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1
المؤلفون: Montse Erra, Jordi Gràcia, Joan Taltavull, Lluís Pagès, Elena Calama, María Domínguez, J.F. Caturla, Sonia Espinosa, F.J. Bernal, M. Carrascal, Mónica Bravo, M. I. Maldonado, Begoña Hernández, M Sabate, Montserrat Miralpeix, Marta Calbet, Stephane Paris, Lehner, M. Mir
المصدر: Journal of Medicinal Chemistry. 61:9551-9567
مصطلحات موضوعية: Models, Molecular, 0301 basic medicine, Drug, Class I Phosphatidylinositol 3-Kinases, Protein Conformation, media_common.quotation_subject, Perforation (oil well), Pharmacology, 01 natural sciences, Inhibitory Concentration 50, Pulmonary Disease, Chronic Obstructive, 03 medical and health sciences, chemistry.chemical_compound, Therapeutic index, Administration, Inhalation, Drug Discovery, medicine, Humans, Enzyme Inhibitors, Pneumonitis, media_common, COPD, Dose-Response Relationship, Drug, Inhalation, 010405 organic chemistry, Chemistry, medicine.disease, Duvelisib, Asthma, 0104 chemical sciences, 030104 developmental biology, Molecular Medicine, Idelalisib
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2
المؤلفون: Montserrat Miralpeix, Montse Erra, Stephane Paris, Elena Calama, Francisco Javier Bernal, Jordi Gràcia, Martin D. Lehner, María Domínguez, Joan Taltavull, Salome Soria, Mónica Bravo, Clara Armengol, Begoña Hernández, Juan Francisco Caturla, Judit Cabedo, M Sabate, Angelique Gréco
المصدر: ACS Medicinal Chemistry Letters. 8:118-123
مصطلحات موضوعية: 0301 basic medicine, Organic Chemistry, Dosing regimen, Pharmacology, Biology, Biochemistry, 03 medical and health sciences, chemistry.chemical_compound, 030104 developmental biology, Pharmacokinetics, chemistry, Drug Discovery, Structure–activity relationship, Specific immune cell, Phosphatidylinositol
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3
المؤلفون: Manel Ferrer, Elena Calama, Richard S. Roberts, Begoña Hernández, Sara Sevilla, Judit Cabedo, Dolors Vilella, Peter Eichhorn, Amadeu Gavaldà, Miriam Andrés, Jordi Gràcia, Martin D. Lehner, Carla Carcasona, Joan Taltavull, Victor Segarra, Montserrat Miralpeix
المصدر: Journal of medicinal chemistry. 61(6)
مصطلحات موضوعية: 0301 basic medicine, Drug, Lipopolysaccharides, Male, Neutrophils, media_common.quotation_subject, Pharmacology, Crystallography, X-Ray, Rats, Sprague-Dawley, 03 medical and health sciences, Structure-Activity Relationship, 0302 clinical medicine, In vivo, Drug Discovery, Hydrolase, Administration, Inhalation, Structure–activity relationship, Animals, Naphthyridines, Lung, media_common, chemistry.chemical_classification, Dose-Response Relationship, Drug, Tumor Necrosis Factor-alpha, Rational design, Dry Powder Inhalers, Rats, Dose–response relationship, 030104 developmental biology, Enzyme, chemistry, Structural biology, 030220 oncology & carcinogenesis, Drug Design, Molecular Medicine, Phosphodiesterase 4 Inhibitors
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4
المؤلفون: Jordi Serrat, Jordi Gràcia, Judit Cabedo, Lluís Pagès, Dolors Vilella, Martin D. Lehner, Manel Ferrer, Montserrat Miralpeix, Peter Eichhorn, Jordi Castro, Begoña Hernández, Maria Antonia Buil, Victor Segarra, Elena Calama, Sara Sevilla, Carla Carcasona, Miriam Andrés, Joan Taltavull, Imma Moreno, Richard S. Roberts, Amadeu Gavaldà
