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المؤلفون: Arunachalam Arumugam, Dietmar A. Seiffert, Arvind Mathur, Joanna J. Zheng, Ruth R. Wexler, Jeon Yoon T, Premsai Rai Neithnadka, Earl J. Crain, Paul J. Gilligan, Patrick Y.S. Lam, Yiming Wu, Mahammed Kaspady, Pancras C. Wong, Tianan Fang, Silvi A. Chacko, William R. Ewing, Pabbisetty Kumar Balashanmuga, Zhen Lou, Steven Sheriff, Joseph M. Luettgen, Joseph E. Myers, Wu Yang, Karen A. Rossi, Richard Rampulla, James R. Corte, Amy Lai, Charles G. Clark, Jeffrey M. Bozarth, Yufeng Wang, Sivashankaran Raju
المصدر: Journal of Medicinal Chemistry. 63:7226-7242
مصطلحات موضوعية: Models, Molecular, Proteases, Macrocyclic Compounds, Drug Evaluation, Preclinical, Administration, Oral, Biological Availability, Pharmacology, Crystallography, X-Ray, 01 natural sciences, Factor XIa, Serine, Structure-Activity Relationship, 03 medical and health sciences, Dogs, Fibrinolytic Agents, Pharmacokinetics, In vivo, Drug Discovery, Antithrombotic, Animals, Humans, Structure–activity relationship, 030304 developmental biology, 0303 health sciences, Chemistry, 0104 chemical sciences, Bioavailability, 010404 medicinal & biomolecular chemistry, Molecular Medicine, Rabbits, Hydrophobic and Hydrophilic Interactions, Linker
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المؤلفون: Karen A. Rossi, Ruth R. Wexler, Steven Sheriff, Dawn Sun, Jeffrey M. Bozarth, Jianqing Li, Elizabeth A. Dierks, James R. Corte, Yiming Wu, Donald J. P. Pinto, Silvi A. Chacko, Michael Galella, Joanna J. Zheng, Joseph E. Myers, Dauh-Rurng Wu, Tianan Fang, Joseph M. Luettgen, Pancras C. Wong, Xiaoping Hou, Pabbisetty Kumar Balashanmuga, Daniel Smith, Indawati De Lucca, Huiping Zhang, Wu Yang, Arvind Mathur, Yufeng Wang, Dilger Andrew K, William R. Ewing, Subramaniam Krishnananthan, Yeheng Zhu, Earl J. Crain, Theresa Ziemba
المصدر: Journal of medicinal chemistry. 65(3)
مصطلحات موضوعية: Administration, Oral, Factor XIa, Pharmacology, Rats, Sprague-Dawley, Mice, Structure-Activity Relationship, Pharmacokinetics, Fibrinolytic Agents, Bleeding time, Oral administration, Drug Discovery, Antithrombotic, medicine, Animals, Carotid Artery Thrombosis, medicine.diagnostic_test, Molecular Structure, Chemistry, Triazoles, Bioavailability, Macaca fascicularis, Pyrimidines, Free fraction, Hemostasis, Molecular Medicine, Pyrazoles, Rabbits
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المؤلفون: James R. Corte, Donald J. P. Pinto, Tianan Fang, Honey Osuna, Wu Yang, Yufeng Wang, Amy Lai, Charles G. Clark, Jung-Hui Sun, Richard Rampulla, Arvind Mathur, Mahammed Kaspady, Premsai Rai Neithnadka, Yi-Xin Cindy Li, Karen A. Rossi, Joseph E. Myers, Steven Sheriff, Zhen Lou, Timothy W. Harper, Christine Huang, Joanna J. Zheng, Jeffrey M. Bozarth, Yiming Wu, Pancras C. Wong, Earl J. Crain, Dietmar A. Seiffert, Joseph M. Luettgen, Patrick Y. S. Lam, Ruth R. Wexler, William R. Ewing
المصدر: Journal of medicinal chemistry. 63(2)
مصطلحات موضوعية: Models, Molecular, Macrocyclic Compounds, Serine Proteinase Inhibitors, Pyridines, Imidazoles, Biological Availability, Thrombosis, Crystallography, X-Ray, Factor XIa, Structure-Activity Relationship, Fibrinolytic Agents, Drug Design, Drug Discovery, Molecular Medicine, Animals, Humans, Partial Thromboplastin Time, Rabbits, Blood Coagulation
