المؤلفون: Digles D, Zdrazil B, Jm, Neefs, Van Vlijmen H, Herhaus C, Caracoti A, Brea J, Roibás B, Mi, Loza, Queralt-Rosinach N, Li, Furlong, Anna Gaulton, Bartek L, Senger S, Chichester C, Engkvist O, Ct, Evelo, Ni, Franklin, Marren D, Gf, Ecker

المصدر: Europe PubMed Central

URL الوصول: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::0726c399cf1eb3721965f060c6d6ce51
http://europepmc.org/abstract/med/27774140

المؤلفون: Yu X; Structural & Protein Sciences, Janssen Research and Development, Spring House, Pennsylvania, United States of America., Juraszek J; Janssen Vaccines & Prevention BV, Leiden, the Netherlands., Rutten L; Janssen Vaccines & Prevention BV, Leiden, the Netherlands., Bakkers MJG; Janssen Vaccines & Prevention BV, Leiden, the Netherlands., Blokland S; Janssen Vaccines & Prevention BV, Leiden, the Netherlands., Melchers JM; Janssen Vaccines & Prevention BV, Leiden, the Netherlands., van den Broek NJF; Janssen Vaccines & Prevention BV, Leiden, the Netherlands., Verwilligen AYW; Janssen Vaccines & Prevention BV, Leiden, the Netherlands., Abeywickrema P; Structural & Protein Sciences, Janssen Research and Development, Spring House, Pennsylvania, United States of America., Vingerhoets J; Janssen Pharmaceutica N.V., Clinical Microbiology and Immunology, Beerse, Belgium., Neefs JM; Janssen Pharmaceutica N.V., Discovery Sciences, Beerse, Belgium., Bakhash SAM; Department of Laboratory Medicine and Pathology, Virology Division, University of Washington, Seattle, Washington, United States of America., Roychoudhury P; Department of Laboratory Medicine and Pathology, Virology Division, University of Washington, Seattle, Washington, United States of America., Greninger A; Department of Laboratory Medicine and Pathology, Virology Division, University of Washington, Seattle, Washington, United States of America., Sharma S; Structural & Protein Sciences, Janssen Research and Development, Spring House, Pennsylvania, United States of America., Langedijk JPM; Janssen Vaccines & Prevention BV, Leiden, the Netherlands.

المصدر: PLoS pathogens [PLoS Pathog] 2023 May 01; Vol. 19 (5), pp. e1011308. Date of Electronic Publication: 2023 May 01 (Print Publication: 2023).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101238921 Publication Model: eCollection Cited Medium: Internet ISSN: 1553-7374 (Electronic) Linking ISSN: 15537366 NLM ISO Abbreviation: PLoS Pathog Subsets: MEDLINE

مواضيع طبية MeSH: COVID-19*, Humans ; SARS-CoV-2/genetics ; Antibodies, Neutralizing ; Disulfides ; Immunotherapy ; Spike Glycoprotein, Coronavirus/genetics ; Antibodies, Viral

المؤلفون: Grosse S; Janssen Research and Development, Turnhoutseweg 30, 2340 Beerse, Belgium., Tahri A; Janssen Research and Development, Turnhoutseweg 30, 2340 Beerse, Belgium., Raboisson P; Janssen Research and Development, Turnhoutseweg 30, 2340 Beerse, Belgium., Houpis Y; Janssen Research and Development, Turnhoutseweg 30, 2340 Beerse, Belgium., Stoops B; Janssen Research and Development, Turnhoutseweg 30, 2340 Beerse, Belgium., Jacoby E; Janssen Research and Development, Turnhoutseweg 30, 2340 Beerse, Belgium., Neefs JM; Janssen Research and Development, Turnhoutseweg 30, 2340 Beerse, Belgium., Van Loock M; Janssen Global Public Health, R&D, Turnhoutseweg 30, 2340 Beerse, Belgium., Goethals O; Janssen Global Public Health, R&D, Turnhoutseweg 30, 2340 Beerse, Belgium., Geluykens P; Charles River, Discovery, Turnhoutseweg 30, 2340 Beerse, Belgium., Bonfanti JF; Janssen Research and Development, Chaussée du Vexin, 27100 Val de Reuil, France., Jonckers THM; Janssen Research and Development, Turnhoutseweg 30, 2340 Beerse, Belgium.

