المؤلفون: Stacia K. Wyman, Johannes C. Walter, Leo C. Chen, Jonathan T. Vu, Jiyung J. Shin, Katelynn R. Kazane, R. Alex Wu, Benjamin G. Gowen, Christopher D. Richardson, Jacob E. Corn, Alan S. Wang

المصدر: Molecular cell, vol 79, iss 2

مصطلحات موضوعية: DNA Repair, CRISPR-Associated Proteins, Xenopus, SSRP1, Medical and Health Sciences, Genome, Xenopus laevis, Double-Stranded, 0302 clinical medicine, Genome editing, CRISPR-Associated Protein 9, Cas9, Gene Editing, 0303 health sciences, biology, Chemistry, High Mobility Group Proteins, Biological Sciences, Nucleosomes, Cell biology, DNA-Binding Proteins, Histone, Gene Knockdown Techniques, CRISPR, SPT16, Transcriptional Elongation Factors, Human, 1.1 Normal biological development and functioning, Cell Line, Genome engineering, Homology directed repair, CRISPRa, 03 medical and health sciences, Genetic, Underpinning research, Genetics, Animals, Humans, Epigenetics, 030304 developmental biology, DNA Breaks, Human Genome, CRISPRi, DNA, biology.organism_classification, FACT complex, histone chaperone, Chaperone (protein), biology.protein, Generic health relevance, 030217 neurology & neurosurgery, Epigenesis, Developmental Biology

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4df03a53b46269259f32a76c35ec6542
https://doi.org/10.1101/705657

المؤلفون: Mary Mohrin, Rika Ohkubo, Wei Chieh Mu, Hanzhi Luo, Rajendra Karki, Jiyung J. Shin, Danica Chen, Keisuke Ito, Hou Hsien Chiang, Thirumala-Devi Kanneganti

المصدر: Cell Reports, 26 (4)
Cell reports, vol 26, iss 4
Cell reports

مصطلحات موضوعية: 0301 basic medicine, Inflammasomes, Medical Physiology, Mice, Sirtuin 2, 0302 clinical medicine, oxidative stress, Cellular Senescence, Mice, Knockout, integumentary system, Hematopoietic stem cell, Inflammasome, hemic and immune systems, mitochondrial UPR, Mitochondria, Cell biology, Haematopoiesis, Physiological Aging, medicine.anatomical_structure, Stem cell, medicine.drug, SIRT3, Knockout, Physiological, Caspase 1, NLR Family, Biology, Stress, SIRT2, Article, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, NLRP3, Stress, Physiological, SIRT7, inflammasome, NLR Family, Pyrin Domain-Containing 3 Protein, clonal hematopoiesis, medicine, Animals, aging, Hematopoietic Stem Cells, Pyrin Domain-Containing 3 Protein, 030104 developmental biology, hematopoietic stem cell, Biochemistry and Cell Biology, 030217 neurology & neurosurgery

وصف الملف: application/application/pdf; application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::babafe874fd7b9d658b87b0fbaf9a383
https://hdl.handle.net/20.500.11850/323374

المؤلفون: Markus G. Manz, Dirk Hockemeyer, Nicolas Bray, Jiyung J. Shin, Won-Tae Kim, Stacia K. Wyman, Mark A. DeWitt, Jonathan T. Vu, Matteo Bordi, Francisco Caiado, Markus S. Schröder, Jacob E. Corn

المساهمون: University of Zurich, Corn, Jacob E

المصدر: Cell Reports
Cell Reports, 32 (9)

مصطلحات موضوعية: 0301 basic medicine, Genetic enhancement, 610 Medicine & health, GATA3 Transcription Factor, Biology, Article, General Biochemistry, Genetics and Molecular Biology, Homology directed repair, 03 medical and health sciences, 0302 clinical medicine, Immunophenotyping, Genome editing, 1300 General Biochemistry, Genetics and Molecular Biology, Humans, CRISPR, quiescence, Progenitor cell, Gene Editing, Stem Cells, Recombinational DNA Repair, Genetic Therapy, Hematopoietic Stem Cells, gene therapy, Cell biology, adult hematopoietic stem cells, homology-directed repair, Haematopoiesis, 030104 developmental biology, 10032 Clinic for Oncology and Hematology, cell cycle, CRISPR-Cas Systems, Stem cell, 030217 neurology & neurosurgery

