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1دورية أكاديمية
المؤلفون: David W. Frederick, Alan V. McDougal, Melisa Semenas, Johanna Vappiani, Andrea Nuzzo, John C. Ulrich, J. David Becherer, Frank Preugschat, Eugene L. Stewart, Daniel C. Sévin, H. Fritz Kramer
المصدر: Skeletal Muscle, Vol 10, Iss 1, Pp 1-14 (2020)
مصطلحات موضوعية: MDX, NAD+, CD38, NR, Eccentric, Injury, Diseases of the musculoskeletal system, RC925-935
وصف الملف: electronic resource
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المؤلفون: David Frederick, Alan V. McDougal, Melisa Semenas, Johanna Vappiani, Andrea Nuzzo, John C. Ulrich, Eugene L. Stewart, Daniel C. Sévin, H. Fritz Kramer
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::21136c34e5f1b7bb25b07f869525d926
https://doi.org/10.21203/rs.3.rs-28529/v1 -
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المؤلفون: Brad R. Henke, Eugene L. Stewart, John C. Ulrich, Curt D. Haffner, J. Darren Stuart, David N. Deaton, Barry G. Shearer, Michael R. Jeune
المصدر: Bioorganic & Medicinal Chemistry. 26:2107-2150
مصطلحات موضوعية: 0301 basic medicine, medicine.drug_class, Stereochemistry, Clinical Biochemistry, hERG, Pharmaceutical Science, Carboxamide, Nicotinamide adenine dinucleotide, 01 natural sciences, Biochemistry, Mice, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, In vivo, Drug Discovery, medicine, Quinazoline, Animals, Humans, Enzyme Inhibitors, Molecular Biology, chemistry.chemical_classification, Binding Sites, biology, 010405 organic chemistry, Organic Chemistry, NAD, ADP-ribosyl Cyclase 1, Amides, Protein Structure, Tertiary, 0104 chemical sciences, Bioavailability, Molecular Docking Simulation, 030104 developmental biology, Enzyme, chemistry, Quinazolines, biology.protein, Molecular Medicine, NAD+ kinase, Half-Life
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المؤلفون: Anthony L. Handlon, Lisa M. Leesnitzer, Joseph Wendell Wilson, Rodolfo Cadilla, Philip Stewart Turnbull, Chuck Poole, Raymond V. Merrihew, Lee T. Schaller, John C. Ulrich
المصدر: ACS Medicinal Chemistry Letters. 7:83-88
مصطلحات موضوعية: Ligand efficiency, Trifluoromethyl, 010405 organic chemistry, Stereochemistry, Organic Chemistry, 010402 general chemistry, 01 natural sciences, Biochemistry, 0104 chemical sciences, Bioavailability, Androgen receptor, chemistry.chemical_compound, chemistry, Selective androgen receptor modulator, Benzyl alcohol, Drug Discovery, Potency, Solubility
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المؤلفون: Chuck Poole, Pierette Banker, Yu Guo, Gregory Schaaf, Tiffany Carpenter, Stephen A. Thomson, Dan Gillie, Curt D. Haffner, John C. Ulrich, Scott Howard Dickerson, Petrov Kimberly, J. Patrick Condreay, Jeff Gobel, Andrew L. Larkin
المصدر: Bioorganic & Medicinal Chemistry Letters. 20:6989-6992
مصطلحات موضوعية: Patch-Clamp Techniques, Nitrile, medicine.drug_class, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Pancreatitis-Associated Proteins, Carboxamide, Biochemistry, Chemical synthesis, Cell Line, Structure-Activity Relationship, chemistry.chemical_compound, In vivo, Drug Discovery, medicine, Animals, Humans, Benzothiazoles, Patch clamp, Benzamide, Molecular Biology, Ion channel, Kv1.3 Potassium Channel, Organic Chemistry, Amides, In vitro, Rats, chemistry, Benzamides, Molecular Medicine
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المؤلفون: Adam Ashe, Thomas B. Stanley, Todd W Shearer, Craig D. Wagner, John C. Ulrich, Lisa M. Leesnitzer, Barry G. Shearer, Raymond V. Merrihew, Robert W. Wiethe, James M. Way, Robert X. Xu, Andrew N. Billin, Timothy M. Willson, Michael R. Jeune
المصدر: Journal of Medicinal Chemistry. 53:1857-1861
مصطلحات موضوعية: Male, Transcription, Genetic, Stereochemistry, Muscle Fibers, Skeletal, Peroxisome proliferator-activated receptor, Antineoplastic Agents, Protein Serine-Threonine Kinases, Ligands, Mass Spectrometry, Sulfone, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Genes, Reporter, Cell Line, Tumor, Drug Discovery, Animals, Humans, Structure–activity relationship, Tissue Distribution, Cysteine, PPAR delta, Sulfones, Binding site, Benzamide, chemistry.chemical_classification, Sulfonyl, Binding Sites, Carnitine O-Palmitoyltransferase, Ligand, Antagonist, Pyruvate Dehydrogenase Acetyl-Transferring Kinase, Mice, Inbred C57BL, chemistry, Benzamides, Molecular Medicine, Drug Screening Assays, Antitumor
