-
1
المؤلفون: Julia H Shin, Steven A. Gilbert, Vikram R. Rao, Betsy J. Barnes, Lih-Ling Lin, Ken Dower, Virginia Pascual, Bruce A. Jacobson, Iain Kilty, Jean J Beebe, Tatyana Andreyeva, Bruce L. Homer, Joanne Brodfuehrer, Weiyong Sun, Martin Hegen, Simeon Ramsey, M Nusrat Sharif, Margaret Fleming, Mera Tilley, Heng Liu, Aaron Winkler, Aiping Jiao, Saurav De, Shruti Athale, Peter T. Symanowicz, Ju Wang, Spencer I. Danto
المصدر: Arthritis & Rheumatology. 73:2206-2218
مصطلحات موضوعية: Lactams, Immunology, Arthritis, Inflammation, Peripheral blood mononuclear cell, Mice, Rheumatology, In vivo, Rheumatic Diseases, medicine, Animals, Humans, Immunology and Allergy, Kinase activity, skin and connective tissue diseases, Systemic lupus erythematosus, business.industry, Macrophages, Autoantibody, Dendritic Cells, Isoquinolines, medicine.disease, IRAK4, Arthritis, Experimental, Synoviocytes, Rats, Disease Models, Animal, Interleukin-1 Receptor-Associated Kinases, Leukocytes, Mononuclear, medicine.symptom, business
-
2
المؤلفون: Vahid Farrokhi, Hendrik Neubert, Pinky Dua, Florence H. Yong, Teresa M Caiazzo, Srividya Neelakantan, Jane Owens, Michael Binks, Caroline Le Guiner, Jason Walsh, Joanne Brodfuehrer, Joe Palandra
المصدر: Gene therapy. 29(10-11)
مصطلحات موضوعية: musculoskeletal diseases, congenital, hereditary, and neonatal diseases and abnormalities, medicine.medical_specialty, Transgene, Duchenne muscular dystrophy, Genetic enhancement, Viral vector, Dystrophin, Tandem Mass Spectrometry, Internal medicine, Genetics, medicine, Humans, Animals, Muscular dystrophy, Muscle, Skeletal, Molecular Biology, biology, Wild type, Skeletal muscle, Genetic Therapy, medicine.disease, Rats, Muscular Dystrophy, Duchenne, Endocrinology, medicine.anatomical_structure, biology.protein, Molecular Medicine, Chromatography, Liquid
-
3
المؤلفون: Jeanne Chang, Ravi G. Kurumbail, Margaret Fleming, Joanne Brodfuehrer, Katherine L. Lee, Frank Lovering, Shashi Mohan, Heather V. Dowty, Fabien Vincent, Jayasankar Jasti, Steve Kortum, Christoph W. Zapf, Jotham Wadsworth Coe, Christophe Allais, Strohbach Joseph Walter, Nikolaos Papaioannou, Ann Aulabaugh, Julia A. Guzova, Paul Morgan, Richard K. Frisbie, WeiDong Ding, David Hepworth
المصدر: European Journal of Medicinal Chemistry. 145:606-621
مصطلحات موضوعية: Models, Molecular, 0301 basic medicine, Pharmacology, Crystallography, X-Ray, MAP Kinase Kinase Kinase 5, medicine.disease_cause, Structure-Activity Relationship, 03 medical and health sciences, 0302 clinical medicine, Drug Discovery, medicine, Humans, Structure–activity relationship, ASK1, Kinome, Protein Kinase Inhibitors, Cells, Cultured, chemistry.chemical_classification, Reactive oxygen species, Dose-Response Relationship, Drug, Molecular Structure, Kinase, Organic Chemistry, HEK 293 cells, General Medicine, Amides, Recombinant Proteins, HEK293 Cells, 030104 developmental biology, chemistry, Apoptosis, 030220 oncology & carcinogenesis, Oxidative stress
-
4
المؤلفون: Lih-Ling Lin, Jenil Patel, Vahid Farrokhi, Joanne Brodfuehrer, Xiaoying Chen, Hendrik Neubert, Pratap Singh, Mireia Fernández Ocaña
