يعرض 1 - 10 نتائج من 49 نتيجة بحث عن '"John, de Kruif"', وقت الاستعلام: 1.22s تنقيح النتائج
  1. 1
    دورية أكاديمية
    A human CD137×PD-L1 bispecific antibody promotes anti-tumor immunity via context-dependent T cell costimulation and checkpoint blockade

    المؤلفون: Cecile Geuijen, Paul Tacken, Liang-Chuan Wang, Rinse Klooster, Pieter Fokko van Loo, Jing Zhou, Arpita Mondal, Yao-bin Liu, Arjen Kramer, Thomas Condamine, Alla Volgina, Linda J. A. Hendriks, Hans van der Maaden, Eric Rovers, Steef Engels, Floris Fransen, Renate den Blanken-Smit, Vanessa Zondag-van der Zande, Abdul Basmeleh, Willem Bartelink, Ashwini Kulkarni, Wilfred Marissen, Cheng-Yen Huang, Leslie Hall, Shane Harvey, Soyeon Kim, Marina Martinez, Shaun O’Brien, Edmund Moon, Steven Albelda, Chrysi Kanellopoulou, Shaun Stewart, Horacio Nastri, Alexander B. H. Bakker, Peggy Scherle, Ton Logtenberg, Gregory Hollis, John de Kruif, Reid Huber, Patrick A. Mayes, Mark Throsby

    المصدر: Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)

    مصطلحات موضوعية: Science

    وصف الملف: electronic resource

    Relation: https://doaj.org/toc/2041-1723

    URL الوصول: https://doaj.org/article/4044cbbb9c1d4937ac08f857eba69b30

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  2. 2
    1210 A human bispecific antibody targeting LAG-3 and PD-1 (INCA32459) potently activates exhausted T cells

    المؤلفون: Shaun Stewart, Floris Fransen, Shane Harvey, Franziska Mortensen, Anita Stam, Rahel Awdew, Arpita Mondal, Christina Stevens, Eric Rovers, Steef Engels, Melissa Rentrop-Boeijen, Linda Hendriks, Brenda van Dieren, Rebecca Buonpane, Therese Visser, Pepijn Schellen, Ashwini Kulkarni, Jonathan Rios-Doria, Jing Zhou, Paul Tacken, Lu Lu, Vanessa Zondag-van der Zande, Cheng-Yen Huang, Renate den Blanken-Smit, John de Kruif, Rinse Klooster, Simon Plyte, Horacio Nastri, Patrick Mayes

    المصدر: Regular and Young Investigator Award Abstracts.

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::5958541998ef9b95a1ba0943aad1d22b
    https://doi.org/10.1136/jitc-2022-sitc2022.1210

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  3. 3
    Abstract 2936: INCA33890, a novel PD-1×TGFꞵR2 bispecific antibody conditionally antagonizes TGFꞵ signaling in primary immune cells co-expressing PD-1

    المؤلفون: Liang-Chuan S. Wang, Rinse Klooster, Ashwini Kulkarni, Amaya Garcia de Vinuesa, Maxim Soloviev, Linda JA Hendriks, Lu Huo, Michael Weber, Arpita Mondal, Yonghong Zhao, Shane Harvey, Xin He, Hong Chang, April Horsey, Alla Volgina, Yue Zhang, Veethika Pandey, Yan-Ou Yang, Jonathan Rios-Doria, Evgeniy Eruslanov, Daniel J. Powell, Steven M. Albelda, John de Kruif, Horacio Nastri, Cecile Geuijen, Patrick A. Mayes

    المصدر: Cancer Research. 83:2936-2936

    مصطلحات موضوعية: Cancer Research, Oncology

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::e70aa438b958ff079d7f442b29dd7938
    https://doi.org/10.1158/1538-7445.am2023-2936

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  4. 4
    Functional patient-derived organoid screenings identify MCLA-158 as a therapeutic EGFR × LGR5 bispecific antibody with efficacy in epithelial tumors

    المؤلفون: Bram Herpers, Berina Eppink, Mark I. James, Carme Cortina, Adrià Cañellas-Socias, Sylvia F. Boj, Xavier Hernando-Momblona, Dominik Glodzik, Rob C. Roovers, Marc van de Wetering, Carina Bartelink-Clements, Vanessa Zondag-van der Zande, Jara García Mateos, Kuan Yan, Lucia Salinaro, Abdul Basmeleh, Szabolcs Fatrai, David Maussang, Jeroen J. Lammerts van Bueren, Irene Chicote, Garazi Serna, Laia Cabellos, Lorena Ramírez, Paolo Nuciforo, Ramon Salazar, Cristina Santos, Alberto Villanueva, Camille Stephan-Otto Attolini, Elena Sancho, Hector G. Palmer, Josep Tabernero, Michael R. Stratton, John de Kruif, Ton Logtenberg, Hans Clevers, Leo S. Price, Robert G. J. Vries, Eduard Batlle, Mark Throsby

