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1دورية أكاديمية
المؤلفون: Hannah M. Jones, John Tolsma, Zhiwei Zhang, Paul Jasper, Haobin Luo, Gregory L. Weber, Katherine Wright, Joel Bard, Robert Bell, Dean Messing, Kerry Kelleher, Nicole Piche‐Nicholas, Robert Webster
المصدر: CPT: Pharmacometrics & Systems Pharmacology, Vol 9, Iss 9, Pp 534-541 (2020)
مصطلحات موضوعية: Therapeutics. Pharmacology, RM1-950
وصف الملف: electronic resource
Relation: https://doaj.org/toc/2163-8306
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2دورية أكاديمية
المؤلفون: Kenneth G. Geles, Yijie Gao, Andreas Giannakou, Latha Sridharan, Ting-Ting Yamin, Jing Zhang, Riyez Karim, Joel Bard, Nicole Piche-Nicholas, Manoj Charati, Andreas Maderna, Judy Lucas, Jonathon Golas, Magali Guffroy, Steven Pirie-Shepherd, Marc Roy, Jessie Qian, Tania Franks, Wenyan Zhong, Christopher J. O’Donnell, Lioudmila Tchistiakova, Hans-Peter Gerber, Puja Sapra
المصدر: Cell Reports Medicine, Vol 2, Iss 5, Pp 100279- (2021)
مصطلحات موضوعية: notch signaling, NOTCH3 receptor, DLL4, JAG1, antibody drug conjugates, cancer stem cells, Medicine (General), R5-920
وصف الملف: electronic resource
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المؤلفون: Nicole Piche-Nicholas, Rob Webster, Gregory Weber, John Tolsma, Kerry Kelleher, Haobin Luo, Katherine Wright, Robert D. Bell, Dean Messing, Joel Bard, Hannah M. Jones, Zhiwei Zhang, Paul Jasper
المصدر: CPT: Pharmacometrics & Systems Pharmacology
CPT: Pharmacometrics & Systems Pharmacology, Vol 9, Iss 9, Pp 534-541 (2020)مصطلحات موضوعية: Physiologically based pharmacokinetic modelling, medicine.drug_class, Druggability, Mice, Transgenic, Computational biology, Receptors, Fc, HIV Antibodies, Monoclonal antibody, Antibodies, Monoclonal, Humanized, Protein Engineering, Article, Mice, Neonatal Fc receptor, Pharmacokinetics, Drug Development, Drug Discovery, medicine, Animals, Humans, Pharmacology (medical), Computer Simulation, biology, Drug discovery, Chemistry, Research, lcsh:RM1-950, Histocompatibility Antigens Class I, Homozygote, Models, Immunological, Antibodies, Monoclonal, Articles, lcsh:Therapeutics. Pharmacology, Modeling and Simulation, Mutation, biology.protein, Antibody, Intracellular, Broadly Neutralizing Antibodies, Half-Life, Protein Binding
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المؤلفون: Magali Guffroy, Steven Pirie-Shepherd, Puja Sapra, Judy Lucas, Jonathon Golas, Kenneth G. Geles, Joel Bard, Nicole Piche-Nicholas, Riyez Karim, Hans-Peter Gerber, Latha Sridharan, Lioudmila Tchistiakova, Andreas Giannakou, Jing Zhang, Manoj Charati, Tania Franks, Wenyan Zhong, Ting-Ting Yamin, Yijie Gao, Jessie Qian, Marc D. Roy, Andreas Maderna, Christopher J. O’Donnell
المصدر: Cell Reports Medicine, Vol 2, Iss 5, Pp 100279-(2021)
Cell Reports Medicineمصطلحات موضوعية: cancer stem cells, Medicine (General), Immunoconjugates, Notch signaling pathway, Antineoplastic Agents, Apoptosis, DLL4, Clathrin, Article, General Biochemistry, Genetics and Molecular Biology, R5-920, biotherapeutic, Cancer stem cell, Cell Line, Tumor, Caveolin, Humans, Receptor, Cytotoxicity, Receptor, Notch3, Receptors, Notch, tumor initiating cells, antibody drug conjugates, biology, Chemistry, Oncogenes, Ligand (biochemistry), Xenograft Model Antitumor Assays, notch signaling, NOTCH3 receptor, body regions, transendocytosis, oncology, biology.protein, Cancer research, Receptor clustering, JAG1