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المؤلفون: Karen A. Rossi, Tianan Fang, Wu Yang, Dietmar A. Seiffert, Yiming Wu, Mimi L. Quan, Zhen Lou, Honey Osuna, Joseph E. Myers, Steven Sheriff, William R. Ewing, Ruth R. Wexler, Joseph M. Luettgen, Amy Lai, Joanna J. Zheng, James R. Corte, Patrick Y.S. Lam, Timothy W. Harper, Yufeng Wang, Jeffrey M. Bozarth
المصدر: Bioorganic & Medicinal Chemistry Letters. 27:3833-3839
مصطلحات موضوعية: Models, Molecular, 0301 basic medicine, Macrocyclic Compounds, Serine Proteinase Inhibitors, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Factor XIa, 030204 cardiovascular system & hematology, Crystallography, X-Ray, Biochemistry, Polar surface area, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Amide, Drug Discovery, Humans, Potency, Molecular Biology, Alkyl, chemistry.chemical_classification, Dose-Response Relationship, Drug, Molecular Structure, Organic Chemistry, Amides, Combinatorial chemistry, Ring size, 030104 developmental biology, chemistry, Molecular Medicine, Linker
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المؤلفون: Baomin Xin, Timothy V Olah, Eric Shields, Dieter M. Drexler, Steven A. Stryker, Donald G. Robertson, Michael D. Reily, David M. Nelson, Petia Shipkova, Joanna J. Zheng, Kimberly Snow
المصدر: Analytical Biochemistry. 503:71-78
مصطلحات موضوعية: 0301 basic medicine, Analyte, Bioanalysis, Calibration curve, education, Biophysics, Food consumption, Endogeny, 01 natural sciences, Biochemistry, Mass Spectrometry, Bile Acids and Salts, 03 medical and health sciences, Metabolomics, Liquid chromatography–mass spectrometry, Animals, Humans, Molecular Biology, Chromatography, Molecular Structure, Stable isotope ratio, Chemistry, 010401 analytical chemistry, Cell Biology, Rats, 0104 chemical sciences, 030104 developmental biology, Isotope Labeling, Chromatography, Liquid
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المؤلفون: Tianan Fang, James R. Corte, Paul J. Gilligan, Yoon Jeon, Honey Osuna, Karen A. Rossi, Joseph E. Myers, Steven Sheriff, Zhen Lou, Joanna J. Zheng, Timothy W. Harper, Jeffrey M. Bozarth, Yiming Wu, Joseph M. Luettgen, Dietmar A. Seiffert, Ruth R. Wexler, Patrick Y.S. Lam
المصدر: Bioorganic & Medicinal Chemistry Letters. 30:126949
مصطلحات موضوعية: Binding Sites, Macrocyclic Compounds, Serine Proteinase Inhibitors, Pyridines, Organic Chemistry, Clinical Biochemistry, Administration, Oral, Pharmaceutical Science, Molecular Dynamics Simulation, Biochemistry, Factor XIa, Protein Structure, Tertiary, Rats, Structure-Activity Relationship, Drug Design, Drug Discovery, Animals, Molecular Medicine, Amines, Molecular Biology, Half-Life
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المؤلفون: Atsu Apedo, Pancras C. Wong, Olafur S. Gudmundsson, Nathalie Toussaint, Yiming Wu, Timothy W. Harper, Silvi A. Chacko, Leon M. Smith, Baomin Xin, Dietmar A. Seiffert, Steven Sheriff, Ruth R. Wexler, William R. Ewing, Jeffrery M. Bozarth, Mimi L. Quan, Zhen Lou, Earl J. Crain, Brad D. Maxwell, Joanna J. Zheng, Arvind Mathur, Paul Stetsko, Joseph E. Myers, Donald J. P. Pinto, Michael J. Orwat, Karen A. Rossi, Patrick Y.S. Lam, Xiaoping Hou, Joseph M. Luettgen, Huiping Zhang
