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1
المؤلفون: Virginia C. Moser, Joanne R. Mathiasen
المصدر: Current protocols in pharmacology. 83(1)
مصطلحات موضوعية: Battery (electricity), Central Nervous System, Male, Drug Evaluation, Preclinical, Health Informatics, Bioinformatics, 030226 pharmacology & pharmacy, Risk Assessment, General Biochemistry, Genetics and Molecular Biology, Rats, Sprague-Dawley, 03 medical and health sciences, Mice, 0302 clinical medicine, Therapeutic index, Medicine, Animals, General Pharmacology, Toxicology and Pharmaceutics, Reference standards, General Immunology and Microbiology, Behavior, Animal, business.industry, Safety pharmacology, General Neuroscience, General Medicine, Rats, Mice, Inbred C57BL, Medical Laboratory Technology, Observational study, Female, Nervous System Diseases, business, 030217 neurology & neurosurgery
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2
المؤلفون: Robert L. Hudkins, Joanne R. Mathiasen, Rita Raddatz, Edward R. Bacon, Michael J. Marino, Mark A. Ator, Michael Williams, Lisa D. Aimone, John A. Gruner
المصدر: Neuropharmacology. 106:37-45
مصطلحات موضوعية: Male, 0301 basic medicine, medicine.medical_specialty, Drug Inverse Agonism, Drinking, Drug Evaluation, Preclinical, Administration, Oral, Biological Availability, Motor Activity, Pharmacology, Histamine agonist, Histamine Agonists, Rats, Sprague-Dawley, 03 medical and health sciences, Cellular and Molecular Neuroscience, Histamine receptor, chemistry.chemical_compound, Dogs, 0302 clinical medicine, Therapeutic index, Piperidines, Internal medicine, medicine, Animals, Humans, Receptors, Histamine H3, Inverse agonist, Spiro Compounds, Wakefulness, Chemistry, Methylhistamines, Antagonist, Brain, Macaca fascicularis, 030104 developmental biology, Endocrinology, Pyrazines, Histamine H3 receptor, Sleep, 030217 neurology & neurosurgery, Histamine, Histamine H3 Antagonists
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3
المؤلفون: Nadine C. Becknell, Joanne R. Mathiasen, Jacquelyn A. Lyons, John A. Gruner, Robert L. Hudkins, Mark A. Olsen, Lisa D. Aimone, Rita Raddatz, R. Curtis Haltiwanger
المصدر: European Journal of Medicinal Chemistry. 95:349-356
مصطلحات موضوعية: Pyrrolidines, Drug Inverse Agonism, Stereochemistry, Histamine Antagonists, Structure-Activity Relationship, chemistry.chemical_compound, Irdabisant, Drug Discovery, Animals, Humans, Receptors, Histamine H3, Inverse agonist, Wakefulness, Receptor, Pharmacology, Dose-Response Relationship, Drug, Bicyclic molecule, Organic Chemistry, Diastereomer, Stereoisomerism, General Medicine, Combinatorial chemistry, Rats, Functional antagonism, Pyridazines, chemistry, Drug Design, Selectivity, Histamine
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4
المؤلفون: Robert L. Hudkins, Allison L. Zulli, Rita Raddatz, Lisa D. Aimone, John A. Gruner, Edward R. Bacon, Joanne R. Mathiasen
المصدر: Bioorganic & Medicinal Chemistry Letters. 22:2807-2810
مصطلحات موضوعية: Pyrrolidines, Ketone, Drug Inverse Agonism, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, 1-Propanol, Biochemistry, Histamine Agonists, Methylamines, chemistry.chemical_compound, Phenols, Pharmacokinetics, Sleep Disorders, Circadian Rhythm, In vivo, Diamine, Drug Discovery, Animals, Humans, Inverse agonist, Molecule, Wakefulness, Receptor, Molecular Biology, chemistry.chemical_classification, Organic Chemistry, Ketones, Rats, chemistry, Molecular Medicine, Histamine
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5
المؤلفون: Thomas J. Connors, Jie Qian, Zeck Huang, Joanne R. Mathiasen, Edward R. Bacon, Thelma S. Angeles, Mark J. Huffman, Emir Duzic, Joseph M. Salvino, Beth Ann McKenna, Hervé Schaffhauser, Robert J. McHugh, Lily D. Lu, George C. Morton, Beverly P. Holskin, Karla Kopec, Amy DiCamillo, Gerard C. Rosse, Chrysanthe Spais, Rabindranath Tripathy, Lisa D. Aimone
