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1دورية أكاديمية
المؤلفون: Ling Li, Hailong Zhang, Man Zhang, Mengxi Zhao, Lijian Feng, Xiao Luo, Zhenting Gao, Ying Huang, Ophelia Ardayfio, Ji-Hu Zhang, Ying Lin, Hong Fan, Yuan Mi, Guobin Li, Lei Liu, Leying Feng, Fangjun Luo, Lin Teng, Wei Qi, Johannes Ottl, Andreas Lingel, Dirksen E Bussiere, Zhengtian Yu, Peter Atadja, Chris Lu, En Li, Justin Gu, Kehao Zhao
المصدر: PLoS ONE, Vol 12, Iss 1, p e0169855 (2017)
وصف الملف: electronic resource
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المؤلفون: Kelly Slocum, Jianmei Fan, Michael Dore, Palermo Mark G, Zhan Deng, Bakary-Barry Toure, Jorge Garcia-Fortanet, Dyuti Majumdar, Martin F. Hentemann, Nick Keen, Suzanne Zhu, Christopher Towler, Michael Shultz, William R. Sellers, Simon Mathieu, Denise Grunenfelder, Robert Koenig, Douglas C. Bauer, Shumei Liu, Jay Larrow, Victoriano Tamez, David Dunstan, Andreea Argintaru, Timothy Michael Ramsey, Zhouliang Chen, Gang Liu, Ying-Nan Chen, Rukundo Ntaganda, Bing Yu, Joanna Slisz, Hongyun Wang, Pascal D. Fortin, Christopher Sean Straub, Ji-Hu Zhang, Ping Wang, Laura R. LaBonte, Mitsunori Kato, Matthew J. Meyer, Fan Yang, Patrick James Sarver, Samuel B. Ho, Brant Firestone, Rajesh Karki, John F. Reilly, Troy Smith, Ho Man Chan, Cary Fridrich, John William Giraldes, Julie Boisclair, Chen Christine Hiu-Tung, Meir Glick, Zhao B. Kang, Morvarid Mohseni, Lawrence Blas Perez, Michael G. Acker, Sarah Williams, Matthew J. LaMarche, Martin Sendzik, Michelle Fodor, Huia-Xiang Hao, Peter Fekkes, Minying Pu, Travis Stams, Stanley Spence, Andriana Jouk
المصدر: Journal of medicinal chemistry. 63(22)
مصطلحات موضوعية: Drug, Programmed cell death, media_common.quotation_subject, Allosteric regulation, Antineoplastic Agents, Protein Tyrosine Phosphatase, Non-Receptor Type 11, Protein tyrosine phosphatase, Pharmacology, 01 natural sciences, 03 medical and health sciences, Mice, Dogs, Allosteric Regulation, In vivo, Neoplasms, Drug Discovery, medicine, Tumor Cells, Cultured, Animals, Humans, Enzyme Inhibitors, Gene, 030304 developmental biology, media_common, 0303 health sciences, Chemistry, Cancer, medicine.disease, Xenograft Model Antitumor Assays, 0104 chemical sciences, Rats, PTPN11, 010404 medicinal & biomolecular chemistry, Macaca fascicularis, Molecular Medicine
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المؤلفون: Douglas S. Auld, Marta Jimenez, Scott Bowes, Greg Wendel, Thomas M. Smith, Kimberley Yue, Ji-Hu Zhang, Yu-Chi Chen, Scott A. Busby
المصدر: SLAS Discovery. 21:1075-1089
مصطلحات موضوعية: 0301 basic medicine, viruses, High-throughput screening, Drug Evaluation, Preclinical, Computational biology, Biology, 01 natural sciences, Biochemistry, Analytical Chemistry, Matrix (chemical analysis), 03 medical and health sciences, Humans, Enzyme Inhibitors, chemistry.chemical_classification, biochemical phenomena, metabolism, and nutrition, Molecular biology, Enzymes, High-Throughput Screening Assays, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Enzyme inhibition, 030104 developmental biology, Enzyme, chemistry, Curve fitting, Molecular Medicine, Classification methods, Biotechnology
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e5f604afe44c51e7f44a76485d44902
https://doi.org/10.1177/1087057116667255 -
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المؤلفون: Mitsunori Kato, Jason Gunawan, Xiaoling Xie, Muneto Mogi, Neeraja Idamakanti, Waan-Jeng Huang, Daniel LaSala, Ken Yamada, Hajime Yoshisue, Hyi-Man Park, Zhan Deng, Darcy Kohls, Yukiko I. Yagi, David Yowe, Kayo Yasoshima, Amy Qiongshu Xie, Reinhardt Juergen, Debra Burdick, Natasha Kreder, Q. Kimberley Yue, Pramod Pandey, Peter Drueckes, Isabel Schmidt, Toshio Kawanami, Hiromichi Wakai, Ji-Hu Zhang
المصدر: ACS Chemical Biology. 11:3338-3346