المصدر: ACS medicinal chemistry letters [ACS Med Chem Lett] 2022 Nov 28; Vol. 13 (12), pp. 1879-1884. Date of Electronic Publication: 2022 Nov 28 (Print Publication: 2022).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101521073 Publication Model: eCollection Cited Medium: Print ISSN: 1948-5875 (Print) Linking ISSN: 19485875 NLM ISO Abbreviation: ACS Med Chem Lett Subsets: PubMed not MEDLINE

المؤلفون: De Pooter D; Janssen Infectious Diseases, Janssen Research and Development, Division of Janssen Pharmaceutica NV, Turnhoutseweg 30, 2340 Beerse, Belgium., Van Gulck E; Janssen Infectious Diseases, Janssen Research and Development, Division of Janssen Pharmaceutica NV, Turnhoutseweg 30, 2340 Beerse, Belgium., Chen A; Janssen Infectious Diseases, Janssen Research and Development, Division of Janssen Pharmaceutica NV, Turnhoutseweg 30, 2340 Beerse, Belgium., Evans CF; Ichor Medical Systems Inc., 6310 Nancy Ridge Drive, Suite 107, San Diego, CA 92121, USA., Neefs JM; Discovery Sciences, Janssen Research and Development, Division of Janssen Pharmaceutica NV, Turn-houtseweg 30, 2340 Beerse, Belgium., Horton H; Janssen Infectious Diseases, Janssen Research and Development, Division of Janssen Pharmaceutica NV, Turnhoutseweg 30, 2340 Beerse, Belgium., Boden D; Janssen Infectious Diseases, Division of Janssen Pharmaceutica NV, 260 E. Grand Avenue, South San Francisco, CA 94080, USA.

المصدر: Vaccines [Vaccines (Basel)] 2021 Aug 29; Vol. 9 (9). Date of Electronic Publication: 2021 Aug 29.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101629355 Publication Model: Electronic Cited Medium: Print ISSN: 2076-393X (Print) Linking ISSN: 2076393X NLM ISO Abbreviation: Vaccines (Basel) Subsets: PubMed not MEDLINE

المؤلفون: Verbinnen T; Janssen Research and Development, Turnhoutseweg 30, 2340 Beerse, Belgium., Tan Y; Janssen China Research & Development Center, 5F North Building #1 Jinchuang Mansion, 4560 Jinke Road, Shanghai 201210, China., Wang G; Janssen China Research & Development Center, 5F North Building #1 Jinchuang Mansion, 4560 Jinke Road, Shanghai 201210, China., Dehertogh P; Janssen Research and Development, Turnhoutseweg 30, 2340 Beerse, Belgium., Vergauwen K; Janssen Research and Development, Turnhoutseweg 30, 2340 Beerse, Belgium., Neefs JM; Janssen Research and Development, Turnhoutseweg 30, 2340 Beerse, Belgium., Jacoby E; Janssen Research and Development, Turnhoutseweg 30, 2340 Beerse, Belgium., Lenz O; Janssen Research and Development, Turnhoutseweg 30, 2340 Beerse, Belgium., Berke JM; Janssen Research and Development, Turnhoutseweg 30, 2340 Beerse, Belgium.

المصدر: The Journal of antimicrobial chemotherapy [J Antimicrob Chemother] 2020 Sep 01; Vol. 75 (9), pp. 2526-2534.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Oxford University Press Country of Publication: England NLM ID: 7513617 Publication Model: Print Cited Medium: Internet ISSN: 1460-2091 (Electronic) Linking ISSN: 03057453 NLM ISO Abbreviation: J Antimicrob Chemother Subsets: MEDLINE

مواضيع طبية MeSH: Hepatitis B virus*/genetics , Hepatitis B, Chronic*/drug therapy, Antiviral Agents/pharmacology ; Antiviral Agents/therapeutic use ; Capsid ; Capsid Proteins ; DNA, Viral ; Genotype ; Hepatitis B e Antigens/therapeutic use ; Humans ; Mutation