وصف الملف: 1-s2.0-S2211124720310822-main.pdf - application/pdf; application/application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d17fe1a8fdfc12b2485f2f75f4983627
https://doi.org/10.1016/j.celrep.2020.108093

المؤلفون: Yvonne Hao, Leo C. Chen, Alan S. Wang, David T. McSwiggen, Christopher D. Richardson, Alec Heckert, R. Alex Wu, Jacob E. Corn, Johannes C. Walter, Jonathan T. Vu, Stacia K. Wyman, Benjamin G. Gowen, Jiyung J. Shin, Katelynn R. Kazane, Xavier Darzacq

المصدر: Mol Cell

مصطلحات موضوعية: DNA Repair, CRISPR-Associated Proteins, Xenopus, Genome, Article, Cell Line, Epigenesis, Genetic, Genome engineering, Xenopus laevis, 03 medical and health sciences, 0302 clinical medicine, Genome editing, CRISPR-Associated Protein 9, Animals, Humans, DNA Breaks, Double-Stranded, Epigenetics, Molecular Biology, 030304 developmental biology, Gene Editing, 0303 health sciences, biology, Genome, Human, High Mobility Group Proteins, DNA, Cell Biology, FACT complex, biology.organism_classification, Nucleosomes, Chromatin, Cell biology, DNA-Binding Proteins, Histone, Gene Knockdown Techniques, biology.protein, Transcriptional Elongation Factors, 030217 neurology & neurosurgery

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ea8dddc1deb4caf4bc18de98ed374c7
https://doi.org/10.1016/j.molcel.2020.06.014

المؤلفون: Wienert B; Innovative Genomics Institute, University of California, Berkeley, CA, 94703, USA.; Department of Molecular and Cell Biology, University of California, Berkeley, CA, 94703, USA.; Gladstone Institutes, San Francisco, CA, 94158, USA., Nguyen DN; Department of Microbiology and Immunology, University of California, San Francisco, CA, 94143, USA.; Diabetes Center, University of California, San Francisco, CA, 94143, USA.; Department of Medicine, University of California, San Francisco, CA, 94143, USA., Guenther A; Department of Molecular, Cellular, and Developmental Biology, University of California, Santa Barbara, CA, 93106, USA., Feng SJ; Innovative Genomics Institute, University of California, Berkeley, CA, 94703, USA.; Department of Molecular and Cell Biology, University of California, Berkeley, CA, 94703, USA., Locke MN; Department of Molecular and Cell Biology, University of California, Berkeley, CA, 94703, USA., Wyman SK; Innovative Genomics Institute, University of California, Berkeley, CA, 94703, USA., Shin J; Department of Biology, Institute of Molecular Health Sciences, ETH Zürich, 8093, Zurich, Switzerland., Kazane KR; Innovative Genomics Institute, University of California, Berkeley, CA, 94703, USA.; Department of Molecular and Cell Biology, University of California, Berkeley, CA, 94703, USA., Gregory GL; Gladstone Institutes, San Francisco, CA, 94158, USA., Carter MAM; Gladstone Institutes, San Francisco, CA, 94158, USA., Wright F; Department of Microbiology and Immunology, University of California, San Francisco, CA, 94143, USA., Conklin BR; Gladstone Institutes, San Francisco, CA, 94158, USA.; Departments of Medicine, Ophthalmology, and Pharmacology, University of California, San Francisco, CA, 94143, USA., Marson A; Innovative Genomics Institute, University of California, Berkeley, CA, 94703, USA.; Department of Microbiology and Immunology, University of California, San Francisco, CA, 94143, USA.; Diabetes Center, University of California, San Francisco, CA, 94143, USA.; Department of Medicine, University of California, San Francisco, CA, 94143, USA.; Parker Institute for Cancer Immunotherapy, San Francisco, CA, 94129, USA.; Chan Zuckerberg Biohub, San Francisco, CA, 94158, USA., Richardson CD; Innovative Genomics Institute, University of California, Berkeley, CA, 94703, USA. chris.richardson@lifesci.ucsb.edu.; Department of Molecular and Cell Biology, University of California, Berkeley, CA, 94703, USA. chris.richardson@lifesci.ucsb.edu.; Department of Molecular, Cellular, and Developmental Biology, University of California, Santa Barbara, CA, 93106, USA. chris.richardson@lifesci.ucsb.edu., Corn JE; Innovative Genomics Institute, University of California, Berkeley, CA, 94703, USA. jacob.corn@biol.ethz.ch.; Department of Molecular and Cell Biology, University of California, Berkeley, CA, 94703, USA. jacob.corn@biol.ethz.ch.; Department of Biology, Institute of Molecular Health Sciences, ETH Zürich, 8093, Zurich, Switzerland. jacob.corn@biol.ethz.ch.

