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المؤلفون: Qing Rao, Min Wang, Shouyun Li, Xing Yuanyuan, Zhang Shuzu, Wenting Lu, Yingxi Xu, Jianxiang Wang, Joe Zhongxiang Zhou, Deng Chengjun, Saisai Li, Jia Liu, Shuang Liu, Haiyan Xing
المصدر: Oncotarget
مصطلحات موضوعية: LSD1 inhibitor, 0301 basic medicine, autophagy, medicine.medical_specialty, Cell, Antineoplastic Agents, Mice, 03 medical and health sciences, 0302 clinical medicine, Cell Line, Tumor, Internal medicine, medicine, Animals, Humans, Histone Demethylases, Hematology, Cell growth, business.industry, Cell Cycle, Autophagy, leukemia, apoptosis, Myeloid leukemia, Cell cycle, medicine.disease, Xenograft Model Antitumor Assays, proliferation inhibition, Enzyme Activation, Histone Deacetylase Inhibitors, Disease Models, Animal, Leukemia, Myeloid, Acute, Leukemia, 030104 developmental biology, medicine.anatomical_structure, Oncology, Apoptosis, 030220 oncology & carcinogenesis, Immunology, Cancer research, business, Research Paper
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31b76eb5f567fda90a997d1a2070c874
https://doi.org/10.18632/oncotarget.16650 -
2
المؤلفون: Ilya Chorny, Trevor E. Swartz, Joe Zhongxiang Zhou, Ken A. Dill, Ekaterine Kortkhonjia, Vincent A. Voelz, Thomas W. Patapoff, Relly Brandman, Bruce Kabakoff
المصدر: mAbs
مصطلحات موضوعية: Models, Molecular, solution dynamics, Protein Conformation, Immunology, therapeutic antibodies, Fluorescence Polarization, Molecular Dynamics Simulation, Antibodies, Monoclonal, Humanized, fluorescence anisotropy, Mice, Molecular dynamics, Antibodies monoclonal, Report, Animals, Humans, Immunology and Allergy, Molecule, Chemistry, Antibodies, Monoclonal, molecular dynamics simulations, Mutual information, Trastuzumab, Markov Chains, Microsecond, Crystallography, Chemical physics, Immunoglobulin G, Polar, monoclonal antibodies, Order of magnitude, Fluorescence anisotropy
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المؤلفون: Tanya Michelle Jewell, Robert Steven Kania, Anand Sistla, Bennett Michael John, Michael R. Gehring, Evan Smith, Zehnder Luke Raymond, Shinji Yamazaki, Karen A. Maegley, Elena Z. Dovalsantos, Ben Burke, Fen Wang, Sacha Ninkovic, Jeff Wang, Joe Zhongxiang Zhou, Pei-Pei Kung, Min-Jean Yin, Michael J. Hickey, Martin James Wythes, Jerry Meng, Buwen Huang, Ping Kang, John F. Braganza, Ketan S. Gajiwala, Tatlock John H, Pramod P. Mehta
المصدر: Journal of Medicinal Chemistry. 54:3368-3385
مصطلحات موضوعية: Pyrimidine, biology, Chemistry, Stereochemistry, medicine.drug_class, Carboxamide, Metabolic stability, Combinatorial chemistry, Hsp90, Bioavailability, chemistry.chemical_compound, Heat shock protein, Drug Discovery, Alkoxy group, biology.protein, medicine, Molecular Medicine, Potency
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المؤلفون: Jennifer A. Digits, Jeff Elleraas, Gang Zhang, Ketan S. Gajiwala, Pei-Pei Kung, Michael J. Hickey, Min-Jean Yin, Michael Zientek, Buwen Huang, Caroline Rodgers, Shinji Yamazaki, Michael R. Gehring, Joe Zhongxiang Zhou, Jay F. Davies, Judith Skaptason, Jeff Wang, David Neul, Pramod P. Mehta
المصدر: Journal of Medicinal Chemistry. 53:499-503
مصطلحات موضوعية: Models, Molecular, medicine.drug_class, Molecular Conformation, Biological Availability, Carboxamide, Isoindoles, Crystallography, X-Ray, Chemical synthesis, Cell Line, Structure-Activity Relationship, Heat shock protein, Drug Discovery, medicine, Humans, Potency, HSP90 Heat-Shock Proteins, chemistry.chemical_classification, biology, Stereoisomerism, Amides, Hsp90, Enzyme, chemistry, Biochemistry, Enzyme inhibitor, Chaperone (protein), biology.protein, Molecular Medicine
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المؤلفون: Joe Zhongxiang Zhou
المصدر: Current Opinion in Chemical Biology. 12:379-385
