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1
المؤلفون: Fiona S. Lucas, Helen Susanne Price, John Andrew Corfield, Graham Webb, Steve B. Guntrip, Sean J. Hindley, Alan Naylor, Robert Gleave, Neil Mathews, C. Bountra, Hazel Player, Paul F. Lambeth, Richard M. Hall, Ian B. Campbell, Terry Brown, Andrew P. Blackaby, Joanne O. Wiseman, Kerry Browning, Paul John Beswick, Phillip J. Sidebottom, Nicholas L. Taylor
المصدر: Bioorganicmedicinal chemistry letters. 19(15)
مصطلحات موضوعية: Pyrimidine, Chemistry, Pharmaceutical, Clinical Biochemistry, Pharmaceutical Science, Biochemistry, chemistry.chemical_compound, Inhibitory Concentration 50, Structure-Activity Relationship, Biotransformation, Drug Discovery, Humans, Molecular Biology, Inflammation, biology, Cyclooxygenase 2 Inhibitors, Molecular Structure, Organic Chemistry, Inflammatory pain, Enzyme inhibition, chemistry, Models, Chemical, Enzyme inhibitor, Cyclooxygenase 2, Drug Design, Lipophilicity, biology.protein, Molecular Medicine, Identification (biology), Cyclooxygenase
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2
المؤلفون: Paul F. Lambeth, Fiona S. Lucas, Richard Howard Green, Martin E. Swarbrick, Jeremy John Payne, Lee William Page, Malcolm Clive Carter, Paul John Beswick, Alexander J. Stevens, Sharon C Stratton, Neil Anthony Pegg, John Skidmore, Savvas Kleanthous, Alastair J. Stuart, Sue D. Collins, Sharon Bingham, John Andrew Corfield, Richard Stocker, Joanne O. Wiseman, C. David Hartley, Helen Susanne Price, Neil Mathews, Laura J. Chambers, Iain P. Chessell, Robert Gleave, Nick M. Clayton, Alan Naylor, C. Bountra
المصدر: Bioorganicmedicinal chemistry letters. 19(15)
مصطلحات موضوعية: Pyrimidine, Stereochemistry, Chemistry, Pharmaceutical, Clinical Biochemistry, Pharmaceutical Science, Ether, Biochemistry, Chemical synthesis, Sulfone, chemistry.chemical_compound, Inhibitory Concentration 50, Mice, Drug Discovery, Animals, Humans, Sulfones, Amines, Molecular Biology, chemistry.chemical_classification, Inflammation, Trifluoromethyl, biology, Cyclooxygenase 2 Inhibitors, Molecular Structure, Organic Chemistry, Brain, Neurodegenerative Diseases, Rats, Disease Models, Animal, Enzyme, Pyrimidines, chemistry, Enzyme inhibitor, Cyclooxygenase 2, Drug Design, biology.protein, Molecular Medicine, Selectivity, Ethers
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3
المؤلفون: John Andrew Corfield, Bobby N. Glover, Rossella Guidetti, David Haigh, Katrina Jane Medhurst, Armel A. Agbodjan, Richard T. Matsuoka, Mary M. Jackson, Matthew J. Sharp, Royston C. B. Copley, Martin John Slater, Alan Millar, Jennifer F. Toczko, Roy C. Flanagan, Shiping Xie, Bob E. Cooley, P.D. Howes
المصدر: The Journal of organic chemistry. 73(8)
مصطلحات موضوعية: Models, Molecular, Pyrrolidines, Silver, Molecular Structure, Stereochemistry, Acylation, Organic Chemistry, Enantioselective synthesis, Azomethine ylide, Silver acetate, Stereoisomerism, Cinchonine, DNA-Directed RNA Polymerases, Hepacivirus, Crystallography, X-Ray, Chemical synthesis, Cycloaddition, chemistry.chemical_compound, Alkaloids, chemistry, Acrylates, Solvents, Imines, Cinchonidine, Methyl acrylate
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المؤلفون: Richard L. Jarvest, Richard Stocker, John Andrew Corfield, S. Fernandes, Martin John Slater, C.D. Hartley, Onkar M. P. Singh, C. Wilkinson, V.L.H. Lovegrove, K.J. Medhurst, Malcolm Ellis, George Burton, Pia Thommes, Deborah Lynette Jackson, David Haigh, Nigel R. Parry, E.M. Amphlett, G. Bravi, Alan J. Wonacott, R. Guidetti, Helen Susanne Price, Anne Cheasty, R. Fenwick, P. Shah, David M. Andrews, Peter David Howes
المصدر: Journal of medicinal chemistry. 50(5)
مصطلحات موضوعية: Models, Molecular, Pyrrolidines, Stereochemistry, Hepacivirus, Hepatitis C virus, Biological Availability, medicine.disease_cause, Antiviral Agents, Virus, Pyrrolidine, chemistry.chemical_compound, Structure-Activity Relationship, RNA polymerase, Drug Discovery, Chlorocebus aethiops, medicine, Animals, Vero Cells, chemistry.chemical_classification, Binding Sites, biology, Stereoisomerism, biology.organism_classification, Nucleotidyltransferase, RNA-Dependent RNA Polymerase, Rats, Enzyme, Biochemistry, chemistry, Enzyme inhibitor, biology.protein, Molecular Medicine
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5
المؤلفون: Hazel Player, John Andrew Corfield, Iain P. Chessell, Helen Susanne Price, Sharon C Stratton, Stephen Barry Guntrip, Neil Anthony Pegg, Elizabeth Pickup, Sue D. Collins, Terry Brown, Paul F. Lambeth, Kerry Browning, Sharon Bingham, Paul John Beswick, Alan Naylor, C. Bountra, Claudine Haslam, Ian B. Campbell, Nick M. Clayton, Alexander J. Stevens, Graham Murkit, Fiona S. Lucas, Joanne O. Wiseman, Neil Mathews
المصدر: Bioorganic and medicinal chemistry letters. 14(21)
مصطلحات موضوعية: Male, Clinical Biochemistry, Analgesic, Freund's Adjuvant, Pharmaceutical Science, Administration, Oral, Biological Availability, Pharmacology, Biochemistry, Chemical synthesis, Pyridazine, chemistry.chemical_compound, Structure-Activity Relationship, In vivo, Drug Discovery, Structure–activity relationship, Animals, Humans, Cyclooxygenase Inhibitors, Infusions, Intravenous, Molecular Biology, biology, Bicyclic molecule, Cyclooxygenase 2 Inhibitors, Organic Chemistry, Brain, Membrane Proteins, Arthritis, Experimental, Rats, Pyridazines, chemistry, Enzyme inhibitor, Cyclooxygenase 2, Prostaglandin-Endoperoxide Synthases, biology.protein, Molecular Medicine, Pyrazoles, Cyclooxygenase
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