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المؤلفون: Valeria Guaschino, Valentina Bordano, Stefania Cannito, Gianluca Miglio, Elisa Benetti, John C. Stephens, Valeria Iannaccone, John B. C. Findlay, Gemma K. Kinsella, Arianna Carolina Rosa
المساهمون: Progetto di Ateneo/CSP 2016- CSTO161899 cod. S1618 L1 BENE02
المصدر: International Journal of Molecular Sciences
Volume 22
Issue 19
International Journal of Molecular Sciences, Vol 22, Iss 10784, p 10784 (2021)
Articlesمصطلحات موضوعية: MAPK/ERK pathway, GPCRs, GPR21, Hepatic insulin resistance, Hepatocytes, Glucose, Hep G2 Cells, medicine.medical_specialty, QH301-705.5, Glucose uptake, hepatic insulin resistance, Carbohydrate metabolism, Catalysis, Article, Receptors, G-Protein-Coupled, Inorganic Chemistry, Insulin resistance, Downregulation and upregulation, In vivo, Internal medicine, medicine, Glucose homeostasis, Humans, Insulin, Physical and Theoretical Chemistry, Biology (General), Receptor, Molecular Biology, QD1-999, Spectroscopy, Chemistry, Organic Chemistry, General Medicine, medicine.disease, Computer Science Applications, Endocrinology, hepatocytes, Insulin Resistance, Signal Transduction
وصف الملف: application/pdf
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المؤلفون: John E. Ladbury, Ana C. Redondo, Adam F. Odell, Gareth W. Fearnley, Leyuan Bao, Michael A. Harrison, Gemma K. Kinsella, Sreenivasan Ponnambalam, Chi-Chuan Lin, John B. C. Findlay
المصدر: BioRxiv
مصطلحات موضوعية: MAPK/ERK pathway, Endothelial stem cell, Vascular endothelial growth factor A, biology, Chemistry, Calcium-binding protein, cardiovascular system, biology.protein, Signal transduction, Protein kinase A, Tyrosine kinase, Receptor tyrosine kinase, Cell biology
وصف الملف: application/pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0411c463d096dfac652827ba65eae711
https://doi.org/10.1101/2021.07.29.454311 -
3دورية أكاديمية
المؤلفون: Conor J Breen, Darren S Martin, Hui Ma, Kate McQuaid, Richard O'Kennedy, John B C Findlay
المصدر: PLoS ONE, Vol 10, Iss 3, p e0122293 (2015)
وصف الملف: electronic resource
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المؤلفون: John C. Stephens, Darren S. D. Martin, Gemma K. Kinsella, Robert Devine, John B. C. Findlay
المصدر: Results in Chemistry, Vol 2, Iss, Pp 100026-(2020)
Articlesمصطلحات موضوعية: Trifluoromethyl, Aryl, Diabetes, 2-Hydroxypropyl-β-cyclodextrin, General Chemistry, In vitro, lcsh:Chemistry, chemistry.chemical_compound, Piperazine, Differential scanning calorimetry, 2 hydroxypropyl β cyclodextrin, Aryl piperazine, chemistry, lcsh:QD1-999, Stability constants of complexes, Stoichiometry, Biochemistry, Biophysics, and Structural Biology, Nuclear chemistry
وصف الملف: application/pdf; text
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3dfc947149a5d4b9c0ac88a73ea33ca7
https://eprints.whiterose.ac.uk/175575/1/1-s2.0-S2211715620300047-main.pdf -
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المؤلفون: Gemma K. Kinsella, John B. C. Findlay, Siobhán Leonard, John M.D. Walsh, Darren S. D. Martin, Conor J Breen, Mark Kelada, John C. Stephens, R.B. Driver, Robert Devine
المصدر: Articles
مصطلحات موضوعية: Models, Molecular, Glucose uptake, Stimulation, Pharmacology, 01 natural sciences, Piperazines, 03 medical and health sciences, chemistry.chemical_compound, Mice, Structure-Activity Relationship, Pharmacokinetics, Oxidoreductase, Diabetes mellitus, Drug Discovery, medicine, Structure–activity relationship, Animals, Humans, Hypoglycemic Agents, NADH, NADPH Oxidoreductases, Enzyme Inhibitors, Piperazine, Cells, Cultured, 030304 developmental biology, Medicinal and Pharmaceutical Chemistry, chemistry.chemical_classification, 0303 health sciences, Dose-Response Relationship, Drug, Molecular Structure, 010405 organic chemistry, Aryl, Organic Chemistry, Diabetes, Biological Transport, General Medicine, medicine.disease, Structure activity relationship, 0104 chemical sciences, Glucose, chemistry, Drug Design, Complex 1