المصدر: mAbs. 10:62-70
مصطلحات موضوعية: 0301 basic medicine, medicine.drug_class, Immunology, Pharmacology, Kidney, Monoclonal antibody, Models, Biological, Risk Assessment, Drug Administration Schedule, 03 medical and health sciences, 0302 clinical medicine, Drug Development, Pharmacokinetics, Downregulation and upregulation, Risk Factors, medicine, Humans, Immunology and Allergy, Drug Dosage Calculations, Receptor, PK/PD models, biology, Chemistry, Brief Report, Antibodies, Monoclonal, 030104 developmental biology, Drug development, TWEAK Receptor, 030220 oncology & carcinogenesis, Pharmacodynamics, biology.protein, Feasibility Studies, Kidney Diseases, Antibody
-
5
المؤلفون: Lori Krim Gavrin, David Hepworth, Jennifer R. Thomason, Iain Kilty, Joel Adam Goldberg, Christoph W. Zapf, Vikram R. Rao, Brian P. Boscoe, Akshay Patny, Peter T. Symanowicz, Marina W.H. Shen, Kevin J. Curran, Elizabeth Murphy, Martin Hegen, Fabien Vincent, Richard Vargas, Satwik Kamtekar, Heidi M. Morgan, Heidi R. Hope, Richard K. Frisbie, Jeanne S. Chang, Ken Dower, Susan E. Drozda, Strohbach Joseph Walter, Mathias John Paul, David R. Anderson, Jacqueline E. Day, Stephen W. Wright, Ivan J. Samardjiev, Seungil Han, Julia H Shin, Frank Lovering, Andrea G Bree, Arthur Lee, Holly H. Soutter, Joanne Brodfuehrer, John David Trzupek, Brian Samas, Christoph Martin Dehnhardt, Michael Dennis Lowe, Catherine M. Ambler, Seung Won Chung, Eddine Saiah, Nikolaos Papaioannou, Pierce Betsy S, Jiangli Yan, Katherine L. Lee, Lih-Ling Lin, Chulho Choi
المصدر: Journal of Medicinal Chemistry. 60:5521-5542
مصطلحات موضوعية: Models, Molecular, 0301 basic medicine, Lactams, Stereochemistry, medicine.drug_class, Administration, Oral, Carboxamide, Structure-Activity Relationship, 03 medical and health sciences, Drug Discovery, medicine, Humans, Structure–activity relationship, Protein Kinase Inhibitors, ADME, Dose-Response Relationship, Drug, Molecular Structure, biology, Drug discovery, Chemistry, Active site, Isoquinolines, IRAK4, Combinatorial chemistry, Interleukin-1 Receptor-Associated Kinases, 030104 developmental biology, Lipophilic efficiency, Lipophilicity, biology.protein, Molecular Medicine
-
6
المؤلفون: Joanne Brodfuehrer, Tatyana Andreyeva, Julie Lee, Wenyan Miao, Khetemenee Lam, Jameel Syed, Rosemary Lawrence-Henderson, Josef S. Ozer, Jason Edmonds, Andrew L. Rankin, Angela Boisvert, Sean Keegan, Huilan Gao, Pratap Singh, Timothy P. LaBranche, Laird Bloom
المصدر: Pharmaceutical Research. 31:635-648
مصطلحات موضوعية: medicine.drug_class, T-Lymphocytes, Pharmaceutical Science, Spleen, Monoclonal antibody, Models, Biological, Rats, Sprague-Dawley, Mice, In vivo, medicine, Animals, Pharmacology (medical), Neutralizing antibody, PK/PD models, Pharmacology, B-Lymphocytes, biology, Organic Chemistry, Germinal center, Germinal Center, Antibodies, Neutralizing, Chemokine CXCL13, Molecular biology, Rats, Mice, Inbred C57BL, medicine.anatomical_structure, biology.protein, Molecular Medicine, Female, Immunization, Antibody, Quantitative analysis (chemistry), Biotechnology
