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1
المؤلفون: Hong Wu, Gary L. Schieven, Joel C. Barrish, Bei Wang, Bang Chi Chen, Sam T. Chao, Gerry Everlof, Jung Hui Sun, Chunjian Liu, John H. Dodd, Murray McKinnon, Kathleen M. Gillooly, Katerina Leftheris, John Hynes, Tracy L. Taylor, Vivekananda M. Vrudhula, T. G. Murali Dhar, Stephen T. Wrobleski, Hongjian Zhang, David J. Shuster, Shuqun Lin, Kim W. McIntyre, Rulin Zhao, Christoph Gesenberg, James Lin, Punit Marathe
المصدر: Journal of Medicinal Chemistry. 58:7775-7784
مصطلحات موضوعية: Male, Phenylacetates, Stereochemistry, Phenyl acetate, Drug Evaluation, Preclinical, Administration, Oral, Biological Availability, Chemistry Techniques, Synthetic, Mitogen-Activated Protein Kinase 14, Rats, Sprague-Dawley, Structure-Activity Relationship, Acetic acid, chemistry.chemical_compound, In vivo, Drug Discovery, Animals, Structure–activity relationship, Prodrugs, Protein Kinase Inhibitors, Triazine, Dose-Response Relationship, Drug, Molecular Structure, Prodrug, Arthritis, Experimental, Organophosphates, Macaca fascicularis, Solubility, chemistry, Rats, Inbred Lew, Molecular Medicine, Alkaline phosphatase
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2
المؤلفون: Sium Habte, Mark D. Cunningham, Cullen L. Cavallaro, T. G. Murali Dhar, John H. Dodd, Arthur M. Doweyko, James E. Sheppeck, Joel C. Barrish, Jim Wang, John E. Somerville, Lorraine I. McKay, John L. Gilmore, Steven G. Nadler
المصدر: Bioorganic & Medicinal Chemistry Letters. 23:5448-5451
مصطلحات موضوعية: Models, Molecular, Agonist, Indazoles, medicine.drug_class, Clinical Biochemistry, Pharmaceutical Science, Pharmacology, Biochemistry, Partial agonist, Structure-Activity Relationship, chemistry.chemical_compound, Receptors, Glucocorticoid, Glucocorticoid receptor, Drug Discovery, Glucocorticoid Receptor Agonists, medicine, Humans, Urea, Molecular Biology, Sulfonamides, Indazole, Chemistry, Organic Chemistry, In vitro toxicology, Amides, Cell biology, Nuclear receptor, Molecular Medicine, Protein Binding
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3
المؤلفون: John H. Dodd, John L. Gilmore, Joel C. Barrish, Hai Yun Xiao, Jack S. Sack, Martin J. Corbett, James E. Sheppeck, Mark D. Cunningham, Mary F. Malley, John E. Somerville, Lorraine I. McKay, Jack Z. Gougoutas, Steven G. Nadler, David S. Nirschl, Sium Habte, T. G. Murali Dhar, Arthur M. Doweyko
المصدر: Bioorganic & Medicinal Chemistry Letters. 23:5442-5447
مصطلحات موضوعية: Agonist, Indazoles, medicine.drug_class, Clinical Biochemistry, Pharmaceutical Science, Pharmacology, Crystallography, X-Ray, Biochemistry, Structure-Activity Relationship, chemistry.chemical_compound, Receptors, Glucocorticoid, Amide, Drug Discovery, medicine, Humans, Potency, Molecular Biology, Indazole, Binding Sites, Nonsteroidal, Molecular Structure, Organic Chemistry, In vitro toxicology, Amides, chemistry, Nuclear receptor, Molecular Medicine, Steroids, Glucocorticoid, Protein Binding, medicine.drug
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4
المؤلفون: Kevin Kish, Tianle Li, Shuqun Lin, Yi Fan, Alaric J. Dyckman, John H. Dodd, Murray McKinnon, Rosemary Zhang, John S. Sack, Katerina Leftheris, John S. Tokarski, T. G. Murali Dhar, Gary L. Schieven, Susan E. Kiefer, Arthur M. Doweyko, Joel C. Barrish, Mark R. Witmer, Stephen T. Wrobleski, Sidney Pitt, John A. Newitt
