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1
المؤلفون: Alaric J. Dyckman, Lois D. Lehman-McKeeman, Huadong Sun, Hong Shi, Mary Ellen Cvijic, Ding Ren Shen, Xiaoxia Yang, Michael Yang, Tracy L. Taylor, Hai-Yun Xiao, Zili Xiao, Luisa Salter-Cid, Jian Pang, Percy H. Carter, Paul Levesque, Arvind Mathur, John L. Gilmore, Jenny Xie, T. G. Murali Dhar, Georgia Cornelius, Anthony M. Marino, Kim W. McIntyre, Bethanne M. Warrack
المصدر: Journal of Medicinal Chemistry. 64:1454-1480
مصطلحات موضوعية: Chemistry, Metabolite, Arthritis, Pharmacology, medicine.disease, Ligand (biochemistry), chemistry.chemical_compound, Immune system, Pharmacokinetics, In vivo, Drug Discovery, medicine, Molecular Medicine, Receptor, PK/PD models
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2
المؤلفون: John L. Gilmore, Kim W. McIntyre, Lois D. Lehman-McKeeman, David Marcoux, Hai-Yun Xiao, Georgia Cornelius, Alaric J. Dyckman, Mary Ellen Cvijic, Jenny Xie, Yang Michael G, T. G. Murali Dhar, Zili Xiao, Tracy L. Taylor, Anthony M. Marino, Ding Ren Shen, Percy H. Carter, Paul Levesque, Arvind Mathur, Huadong Sun, Hong Shi
المصدر: ACS Med Chem Lett
مصطلحات موضوعية: Bicyclic molecule, 010405 organic chemistry, Stereochemistry, Aryl, Sphingosine-1-phosphate receptor, Organic Chemistry, Ether, 01 natural sciences, Biochemistry, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, chemistry.chemical_compound, chemistry, In vivo, Drug Discovery, Potency, PK/PD models, ED50
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3
المؤلفون: Lloyd Lecureux, Elizabeth M. Heimrich, Rochelle Thomas, Lois D. Lehman-McKeeman, Hai-Yun Xiao, Georgia Cornelius, Zheng Yang, Alaric J. Dyckman, Anuradha Gupta, Percy H. Carter, Yu-Wen Li, Paul Levesque, Tracy L. Taylor, Zili Xiao, Mary Ellen Cvijic, Arvind Mathur, John L. Gilmore, Lei Gong, Jenny Xie, Marta Dabros, Ding Ren Shen, Xiaoxia Yang, T. G. Murali Dhar, Xia D. Zhou, Yang Michael G, Bala Pragalathan, Huadong Sun, Anthony M. Marino, Hong Shi, Dauh-Rurng Wu, Richard Rampulla, Kim W. McIntyre, Cliff Chen, Luisa Salter-Cid, Bethanne M. Warrack, Celia D’Arienzo, Virna Borowski
المصدر: Journal of Medicinal Chemistry. 62:2265-2285
مصطلحات موضوعية: Agonist, 0303 health sciences, medicine.drug_class, Sphingosine-1-phosphate receptor, Metabolite, Pharmacology, 01 natural sciences, Fingolimod, Partial agonist, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, 03 medical and health sciences, chemistry.chemical_compound, chemistry, Pharmacokinetics, In vivo, Pharmacodynamics, Drug Discovery, medicine, Molecular Medicine, 030304 developmental biology, medicine.drug
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4
المؤلفون: John L, Gilmore, Hai-Yun, Xiao, T G Murali, Dhar, Michael, Yang, Zili, Xiao, Xiaoxia, Yang, Tracy L, Taylor, Kim W, McIntyre, Bethanne M, Warrack, Hong, Shi, Paul C, Levesque, Anthony M, Marino, Georgia, Cornelius, Arvind, Mathur, Ding Ren, Shen, Jian, Pang, Mary Ellen, Cvijic, Lois D, Lehman-McKeeman, Huadong, Sun, Jenny, Xie, Luisa, Salter-Cid, Percy H, Carter, Alaric J, Dyckman
المصدر: Journal of medicinal chemistry. 64(3)