المؤلفون: Cox MJ; Janssen Pharmaceutica N.V., Turnhoutseweg 30, 2340, Beerse, Belgium., Jaensch S; Janssen Pharmaceutica N.V., Turnhoutseweg 30, 2340, Beerse, Belgium. SJAENSCH@its.jnj.com., Van de Waeter J; Janssen Pharmaceutica N.V., Turnhoutseweg 30, 2340, Beerse, Belgium., Cougnaud L; Open Analytics N.V., Antwerp, Belgium., Seynaeve D; Open Analytics N.V., Antwerp, Belgium., Benalla S; Janssen Pharmaceutica N.V., Turnhoutseweg 30, 2340, Beerse, Belgium., Koo SJ; Janssen Pharmaceutica N.V., Turnhoutseweg 30, 2340, Beerse, Belgium., Van Den Wyngaert I; Janssen Pharmaceutica N.V., Turnhoutseweg 30, 2340, Beerse, Belgium., Neefs JM; Janssen Pharmaceutica N.V., Turnhoutseweg 30, 2340, Beerse, Belgium., Malkov D; MilliporeSigma, Saint Louis, MO, USA., Bittremieux M; Janssen Pharmaceutica N.V., Turnhoutseweg 30, 2340, Beerse, Belgium., Steemans M; Janssen Pharmaceutica N.V., Turnhoutseweg 30, 2340, Beerse, Belgium., Peeters PJ; Janssen Pharmaceutica N.V., Turnhoutseweg 30, 2340, Beerse, Belgium., Wegner JK; Janssen Pharmaceutica N.V., Turnhoutseweg 30, 2340, Beerse, Belgium., Ceulemans H; Janssen Pharmaceutica N.V., Turnhoutseweg 30, 2340, Beerse, Belgium., Gustin E; Janssen Pharmaceutica N.V., Turnhoutseweg 30, 2340, Beerse, Belgium., Chong YT; Janssen Pharmaceutica N.V., Turnhoutseweg 30, 2340, Beerse, Belgium.; Recursion, Salt Lake City, UT, USA., Göhlmann HWH; Janssen Pharmaceutica N.V., Turnhoutseweg 30, 2340, Beerse, Belgium.

المصدر: Scientific reports [Sci Rep] 2020 Aug 06; Vol. 10 (1), pp. 13262. Date of Electronic Publication: 2020 Aug 06.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

مواضيع طبية MeSH: Biological Products/*pharmacology , Luminescent Proteins/*genetics , Phenomics/*methods , Small Molecule Libraries/*pharmacology, A549 Cells ; Cell Line ; Drug Discovery ; Gene Expression Regulation/drug effects ; Hep G2 Cells ; Humans ; Luminescent Proteins/metabolism

المؤلفون: Jacoby E; Janssen Research & Development, Turnhoutseweg 30, 2340, Beerse, Belgium., Wroblowski B; Janssen Research & Development, Turnhoutseweg 30, 2340, Beerse, Belgium., Buyck C; Janssen Research & Development, Turnhoutseweg 30, 2340, Beerse, Belgium., Neefs JM; Janssen Research & Development, Turnhoutseweg 30, 2340, Beerse, Belgium., Meyer C; Janssen Cilag, Chaussée du Vexin, 27100, Val-de-Reuil, France., Cummings MD; Janssen Research & Development, 1400 McKean Rd, Spring House, PA 19477, USA., van Vlijmen H; Janssen Research & Development, Turnhoutseweg 30, 2340, Beerse, Belgium.

المصدر: Molecular informatics [Mol Inform] 2018 May; Vol. 37 (5), pp. e1700119. Date of Electronic Publication: 2017 Nov 08.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Wiley-VCH Verlag Country of Publication: Germany NLM ID: 101529315 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1868-1751 (Electronic) Linking ISSN: 18681743 NLM ISO Abbreviation: Mol Inform Subsets: MEDLINE

مواضيع طبية MeSH: Structure-Activity Relationship*, Drug Discovery/*methods , Protein Kinase Inhibitors/*chemistry , Small Molecule Libraries/*chemistry, Data Mining/methods ; Protein Kinase Inhibitors/chemical synthesis ; Protein Kinase Inhibitors/pharmacology ; Small Molecule Libraries/chemical synthesis ; Small Molecule Libraries/pharmacology

