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المؤلفون: Andrew G. Leach, John G. Cumming, Philip A. MacFaul
المصدر: MedChemComm. 6:2140-2145
مصطلحات موضوعية: Pharmacology, Nucleophilic addition, medicine.drug_class, Stereochemistry, Chemistry, Organic Chemistry, Pharmaceutical Science, Carboxamide, Glutathione, Biochemistry, Tautomer, Piperazine, chemistry.chemical_compound, Deprotonation, Drug Discovery, medicine, Molecular Medicine
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::87b4a7edcca99785efcb49fe34960bb3
https://doi.org/10.1039/c5md00362h -
2
المؤلفون: Paul A. Bethel, Kurt Gordon Pike, Alan C. Reid, Wendy L. Snelson, John G. Cumming, Stefan Gerhardt, Richard A. Pauptit, Dearg S. Brown, Thompson Caroline Rachel, Nash Ian Alun, Jonathan E. Finlayson, Steve Swallow
المصدر: Bioorganic & Medicinal Chemistry Letters. 22:3879-3883
مصطلحات موضوعية: Models, Molecular, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Plasma protein binding, Crystallography, X-Ray, Biochemistry, Piperazines, Mitogen-Activated Protein Kinase 14, Structure-Activity Relationship, chemistry.chemical_compound, Dogs, Aniline, Drug Discovery, Animals, Humans, Structure–activity relationship, Transferase, Benzamide, Protein Kinase Inhibitors, Molecular Biology, Quinazolinone, Inflammation, biology, Chemistry, Drug discovery, Anti-Inflammatory Agents, Non-Steroidal, Organic Chemistry, Blood Proteins, Rats, Molecular Weight, Solubility, Mitogen-activated protein kinase, biology.protein, Molecular Medicine, Protein Binding
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3
المؤلفون: John S. Shaw, Martin Wild, Dearg S. Brown, Howard Tucker, Adrian John Highton, Alan Wellington Faull, John Oldfield, John G. Cumming, Colin Fielding, Stuart L. Wells
المصدر: Bioorganic & Medicinal Chemistry Letters. 22:1655-1659
مصطلحات موضوعية: ERG1 Potassium Channel, Receptors, CCR5, Clinical Biochemistry, hERG, Benzeneacetamides, Administration, Oral, Pharmaceutical Science, Arthritis, CCR5 receptor antagonist, Pharmacology, Biochemistry, Absorption, Arthritis, Rheumatoid, Inhibitory Concentration 50, Drug Discovery, medicine, Humans, Potency, Receptor, Molecular Biology, Ion channel, Sulfonamides, Molecular Structure, biology, Drug discovery, Chemistry, Organic Chemistry, medicine.disease, Ether-A-Go-Go Potassium Channels, CCR5 Receptor Antagonists, Lipophilicity, biology.protein, Molecular Medicine, Protein Binding
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4
المؤلفون: Sarah L. Rodgers, David Wood, Andrew M. Davis, David Buttar, John G. Cumming, Ulf Norinder
المصدر: Molecular Informatics. 30:960-972
مصطلحات موضوعية: Quantitative structure–activity relationship, Hierarchy (mathematics), Computer science, business.industry, Model selection, Organic Chemistry, Global strategy, computer.software_genre, Machine learning, Global model, Computer Science Applications, Structural Biology, Human plasma, Drug Discovery, Molecular Medicine, Artificial intelligence, Data mining, business, computer, Selection (genetic algorithm)
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المؤلفون: Stefan Gerhardt, Andrew Pape, Christopher D. Davies, Attilla Ting, Scott G. Lamont, David Milne, Chris De Savi, Peter R. Moore, Jeremy N. Burrows, Yvonne Sawyer, Mark Mills, John G. Cumming, Calum Cook, Peter D. Smith
المصدر: Bioorganic & Medicinal Chemistry Letters. 21:1376-1381
مصطلحات موضوعية: Models, Molecular, Quantitative structure–activity relationship, Clinical Biochemistry, Anti-Inflammatory Agents, Quantitative Structure-Activity Relationship, Pharmaceutical Science, Biochemistry, Chemical synthesis, Inhibitory Concentration 50, chemistry.chemical_compound, Enzyme activator, In vivo, Osteoarthritis, Drug Discovery, Humans, Molecular Biology, chemistry.chemical_classification, Hydroxamic acid, Formamides, biology, Chemistry, Organic Chemistry, ADAM Proteins, Enzyme Activation, carbohydrates (lipids), Enzyme, Enzyme inhibitor, Drug Design, ADAMTS4 Protein, biology.protein, Molecular Medicine, Procollagen N-Endopeptidase
