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المؤلفون: Mark Munson, James Pribish, Lim Sungtaek, Maniar Sachin, Bradford H. Hirth, Robert H. Barker, Jiang John Z, Yong Mi Choi-Sledeski, Sukanthini Thurairatnam, Kwon Yon Musick, Elina Makino, John E. Macor
المصدر: ACS Med Chem Lett
مصطلحات موضوعية: Arylsulfatase A, biology, Chemistry, Organic Chemistry, Neurodegeneration, Pharmacology, medicine.disease, Biochemistry, Metachromatic leukodystrophy, UGT8, medicine.anatomical_structure, In vivo, Lysosome, Drug Discovery, biology.protein, medicine, Substrate reduction therapy, Arylsulfatase
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee0e9cd71be8f13535f7151488851852
https://europepmc.org/articles/PMC7549271/ -
2Discovery of N-substituted 7-azaindoles as Pan-PIM kinases inhibitors - Lead optimization - Part III
المؤلفون: Andrew Hebert, Paul Erdman, Maniar Sachin, Anlai Wang, Alexandre Gross, Elina Tserlin, Claude Barberis, Vinod F. Patel, Jiang John Z, Mark Czekaj, Mikhail Levit, James Pribish, Frank Sun, Matthieu Barrague, Luke Fire, Shih-Min A. Huang
المصدر: Bioorganicmedicinal chemistry letters. 29(3)
مصطلحات موضوعية: Indoles, Clinical Biochemistry, hERG, Compound 17, Pharmaceutical Science, Antineoplastic Agents, 01 natural sciences, Biochemistry, Part iii, Mice, Structure-Activity Relationship, Proto-Oncogene Proteins c-pim-1, Cell Line, Tumor, Drug Discovery, Animals, Humans, Molecular Biology, Protein Kinase Inhibitors, Cell Proliferation, biology, Dose-Response Relationship, Drug, Molecular Structure, 010405 organic chemistry, Chemistry, Organic Chemistry, Neoplasms, Experimental, Combinatorial chemistry, 0104 chemical sciences, Rats, 010404 medicinal & biomolecular chemistry, Pim kinases, biology.protein, Molecular Medicine, Tumor growth inhibition, Drug Screening Assays, Antitumor
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3دورية أكاديمية
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