مصطلحات موضوعية: 0301 basic medicine, Allosteric regulation, Protein Serine-Threonine Kinases, Biology, Biochemistry, Minor Histocompatibility Antigens, 03 medical and health sciences, chemistry.chemical_compound, Adenosine Triphosphate, Allosteric Regulation, WNK Lysine-Deficient Protein Kinase 1, Drug Discovery, Humans, Solute Carrier Family 12, Member 2, Protein Kinase Inhibitors, Kinase, Drug discovery, HEK 293 cells, Intracellular Signaling Peptides and Proteins, Wnk kinase, General Medicine, WNK1, HEK293 Cells, 030104 developmental biology, chemistry, Molecular Medicine, HT29 Cells, Adenosine triphosphate, HeLa Cells
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المؤلفون: Matthew J. LaMarche, Peter Fekkes, Jorge Garcia Fortanet, Michael Shultz, Denise Grunenfelder, Zhouliang Chen, Gang Liu, Chen Christine Hiu-Tung, Minying Pu, Travis Stams, Pascal D. Fortin, Palermo Mark G, Ping Wang, Samuel B. Ho, Brant Firestone, Matthew J. Meyer, Dyuti Majumdar, Laura R. LaBonte, Francois Lenoir, Rajesh Karki, Nick Keen, Cary Fridrich, Michelle Fodor, Jay Larrow, Sarah Williams, Christopher Towler, Timothy Michael Ramsey, Ji-Hu Zhang, Franco Lombardo, Ying-Nan P. Chen, Zhan Deng, Mitsunori Kato, Zhao B. Kang, Lawrence Blas Perez, Shumei Liu, William R. Sellers
المصدر: Journal of Medicinal Chemistry. 59:7773-7782
مصطلحات موضوعية: Male, Models, Molecular, 0301 basic medicine, Programmed cell death, Allosteric modulator, Protein Conformation, Allosteric regulation, Administration, Oral, Mice, Nude, Antineoplastic Agents, Protein Tyrosine Phosphatase, Non-Receptor Type 11, Protein tyrosine phosphatase, Crystallography, X-Ray, Structure-Activity Relationship, 03 medical and health sciences, 0302 clinical medicine, Protein structure, Allosteric Regulation, Piperidines, Cell Line, Tumor, Drug Discovery, Animals, Humans, Structure–activity relationship, Chemistry, Small molecule, High-Throughput Screening Assays, Mice, Inbred C57BL, PTPN11, Pyrimidines, 030104 developmental biology, Biochemistry, Drug Design, Pyrazines, 030220 oncology & carcinogenesis, Heterografts, Molecular Medicine, Female, Allosteric Site, Neoplasm Transplantation
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المؤلفون: Palermo Mark G, Timothy Michael Ramsey, Ping Zhu, Shumei Liu, Jay Larrow, Laura R. La Bonte, Rajesh Karki, Chen Christine Hiu-Tung, Kavitha Venkatesan, Jaison Jacob, Pascal D. Fortin, Francois Lenoir, Hui Gao, Guizhi Yang, Matthew J. Meyer, Ji-Hu Zhang, William R. Sellers, Michael Shultz, Denise Grunenfelder, Edmund Price, Jorge Garcia-Fortanet, Feng Fei, Zhouliang Chen, Gang Liu, Vesselina G. Cooke, Jing Yuan, Michelle Fodor, Ping Wang, Minying Pu, Nicholas Keen, Samuel B. Ho, Kathy Hsiao, Markus Warmuth, Travis Stams, Christopher Quinn, Mitsunori Kato, Subarna Shakya, Sarah Williams, Dyuti Majumdar, Peter Fekkes, Michael G. Acker, Cary Fridrich, Joanna Slisz, Huaixiang Hao, Matthew J. LaMarche, Ying-Nan P. Chen, Brandon Antonakos, Jason R. Dobson, Brant Firestone, Lawrence Blas Perez, Zhao B. Kang, Ho Man Chan, Zhan Deng
المصدر: Nature. 535:148-152
مصطلحات موضوعية: 0301 basic medicine, Multidisciplinary, biology, Cell growth, Protein tyrosine phosphatase, Receptor tyrosine kinase, Immune checkpoint, Cell biology, PTPN11, 03 medical and health sciences, 030104 developmental biology, Growth factor receptor, biology.protein, Signal transduction, Tyrosine
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المؤلفون: Guobin Li, Leying Feng, Fangjun Luo, Justin Gu, Hailong Zhang, En Li, Mengxi Zhao, Andreas Lingel, Ling Li, Ophelia Ardayfio, Wei Qi, Zhenting Gao, Lin Teng, Chris Lu, Ying Huang, Johannes Ottl, Peter Atadja, Hong Fan, Zhengtian Yu, Ying Lin, Yuan Mi, Lijian Feng, Xiao Luo, Dirksen E. Bussiere, Kehao Zhao, Ji-Hu Zhang, Man Zhang, Lei Liu
المصدر: PLoS ONE, Vol 12, Iss 1, p e0169855 (2017)