مصطلحات موضوعية: Lung Diseases, Male, Serine Endopeptidases, Drug Evaluation, Preclinical, Arthritis, Experimental, Autoimmune Diseases, Rats, Bridged Bicyclo Compounds, Chemotaxis, Leukocyte, Structure-Activity Relationship, Rats, Inbred Lew, Animals, Humans, Myocytes, Cardiac, Proprotein Convertases, Phosphorylation, Bronchoalveolar Lavage Fluid, Biotransformation, Half-Life
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5
المؤلفون: Alaric J. Dyckman, Bang-Chi Chen, Percy H. Carter, Zhiwei Guo, Amarjit Singh, John L. Gilmore, James E. Sheppeck, Animesh Goswami, Huiping Zhang, Xiaoping Hou, Arvind Mathur
المصدر: Organic Process Research & Development. 21:200-207
مصطلحات موضوعية: Agonist, Trifluoromethyl, 010405 organic chemistry, medicine.drug_class, Stereochemistry, Organic Chemistry, Epoxide, Regioselectivity, Alcohol, 010402 general chemistry, 01 natural sciences, 0104 chemical sciences, Benzonitrile, chemistry.chemical_compound, Stereospecificity, chemistry, medicine, Physical and Theoretical Chemistry, Isoxazole
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6
المؤلفون: Ding Ren Shen, Mary Ellen Cvijic, Hai-Yun Xiao, Alaric J. Dyckman, Yu-Wen Li, Bala Pragalathan, Joel C. Barrish, Georgia Cornelius, Peng Li, Tracy L. Taylor, Zili Xiao, Lois D. Lehman-McKeeman, Jianlin Feng, Dauh-Rurng Wu, John L. Gilmore, Percy H. Carter, David Marcoux, Zheng Yang, Arvind Mathur, Elizabeth M. Heimrich, Kim W. McIntyre, Bethanne M. Warrack, Anuradha Gupta, Yang Michael G, Luisa Salter-Cid, Praveen Balimane, Virna Borowski, Jenny Xie, T. G. Murali Dhar, Alda Fernandes, Anthony M. Marino
المصدر: Journal of Medicinal Chemistry. 59:11138-11147
مصطلحات موضوعية: 0301 basic medicine, chemistry.chemical_classification, Alkene, S1p1 receptor, Stereochemistry, Combinatorial chemistry, Brain Cell, 03 medical and health sciences, chemistry.chemical_compound, Hydroboration, 030104 developmental biology, 0302 clinical medicine, Lysophosphatidylcholine, chemistry, Drug Discovery, Molecular Medicine, Methanol, 030217 neurology & neurosurgery
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7
المؤلفون: John L, Gilmore, Hai-Yun, Xiao, T G Murali, Dhar, Michael G, Yang, Zili, Xiao, Jenny, Xie, Lois D, Lehman-McKeeman, Lei, Gong, Huadong, Sun, Lloyd, Lecureux, Cliff, Chen, Dauh-Rurng, Wu, Marta, Dabros, Xiaoxia, Yang, Tracy L, Taylor, Xia D, Zhou, Elizabeth M, Heimrich, Rochelle, Thomas, Kim W, McIntyre, Virna, Borowski, Bethanne M, Warrack, Yuwen, Li, Hong, Shi, Paul C, Levesque, Zheng, Yang, Anthony M, Marino, Georgia, Cornelius, Celia J, D'Arienzo, Arvind, Mathur, Richard, Rampulla, Anuradha, Gupta, Bala, Pragalathan, Ding Ren, Shen, Mary Ellen, Cvijic, Luisa M, Salter-Cid, Percy H, Carter, Alaric J, Dyckman
المصدر: Journal of medicinal chemistry. 62(5)
مصطلحات موضوعية: Clinical Trials as Topic, Dose-Response Relationship, Drug, Tetrahydronaphthalenes, Rats, Inbred Lew, Animals, Humans, Naphthalenes, Bronchoalveolar Lavage Fluid, Sphingosine-1-Phosphate Receptors, Half-Life, Rats
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8