المصدر: Journal of medicinal chemistry. 59(23)
مصطلحات موضوعية: 0301 basic medicine, Male, Models, Molecular, Pharmacology, Adenylyl cyclase, Rats, Sprague-Dawley, 03 medical and health sciences, Cyclic nucleotide, chemistry.chemical_compound, Structure-Activity Relationship, Drug Discovery, Animals, Humans, chemistry.chemical_classification, Cyclic nucleotide phosphodiesterase, Dose-Response Relationship, Drug, Molecular Structure, Biphenyl Compounds, Adenosine receptor, Cyclic Nucleotide Phosphodiesterases, Type 4, Rats, Pyridazines, 030104 developmental biology, Enzyme, chemistry, Biochemistry, Structural biology, Second messenger system, Molecular Medicine, Phosphodiesterase 4 Inhibitors, Intracellular
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5
المؤلفون: Mònica Córdoba, Amadeu Gavaldà, Montserrat Miralpeix, Jordi Serrat, Elena Calama, Lluís Pagès, Jorge Beleta, Joan Taltavull, Jose Luis Montero, Miriam Andrés, Hamish Ryder, Dolors Vilella, Begoña Hernández, Jordi Gràcia
المصدر: European Journal of Medicinal Chemistry. 46:4946-4956
مصطلحات موضوعية: Models, Molecular, Cell Membrane Permeability, Phosphodiesterase Type 4, Pyrimidine, Stereochemistry, Pulmonary disease, Ring (chemistry), Pulmonary Disease, Chronic Obstructive, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, Pyridine, Animals, Humans, Potency, Pharmacology, chemistry.chemical_classification, Organic Chemistry, Ferrets, Biological activity, General Medicine, Asthma, Cyclic Nucleotide Phosphodiesterases, Type 4, Pyrimidines, Enzyme, chemistry, Phosphodiesterase 4 Inhibitors, Caco-2 Cells
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6
المؤلفون: Jordi Serrat, Jordi Gràcia, Montserrat Miralpeix, Joan Taltavull, Lluís Pagès, Amadeu Gavaldà, Mònica Córdoba, Hamish Ryder, Miriam Andrés, Dolors Vilella, Jorge Beleta
المصدر: Journal of Medicinal Chemistry. 53:6912-6922
مصطلحات موضوعية: chemistry.chemical_classification, Phosphodiesterase Type 4, Pyridines, Chemistry, Stereochemistry, Pulmonary disease, Biological activity, Thiophenes, Ring (chemistry), Pichia, Recombinant Proteins, Structure-Activity Relationship, chemistry.chemical_compound, Pyrimidines, Enzyme, Drug Discovery, Pyridine, Humans, Molecular Medicine, Moiety, Potency, Phosphodiesterase 4 Inhibitors
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7
المؤلفون: Xavier Ginesta, Frank Egeler, Jaume Farràs, Joan Taltavull, Fèlix Urpí, Pedro Romea, Jaume Vilarrasa, Peter W. Sutton
المصدر: Tetrahedron. 57:7665-7674
مصطلحات موضوعية: chemistry.chemical_classification, chemistry.chemical_compound, Hydrolysis, Nucleophile, Chemistry, Cyanide, Organic Chemistry, Drug Discovery, Peptide synthesis, Ring (chemistry), Biochemistry, Combinatorial chemistry, Amino acid
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8
المؤلفون: Pedro Romea, Peter W. Sutton, Frank Egeler, Fèlix Urpí, Jaume Vilarrasa, Xavier Ginesta, Jaume Farràs, Joan Taltavull
المصدر: ChemInform. 33
مصطلحات موضوعية: chemistry.chemical_classification, chemistry.chemical_compound, Hydrolysis, Nucleophile, Chemistry, Cyanide, Peptide synthesis, General Medicine, Ring (chemistry), Combinatorial chemistry, Amino acid