مصطلحات موضوعية: Models, Molecular, Library design, Structure (mathematical logic), Drug discovery, Management science, business.industry, Computer science, Drug Evaluation, Preclinical, Nanotechnology, Biochemistry, Toolbox, Field (computer science), Analytical Chemistry, Lead (geology), Drug Design, Animals, Combinatorial Chemistry Techniques, Humans, business, Software, Pharmaceutical industry
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المؤلفون: Michele Ramirez-Weinhouse, Jaroslav Kostrowicki, Zhengwei Peng, Atsuo Kuki, Xianjun Kong, Jim Na, Joe Zhongxiang Zhou, Sarathy Mattaparti, Javier Gonzalez, Bo Yang, Qiyue Hu, Thomas Thacher, Sutton Scott Channing
المصدر: ACS combinatorial science. 14(11)
مصطلحات موضوعية: business.industry, Chemistry, Design information, Design tool, General Chemistry, General Medicine, Biology, Combinatorial chemistry, Reaction product, Modeling and simulation, Structural bioinformatics, Cheminformatics, Informatics, Drug Design, business, Software engineering, Graphical user interface
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المؤلفون: Victoria Jones, Joe Zhongxiang Zhou, J. Andrew McCammon, Yi Wang, Michael R. McNeil, Tamara Hess
مصطلحات موضوعية: Models, Molecular, High-throughput screening, Clinical Biochemistry, Antitubercular Agents, Pharmaceutical Science, Reductase, Crystallography, X-Ray, Biochemistry, Article, Microbiology, Mycobacterium tuberculosis, Enzyme activator, Inhibitory Concentration 50, Drug Discovery, Enzyme Inhibitors, Molecular Biology, chemistry.chemical_classification, Virtual screening, Binding Sites, biology, Drug discovery, Organic Chemistry, biology.organism_classification, Enzyme Activation, Enzyme, chemistry, Molecular Medicine, Computer-Aided Design, Mycobacterium, Sugar Alcohol Dehydrogenases
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::677a7741d58df4092b41aeaa7dcf89ec
https://europepmc.org/articles/PMC3223023/ -
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المؤلفون: Luke, Zehnder, Michael, Bennett, Jerry, Meng, Buwen, Huang, Sacha, Ninkovic, Fen, Wang, John, Braganza, John, Tatlock, Tanya, Jewell, Joe Zhongxiang, Zhou, Ben, Burke, Jeff, Wang, Karen, Maegley, Pramod P, Mehta, Min-Jean, Yin, Ketan S, Gajiwala, Michael J, Hickey, Shinji, Yamazaki, Evan, Smith, Ping, Kang, Anand, Sistla, Elena, Dovalsantos, Michael R, Gehring, Robert, Kania, Martin, Wythes, Pei-Pei, Kung
المصدر: Journal of medicinal chemistry. 54(9)
مصطلحات موضوعية: Male, Models, Molecular, Cell Membrane Permeability, Transplantation, Heterologous, Administration, Oral, Biological Availability, Mice, Nude, Antineoplastic Agents, In Vitro Techniques, Binding, Competitive, Mice, Structure-Activity Relationship, Drug Stability, Cell Line, Tumor, Animals, Humans, HSP90 Heat-Shock Proteins, Melanoma, Blood Proteins, Rats, Pyrimidines, Microsomes, Liver, Pyrazoles, Female, Drug Screening Assays, Antitumor, Hydrophobic and Hydrophilic Interactions, Neoplasm Transplantation, Protein Binding
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المؤلفون: Joe Zhongxiang Zhou
المصدر: Methods in Molecular Biology ISBN: 9781607619307
Chemical Library Designمصطلحات موضوعية: Library design, Engineering, Kinase Family, business.industry, Chk1 Kinase, Design tool, Art history, Chemical library, Part iii, chemistry.chemical_compound, chemistry, Optimization methods, business, Cartography
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::f15a39c5515814c8b97738c25786b648
https://doi.org/10.1007/978-1-60761-931-4 -
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المؤلفون: Zhengwei, Peng, Bo, Yang, Sarathy, Mattaparti, Thom, Shulok, Thomas, Thacher, James, Kong, Jaroslav, Kostrowicki, Qiyue, Hu, James, Na, Joe Zhongxiang, Zhou, David, Klatte, Bo, Chao, Shogo, Ito, John, Clark, Nunzio, Sciammetta, Bob, Coner, Chris, Waller, Atsuo, Kuki
المصدر: Methods in molecular biology (Clifton, N.J.). 685
مصطلحات موضوعية: Small Molecule Libraries, User-Computer Interface, Drug Industry, Chemistry, Pharmaceutical, Drug Discovery, Data Mining, Software
URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::11cd9d5380375c6e733b5b3e52a1a679
https://pubmed.ncbi.nlm.nih.gov/20981530