system diseases, pharmacodynamic, 030104 developmental biology, Neurology, Mutation, Leukocytes, Mononuclear, biomarker, Neurology (clinical), business, 030217 neurology & neurosurgery, Ex vivo, Research Article
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المؤلفون: Peng Gao, Paolo Vincetti, Fabio Maria Sabbatini, Holly J. Carlisle, Luisa Mengatto, Stéphane De Lombaert, Anna Sava, Kerry Zobel, Xinying Liu, Claudia Beato, Jessica M. Bright, Alyssa M. A. Toda, Elena Serra, Federica Budassi, Marco Migliore, Laura Caberlotto, Cristiana Griffante, Silvia Bernardi, Mingliang Zhang, Albert W. Garofalo, Daniele Andreotti
المصدر: Journal of Medicinal Chemistry. 63:14821-14839
مصطلحات موضوعية: Indazoles, Tetrazoles, Leucine-Rich Repeat Serine-Threonine Protein Kinase-2, 01 natural sciences, Small Molecule Libraries, Mice, Structure-Activity Relationship, 03 medical and health sciences, Drug Discovery, Animals, Humans, Kinase activity, Protein Kinase Inhibitors, Gene, 030304 developmental biology, 0303 health sciences, Molecular Structure, Chemistry, Kinase, Highly selective, LRRK2, High-Throughput Screening Assays, nervous system diseases, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, HEK293 Cells, Pyrimidines, Mutation, Cancer research, Molecular Medicine
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المؤلفون: Jason Williams, Leonard D. Shultz, Dale L. Greiner, Bradford A. Youngblood, Nenad Tomasevic, John Leung, Michael A. Brehm, Christopher R. Bebbington, Jessica M. Bright, Emily C. Brock, Paul J. Bryce, Rustom Falahati
المصدر: International Archives of Allergy and Immunology. 180:91-102
مصطلحات موضوعية: Immunology, Experimental Allergy - Research Article, Sialic acid binding, CD16, Antibodies, Monoclonal, Humanized, Mice, Antigens, CD, Lectins, medicine, Animals, Humans, Immunology and Allergy, Mast Cells, Anaphylaxis, Antibody-dependent cell-mediated cytotoxicity, biology, Chemistry, Receptors, IgG, Antibody-Dependent Cell Cytotoxicity, SIGLEC, General Medicine, respiratory system, Mast cell, Molecular biology, N-Acetylneuraminic Acid, Basophils, Antigens, Differentiation, B-Lymphocyte, Eosinophils, medicine.anatomical_structure, Humanized mouse, biology.protein, Antibody, Ex vivo
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbc86e19e38c5de0589c2c84b9692ac5
https://doi.org/10.1159/000501637 -
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المؤلفون: Minke E. Binnerts, Julia Luther, Alfiya Akhmetshina, Michael Stock, Kyung Ah Kim, Stefan Uderhardt, Cordula Surmann-Schmitt, Jessica M. Bright, Gerhard Krönke, Shahla Abdollahi-Roodsaz, Arie Abo, Georg Schett, Karolyn Tran, Leo A. B. Joosten, Mario M. Zaiss, Christina Böhm, Jean-Pierre David, Julia Katzenbeisser, Carina Scholtysek, Jörg H W Distler
المصدر: Arthritis and Rheumatism, 62, 8, pp. 2303-12
Arthritis and Rheumatism, 62, 2303-12مصطلحات موضوعية: musculoskeletal diseases, Inflammatory arthritis, Blotting, Western, Immunology, Fluorescent Antibody Technique, Arthritis, Mice, Transgenic, Cartilage metabolism, Auto-immunity, transplantation and immunotherapy [N4i 4], Bone and Bones, Mice, Rheumatology, Osteoprotegerin, Osteoclast, medicine, Animals, Immunology and Allergy, Pharmacology (medical), RSPO1, In Situ Hybridization, Inflammation, Osteoblasts, Reverse Transcriptase Polymerase Chain Reaction, Tumor Necrosis Factor-alpha, business.industry, Wnt signaling pathway, Osteoblast, medicine.disease, Arthritis, Experimental, Wnt Proteins, Pathogenesis and modulation of inflammation [N4i 1], Cartilage, medicine.anatomical_structure, Cancer research, Thrombospondins, business, Infection and autoimmunity [NCMLS 1], Signal Transduction
وصف الملف: application/pdf
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المؤلفون: Peter C. R. Emtage, Y. Tom Tang, Walter D. Funk, Tianhua Hu, Matthew Arterburn, Jessica M. Bright, Bryan J. Boyle
المصدر: Journal of Molecular Evolution. 61:372-380
مصطلحات موضوعية: Genetics, Sequence Homology, Amino Acid, Protein family, Cell Membrane, Molecular Sequence Data, Receptors, Cell Surface, Biology, Membrane progesterone receptor, Transmembrane protein, Rhodopsin-like receptors, Evolution, Molecular, Mice, Cell surface receptor, Animals, Humans, Human genome, Amino Acid Sequence, RNA, Messenger, Receptor, Sequence Alignment, Molecular Biology, Gene, Phylogeny, Ecology, Evolution, Behavior and Systematics
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المؤلفون: Fabio Rupp, Sarah T. Nelken, Dennis G. Ballinger, Tam T. Ho, John E. Ford, Julio J. Mulero, John Childs, Shannon Bradley, Bryan J. Boyle, Nancy K. Mize, Jessica M. Bright