المصدر: Bioorganic & Medicinal Chemistry Letters. 23:4120-4126
مصطلحات موضوعية: Gene isoform, Clinical Biochemistry, Pharmaceutical Science, Peptide, Molecular Dynamics Simulation, Crystallography, X-Ray, Biochemistry, Mitogen-Activated Protein Kinase 14, Structure-Activity Relationship, Drug Discovery, Humans, Protein Isoforms, Protein Kinase Inhibitors, Molecular Biology, chemistry.chemical_classification, Binding Sites, biology, Kinase, Chemistry, Organic Chemistry, Rational design, Hydrogen Bonding, Protein Structure, Tertiary, Flip, Mitogen-activated protein kinase, biology.protein, Molecular Medicine, Cyclin-dependent kinase 9, Kinase binding, Protein Binding
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5
المؤلفون: Michael Galella, Gary L. Schieven, Chunjian Liu, Joel C. Barrish, Punit Marathe, Mary F. Malley, James Lin, Hongjian Zhang, Gerry Everlof, John H. Dodd, Murray McKinnon, Katerina Leftheris, Christoph Gesenberg
المصدر: Bioorganic & Medicinal Chemistry Letters. 23:3028-3033
مصطلحات موضوعية: Models, Molecular, Drug, Fumaric acid, media_common.quotation_subject, Clinical Biochemistry, Pharmaceutical Science, Crystallography, X-Ray, p38 Mitogen-Activated Protein Kinases, Biochemistry, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, Animals, Structure–activity relationship, Organic chemistry, Prodrugs, Pyrroles, Solubility, Neutral ph, Protein Kinase Inhibitors, Molecular Biology, media_common, Dose-Response Relationship, Drug, Molecular Structure, Triazines, Organic Chemistry, Temperature, Hydrogen-Ion Concentration, Prodrug, Combinatorial chemistry, Rats, Dacarbazine, chemistry, Molecular Medicine
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6
المؤلفون: William J. Pitts, Alaric J. Dyckman, Scott H. Watterson, Robert V. Moquin, Kim W. McIntyre, Zheng Yang, Jagabandhu Das, Katy Van Kirk, James R. Burke, David B. Wang-Iverson, Hollie Booth-Lute, James Kempson, Laishun Chen, Charles M. Langevine, Joel C. Barrish, Guchen Yang, Xiaoxia Yang, John H. Dodd, David S. Nirschl, Murray McKinnon, Steven H. Spergel, Mark A. Pattoli, Michael Galella, Kurt R. Gregor, Junquing Guo
المصدر: Bioorganic & Medicinal Chemistry Letters. 21:7006-7012
مصطلحات موضوعية: Stereochemistry, Clinical Biochemistry, Administration, Oral, Pharmaceutical Science, Biochemistry, Inhibitory Concentration 50, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Acetamides, Drug Discovery, Animals, Humans, Inhibitory concentration 50, Structure–activity relationship, Potency, Enzyme Inhibitors, Molecular Biology, chemistry.chemical_classification, Molecular Structure, Drug discovery, Organic Chemistry, Inflammatory Bowel Diseases, In vitro, I-kappa B Kinase, Rats, Enzyme Activation, chemistry, Molecular Medicine, Heterocyclic Compounds, 3-Ring, Acetamide, Tricyclic
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7
المؤلفون: Hua Gong, Ling Gao, Joel C. Barrish, Mark D. Cunningham, Sium Habte, Julie Carman, John E. Somerville, Steven G. Nadler, Christine Burke, John H. Dodd, Jin Hong Wang, Victor R. Guarino, Arthur M. Doweyko, David J. Shuster, David S. Weinstein, Deborah A. Holloway, Luisa Salter-Cid
المصدر: Journal of Medicinal Chemistry. 54:7318-7333