المصدر: Journal of medicinal chemistry. 60(23)
مصطلحات موضوعية: 0301 basic medicine, Male, Factor XIa, 030204 cardiovascular system & hematology, Pharmacology, Crystallography, X-Ray, Normal hemostasis, Small Molecule Libraries, 03 medical and health sciences, 0302 clinical medicine, Dogs, Antithrombotic, Drug Discovery, medicine, para-Aminobenzoates, Animals, Humans, Thrombus, Blood Coagulation, Chemistry, Drug discovery, Anticoagulants, Thrombosis, medicine.disease, Isoquinolines, Small molecule, Rats, Molecular Docking Simulation, 030104 developmental biology, Coagulation, Coagulation factor XIa, Molecular Medicine, Rabbits
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المؤلفون: Timothy V Olah, John T Mehl, Joanna J. Zheng
المصدر: Eliminating Bottlenecks for Efficient Bioanalysis: Practices and Applications in Drug Discovery and Development. :200-215
مصطلحات موضوعية: Chemistry, Quantitative proteomics, Computational biology
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::3bcca89bf94db1ef07e0cbc32c0d3dd8
https://doi.org/10.4155/fseb2013.13.21 -
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المؤلفون: Karen A. Rossi, Yiming Wu, Joseph M. Luettgen, Mimi L. Quan, Zhen Lou, James R. Corte, Carl P. Decicco, Joanna J. Zheng, Steven Sheriff, Tianan Fang, Joseph E. Myers, Donald J. P. Pinto, Dietmar A. Seiffert, Ruth R. Wexler, Honey Osuna, Timothy W. Harper, Jeffrey M. Bozarth
المصدر: Journal of medicinal chemistry. 60(3)
مصطلحات موضوعية: Macrocyclic Compounds, Serine Proteinase Inhibitors, Stereochemistry, 030204 cardiovascular system & hematology, Ligands, 01 natural sciences, Factor XIa, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Amide, Drug Discovery, Imidazole, chemistry.chemical_classification, biology, Molecular Structure, 010405 organic chemistry, Hydrogen bond, Active site, Hydrogen Bonding, Ligand (biochemistry), Combinatorial chemistry, Amides, 0104 chemical sciences, Enzyme, chemistry, biology.protein, Molecular Medicine, Selectivity, Linker
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المؤلفون: Mimi L. Quan, Ruth R. Wexler, Joseph E. Myers, Joseph M. Luettgen, Donald J. P. Pinto, Dietmar A. Seiffert, Yi-Xin Li, Steven Sheriff, Timothy W. Harper, Rangaraj Narayanan, Michael J. Orwat, Anzhi Wei, James R. Corte, Tianan Fang, Joanna J. Zheng, Karen A. Rossi, Vidhyashankar Ramamurthy, Alan R. Rendina
المصدر: Bioorganicmedicinal chemistry. 24(10)
مصطلحات موضوعية: Models, Molecular, Carbamate, Pyrimidine, Stereochemistry, Pyridines, medicine.medical_treatment, Clinical Biochemistry, Phenylcarbamates, Pharmaceutical Science, Administration, Oral, 030204 cardiovascular system & hematology, Ring (chemistry), Crystallography, X-Ray, 01 natural sciences, Biochemistry, Factor XIa, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Dogs, Drug Discovery, Pyridine, medicine, Imidazole, Moiety, Animals, Humans, Molecular Biology, Blood Coagulation, Indazole, 010405 organic chemistry, Chemistry, Organic Chemistry, Anticoagulants, 0104 chemical sciences, Bioavailability, Pyrimidines, Molecular Medicine
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