    المساهمون: Hubrecht Institute for Developmental Biology and Stem Cell Research

    المصدر: Nature cancer, 3(4), 418-436

    مصطلحات موضوعية: Cancer Research, Glandular and Epithelial/metabolism, Drug development, Antibodies, Desenvolupament de medicaments, Receptors, G-Protein-Coupled, Neoplastic Stem Cells/metabolism, Càncer colorectal, Neoplasms, Antibodies, Bispecific, Receptors, Humans, Neoplasms, Glandular and Epithelial, Antibodies, Bispecific/pharmacology, G-Protein-Coupled/metabolism, ErbB Receptors/metabolism, Imidazoles, Receptors, G-Protein-Coupled/metabolism, Colorectal cancer, ErbB Receptors, Organoids, Oncology, Neoplasms, Glandular and Epithelial/metabolism, Pyrazines, Neoplastic Stem Cells, Bispecific/pharmacology

    وصف الملف: application/pdf

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd6787d32a1a24821ce4603c0851f3e6
    https://pure.knaw.nl/portal/en/publications/06b7bea9-adb4-44dc-9013-631489b16e6a

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  5. 5
    A human CD137×PD-L1 bispecific antibody promotes anti-tumor immunity via context-dependent T cell costimulation and checkpoint blockade

    المؤلفون: Steven M. Albelda, Steef Engels, Soyeon Kim, Alla Volgina, Floris Fransen, Linda Johanna Aleida Hendriks, Cecile Geuijen, Shane Harvey, Horacio Nastri, Reid Huber, Leslie Hall, Gregory Hollis, John de Kruif, Jing Zhou, Abdul Basmeleh, Pieter Fokko Van Loo, Mark Throsby, Edmund K. Moon, Arjen Kramer, Willem Bartelink, Eric Rovers, Paul Tacken, Hans van der Maaden, Vanessa Zondag-van der Zande, Cheng Yen Huang, Rinse Klooster, Liang Chuan Wang, Ashwini Kulkarni, Chrysi Kanellopoulou, Marina Martinez, Wilfred E. Marissen, Shaun O'Brien, Alexander Berthold Hendrik Bakker, Ton Logtenberg, Renate den Blanken-Smit, Shaun Stewart, Peggy Scherle, Arpita Mondal, Patrick Mayes, Yao bin Liu, Thomas Condamine

    المصدر: Nature Communications
    Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)

    مصطلحات موضوعية: 0301 basic medicine, medicine.medical_treatment, T cell, Science, General Physics and Astronomy, Priming (immunology), Cancer immunotherapy, CD8-Positive T-Lymphocytes, Lymphocyte Activation, General Biochemistry, Genetics and Molecular Biology, Epitope, Article, B7-H1 Antigen, 03 medical and health sciences, Epitopes, 0302 clinical medicine, PD-L1, Antibodies, Bispecific, Immune Tolerance, Medicine, Animals, Humans, Immune Checkpoint Inhibitors, Multidisciplinary, biology, business.industry, CD137, General Chemistry, Immunotherapy, 030104 developmental biology, medicine.anatomical_structure, 4-1BB Ligand, biology.protein, Cancer research, Antibody therapy, Antibody, business, Immunologic Memory, 030215 immunology

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f69ccb4c8aa2845dfcef907bf76c0bc4
    http://europepmc.org/articles/PMC8295259

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  6. 6
    دورية أكاديمية
    Heterosubtypic neutralizing monoclonal antibodies cross-protective against H5N1 and H1N1 recovered from human IgM+ memory B cells.

    المؤلفون: Mark Throsby, Edward van den Brink, Mandy Jongeneelen, Leo L M Poon, Philippe Alard, Lisette Cornelissen, Arjen Bakker, Freek Cox, Els van Deventer, Yi Guan, Jindrich Cinatl, Jan ter Meulen, Ignace Lasters, Rita Carsetti, Malik Peiris, John de Kruif, Jaap Goudsmit

    المصدر: PLoS ONE, Vol 3, Iss 12, p e3942 (2008)

    مصطلحات موضوعية: Medicine, Science

    وصف الملف: electronic resource

    Relation: https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/19079604/?tool=EBI; https://doaj.org/toc/1932-6203

    URL الوصول: https://doaj.org/article/bcfe0b05bd384f00880815666d14f350

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  7. 7
    Abstract 952: The bispecific antibody MCLA-129 impairs NSCLC tumor growth by targeting EGFR and c-MET, inhibiting ligand-induced signaling and promoting ADCC and ADCP

