المؤلفون: Sebastian K Wandinger, Idoya Lahortiga, Kris Jacobs, Martin Klammer, Nicole Jordan, Sarah Elschenbroich, Marc Parade, Edgar Jacoby, Joannes T M Linders, Dirk Brehmer, Jan Cools, Henrik Daub

المصدر: PLoS ONE, Vol 11, Iss 1, p e0146100 (2016)

مصطلحات موضوعية: Medicine, Science

وصف الملف: electronic resource

Relation: http://europepmc.org/articles/PMC4706443?pdf=render; https://doaj.org/toc/1932-6203

URL الوصول: https://doaj.org/article/26db43b838524974a1a9f9e2ce99ecbe

المؤلفون: Eva Wrobel, Ina Rothenberg, Christoph Krisp, Franziska Hundt, Benjamin Fraenzel, Karina Eckey, Joannes T. M. Linders, David J. Gallacher, Rob Towart, Lutz Pott, Michael Pusch, Tao Yang, Dan M. Roden, Harley T. Kurata, Eric Schulze-Bahr, Nathalie Strutz-Seebohm, Dirk Wolters, Guiscard Seebohm

المصدر: Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)

مصطلحات موضوعية: Science

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2041-1723

URL الوصول: https://doaj.org/article/6f13dc5b883d4828afc6c8522bd13d5d

المؤلفون: Lijs Beke, Cenk Kig, Joannes T. M. Linders, Shannah Boens, An Boeckx, Erika van Heerde, Marc Parade, An De Bondt, Ilse Van den Wyngaert, Tarig Bashir, Souichi Ogata, Lieven Meerpoel, Aleyde Van Eynde, Christopher N. Johnson, Monique Beullens, Dirk Brehmer, Mathieu Bollen

المصدر: Bioscience Reports

مصطلحات موضوعية: Original Paper, senescence, Biophysics, chemical biology, Cell Biology, deoxyribonucleic acid (DNA) damage response, Molecular Biology, Biochemistry, Original Papers, small molecule inhibitors, maternal embryonic leucine zipper kinase (MELK) kinase

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::891938c6105848dc771495fd681f3c57
https://pubmed.ncbi.nlm.nih.gov/26431963

المؤلفون: Dushen Chetty, Matthew V. Lorenzi, Sylvie Laquerre, Gaston Stanislas Marcella Diels, Edward C. Lawson, Carol Yanovich, Italo Poggesi, Ivan Somers, Dana Gaffney, Wim Bert Griet Schepens, Hillary Millar, Weimei Sun, Tongfei Wu, Lijs Beke, Viellevoye Marcel, Marc Du Jardin, Petra Vinken, Erika van Heerde, Tinne Verhulst, James P. Edwards, Dirk Brehmer, Barbara Herkert, Geert Mannens, Vineet Pande, Alain Philippe Poncelet, Christopher Moy, An Boeckx, Marc Parade, Thomas Nys, Jan-Willem Thuring, Lieven Meerpoel, Joannes T. M. Linders

المصدر: Cancer Research. 77:DDT02-04

مصطلحات موضوعية: 0301 basic medicine, Cancer Research, Methyltransferase, business.industry, Protein arginine methyltransferase 5, Methylation, medicine.disease_cause, medicine.disease, In vitro, 03 medical and health sciences, 030104 developmental biology, Oncology, In vivo, Cancer research, medicine, Cytotoxic T cell, Carcinogenesis, business, Lung cancer

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::987bd807a6c9b8052bd2995cb8ff5795
https://doi.org/10.1158/1538-7445.am2017-ddt02-04

المؤلفون: Ricardo Attar, Weimei Sun, Peter J. Connolly, Yann Abraham, Joannes T. M. Linders, Bart Petrus Anna Maria Jozef Medaer, Jenna D. Goldberg, L. van Nuffel, Kristof Kimpe, Marcello Gaudiano, Greet Vanhoof, Johannes Wilhelmus John F. Thuring, James P. Edwards, Nele Vloemans, Mariette Bekkers, Yusri Elsayed, John Gerecitano, Katie Amssoms, B.M. van der Leede, Tony Greway, E. Trella, Ulrike Philippar, K. Wnuk-Lipinska, Jennifer Smit, Maxwell D. Cummings, Tianbao Lu, Jacqueline Bussolari

المصدر: Hematological Oncology. 37:128-128

مصطلحات موضوعية: Cancer Research, Class (set theory), medicine.anatomical_structure, Oncology, MALT1 protease, business.industry, medicine, Cancer research, Hematology, General Medicine, business, B cell

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::7d6c0cefd5ac788558266b0caa15d9c6
https://doi.org/10.1002/hon.88_2629

المؤلفون: Dirk Brehmer, Lennart Martens, Pascal Bonnet, Michela Di Michele, Rohit Arora, Edgar Jacoby, Erika van Heerde, Kris Gevaert, Elien Vandermarliere, Joannes T. M. Linders, Elisabeth Stes

المصدر: Journal of medicinal chemistry. 59(14)

مصطلحات موضوعية: Chemistry, Drug Discovery, Molecular Medicine, Inducer, Computational biology, Circuit breaker

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbcc96aca4c30f33d0313bf963e93f44
https://pubmed.ncbi.nlm.nih.gov/25611072