المصدر: Bioorganic & Medicinal Chemistry Letters. 22:1421-1426
مصطلحات موضوعية: Stereochemistry, Chemistry, Organic Chemistry, Clinical Biochemistry, Antagonist, Pharmaceutical Science, Stereoisomerism, Biochemistry, Sulfone, chemistry.chemical_compound, In vivo, Drug Discovery, 5-HT6 receptor, Molecular Medicine, Pharmacophore, Receptor, Molecular Biology, 5-HT receptor
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6
المؤلفون: Beverly P. Holskin, Karla Kopec, Joanne R. Mathiasen, Amy DiCamillo, Babu G. Sundar, Thomas J. Connors, Emir Duzic, Edward R. Bacon, Gerard C. Rosse, Chrysanthe Spais, Thomas R. Bailey, Beth Ann McKenna, Rebecca A. Brown, Jie Qian, Derek Dunn, Mark J. Huffman, Joseph M. Salvino, Huang Zeqi, Lisa D. Aimone, Hervé Schaffhauser, Deborah Galinis, Thelma S. Angeles, Lily D. Lu, George C. Morton
المصدر: Bioorganic & Medicinal Chemistry Letters. 22:120-123
مصطلحات موضوعية: biology, Organic Chemistry, Clinical Biochemistry, hERG, Pharmaceutical Science, Pharmacology, Biochemistry, Social recognition, chemistry.chemical_compound, chemistry, Drug Discovery, biology.protein, 5-HT6 receptor, Molecular Medicine, Structure–activity relationship, Serotonin Antagonists, Penetrant (biochemical), Receptor, Molecular Biology, 5-HT receptor
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7
المؤلفون: Reddeppa reddy Dandu, Jacquelyn A. Lyons, Kurt A. Josef, Joanne R. Mathiasen, Robert L. Hudkins, Zeqi Huang, Ming Tao, Lisa D. Aimone, John A. Gruner, Derek Dunn, Allison L. Zulli, Rita Raddatz
المصدر: Bioorganic & Medicinal Chemistry Letters. 22:194-198
مصطلحات موضوعية: Stereochemistry, Chemistry, Sleep wake, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, In vivo metabolism, Histamine h, Pharmacology, Biochemistry, In vivo, Drug Discovery, Molecular Medicine, Moiety, Inverse agonist, Histamine H3 receptor, Antagonism, Molecular Biology
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8
المؤلفون: Joanne R. Mathiasen, Lisa D. Aimone, Robert L. Hudkins, Jacquelyn A. Lyons, Rita Raddatz, Ming Tao, Zeqi Huang
المصدر: Journal of Medicinal Chemistry. 55:414-423
مصطلحات موضوعية: Gene isoform, biology, Chemistry, Stereochemistry, Antagonist, Cytochrome P450, Pharmacology, Bioavailability, Histamine receptor, Pharmacokinetics, Drug Discovery, biology.protein, Molecular Medicine, Receptor, Selectivity
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9
المؤلفون: John A. Gruner, Jacquelyn A. Lyons, Lisa D. Aimone, Robert L. Hudkins, Nadine C. Becknell, Joanne R. Mathiasen, Rita Raddatz
المصدر: Bioorganic & Medicinal Chemistry Letters. 21:7076-7080
مصطلحات موضوعية: Pyrrolidines, Stereochemistry, Sleep wake, Clinical Biochemistry, Pharmaceutical Science, Biochemistry, Structure-Activity Relationship, Irdabisant, Pharmacokinetics, In vivo, Drug Discovery, Animals, Humans, Structure–activity relationship, Molecular Biology, Molecular Structure, Chemistry, Organic Chemistry, Antagonist, Rats, Pyridazines, Disease Models, Animal, Molecular Medicine, Histamine H3 receptor, Clinical evaluation, Histamine H3 Antagonists, Protein Binding
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10
المؤلفون: Robert L. Hudkins, Joanne R. Mathiasen, Reddeppa reddy Dandu, Lisa D. Aimone, Rita Raddatz, Val R. Marcy, Greg A. Hostetler, John A. Gruner, Caitlyn Benfield, Robert J. Bendesky
المصدر: Bioorganic & Medicinal Chemistry Letters. 21:6362-6365
مصطلحات موضوعية: Phenethylamine, Clinical Biochemistry, Administration, Oral, Biological Availability, Pharmaceutical Science, Pharmacology, Biochemistry, Structure-Activity Relationship, chemistry.chemical_compound, Pharmacokinetics, In vivo, Drug Discovery, Animals, Humans, Structure–activity relationship, Molecular Biology, Electromyography, Organic Chemistry, Electroencephalography, Metabolic stability, Rats, Bioavailability, chemistry, Molecular Medicine, Histamine H3 receptor, Selectivity, Histamine H3 Antagonists