المؤلفون: Sven Ruf, Sridharan Rajagopal, Sanjay Venkatachalapathi Kadnur, Mahanandeesha S. Hallur, Shilpa Rani, Rajendra Kristam, Srinivasan Swaminathan, Bharat Ravindra Zope, Pavan Kumar Gondrala, Indu Swamy, V. P. Rama Kishore Putta, Saravanan Kandan, Gernot Zech, Herman Schreuder, Christine Rudolph, Ralf Elvert, Joerg Czech, Swarnakumari Birudukota, M. Amir Siddiqui, Niranjan Naranapura Anand, Vishal Subhash Mane, Sreekanth Dittakavi, Juluri Suresh, Ramachandraiah Gosu, Mullangi Ramesh, Takeshi Yura, Saravanakumar Dhakshinamoorthy, Aimo Kannt

المصدر: Scientific Reports, Vol 12, Iss 1, Pp 1-18 (2022)

مصطلحات موضوعية: Medicine, Science

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2045-2322

URL الوصول: https://doaj.org/article/1bd53e86e70b4c66b07f2146adca9f2e

المؤلفون: Aimo Kannt, Sridharan Rajagopal, Mahanandeesha S. Hallur, Indu Swamy, Rajendra Kristam, Saravanakumar Dhakshinamoorthy, Joerg Czech, Gernot Zech, Herman Schreuder, Sven Ruf

المصدر: Molecules, Vol 26, Iss 4, p 991 (2021)

مصطلحات موضوعية: nicotinamide-N-methyltransferase, small molecule inhibitor, nicotinamide, metabolic disease, X-ray, Organic chemistry, QD241-441

وصف الملف: electronic resource

Relation: https://www.mdpi.com/1420-3049/26/4/991; https://doaj.org/toc/1420-3049

URL الوصول: https://doaj.org/article/61332a9f60cc407593eef5ac0b48e04f

المؤلفون: Patrick Shum, Thomas Licher, John L. Kane, Carolin Gerbeth-Kreul, Gerhard Hessler, Antje Pommereau, Sven Ruf, Christian Engel, Linli Wei, Joerg Czech, Theresa A Kuntzweiler

المصدر: SLAS Discovery. 26:783-797

مصطلحات موضوعية: 0301 basic medicine, Chemistry, Biological membrane, Transporter, Biochemistry, Small molecule, Analytical Chemistry, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Membrane, Direct assay, Biological target, Biophysics, Molecular Medicine, Amino acid transporter, Patch clamp, 030217 neurology & neurosurgery, Biotechnology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::44e4fb083c4e35d492c537df0250e79a
https://doi.org/10.1177/24725552211011180

المؤلفون: Carolin, Gerbeth-Kreul, Antje, Pommereau, Sven, Ruf, John L, Kane, Theresa, Kuntzweiler, Gerhard, Hessler, Christian K, Engel, Patrick, Shum, LinLi, Wei, Joerg, Czech, Thomas, Licher

المصدر: SLAS discovery : advancing life sciences RD. 26(6)

مصطلحات موضوعية: Patch-Clamp Techniques, Cell Membrane, Reproducibility of Results, Biological Transport, CHO Cells, Electrophysiological Phenomena, High-Throughput Screening Assays, Small Molecule Libraries, Mice, Amino Acid Transport Systems, Neutral, Cricetulus, Animals, Humans, Biological Assay

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::b9160baf68ccf7faf0016023ba5f4dc1
https://pubmed.ncbi.nlm.nih.gov/33955247

المؤلفون: Indu N. Swamy, Mahanandeesha S. Hallur, Saravanakumar Dhakshinamoorthy, Rajendra Kristam, Sven Ruf, Aimo Kannt, Sridharan Rajagopal, Gernot Zech, Herman Schreuder, Joerg Czech

المساهمون: Publica

المصدر: Molecules
Volume 26
Issue 4
Molecules, Vol 26, Iss 991, p 991 (2021)

مصطلحات موضوعية: Models, Molecular, Niacinamide, Pharmaceutical Science, Adipose tissue, nicotinamide, Nicotinamide N-methyltransferase, Ligands, Article, Analytical Chemistry, Substrate Specificity, lcsh:QD241-441, X-ray, 03 medical and health sciences, chemistry.chemical_compound, Mice, 0302 clinical medicine, lcsh:Organic chemistry, Metabolic Diseases, Drug Discovery, medicine, Nicotinamide N-Methyltransferase, Animals, Humans, nicotinamide-N-methyltransferase, Physical and Theoretical Chemistry, Enzyme Inhibitors, 030304 developmental biology, chemistry.chemical_classification, 0303 health sciences, Binding Sites, Nicotinamide, Organic Chemistry, Skeletal muscle, small molecule inhibitor, metabolic disease, Small molecule, High-Throughput Screening Assays, Rats, Cytosol, medicine.anatomical_structure, Enzyme, chemistry, Biochemistry, Chemistry (miscellaneous), 030220 oncology & carcinogenesis, Microsomes, Liver, Molecular Medicine, Cancer cell lines

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::304d1f534180ae4303006d998f29ee1a