المؤلفون: Karina Eckey, Tao Yang, Christoph Krisp, Ina Rothenberg, Dan M. Roden, Nathalie Strutz-Seebohm, Michael Pusch, Eric Schulze-Bahr, Harley T. Kurata, Joannes T. M. Linders, Rob Towart, Dirk Wolters, Guiscard Seebohm, Eva Wrobel, Benjamin Fraenzel, Lutz Pott, Franziska Hundt, David J. Gallacher

المصدر: Nature communications 7 (2016). doi:10.1038/ncomms12795
info:cnr-pdr/source/autori:Wrobel E, Rothenberg I, Krisp C, Hundt F, Fraenzel B, Eckey K, Linders JT, Gallacher DJ, Towart R, Pott L, Pusch M, Yang T, Roden DM, Kurata HT, Schulze-Bahr E, Strutz-Seebohm N, Wolters D, Seebohm G/titolo:KCNE1 induces fenestration in the Kv7.1%2FKCNE1 channel complex that allows for highly specific pharmacological targeting/doi:10.1038%2Fncomms12795/rivista:Nature communications/anno:2016/pagina_da:/pagina_a:/intervallo_pagine:/volume:7
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Nature Communications

مصطلحات موضوعية: Models, Molecular, 0301 basic medicine, Adamantane, General Physics and Astronomy, Gating, ligand, Xenopus laevis, chemistry.chemical_compound, Tandem Mass Spectrometry, i-ks, long qt syndrome, mass spectrometry, Multidisciplinary, gating modifier, Ligand (biochemistry), Cross-Linking Reagents, Biochemistry, Potassium Channels, Voltage-Gated, KCNQ1 Potassium Channel, gating, Ion Channel Gating, medicine.drug, potassium channel, Science, beta subunit, Allosteric regulation, Biology, kcnq1, Article, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, Allosteric Regulation, Potassium Channel Blockers, medicine, Animals, Humans, Binding site, Ion channel, Binding Sites, Mutagenesis, binding-sites, crystal-structure, Potassium channel blocker, structural basis, General Chemistry, mutations, 030104 developmental biology, k+ channels, chemistry, Mutation, ion channel, Oocytes, Biophysics

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a7b21cbf9257e48ed4bd20e6d4cb4ee
http://www.scopus.com/inward/record.url?eid=2-s2.0-84991508551&partnerID=q2rCbXpz

المؤلفون: Dirk Brehmer, Christopher N. Johnson, Souichi Ogata, An Boeckx, Erika van Heerde, Lieven Meerpoel, Monique Beullens, Cenk Kig, Marc Parade, Joannes T. M. Linders, Aleyde Van Eynde, Tarig Bashir, An De Bondt, Shannah Boens, Ilse Van den Wyngaert, Mathieu Bollen, Lijs Beke

المصدر: Bioscience Reports

مصطلحات موضوعية: Biophysics, Apoptosis, Breast Neoplasms, Ataxia Telangiectasia Mutated Proteins, Protein Serine-Threonine Kinases, Biology, Corrections, Biochemistry, Maternal embryonic leucine zipper kinase, Cell Line, Tumor, Humans, Enzyme Inhibitors, Protein kinase A, Molecular Biology, Checkpoint Kinase 2, Cell Proliferation, Cell growth, Kinase, Forkhead Box Protein M1, Correction, Forkhead Transcription Factors, Azepines, Cell Biology, Gene Expression Regulation, Neoplastic, Benzamides, Cancer cell, MCF-7 Cells, FOXM1, Cancer research, Phosphorylation, Female, DNA Damage

وصف الملف: Electronic; application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd0f3ce120f4ec7c6b7f3bddfa8c088e
https://doi.org/10.1042/bsr20150194

المؤلفون: Lennart Martens, Roman A. Zubarev, Rohit Arora, Erika van Heerde, Michela Di Michele, Dirk Brehmer, Elisabeth Stes, Elien Vandermarliere, Edgar Jacoby, Jonathan Vandenbussche, Juan Astorga-Wells, Pascal Bonnet, Joannes T. M. Linders, Kris Gevaert

المصدر: Journal of proteome research. 14(10)

مصطلحات موضوعية: MAPK/ERK pathway, Niacinamide, Proteomics, Proto-Oncogene Proteins B-raf, Conformational change, Indoles, Cell Survival, MAP Kinase Signaling System, Adenylyl Imidodiphosphate, Molecular Dynamics Simulation, Biochemistry, Mass Spectrometry, Protein Structure, Secondary, chemistry.chemical_compound, Protein structure, Adenosine Triphosphate, Cell Line, Tumor, Humans, Trypsin, Phosphorylation, Protein Kinase Inhibitors, Sulfonamides, Chemistry, Kinase, Phenylurea Compounds, Deuterium Exchange Measurement, General Chemistry, Sorafenib, Small molecule, Protein Structure, Tertiary, Protein kinase domain, Vemurafenib, Isotope Labeling, Mutation, Proteolysis, Peptides, Adenosine triphosphate, Protein Kinases, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::091805a30a9747a36f36e0eaad4b54d8
https://pubmed.ncbi.nlm.nih.gov/26293246

المؤلفون: Mariena V. Mattson, Kenner C. Rice, Joannes T. M. Linders, Arthur E. Jacobson, David C. Furlano

المصدر: Letters in Drug Design & Discovery. 7:79-87

مصطلحات موضوعية: Chemistry, Drug Discovery, Pharmaceutical Science, Molecular Medicine, Combinatorial chemistry

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::91cc399cc773f81481eef27e85580a1e
https://doi.org/10.2174/157018010790225813