المؤلفون: John L. Gilmore, Georgia Cornelius, Mary Ellen Cvijic, Jenny Xie, Lauren Haque, Andrew J. Tebben, Luisa Salter-Cid, Alaric J. Dyckman, Praveen Balimane, Paul Levesque, Anthony M. Marino, Percy H. Carter, Julia P. Li, Michael Galella, Kathleen M. Gillooly, Kim W. McIntyre, Virna Borowski, Joel C. Barrish, Bethanne M. Warrack, Celia D’Arienzo, William J. Pitts, Parag Mukhopadhyay, Scott H. Watterson, Ding Ren Shen, Melissa Yarde, James E. Sheppeck, Tracy L. Taylor
المصدر: Journal of Medicinal Chemistry. 59:6248-6264
مصطلحات موضوعية: Male, 0301 basic medicine, Encephalomyelitis, Autoimmune, Experimental, Lymphocyte, Metabolite, Carboxylic acid, Inflammation, Pharmacology, 01 natural sciences, Mice, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, Dogs, Ethanolamine, Drug Discovery, medicine, Animals, Humans, Structure–activity relationship, Lymphocyte Count, Lymphocytes, Sphingosine-1-phosphate, chemistry.chemical_classification, 010405 organic chemistry, Chemistry, Arthritis, Haplorhini, Sphingolipid, Rats, 0104 chemical sciences, Mice, Inbred C57BL, Receptors, Lysosphingolipid, 030104 developmental biology, medicine.anatomical_structure, Rats, Inbred Lew, Molecular Medicine, Female, medicine.symptom
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9
المؤلفون: Michael G, Yang, Zili, Xiao, T G Murali, Dhar, Hai-Yun, Xiao, John L, Gilmore, David, Marcoux, Jenny H, Xie, Kim W, McIntyre, Tracy L, Taylor, Virna, Borowski, Elizabeth, Heimrich, Yu-Wen, Li, Jianlin, Feng, Alda, Fernandes, Zheng, Yang, Praveen, Balimane, Anthony M, Marino, Georgia, Cornelius, Bethanne M, Warrack, Arvind, Mathur, Dauh-Rurng, Wu, Peng, Li, Anuradha, Gupta, Bala, Pragalathan, Ding Ren, Shen, Mary Ellen, Cvijic, Lois D, Lehman-McKeeman, Luisa, Salter-Cid, Joel C, Barrish, Percy H, Carter, Alaric J, Dyckman
المصدر: Journal of medicinal chemistry. 59(24)
مصطلحات موضوعية: Mice, Inbred BALB C, Encephalomyelitis, Autoimmune, Experimental, Dose-Response Relationship, Drug, Molecular Structure, Naphthalenes, Mice, Inbred C57BL, Disease Models, Animal, Mice, Receptors, Lysosphingolipid, Structure-Activity Relationship, HEK293 Cells, Animals, Humans, Female, Lymphocytes, Cells, Cultured
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10
المؤلفون: Hai-Yun, Xiao, Scott H, Watterson, Charles M, Langevine, Anurag S, Srivastava, Soo S, Ko, Yanlei, Zhang, Robert J, Cherney, Wei-Wei, Guo, John L, Gilmore, James E, Sheppeck, Dauh-Rurng, Wu, Peng, Li, Duraisamy, Ramasamy, Piramanayagam, Arunachalam, Arvind, Mathur, Tracy L, Taylor, David J, Shuster, Kim W, McIntyre, Ding-Ren, Shen, Melissa, Yarde, Mary Ellen, Cvijic, Anthony M, Marino, Praveen V, Balimane, Zheng, Yang, Dana M, Banas, Georgia, Cornelius, Celia J, D'Arienzo, Bethanne M, Warrack, Lois, Lehman-McKeeman, Luisa M, Salter-Cid, Jenny, Xie, Joel C, Barrish, Percy H, Carter, Alaric J, Dyckman, T G Murali, Dhar
المصدر: Journal of medicinal chemistry. 59(21)
مصطلحات موضوعية: Male, Dose-Response Relationship, Drug, Molecular Structure, Fingolimod Hydrochloride, Freund's Adjuvant, Ligands, Arthritis, Experimental, Mycobacterium, Rats, Macaca fascicularis, Mice, Receptors, Lysosphingolipid, Structure-Activity Relationship, Dogs, Rats, Inbred Lew, Drug Design, Animals, Tissue Distribution, Lymphocytes, Heterocyclic Compounds, 3-Ring