المصدر: Immunogenetics. 54:293-300
مصطلحات موضوعية: Models, Molecular, DNA, Complementary, Protein Conformation, Chromosomes, Human, Pair 22, Molecular Sequence Data, Immunology, Chromosomes, Human, Pair 20, In situ hybridization, Polymerase Chain Reaction, Evolution, Molecular, Exon, Computer Systems, Genetics, Humans, Gene family, Amino Acid Sequence, Cloning, Molecular, Gene, biology, Gene Expression Profiling, Intron, Chromosome Mapping, Chromosome, Molecular biology, Organ Specificity, Multigene Family, biology.protein, Human genome, Carrier Proteins, Lipopolysaccharide binding protein
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المؤلفون: Jason Gotlib, Tracy I. George, Christopher R. Bebbington, Diane S. Lidke, Jessica M. Bright, Rustom Falahati, Alejandro Dorenbaum, Nenad Tomasevic
المصدر: Blood. 126:4092-4092
مصطلحات موضوعية: Antibody-dependent cell-mediated cytotoxicity, biology, medicine.diagnostic_test, business.industry, medicine.drug_class, Immunology, Degranulation, Cell Biology, Hematology, respiratory system, medicine.disease, Monoclonal antibody, Biochemistry, Flow cytometry, biology.protein, Cancer research, Medicine, Sample collection, IL-2 receptor, Systemic mastocytosis, Antibody, business
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::2582fb87f2a6ca26d532534416e55889
https://doi.org/10.1182/blood.v126.23.4092.4092 -
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المؤلفون: Nenad Tomasevic, Victoria E. Ahn, Minke E. Binnerts, Jason Williams, William I. Weis, Kyung Ah Kim, Shirlee Yonkovich, Wouter Korver, Jessica M. Bright, Mei Zhou, John Leung, Shouchun Liu, Melissa Dixon, Delphine Gros, Xiaoming Zhan, Arie Abo
المصدر: Molecular biology of the cell. 20(15)
مصطلحات موضوعية: musculoskeletal diseases, media_common.quotation_subject, Blotting, Western, Plasma protein binding, Biology, Cell Line, Wnt3 Protein, Wnt3A Protein, Humans, Binding site, Internalization, Molecular Biology, LDL-Receptor Related Proteins, media_common, Binding Sites, Wnt signaling pathway, LRP6, Antibodies, Monoclonal, Cell Biology, Articles, Flow Cytometry, Endocytosis, Cell biology, Wnt Proteins, DKK1, Biochemistry, Low Density Lipoprotein Receptor-Related Protein-6, Mutation, Intercellular Signaling Peptides and Proteins, RNA Interference, Signal transduction, Protein Binding, Signal Transduction
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f23f8d6f53efe68392392cfb77b96fda
https://pubmed.ncbi.nlm.nih.gov/19477926 -
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المؤلفون: Nenad Tomasevic, Woodrow E. Lomas, Arie Abo, Sophie A. Hazell, Sejal M. Patel, Mei Zhou, Michael D. Levy, John Leung, Melissa Dixon, Marie Wagle, Wen Sheng Nie, Walter D. Funk, Jason Williams, Karolyn Tran, Jessica M. Bright, Kyung Ah Kim, Minke E. Binnerts, Yi Liu, Xiaoming Zhan
المصدر: Proceedings of the National Academy of Sciences of the United States of America. 104(37)
مصطلحات موضوعية: Beta-catenin, media_common.quotation_subject, Kidney, Ligands, Transfection, Models, Biological, Cell Line, Genes, Reporter, Animals, Humans, Phosphorylation, RNA, Small Interfering, Internalization, RSPO1, Luciferases, RSPO2, LDL-Receptor Related Proteins, beta Catenin, media_common, Multidisciplinary, biology, Wnt signaling pathway, LRP6, Membrane Proteins, LRP5, Biological Sciences, Precipitin Tests, Recombinant Proteins, Cell biology, Wnt Proteins, DKK1, Gene Expression Regulation, Low Density Lipoprotein Receptor-Related Protein-6, biology.protein, Intercellular Signaling Peptides and Proteins, Drosophila, Thrombospondins, Protein Binding, Signal Transduction
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de6aee1f6fcb91971573d6e555f53ef6
https://pubmed.ncbi.nlm.nih.gov/17804805 -
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المؤلفون: Y. Tom Tang, Walter D. Funk, Jessica M. Bright, Peter C. R. Emtage, Servando Palencia, Matthew Arterburn, Bryan J. Boyle, Tianhua Hu
المصدر: Genomics. 86(1)
مصطلحات موضوعية: Signal peptide, Models, Molecular, Protein Conformation, Molecular Sequence Data, Sequence alignment, Biology, Evolution, Molecular, Protein structure, Gene duplication, Genetics, Gene family, Animals, Humans, Amino Acid Sequence, Structural motif, Databases, Protein, Gene, Phylogeny, Sequence Homology, Amino Acid, Genome, Human, Complement C1q, Genetic Variation, Evolutionary biology, C1q domain, Sequence Alignment
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