المؤلفون: Digles D; Department of Pharmaceutical Chemistry , University of Vienna , Pharmacoinformatics Research Group , Althanstraße 14 , 1090 Wien , Austria . Email: daniela.digles@univie.ac.at., Zdrazil B; Department of Pharmaceutical Chemistry , University of Vienna , Pharmacoinformatics Research Group , Althanstraße 14 , 1090 Wien , Austria . Email: daniela.digles@univie.ac.at., Neefs JM; Janssen Research & Development , Turnhoutseweg 30 , B-2340 Beerse , Belgium . Email: ejacoby@its.jnj.com., Van Vlijmen H; Janssen Research & Development , Turnhoutseweg 30 , B-2340 Beerse , Belgium . Email: ejacoby@its.jnj.com., Herhaus C; Merck KGaA, Merck Serono R&D , Computational Chemistry , Frankfurter Straße 250 , 64293 Darmstadt , Germany., Caracoti A; BIOVIA , a Dassault Systèmes brand , 334 Cambridge Science Park , Cambridge CB4 0WN , UK., Brea J; Grupo BioFarma-USEF , Departamento de Farmacología , Facultad de Farmacia , Campus Universitario Sur s/n , 15782 Santiago de Compostela , Spain., Roibás B; Grupo BioFarma-USEF , Departamento de Farmacología , Facultad de Farmacia , Campus Universitario Sur s/n , 15782 Santiago de Compostela , Spain., Loza MI; Grupo BioFarma-USEF , Departamento de Farmacología , Facultad de Farmacia , Campus Universitario Sur s/n , 15782 Santiago de Compostela , Spain., Queralt-Rosinach N; Research Programme on Biomedical Informatics (GRIB) , Hospital del Mar Medical Research Institute (IMIM) , Department of Experimental and Health Sciences , Universitat Pompeu Fabra , C/Dr Aiguader 88 , E-08003 Barcelona , Spain., Furlong LI; Research Programme on Biomedical Informatics (GRIB) , Hospital del Mar Medical Research Institute (IMIM) , Department of Experimental and Health Sciences , Universitat Pompeu Fabra , C/Dr Aiguader 88 , E-08003 Barcelona , Spain., Gaulton A; European Molecular Biology Laboratory , European Bioinformatics Institute (EMBL-EBI) , Wellcome Genome Campus , Hinxton , Cambridge CB10 1SD , UK., Bartek L; GlaxoSmithKline , Medicines Research Centre , Stevenage SG1 2NY , UK., Senger S; GlaxoSmithKline , Medicines Research Centre , Stevenage SG1 2NY , UK., Chichester C; Swiss Institute of Bioinformatics , CALIPHO Group , CMU Rue Michel-Servet 1 , 1211 Geneva 4 , Switzerland ; Nestlé Institute of Health Sciences SA , EPFL Innovation Park, Bâtiment H , 1015 Lausanne , Switzerland., Engkvist O; Chemistry Innovation Centre , Discovery Sciences , AstraZeneca R&D Gothenburg , SE-431 83 Mölndal , Sweden., Evelo CT; Department of Bioinformatics - BiGCaT , P.O. Box 616 , UNS50 Box19 , NL-6200MD Maastricht , The Netherlands., Franklin NI; Open Innovation Drug Discovery , Discovery Chemistry Eli Lilly and Company , Lilly Corporate Center , DC 1920 , Indianapolis , IN 46285 , USA., Marren D; Eli Lilly and Company Ltd. , Lilly Research Centre , Erl Wood Manor, Sunninghill Road , Windlesham , Surrey GU20 6PH , England , UK., Ecker GF; Department of Pharmaceutical Chemistry , University of Vienna , Pharmacoinformatics Research Group , Althanstraße 14 , 1090 Wien , Austria . Email: daniela.digles@univie.ac.at., Jacoby E; Janssen Research & Development , Turnhoutseweg 30 , B-2340 Beerse , Belgium . Email: ejacoby@its.jnj.com.

المصدر: MedChemComm [Medchemcomm] 2016 Jun 01; Vol. 7 (6), pp. 1237-1244. Date of Electronic Publication: 2016 May 11.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101531525 Publication Model: Print-Electronic Cited Medium: Print ISSN: 2040-2503 (Print) Linking ISSN: 20402503 NLM ISO Abbreviation: Medchemcomm Subsets: PubMed not MEDLINE

المؤلفون: Jacoby E; Janssen Research & Development, Turnhoutseweg 30, 2340 Beerse, Belgium. Electronic address: ejacoby@its.jnj.com., Tresadern G; Janssen Research & Development, Turnhoutseweg 30, 2340 Beerse, Belgium., Bembenek S; Janssen Research & Development, La Jolla, 3210 Merryfield Row, San Diego, CA 92121, USA., Wroblowski B; Janssen Research & Development, Turnhoutseweg 30, 2340 Beerse, Belgium., Buyck C; Janssen Research & Development, Turnhoutseweg 30, 2340 Beerse, Belgium., Neefs JM; Janssen Research & Development, Turnhoutseweg 30, 2340 Beerse, Belgium., Rassokhin D; Janssen Research & Development, Spring House, 1400 McKean Road, Spring House, PA 19002, USA., Poncelet A; Janssen Research & Development, Val de Reuil, Campus de Maigremont, B.P. 615, 27106 Val De Reuil Cedex, France., Hunt J; KINOMEscan Division of DiscoveRx Corporation, 11180 Roselle Street, Suite D, San Diego, CA 92121, USA., van Vlijmen H; Janssen Research & Development, Turnhoutseweg 30, 2340 Beerse, Belgium. Electronic address: hvvlijme@its.jnj.com.