PLoS ONEمصطلحات موضوعية: 0301 basic medicine, Competitive Inhibitors, Quantitative Structure-Activity Relationship, lcsh:Medicine, Biochemistry, Mass Spectrometry, Analytical Chemistry, Histones, Binding Analysis, Mice, Spectrum Analysis Techniques, Drug Discovery, Sulfones, Enzyme Inhibitors, Amino Acids, lcsh:Science, Regulation of gene expression, Liquid Chromatography, Multidisciplinary, Crystallography, Drug discovery, Organic Compounds, Physics, Chromatographic Techniques, Polycomb Repressive Complex 2, Condensed Matter Physics, Molecular Docking Simulation, Chemistry, Histone, Bioassays and Physiological Analysis, Recombination-Based Assay, Physical Sciences, Crystal Structure, Basic Amino Acids, PRC2, Research Article, Stereochemistry, Protein subunit, Liquid Chromatography-Mass Spectrometry, Library Screening, macromolecular substances, Biology, Research and Analysis Methods, 03 medical and health sciences, Histone H3, DNA-binding proteins, Solid State Physics, Animals, Binding site, Molecular Biology Techniques, Molecular Biology, Chemical Characterization, Enzyme Assays, Molecular Biology Assays and Analysis Techniques, Binding Sites, Biology and life sciences, Lysine, Organic Chemistry, lcsh:R, Rational design, Chemical Compounds, Proteins, Triazoles, High-Throughput Screening Assays, 030104 developmental biology, biology.protein, Enzymology, lcsh:Q, Biochemical Analysis
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المؤلفون: Zhao B. Kang, Ophelia Ardayfio, Thomas M. Smith, W. Adam Hill, Douglas S. Auld, Iain M. Wallace, Ji-Hu Zhang, Scott Bowes, Pei-i Ho
المصدر: SLAS Discovery. 19:651-660
مصطلحات موضوعية: Computer science, Analytical chemistry, Pilot Projects, Biochemistry, Cell Line, Analytical Chemistry, Genes, Reporter, Humans, Potency, False Positive Reactions, Sample preparation, Process engineering, Throughput (business), Protocol (science), Dose-Response Relationship, Drug, business.industry, Reproducibility of Results, High-Throughput Screening Assays, Rapid assessment, Curve fitting, Molecular Medicine, Biological Assay, Titration, business, Software, Biotechnology
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::815b80704faf450d770c374a114b7840
https://doi.org/10.1177/1087057113512151 -
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المؤلفون: Chunhua Wang, Douglas S. Auld, M G Caron, William Adam Hill, Ji-Hu Zhang, Jaime Padrós, Zhaobin Kang, Debra Burdick
المصدر: ASSAY and Drug Development Technologies. 10:179-186
مصطلحات موضوعية: Substrate Specificity, Europium, Drug Discovery, Histone H2A, Histone methylation, Fluorescence Resonance Energy Transfer, Humans, Nucleosome, Histone demethylase activity, Horseradish Peroxidase, Chelating Agents, Epigenomics, Histone Demethylases, Binding Sites, biology, Antibodies, Monoclonal, Hydrogen Peroxide, Molecular biology, High-Throughput Screening Assays, Histone Deacetylase Inhibitors, Biochemistry, Data Interpretation, Statistical, Histone methyltransferase, biology.protein, Molecular Medicine, Demethylase, Indicators and Reagents
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::074ae68587b1ed6229448982ea3aa58b
https://doi.org/10.1089/adt.2011.0395 -
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المؤلفون: Istvan J. Enyedy, Wanlin Yan, Vinayak Hosagrahara, Timothy A. McKinsey, Erik Meredith, Nicolas Soldermann, Keith A. Koch, Nikos Pagratis, Qingming Zhu, Robin Burgis, Olga Rozhitskaya, Michael Paul Capparelli, Richard B. Vega, Ji-Hu Zhang, Chang Rao, Lauren G. Monovich, Kimberley Beattie, Gabriel G. Gamber
المصدر: Bioorganic & Medicinal Chemistry Letters. 21:1447-1451
مصطلحات موضوعية: Azoles, Clinical Biochemistry, Administration, Oral, Biological Availability, Pharmaceutical Science, Biochemistry, Histone Deacetylases, Rats, Sprague-Dawley, Inhibitory Concentration 50, Structure-Activity Relationship, Drug Discovery, Animals, Structure–activity relationship, Nuclear export signal, Protein Kinase Inhibitors, Molecular Biology, Protein Kinase C, chemistry.chemical_classification, Histone deacetylase 5, Molecular Structure, biology, Kinase, Chemistry, Organic Chemistry, Rats, Enzyme, Enzyme inhibitor, biology.protein, Molecular Medicine, Histone deacetylase, Signal transduction, Signal Transduction
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