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المؤلفون: William S. Somers, Lydia Mosyak, Orla Cunningham, Chao Tu, Amy Tam, Brian J. Fennell, Joel Bard, Edward R. Lavallie, Mark Stahl, Wayne Stochaj, Laura Lin, William J.J. Finlay, Virginie Terraube
المصدر: Journal of Biological Chemistry. 291:1267-1276
مصطلحات موضوعية: Models, Molecular, 0301 basic medicine, Protein Conformation, Recombinant Fusion Proteins, Mutant, Antibody Affinity, Mutagenesis (molecular biology technique), chemical and pharmacologic phenomena, Antigen-Antibody Complex, Computational biology, Complementarity determining region, Protein aggregation, medicine.disease_cause, Biochemistry, law.invention, Protein Aggregates, 03 medical and health sciences, Protein structure, X-Ray Diffraction, Antibody Specificity, law, medicine, Humans, Molecular Biology, Biological Products, Mutation, Protein Stability, Chemistry, Cell Biology, respiratory system, Chemokine CXCL13, Complementarity Determining Regions, Recombinant Proteins, Kinetics, 030104 developmental biology, Amino Acid Substitution, Solubility, Protein Structure and Folding, Recombinant DNA, Binding Sites, Antibody, Single-Chain Antibodies
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::261c02617c3e30bb3256d94b8c8a3cef
https://doi.org/10.1074/jbc.m115.688010 -
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المؤلفون: Renee Ramsey, Sri Laxmanan, Orla Cunningham, Lydia Mosyak, Brian J. Fennell, Joel Bard, Steven P. Braithwaite, Bénédicte Autin, Chao Tu, Christopher John Corcoran, Anne S. Klein, Edward R. Lavallie, Leeying Wu, Wei Cao, Eugenia Kouranova, Heather H. Shih, Anthony J. Milici, William J.J. Finlay, Janet E. Paulsen, Jo Ann Dumin, Deirdre Ní Shúilleabháin, Matthew Allister Lambert, Maya Arai, Mostafa Ait-Zahra, Davinder Gill
المصدر: Journal of Biological Chemistry. 287:44425-44434
مصطلحات موضوعية: Molecular Sequence Data, Tau protein, Mice, Transgenic, tau Proteins, Peptide, Complementarity determining region, Biochemistry, Antibodies, Epitope, Epitopes, Mice, Alzheimer Disease, Animals, Humans, Amino Acid Sequence, Phosphorylation, Molecular Biology, chemistry.chemical_classification, biology, Phosphopeptide, Brain, Cell Biology, Structural biology, chemistry, Immunoglobulin G, Protein Structure and Folding, biology.protein, Antibody, Chickens
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e527a805643d52b9e49f16ee3c80cdac
https://doi.org/10.1074/jbc.m112.415935 -
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المؤلفون: Hwei-Ru Tsou, George Theodore Grosu, Semiramis Ayral-Kaloustian, Natasja Brooijmans, Joel Bard, Ker Yu, Matthew Gregory Bursavich, Tarek S. Mansour, Gary Harold Birnberg, Irwin Hollander, Lourdes Toral-Barza, Gloria Jean Macewan
المصدر: Bioorganic & Medicinal Chemistry Letters. 20:2321-2325
مصطلحات موضوعية: Models, Molecular, Stereochemistry, Clinical Biochemistry, Mice, Nude, Pharmaceutical Science, Antineoplastic Agents, Protein Serine-Threonine Kinases, Crystallography, X-Ray, Biochemistry, Inhibitory Concentration 50, Mice, Phosphatidylinositol 3-Kinases, Structure-Activity Relationship, chemistry.chemical_compound, Adenosine Triphosphate, Microsomes, Neoplasms, Drug Discovery, Animals, Humans, Transferase, Methylene, Protein Kinase Inhibitors, Molecular Biology, PI3K/AKT/mTOR pathway, Benzofurans, Serine/threonine-specific protein kinase, Phosphoinositide 3-kinase, biology, Hydrogen bond, Chemistry, Kinase, TOR Serine-Threonine Kinases, Organic Chemistry, Intracellular Signaling Peptides and Proteins, biology.protein, Molecular Medicine, Selectivity