المصدر: Drug discovery today [Drug Discov Today] 2015 Jun; Vol. 20 (6), pp. 652-8. Date of Electronic Publication: 2015 Jan 14.

نوع المنشور: Journal Article; Review

بيانات الدورية: Publisher: Elsevier Science Ltd. Country of Publication: England NLM ID: 9604391 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-5832 (Electronic) Linking ISSN: 13596446 NLM ISO Abbreviation: Drug Discov Today Subsets: MEDLINE

مواضيع طبية MeSH: Drug Discovery/*methods , Protein Kinase Inhibitors/*pharmacology , Protein Kinases/*metabolism , Proteomics/*methods, Databases, Protein ; High-Throughput Screening Assays ; Humans ; Molecular Structure ; Molecular Targeted Therapy ; Protein Kinase Inhibitors/chemistry ; Protein Kinases/genetics ; Signal Transduction/drug effects ; Small Molecule Libraries ; Structure-Activity Relationship ; Workflow

المؤلفون: Ratnam J; Universidade de Santiago de Compostela, Grupo BioFarma-USEF, Departamento de Farmacología, Campus Universitario Sur s/n, 15782 Santiago de Compostela, Spain., Zdrazil B; University of Vienna, Department of Pharmaceutical Chemistry, Althanstrasse 14, 1090 Vienna, Austria., Digles D; University of Vienna, Department of Pharmaceutical Chemistry, Althanstrasse 14, 1090 Vienna, Austria., Cuadrado-Rodriguez E; Universidade de Santiago de Compostela, Grupo BioFarma-USEF, Departamento de Farmacología, Campus Universitario Sur s/n, 15782 Santiago de Compostela, Spain., Neefs JM; Janssen Research & Development, Turnhoutseweg 30, Beerse, Belgium., Tipney H; GSK Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire, SG1 2NY, United Kingdom., Siebes R; Vrije Universiteit, Faculty of Sciences, division of Math. and Computer Science, De Boelelaan 1081a, 1081 HV Amsterdam, The Netherlands., Waagmeester A; Department of Bioinformatics - BiGCaT, Maastricht University, Maastricht, The Netherlands., Bradley G; GSK Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire, SG1 2NY, United Kingdom., Chau CH; GSK Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire, SG1 2NY, United Kingdom., Richter L; University of Vienna, Department of Pharmaceutical Chemistry, Althanstrasse 14, 1090 Vienna, Austria., Brea J; Universidade de Santiago de Compostela, Grupo BioFarma-USEF, Departamento de Farmacología, Campus Universitario Sur s/n, 15782 Santiago de Compostela, Spain., Evelo CT; Department of Bioinformatics - BiGCaT, Maastricht University, Maastricht, The Netherlands., Jacoby E; Janssen Research & Development, Turnhoutseweg 30, Beerse, Belgium., Senger S; GSK Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire, SG1 2NY, United Kingdom., Loza MI; Universidade de Santiago de Compostela, Grupo BioFarma-USEF, Departamento de Farmacología, Campus Universitario Sur s/n, 15782 Santiago de Compostela, Spain., Ecker GF; University of Vienna, Department of Pharmaceutical Chemistry, Althanstrasse 14, 1090 Vienna, Austria., Chichester C; Swiss Institute of Bioinformatics, CALIPHO Group, CMU - Rue Michel-Servet 1, 1211 Geneva 4, Switzerland.

المصدر: PloS one [PLoS One] 2014 Dec 18; Vol. 9 (12), pp. e115460. Date of Electronic Publication: 2014 Dec 18 (Print Publication: 2014).

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE

مواضيع طبية MeSH: Databases as Topic* , Software*, Drug Discovery/*organization & administration, Drug Discovery/methods ; Drug Discovery/statistics & numerical data