المؤلفون: Nisha K. Anchan, Thomas Langer, Vishal Subhash Mane, Raghunadha Reddy Burri, Christine Rudolph, Herman Schreuder, Joerg Czech, Ramachandraiah Gosu, Rajendra Kristam, Saravanakumar Dhakshinamoorthy, Ramesh Mullangi, Juluri Suresh, Mahanandeesha S. Hallur, Sridharan Rajagopal, Takeshi Yura, Manvi Singh, Aimo Kannt, Devaraj Venkatapura Chandrasekar, Shama Shaik, Sanjay Venkatachalapathi Kadnur, V.P. Rama Kishore Putta, Lokesh Kananti Narasimhulu, Karthikai Raj Murugesan, Ravi Kanth Bhamidipati, Sven Ruf, Indu N. Swamy, Alexander Marker, Sayantani Sarkar

المصدر: Bioorganic & Medicinal Chemistry Letters. 28:922-925

مصطلحات موضوعية: Niacinamide, 0301 basic medicine, Clinical Biochemistry, Pharmaceutical Science, Nicotinamide N-methyltransferase, Pharmacology, Biochemistry, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Diabetes mellitus, Drug Discovery, Nicotinamide N-Methyltransferase, medicine, Humans, Enzyme Inhibitors, Molecular Biology, chemistry.chemical_classification, Dose-Response Relationship, Drug, Molecular Structure, Nicotinamide, Organic Chemistry, Primary metabolite, medicine.disease, 030104 developmental biology, Enzyme, chemistry, 030220 oncology & carcinogenesis, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0692f15941b73b65689828e71e37e26f
https://doi.org/10.1016/j.bmcl.2018.01.058

المؤلفون: Hans-Jörg Czech, Kareen Kümpel, Rita Müller

نوع المادة: eBook.

الموضوعات: AM, P

تصنيفات: ART / Museum Studies, ART / Art & Politics

المؤلفون: Martin Lorenz, Hans Peter Nestler, Otmar Klingler, Monica Donghi, Manfred Schudok, Herman Schreuder, Hauke Szillat, Joerg Czech, Hans Matter

المصدر: Bioorganicmedicinal chemistry letters. 14(14)

مصطلحات موضوعية: Molecular model, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Factor VIIa, Crystallography, X-Ray, Biochemistry, Chemical synthesis, Fibrinolytic Agents, Drug Discovery, Binding site, Molecular Biology, Serine protease, Binding Sites, biology, Molecular Structure, Chemistry, Protease binding, Phenylurea Compounds, Organic Chemistry, Docking (molecular), Enzyme inhibitor, Drug Design, biology.protein, Molecular Medicine, Fibrinolytic agent, Peptide Hydrolases

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c797729e937c8a11a93b66f7815fd006
https://pubmed.ncbi.nlm.nih.gov/15203149

المؤلفون: Hans Matter, Manfred Schudok, Martin Lorenz, Peter Wildgoose, Hans Peter Nestler, Otmar Klingler, S. Paul Bajaj, Joerg Czech, Herman Schreuder

المصدر: ChemInform. 34

مصطلحات موضوعية: Models, Molecular, Molecular model, Stereochemistry, medicine.drug_class, Clinical Biochemistry, Pharmaceutical Science, Carboxamide, Factor VIIa, Selective inhibition, Crystallography, X-Ray, Biochemistry, Chemical synthesis, Amidine, chemistry.chemical_compound, Structure-Activity Relationship, Antithrombotic treatment, Drug Discovery, medicine, otorhinolaryngologic diseases, Humans, Structure–activity relationship, Molecular Biology, biology, Chemistry, Phenylurea Compounds, Organic Chemistry, Coagulation factor VIIa, General Medicine, Combinatorial chemistry, Design synthesis, Enzyme inhibitor, Drug Design, biology.protein, Molecular Medicine, sense organs

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81bb22de0780fdf943fd66180c741dbd
https://doi.org/10.1002/chin.200331252

المؤلفون: Sofia Mitaku, Jean-Claude Jacquesy, Jean-Pierre Gesson, Xia Dong, Manfred Gerken, Klaus Bosslet, François Tillequin, Claude Monneret, Brigitte Renoux, Joerg Czech, Jean-Claude Florent, Sylvie Michel, Rainer Straub, Michel Koch, Martine Mondon, Solo Andrianomenjanahary, Gilbert Gaudel

المصدر: Journal of medicinal chemistry. 41(19)

مصطلحات موضوعية: Daunorubicin, Recombinant Fusion Proteins, Glucuronates, Immunoglobulin Fab Fragments, Mice, Structure-Activity Relationship, Drug Stability, Drug Discovery, medicine, Escherichia coli, Tumor Cells, Cultured, Structure–activity relationship, Animals, Humans, Doxorubicin, Prodrugs, Cytotoxicity, Leukemia L1210, Glucuronidase, chemistry.chemical_classification, Antibiotics, Antineoplastic, Hydrolysis, Antibodies, Monoclonal, Adept, Prodrug, In vitro, Carcinoembryonic Antigen, Rats, Kinetics, Enzyme, chemistry, Biochemistry, Molecular Medicine, Drug Screening Assays, Antitumor, Cell Division, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::796178c7dfafdcc1d44a2c0281a1adc7
https://pubmed.ncbi.nlm.nih.gov/9733483