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المؤلفون: Christie Schulte, Curt D. Haffner, J. Chuck Poole, Eric E. Boros, John C. Ulrich, David J. Cowan, Tiffany Carpenter, Eugene L. Stewart, J. Darren Stuart, Frank Preugschat, David N. Deaton, Tara Renae Rheault, Todd W. Shearer, Barry G. Shearer, J. David Becherer, Michael R. Jeune, Istvan Kaldor, Lisa M. Shewchuk, Terrence L. Smalley
المصدر: Journal of medicinal chemistry. 58(17)
مصطلحات موضوعية: Models, Molecular, medicine.drug_class, Protein Conformation, Biological Availability, Carboxamide, CD38, Pharmacology, Crystallography, X-Ray, Permeability, chemistry.chemical_compound, Structure-Activity Relationship, In vivo, Drug Discovery, Hydrolase, medicine, Structure–activity relationship, Animals, Humans, Obesity, Muscle, Skeletal, chemistry.chemical_classification, Hydrolysis, Quinoline, Membranes, Artificial, Stereoisomerism, NAD, ADP-ribosyl Cyclase 1, Amides, Mice, Inbred C57BL, Enzyme, chemistry, Biochemistry, Liver, Aminoquinolines, Quinolines, Molecular Medicine, NAD+ kinase
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المؤلفون: John C. Ulrich, Petrov Kimberly, Tiffany Carpenter, David J. Cowan, J. Darren Stuart, J. David Becherer, Eugene L. Stewart, Frank Preugschat, David N. Deaton, W. Wallace Harrington, Yu Guo, Naphtali Milliken, Barry G. Shearer, Michael R. Jeune, Istvan Kaldor, Terrence L. Smalley, Curt D. Haffner, Brad R. Henke, Rodolfo Cadilla, Todd W. Shearer, Eric E. Boros, Christie Schulte
المصدر: Journal of medicinal chemistry. 58(8)
مصطلحات موضوعية: Muscle tissue, Pharmacology, CD38, Quinolones, Cell Line, Dogs, Pharmacokinetics, Drug Discovery, medicine, Animals, Humans, Obesity, Chemistry, Drug discovery, Muscles, NAD, Small molecule, ADP-ribosyl Cyclase 1, Mice, Inbred C57BL, Molecular Docking Simulation, Thiazoles, medicine.anatomical_structure, Biochemistry, Liver, Cell culture, Molecular Medicine, NAD+ kinase, Diet-induced obese
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المؤلفون: Sarva M. Tadepalli, Alex G. Waterson, Perry Scott Brignola, Scott Howard Dickerson, Robert J. Mullin, Thomas R. Caferro, Craig D. Wagner, Hamilton D. Dickson, Dana E. Vanderwall, Kimberly G. Petrov, John C. Ulrich, Michael D. Gaul, Lisa M. Shewchuk, Anne M. Hassell, Kelly Horne Donaldson, Edgar R. Wood, David E. Uehling, Jon D. Williams, Ronald L. Brashear, Barry R. Keith, Wendy L. White, David W. Rusnak, Byron Ellis, Robert J. Griffin, Michael J. Reno
مصطلحات موضوعية: Isatin, Models, Molecular, Stereochemistry, Mice, SCID, Crystallography, X-Ray, Mass Spectrometry, Adduct, Mice, Structure-Activity Relationship, ErbB, Moiety, Transferase, Structure–activity relationship, Animals, Cell Proliferation, Multidisciplinary, Aniline Compounds, Dose-Response Relationship, Drug, Molecular Structure, Chemistry, Receptor Protein-Tyrosine Kinases, Biological activity, Xenograft Model Antitumor Assays, ErbB Receptors, Pyrimidines, Covalent bond, Alkynes, Physical Sciences, Female, Cysteine
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ee325f04de0f7f4e5e90c473b3e261b
https://europepmc.org/articles/PMC2268535/ -
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المؤلفون: Jing Chen, Henning F. Kramer, Andrew N. Billin, Ying Qian, Guizhen Luo, Naphtali Milliken, Tiffany Carpenter, J. David Becherer, Frank Preugschat, W. Wallace Harrington, Stephen A. Stimpson, Curt D. Haffner, Shian Huey Chiang, Rusty Murray, Deepak K. Rajpal, John C. Ulrich, Robert S. Geske
المصدر: PLoS ONE, Vol 10, Iss 8, p e0134927 (2015)
PLoS ONEمصطلحات موضوعية: Male, medicine.medical_specialty, lcsh:Medicine, Exercise intolerance, Nicotinamide adenine dinucleotide, CD38, Cofactor, Energy homeostasis, Mice, chemistry.chemical_compound, Metabolic Diseases, Physical Conditioning, Animal, Internal medicine, medicine, Animals, ADP-ribosyl Cyclase, Muscle, Skeletal, lcsh:Science, Mice, Knockout, chemistry.chemical_classification, Cyclic ADP-Ribose, Multidisciplinary, biology, lcsh:R, NAD, ADP-ribosyl Cyclase 1, Mice, Inbred C57BL, Endocrinology, Enzyme, chemistry, Diet, Western, Knockout mouse, biology.protein, lcsh:Q, NAD+ kinase, medicine.symptom, Oxidation-Reduction, Research Article