    المؤلفون: Qingyu Shu, Liang Deng, Rinse Klooster, Wenxin Xu, Cecile Geuijen, John de Kruif, Li Mao, Wei Liu, Martijn van Rosmalen, Mark Throsby, Tristan Gallenne, David J. de Gorter, Mario Di Matteo, Alexandre Deshiere, Christian Wohn, Massimiliano Mazzone, Berina Eppink

    المصدر: Cancer Research. 81:952-952

    مصطلحات موضوعية: Antibody-dependent cell-mediated cytotoxicity, Cancer Research, C-Met, biology, Cancer, medicine.disease, Receptor tyrosine kinase, chemistry.chemical_compound, T790M, Oncology, chemistry, Cancer cell, medicine, biology.protein, Cancer research, Erlotinib, Antibody, medicine.drug

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::02db516a6d3a502f8247e3d00df0acc7
    https://doi.org/10.1158/1538-7445.am2021-952

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  8. 8
    Abstract 957: Zenocutuzumab: An antibody that can overcome HER3 mediated HRG signalling in tumor cells by docking on HER2

    المؤلفون: Linda Johanna Aleida Hendriks, John de Kruif, Tristan Gallenne, David Andre Baptiste Maussang-Detaille, Jan P. Gerlach, Mark Throsby, Cecile Geuijen, Arjen Kramer

    المصدر: Cancer Research. 81:957-957

    مصطلحات موضوعية: Cancer Research, biology, Kinase, medicine.drug_class, Chemistry, Cancer, medicine.disease, Monoclonal antibody, body regions, Oncology, Pancreatic cancer, Cancer research, medicine, biology.protein, Avidity, Antibody, skin and connective tissue diseases, Protein kinase B, PI3K/AKT/mTOR pathway

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::1870ef6a23712987a502e0c5dd841105
    https://doi.org/10.1158/1538-7445.am2021-957

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  9. 9
    دورية أكاديمية
    Human monoclonal antibody combination against SARS coronavirus: synergy and coverage of escape mutants.

    المؤلفون: Jan ter Meulen, Edward N van den Brink, Leo L M Poon, Wilfred E Marissen, Cynthia S W Leung, Freek Cox, Chung Y Cheung, Arjen Q Bakker, Johannes A Bogaards, Els van Deventer, Wolfgang Preiser, Hans Wilhelm Doerr, Vincent T Chow, John de Kruif, Joseph S M Peiris, Jaap Goudsmit

    المصدر: PLoS Medicine, Vol 3, Iss 7, p e237 (2006)

    مصطلحات موضوعية: Medicine

    وصف الملف: electronic resource

    Relation: https://doaj.org/toc/1549-1277; https://doaj.org/toc/1549-1676

    URL الوصول: https://doaj.org/article/557b2e6b1a6245668800763008d7424a

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  10. 10
    MCLA-117, a CLEC12AxCD3 bispecific antibody targeting a leukaemic stem cell antigen, induces T cell-mediated AML blast lysis

    المؤلفون: Harry Dolstra, Andres Sirulnik, Rob Roovers, Alexander Berthold Hendrik Bakker, Linda Johanna Aleida Hendriks, Arjen Kramer, M. Leenders, Mark Throsby, Pieter Fokko Van Loo, Basav N. Hangalapura, John de Kruif, Henrike Veninga, Soley Thordardottir, Robert Doornbos, Ton Logtenberg, John D Gibbins

    المصدر: Expert Opinion on Biological Therapy, 19, 721-733
    Expert Opinion on Biological Therapy, 19(7), 721. Informa Healthcare
    Expert Opinion on Biological Therapy, 19, 7, pp. 721-733

    مصطلحات موضوعية: 0301 basic medicine, CD4-Positive T-Lymphocytes, Lysis, T cell engager, CD3 Complex, Cancer development and immune defence Radboud Institute for Molecular Life Sciences [Radboudumc 2], CD3, T cell, T-Lymphocytes, Cell, Clinical Biochemistry, T cells, HL-60 Cells, CD8-Positive T-Lymphocytes, Lymphocyte Activation, 03 medical and health sciences, Mice, All institutes and research themes of the Radboud University Medical Center, 0302 clinical medicine, Antigen, AML, hemic and lymphatic diseases, Antibodies, Bispecific, Drug Discovery, medicine, Animals, Humans, Lectins, C-Type, Cell Proliferation, CLEC12A, Pharmacology, biology, Chemistry, Drug discovery, Mice, Inbred C57BL, Leukemia, Myeloid, Acute, bispecific antibody, 030104 developmental biology, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Receptors, Mitogen, biology.protein, Cancer research, Cytokines, Stem cell, Antibody, Half-Life

    وصف الملف: image/pdf; application/pdf

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90820939a92daf92169026666cef0b2b
    https://dspace.library.uu.nl/handle/1874/390555

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