وصف الملف: application/pdf
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المصدر: Diabetes/Metabolism Research and Reviews. 32:379-390
مصطلحات موضوعية: 0301 basic medicine, endocrine system, medicine.medical_specialty, Glycogen, Endocrinology, Diabetes and Metabolism, Insulin, medicine.medical_treatment, Glucose uptake, Adipose tissue, Biology, medicine.disease, 03 medical and health sciences, Retinol binding protein, chemistry.chemical_compound, 030104 developmental biology, Endocrinology, Insulin resistance, chemistry, Internal medicine, Internal Medicine, medicine, Myocyte, Phosphorylation
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المؤلفون: John B. C. Findlay, Kathryn L. Chapman
المصدر: Biochimica et Biophysica Acta (BBA) - Biomembranes. 1828:535-542
مصطلحات موضوعية: Agonist, medicine.drug_class, Allosteric regulation, B-cell receptor, Melanocortin 4 receptor, Biophysics, Ligands, Biochemistry, Cyclic AMP Response Element Modulator, 03 medical and health sciences, Transactivation, GPCR, 0302 clinical medicine, GTP-Binding Proteins, Functional selectivity, medicine, Humans, Oligomerization, Amino Acid Sequence, Disulfides, Receptor, 030304 developmental biology, G protein-coupled receptor, 0303 health sciences, Binding Sites, Dose-Response Relationship, Drug, Chemistry, Cell Membrane, Cell Biology, Trans-activation, Cross-Linking Reagents, HEK293 Cells, Mutagenesis, alpha-MSH, Mutation, Receptor, Melanocortin, Type 4, Dimerization, Allosteric Site, 030217 neurology & neurosurgery, Protein Binding
وصف الملف: text
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المؤلفون: Renske W. Hesselink, John B. C. Findlay
المصدر: Molecular Membrane Biology. 30:327-337
مصطلحات موضوعية: Gene Expression, Receptors, Cell Surface, Lipocalin, Ligands, Cell Line, Cell surface receptor, Animals, Humans, Uteroglobin, Surface plasmon resonance, Receptor, Molecular Biology, Lipocalin 1, integumentary system, biology, Ligand, Chemistry, Cell Biology, Surface Plasmon Resonance, Biochemistry, biology.protein, Cattle, Drosophila, Antibody, Protein Binding
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المؤلفون: Laura M. Tobin, John B. C. Findlay, Siobhán Leonard
المصدر: European journal of pharmacology. 800
مصطلحات موضوعية: 0301 basic medicine, medicine.medical_treatment, Glucose uptake, Thiophenes, Biology, Piperazines, 03 medical and health sciences, Mice, 0302 clinical medicine, Insulin resistance, 3T3-L1 Cells, medicine, Animals, Enzyme Inhibitors, Protein kinase A, Protein kinase B, Pharmacology, Electron Transport Complex I, Tumor Necrosis Factor-alpha, Insulin, AMPK, medicine.disease, Lipid Metabolism, Cell biology, 030104 developmental biology, Mitochondrial respiratory chain, Biochemistry, Diabetes Mellitus, Type 2, 030220 oncology & carcinogenesis, Phosphorylation, Female, Insulin Resistance, Energy Metabolism
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المؤلفون: John B. C. Findlay, Elisa Benetti, Gemma K. Kinsella, Siobhán Leonard
المصدر: Scientific Reports
مصطلحات موضوعية: Male, 0301 basic medicine, Sucrose, medicine.medical_specialty, MAP Kinase Kinase 4, G protein, GPR21, type 2 diabetes,G protein-coupled receptors, Diet, High-Fat, p38 Mitogen-Activated Protein Kinases, Article, Receptors, G-Protein-Coupled, Mice, 03 medical and health sciences, Insulin resistance, G protein-coupled receptors, Insulin receptor substrate, Internal medicine, medicine, Animals, Humans, Estrenes, Protein Kinase C, G protein-coupled receptor, Mitogen-Activated Protein Kinase 1, Mitogen-Activated Protein Kinase 3, Multidisciplinary, GPR21, biology, Kinase, Wild type, medicine.disease, Pyrrolidinones, Cell biology, Mice, Inbred C57BL, Insulin receptor, HEK293 Cells, 030104 developmental biology, Endocrinology, Diabetes Mellitus, Type 2, Gene Expression Regulation, biology.protein, GTP-Binding Protein alpha Subunits, Gq-G11, type 2 diabetes, Insulin Resistance, Signal transduction, Signal Transduction