المصدر: Nature communications [Nat Commun] 2020 Apr 30; Vol. 11 (1), pp. 2109. Date of Electronic Publication: 2020 Apr 30.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

مواضيع طبية MeSH: CRISPR-Cas Systems* , Recombinational DNA Repair*, Cell Cycle Proteins/*antagonists & inhibitors , Cell Cycle Proteins/*genetics , Protein Serine-Threonine Kinases/*antagonists & inhibitors , Protein Serine-Threonine Kinases/*genetics, DNA Breaks, Double-Stranded ; Gene Editing ; Genetic Engineering/methods ; HCT116 Cells ; HEK293 Cells ; HeLa Cells ; Homologous Recombination ; Humans ; K562 Cells ; Phenotype ; RNA, Guide, CRISPR-Cas Systems/metabolism ; S Phase

المؤلفون: Wienert B; Innovative Genomics Initiative, University of California, Berkeley, Berkeley, California, United States of America.; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, California, United States of America., Shin J; Innovative Genomics Initiative, University of California, Berkeley, Berkeley, California, United States of America.; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, California, United States of America., Zelin E; Innovative Genomics Initiative, University of California, Berkeley, Berkeley, California, United States of America.; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, California, United States of America., Pestal K; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, California, United States of America., Corn JE; Innovative Genomics Initiative, University of California, Berkeley, Berkeley, California, United States of America.; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, California, United States of America.

المصدر: PLoS biology [PLoS Biol] 2018 Jul 16; Vol. 16 (7), pp. e2005840. Date of Electronic Publication: 2018 Jul 16 (Print Publication: 2018).

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101183755 Publication Model: eCollection Cited Medium: Internet ISSN: 1545-7885 (Electronic) Linking ISSN: 15449173 NLM ISO Abbreviation: PLoS Biol Subsets: MEDLINE

مواضيع طبية MeSH: Transcription, Genetic*, DEAD Box Protein 58/*metabolism , Immunity, Innate/*genetics , RNA, Guide, CRISPR-Cas Systems/*genetics, Cell Line ; Cytosol/metabolism ; Humans ; Interferon Type I/metabolism ; Models, Biological ; RNA, Guide, CRISPR-Cas Systems/metabolism ; Receptors, Immunologic

المؤلفون: Farboud B; Department of Molecular Cell Biology, University of California, Berkeley; Howard Hughes Medical Institute, University of California, Berkeley., Jarvis E; Department of Molecular Cell Biology, University of California, Berkeley., Roth TL; Innovative Genomics Institute, University of California, Berkeley; Biomedical Sciences Graduate Program, University of California, San Francisco; Department of Microbiology and Immunology, University of California, San Francisco; Diabetes Center, University of California, San Francisco., Shin J; Department of Molecular Cell Biology, University of California, Berkeley; Innovative Genomics Institute, University of California, Berkeley., Corn JE; Department of Molecular Cell Biology, University of California, Berkeley; Innovative Genomics Institute, University of California, Berkeley., Marson A; Innovative Genomics Institute, University of California, Berkeley; Department of Microbiology and Immunology, University of California, San Francisco; Diabetes Center, University of California, San Francisco; Chan Zuckerberg Biohub; Department of Medicine, University of California, San Francisco; UCSF Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco., Meyer BJ; Department of Molecular Cell Biology, University of California, Berkeley; Howard Hughes Medical Institute, University of California, Berkeley., Patel NH; Department of Molecular Cell Biology, University of California, Berkeley; Department of Integrative Biology, University of California, Berkeley., Hochstrasser ML; Innovative Genomics Institute, University of California, Berkeley; megan.hochstrasser@berkeley.edu.

