المؤلفون: Alaric J. Dyckman, Lois D. Lehman-McKeeman, Huadong Sun, Hong Shi, Mary Ellen Cvijic, Ding Ren Shen, Xiaoxia Yang, Michael Yang, Tracy L. Taylor, Hai-Yun Xiao, Zili Xiao, Luisa Salter-Cid, Jian Pang, Percy H. Carter, Paul Levesque, Arvind Mathur, John L. Gilmore, Jenny Xie, T. G. Murali Dhar, Georgia Cornelius, Anthony M. Marino, Kim W. McIntyre, Bethanne M. Warrack

المصدر: Journal of Medicinal Chemistry. 64:1454-1480

مصطلحات موضوعية: Chemistry, Metabolite, Arthritis, Pharmacology, medicine.disease, Ligand (biochemistry), chemistry.chemical_compound, Immune system, Pharmacokinetics, In vivo, Drug Discovery, medicine, Molecular Medicine, Receptor, PK/PD models

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::3c93ac373a666f79bb2e7b408fdbd2fc
https://doi.org/10.1021/acs.jmedchem.0c01109

المؤلفون: John L. Gilmore, Kim W. McIntyre, Lois D. Lehman-McKeeman, David Marcoux, Hai-Yun Xiao, Georgia Cornelius, Alaric J. Dyckman, Mary Ellen Cvijic, Jenny Xie, Yang Michael G, T. G. Murali Dhar, Zili Xiao, Tracy L. Taylor, Anthony M. Marino, Ding Ren Shen, Percy H. Carter, Paul Levesque, Arvind Mathur, Huadong Sun, Hong Shi

المصدر: ACS Med Chem Lett

مصطلحات موضوعية: Bicyclic molecule, 010405 organic chemistry, Stereochemistry, Aryl, Sphingosine-1-phosphate receptor, Organic Chemistry, Ether, 01 natural sciences, Biochemistry, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, chemistry.chemical_compound, chemistry, In vivo, Drug Discovery, Potency, PK/PD models, ED50

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::415fc075f357363f95afa2908797c5ae
https://doi.org/10.1021/acsmedchemlett.0c00333

المؤلفون: Lloyd Lecureux, Elizabeth M. Heimrich, Rochelle Thomas, Lois D. Lehman-McKeeman, Hai-Yun Xiao, Georgia Cornelius, Zheng Yang, Alaric J. Dyckman, Anuradha Gupta, Percy H. Carter, Yu-Wen Li, Paul Levesque, Tracy L. Taylor, Zili Xiao, Mary Ellen Cvijic, Arvind Mathur, John L. Gilmore, Lei Gong, Jenny Xie, Marta Dabros, Ding Ren Shen, Xiaoxia Yang, T. G. Murali Dhar, Xia D. Zhou, Yang Michael G, Bala Pragalathan, Huadong Sun, Anthony M. Marino, Hong Shi, Dauh-Rurng Wu, Richard Rampulla, Kim W. McIntyre, Cliff Chen, Luisa Salter-Cid, Bethanne M. Warrack, Celia D’Arienzo, Virna Borowski

المصدر: Journal of Medicinal Chemistry. 62:2265-2285

مصطلحات موضوعية: Agonist, 0303 health sciences, medicine.drug_class, Sphingosine-1-phosphate receptor, Metabolite, Pharmacology, 01 natural sciences, Fingolimod, Partial agonist, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, 03 medical and health sciences, chemistry.chemical_compound, chemistry, Pharmacokinetics, In vivo, Pharmacodynamics, Drug Discovery, medicine, Molecular Medicine, 030304 developmental biology, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::15b124723f06570a19365c4eb5d204b0
https://doi.org/10.1021/acs.jmedchem.8b01695

المؤلفون: John L, Gilmore, Hai-Yun, Xiao, T G Murali, Dhar, Michael, Yang, Zili, Xiao, Xiaoxia, Yang, Tracy L, Taylor, Kim W, McIntyre, Bethanne M, Warrack, Hong, Shi, Paul C, Levesque, Anthony M, Marino, Georgia, Cornelius, Arvind, Mathur, Ding Ren, Shen, Jian, Pang, Mary Ellen, Cvijic, Lois D, Lehman-McKeeman, Huadong, Sun, Jenny, Xie, Luisa, Salter-Cid, Percy H, Carter, Alaric J, Dyckman

المصدر: Journal of medicinal chemistry. 64(3)