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المؤلفون: Darrell Panza, Kristine Svenson, Jason Shaoyun Xiang, Xianbin Tian, Christian E. Johnson, Xin Xu, James Tobin, Xiangping Li, Huan-Qiu Li, Mylene Perreault, Joel Bard, Tarek S. Mansour, Seung Hahm, Eddine Saiah, Ariful Qadri, Vipin Suri, Eva Chenail, Zhao-Kui Wan, Manus Ipek, Yuzhe Xing
المصدر: Journal of Medicinal Chemistry. 52:5449-5461
مصطلحات موضوعية: Male, Models, Molecular, medicine.medical_specialty, medicine.medical_treatment, Molecular Conformation, CHO Cells, Crystallography, X-Ray, Inhibitory Concentration 50, Mice, Structure-Activity Relationship, Cricetulus, Pharmacokinetics, In vivo, Cricetinae, Diabetes mellitus, Internal medicine, 11-beta-Hydroxysteroid Dehydrogenase Type 1, Drug Discovery, medicine, Animals, Humans, Obesity, Enzyme Inhibitors, Hydrocortisone, biology, Chemistry, Insulin, medicine.disease, Diet, Mice, Inbred C57BL, Disease Models, Animal, Endocrinology, Enzyme inhibitor, Drug Design, biology.protein, Molecular Medicine, Cortisone, hormones, hormone substitutes, and hormone antagonists, Ex vivo, medicine.drug
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9
المؤلفون: David Malwitz, David J. Richard, Kristine Svenson, Lourdes Toral-Barza, Natasja Brooijmans, Ker Yu, Kevin J. Curran, Jeroen C. Verheijen, Judy Lucas, Arie Zask, Pawel Nowak, Joshua Kaplan, Weiguo Zhang, Robert T. Abraham, Irwin Hollander, Joel Bard, James Joseph Gibbons, Semiramis Ayral-Kaloustian, Tarek S. Mansour
المصدر: Journal of Medicinal Chemistry. 52:5013-5016
مصطلحات موضوعية: Models, Molecular, Allosteric regulation, Regulator, Mice, Nude, Antineoplastic Agents, Protein Serine-Threonine Kinases, Crystallography, X-Ray, Mice, Phosphatidylinositol 3-Kinases, Structure-Activity Relationship, Adenosine Triphosphate, In vivo, Cell Line, Tumor, Microsomes, Drug Discovery, Animals, Class Ib Phosphatidylinositol 3-Kinase, Urea, Cytotoxicity, PI3K/AKT/mTOR pathway, chemistry.chemical_classification, Binding Sites, biology, Chemistry, TOR Serine-Threonine Kinases, Intracellular Signaling Peptides and Proteins, Xenograft Model Antitumor Assays, Isoenzymes, Pyrimidines, Enzyme, Biochemistry, Enzyme inhibitor, Drug Design, biology.protein, Cancer research, Pyrazoles, Molecular Medicine, Carbamates, Signal transduction
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المؤلفون: Girija Krishnamurthy, Huiming Cheng, Anita Y. M. Howe, S V Johann, Srinivas K. Chunduru, Tarek S. Mansour, John O'Connell, Stanley Mullen, Dorothy C. Young, Joel Bard, Rajiv Chopra
المصدر: Antimicrobial Agents and Chemotherapy. 52:3327-3338
مصطلحات موضوعية: Models, Molecular, Genotype, Sequence analysis, viruses, Hepatitis C virus, Hepacivirus, Viral Nonstructural Proteins, Biology, medicine.disease_cause, Antiviral Agents, chemistry.chemical_compound, Cell Line, Tumor, RNA polymerase, Drug Resistance, Viral, medicine, Humans, Pharmacology (medical), Replicon, Cloning, Molecular, Enzyme Inhibitors, Gene, NS5B, Benzofurans, Pharmacology, chemistry.chemical_classification, Mutation, Genetic Variation, virus diseases, biochemical phenomena, metabolism, and nutrition, RNA-Dependent RNA Polymerase, Virology, Molecular biology, digestive system diseases, Infectious Diseases, Enzyme, chemistry
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2edb40e0684b7d6742a6ea4d89f1a18c
https://doi.org/10.1128/aac.00238-08
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