-
7
المصدر: Current Drug Discovery Technologies. 8:87-101
مصطلحات موضوعية: Chemistry, Pharmaceutical, Disease, Pharmacology, Blood–brain barrier, Permeability, Focused ultrasound, Drug Delivery Systems, Drug Discovery, medicine, Animals, Humans, Technology, Pharmaceutical, Cost of goods, Biological Products, Drug Carriers, Modalities, business.industry, Drug Administration Routes, Biological Transport, Absorptive endocytosis, medicine.anatomical_structure, Drug development, Blood-Brain Barrier, Drug delivery, business, Neuroscience, Central Nervous System Agents
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::756b734ef8558e1fa5e49f5399b750d8
https://doi.org/10.2174/157016311795563866 -
8
المؤلفون: Mark C. Sulavik, Ji-Young Kim, Rose Kelly, Allison Laura Choy, Roger J. Brideau, Poel Toni-Jo, Joanne Brodfuehrer, Gary E. Zurenko, Tong Zhu, Michael Dority, Cai Hongliang, Barbachyn Michael R, Joan K. Brieland, Thomas Richard C, Frederick E. Boyer, Michael R. Dermyer, Martin Joseph P, Michael D. Huband, Alan P. Brown, Daniel E. Ross, Debra Hanna, Laura A. Skerlos, Robert C. Gadwood, Wade J. Adams, Paul J. Pagano, Aristoff Paul A, Christopher Huber, J.V.N. Vara Prasad, Charles W. Ford
المصدر: Journal of Medicinal Chemistry. 50:5886-5889
مصطلحات موضوعية: Male, Staphylococcus aureus, Monoamine Oxidase Inhibitors, Streptococcus pyogenes, medicine.drug_class, Stereochemistry, Carboxylic acid, Administration, Oral, Biological Availability, Carboxamide, Microbial Sensitivity Tests, Gram-Positive Bacteria, Chemical synthesis, Rats, Sprague-Dawley, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Dogs, In vivo, Streptococcal Infections, Amide, Acetamides, Drug Resistance, Bacterial, Gram-Negative Bacteria, Drug Discovery, medicine, Animals, Structure–activity relationship, Oxazolidinones, Antibacterial agent, chemistry.chemical_classification, Linezolid, Staphylococcal Infections, Anti-Bacterial Agents, Cyclic S-Oxides, Rats, chemistry, Injections, Intravenous, Molecular Medicine, Female, Lead compound
-
9
المؤلفون: Susan, Hurst, Cho-Ming, Loi, Joanne, Brodfuehrer, Ayman, El-Kattan
المصدر: Expert Opinion on Drug Metabolism & Toxicology. 3:469-489
مصطلحات موضوعية: Pharmacology, Chemical Phenomena, Intestinal Absorption, Pharmaceutical Preparations, Chemistry, Physical, Chemistry, Pharmaceutical, Animals, Biological Availability, Humans, General Medicine, Toxicology, Rats
-
10
المؤلفون: Joanne Brodfuehrer, Chad L. Stoner, Mathew D Troutman, Hua Gao, Kjell Johnson, Eric M. Gifford, Charles J. Stankovic, Man Chang
المصدر: Letters in Drug Design & Discovery. 3:575-581
مصطلحات موضوعية: Permeability (earth sciences), Chemistry, In silico, Drug Discovery, Pharmaceutical Science, Molecular Medicine, Computational biology, Combinatorial chemistry
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::9b9954d6e80d98b03b841c30e847efe2
https://doi.org/10.2174/157018006778194736
Find this article in full text from Springer Verlag. 
PDF full text from Publisher 
Find this issue from the American Chemical Society