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6
المؤلفون: Tito Akindele, John G. Cumming, Stephen P. Marsden
المصدر: Tetrahedron Letters. 46:7235-7238
مصطلحات موضوعية: chemistry.chemical_classification, Stereochemistry, Organic Chemistry, Enantioselective synthesis, Substituent, Biochemistry, Aldehyde, Cyclopropane, chemistry.chemical_compound, chemistry, Intramolecular force, Drug Discovery, Michael reaction, Enone, Isopropyl
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7
المؤلفون: Stephen P. Marsden, Tito Akindele, John G. Cumming
المصدر: Organic Letters. 7:3685-3688
مصطلحات موضوعية: Aldehydes, Molecular Structure, Siloxanes, Stereochemistry, Chemistry, Aryl, Organic Chemistry, Condensation, Virgatusin, Stereoisomerism, General Medicine, Biochemistry, Lignans, chemistry.chemical_compound, Molecule, Organic chemistry, Stereoselectivity, Lewis acids and bases, Physical and Theoretical Chemistry, Furans
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المؤلفون: Fredrik Edfeldt, John G. Cumming, Stuart L. Wells, Martin Harrison, Scott G. Lamont, Michael James, Emma Evertsson, Keith Oldham, Jane E. Sullivan, Geoffrey A. Holdgate, Judit E. Debreczeni
المصدر: Journal of medicinal chemistry. 58(1)
مصطلحات موضوعية: Models, Molecular, Magnetic Resonance Spectroscopy, MAP Kinase Kinase 2, Plasma protein binding, Crystallography, X-Ray, Binding, Competitive, Ribosomal Protein S6 Kinases, 90-kDa, Substrate Specificity, Mitogen-Activated Protein Kinase 14, Structure-Activity Relationship, Protein structure, Adenosine Triphosphate, Drug Discovery, Structure–activity relationship, Humans, Enzyme kinetics, Binding site, Surface plasmon resonance, Phosphorylation, Protein Kinase Inhibitors, Cells, Cultured, Dose-Response Relationship, Drug, Molecular Structure, Chemistry, Drug discovery, Kinase, Surface Plasmon Resonance, Protein Structure, Tertiary, Enzyme Activation, Kinetics, Biochemistry, Models, Chemical, Molecular Medicine, Protein Binding
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9
المؤلفون: John G. Cumming, Hongming Chen, Mats Eriksson, Ingemar Nilsson, J. Willem M. Nissink, Lars Carlsson
المصدر: Journal of chemical information and modeling. 54(4)
مصطلحات موضوعية: Scheme (programming language), Quantitative structure–activity relationship, Support Vector Machine, General Chemical Engineering, Fingerprint (computing), Quantitative Structure-Activity Relationship, General Chemistry, Library and Information Sciences, computer.software_genre, Signature (logic), Computer Science Applications, Support vector machine, Nonlinear system, Nonlinear Dynamics, Encoding (memory), Data mining, computer, Interpretability, computer.programming_language, Mathematics
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المؤلفون: Martin Hemmerling, Michael J. Waring, Fabrizio Giordanetto, Troy Lister, John G. Cumming, H Sanganee, Mrv Finlay
المصدر: Future medicinal chemistry. 6(5)
مصطلحات موضوعية: Drug Industry, Computer science, Polypharmacology, Process improvement, Drug Evaluation, Preclinical, Receptors, Cell Surface, Small Molecule Libraries, Drug Discovery, Animals, Humans, Pharmacokinetics, Clinical failure, Lean Six Sigma, Productivity, Pharmaceutical industry, Pharmacology, business.industry, Drug discovery, Biotechnology, Enzymes, Disease Models, Animal, Phenotype, Drug Design, Molecular mechanism, Molecular Medicine, Biochemical engineering, business