المصدر: Journal of visualized experiments : JoVE [J Vis Exp] 2018 May 25 (135). Date of Electronic Publication: 2018 May 25.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Video-Audio Media

بيانات الدورية: Publisher: MYJoVE Corporation Country of Publication: United States NLM ID: 101313252 Publication Model: Electronic Cited Medium: Internet ISSN: 1940-087X (Electronic) Linking ISSN: 1940087X NLM ISO Abbreviation: J Vis Exp Subsets: MEDLINE

مواضيع طبية MeSH: CRISPR-Cas Systems/*genetics , Gene Editing/*methods , Ribonucleoproteins/*genetics, Humans ; Ribonucleoproteins/metabolism

المؤلفون: Shin J; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA 94720, USA; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA., Corn JE; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA 94720, USA; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA. Electronic address: jcorn@berkeley.edu.

المصدر: Cell stem cell [Cell Stem Cell] 2017 Oct 05; Vol. 21 (4), pp. 415-416.

نوع المنشور: Journal Article; Comment

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101311472 Publication Model: Print Cited Medium: Internet ISSN: 1875-9777 (Electronic) Linking ISSN: 18759777 NLM ISO Abbreviation: Cell Stem Cell Subsets: MEDLINE

مواضيع طبية MeSH: Gene Editing*, Neoplasms/*genetics, CRISPR-Cas Systems ; Clustered Regularly Interspaced Short Palindromic Repeats ; Hematopoiesis ; Hematopoietic Stem Cells ; Humans

المؤلفون: Shin J; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA 94720, USA.; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA., Jiang F; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.; California Institute for Quantitative Biosciences, University of California, Berkeley, CA 94720, USA., Liu JJ; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.; Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA., Bray NL; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA 94720, USA.; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA., Rauch BJ; Department of Microbiology and Immunology and Quantitative Biosciences Institute, University of California, San Francisco, San Francisco, CA 94158, USA., Baik SH; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA 94720, USA.; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA., Nogales E; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.; Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.; Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA 94720, USA., Bondy-Denomy J; Department of Microbiology and Immunology and Quantitative Biosciences Institute, University of California, San Francisco, San Francisco, CA 94158, USA., Corn JE; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA 94720, USA.; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA., Doudna JA; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA 94720, USA.; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.; California Institute for Quantitative Biosciences, University of California, Berkeley, CA 94720, USA.; Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.; Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA 94720, USA.; Department of Chemistry, University of California, Berkeley, Berkeley, CA 94720, USA.

المصدر: Science advances [Sci Adv] 2017 Jul 12; Vol. 3 (7), pp. e1701620. Date of Electronic Publication: 2017 Jul 12 (Print Publication: 2017).

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101653440 Publication Model: eCollection Cited Medium: Internet ISSN: 2375-2548 (Electronic) Linking ISSN: 23752548 NLM ISO Abbreviation: Sci Adv Subsets: MEDLINE

مواضيع طبية MeSH: Clustered Regularly Interspaced Short Palindromic Repeats* , Gene Silencing*, CRISPR-Associated Protein 9/*genetics , DNA/*chemistry , DNA/*genetics, CRISPR-Associated Protein 9/chemistry ; CRISPR-Associated Protein 9/metabolism ; CRISPR-Cas Systems ; Cell Line ; Gene Editing ; High-Throughput Nucleotide Sequencing ; Humans ; Models, Molecular ; Molecular Conformation ; RNA, Guide, CRISPR-Cas Systems/genetics ; Structure-Activity Relationship

المؤلفون: Shin J; Program in Metabolic Biology, Nutritional Sciences & Toxicology, University of California, Berkeley, CA, 94720, USA., Chen D; Program in Metabolic Biology, Nutritional Sciences & Toxicology, University of California, Berkeley, CA, 94720, USA. danicac@berkeley.edu.

المصدر: Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2016; Vol. 1436, pp. 271-7.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: Humana Press Country of Publication: United States NLM ID: 9214969 Publication Model: Print Cited Medium: Internet ISSN: 1940-6029 (Electronic) Linking ISSN: 10643745 NLM ISO Abbreviation: Methods Mol Biol Subsets: MEDLINE

مواضيع طبية MeSH: Cloning, Molecular/*methods , Sirtuins/*genetics , Sirtuins/*metabolism, Cellular Senescence ; Chromatin/metabolism ; Endoplasmic Reticulum Stress ; Hematopoietic Stem Cells/physiology ; Humans ; Immunoprecipitation ; Lipid Metabolism ; Mitochondria/metabolism ; Protein Binding ; Protein Folding ; Transcription Factors/metabolism