مصطلحات موضوعية: Male, Models, Molecular, Transcriptional Activation, Agonist, medicine.drug_class, Stereochemistry, Interleukin-1beta, Stereoisomerism, In Vitro Techniques, Response Elements, Partial agonist, Rats, Sprague-Dawley, Structure-Activity Relationship, Transactivation, Receptors, Glucocorticoid, Glucocorticoid receptor, Glutamate-Ammonia Ligase, Cell Line, Tumor, Thiadiazoles, Drug Discovery, medicine, Animals, Edema, Humans, Structure–activity relationship, Receptor, Tyrosine Transaminase, Transrepression, Tumor Necrosis Factor-alpha, Chemistry, Anti-Inflammatory Agents, Non-Steroidal, Alkaline Phosphatase, Arthritis, Experimental, Rats, Drug Partial Agonism, Transcription Factor AP-1, Rats, Inbred Lew, Molecular Medicine, Heterocyclic Compounds, 3-Ring
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8
المؤلفون: Robert M. Townsend, Hai Yun Xiao, Joel C. Barrish, Sium Habte, Arthur M. Doweyko, Steven G. Nadler, Hua Gong, Bingwei V. Yang, John H. Dodd, Tram N. Huynh, John E. Somerville, Mark D. Cunningham, Lorraine I. McKay, David J. Shuster, Michele McMahon, David S. Weinstein, Lidia M. Doweyko, Wayne Vaccaro, Deborah A. Holloway
المصدر: Journal of Medicinal Chemistry. 53:8241-8251
مصطلحات موضوعية: Models, Molecular, Agonist, medicine.medical_specialty, Nonsteroidal, medicine.drug_class, Pharmacology, Amides, Propanamide, Rats, chemistry.chemical_compound, Transactivation, Receptors, Glucocorticoid, Endocrinology, Glucocorticoid receptor, Tyrosine aminotransferase, chemistry, Internal medicine, Drug Discovery, medicine, Prednisolone, Animals, Molecular Medicine, medicine.drug, Transrepression
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9
المؤلفون: Rosemary Zhang, Mary F. Malley, Sidney Pitt, John S. Sack, Gary L. Schieven, Susan E. Kiefer, Stephen T. Wrobleski, John A. Newitt, James M. Trzaskos, Kevin Kish, Shuqun Lin, Joel C. Barrish, John H. Dodd, Murray McKinnon, Katerina Leftheris, John Hynes, Arthur M. Doweyko, Yi Fan
المصدر: Bioorganic & Medicinal Chemistry Letters. 20:5864-5868
مصطلحات موضوعية: Molecular model, Nitrogen, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, chemistry.chemical_element, Crystallography, X-Ray, Biochemistry, Chemical synthesis, Mitogen-Activated Protein Kinase 14, Structure-Activity Relationship, Drug Discovery, Protein Kinase Inhibitors, Molecular Biology, chemistry.chemical_classification, Binding Sites, biology, Organic Chemistry, Active site, Sulfur, Protein Structure, Tertiary, Thiazoles, Pyrimidines, Enzyme, chemistry, Enzyme inhibitor, Drug Design, Intramolecular force, Mitogen-activated protein kinase, biology.protein, Molecular Medicine
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10
المؤلفون: Jack Z. Gougoutas, T. G. Murali Dhar, Mark D. Cunningham, Sium Habte, Mary F. Malley, Hai Yun Xiao, Steven G. Nadler, John E. Somerville, Dauh Rurng Wu, John H. Dodd, Joel C. Barrish
المصدر: Journal of Medicinal Chemistry. 53:1270-1280
مصطلحات موضوعية: Transcriptional Activation, Transcription, Genetic, Stereochemistry, Partial agonist, Dexamethasone, Structure-Activity Relationship, chemistry.chemical_compound, Transactivation, Receptors, Glucocorticoid, Glucocorticoid receptor, Genes, Reporter, Drug Discovery, Humans, Imidazole, Moiety, Isoquinoline, Promoter Regions, Genetic, Lung, Molecular Structure, Isoquinolines, In vitro, chemistry, Molecular Medicine, Stereoselectivity, E-Selectin, HeLa Cells
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