مصطلحات موضوعية: Lung Diseases, Male, Serine Endopeptidases, Drug Evaluation, Preclinical, Arthritis, Experimental, Autoimmune Diseases, Rats, Bridged Bicyclo Compounds, Chemotaxis, Leukocyte, Structure-Activity Relationship, Rats, Inbred Lew, Animals, Humans, Myocytes, Cardiac, Proprotein Convertases, Phosphorylation, Bronchoalveolar Lavage Fluid, Biotransformation, Half-Life

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::b171f99d63546ff1524adf2df0c96fa6
https://pubmed.ncbi.nlm.nih.gov/33492963

المؤلفون: Alaric J. Dyckman, Bang-Chi Chen, Percy H. Carter, Zhiwei Guo, Amarjit Singh, John L. Gilmore, James E. Sheppeck, Animesh Goswami, Huiping Zhang, Xiaoping Hou, Arvind Mathur

المصدر: Organic Process Research & Development. 21:200-207

مصطلحات موضوعية: Agonist, Trifluoromethyl, 010405 organic chemistry, medicine.drug_class, Stereochemistry, Organic Chemistry, Epoxide, Regioselectivity, Alcohol, 010402 general chemistry, 01 natural sciences, 0104 chemical sciences, Benzonitrile, chemistry.chemical_compound, Stereospecificity, chemistry, medicine, Physical and Theoretical Chemistry, Isoxazole

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::7f03408f0071ceb43a9b68457e03ff50
https://doi.org/10.1021/acs.oprd.6b00366

المؤلفون: Ding Ren Shen, Mary Ellen Cvijic, Hai-Yun Xiao, Alaric J. Dyckman, Yu-Wen Li, Bala Pragalathan, Joel C. Barrish, Georgia Cornelius, Peng Li, Tracy L. Taylor, Zili Xiao, Lois D. Lehman-McKeeman, Jianlin Feng, Dauh-Rurng Wu, John L. Gilmore, Percy H. Carter, David Marcoux, Zheng Yang, Arvind Mathur, Elizabeth M. Heimrich, Kim W. McIntyre, Bethanne M. Warrack, Anuradha Gupta, Yang Michael G, Luisa Salter-Cid, Praveen Balimane, Virna Borowski, Jenny Xie, T. G. Murali Dhar, Alda Fernandes, Anthony M. Marino

المصدر: Journal of Medicinal Chemistry. 59:11138-11147

مصطلحات موضوعية: 0301 basic medicine, chemistry.chemical_classification, Alkene, S1p1 receptor, Stereochemistry, Combinatorial chemistry, Brain Cell, 03 medical and health sciences, chemistry.chemical_compound, Hydroboration, 030104 developmental biology, 0302 clinical medicine, Lysophosphatidylcholine, chemistry, Drug Discovery, Molecular Medicine, Methanol, 030217 neurology & neurosurgery

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::ec587a5bf6e33d17913adf16699fae01
https://doi.org/10.1021/acs.jmedchem.6b01433

المؤلفون: John L, Gilmore, Hai-Yun, Xiao, T G Murali, Dhar, Michael G, Yang, Zili, Xiao, Jenny, Xie, Lois D, Lehman-McKeeman, Lei, Gong, Huadong, Sun, Lloyd, Lecureux, Cliff, Chen, Dauh-Rurng, Wu, Marta, Dabros, Xiaoxia, Yang, Tracy L, Taylor, Xia D, Zhou, Elizabeth M, Heimrich, Rochelle, Thomas, Kim W, McIntyre, Virna, Borowski, Bethanne M, Warrack, Yuwen, Li, Hong, Shi, Paul C, Levesque, Zheng, Yang, Anthony M, Marino, Georgia, Cornelius, Celia J, D'Arienzo, Arvind, Mathur, Richard, Rampulla, Anuradha, Gupta, Bala, Pragalathan, Ding Ren, Shen, Mary Ellen, Cvijic, Luisa M, Salter-Cid, Percy H, Carter, Alaric J, Dyckman

المصدر: Journal of medicinal chemistry. 62(5)

مصطلحات موضوعية: Clinical Trials as Topic, Dose-Response Relationship, Drug, Tetrahydronaphthalenes, Rats, Inbred Lew, Animals, Humans, Naphthalenes, Bronchoalveolar Lavage Fluid, Sphingosine-1-Phosphate Receptors, Half-Life, Rats

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::2623838f4dd29168bd6b1afa243e02b4
https://pubmed.ncbi.nlm.nih.gov/30785748

المؤلفون: John L. Gilmore, Georgia Cornelius, Mary Ellen Cvijic, Jenny Xie, Lauren Haque, Andrew J. Tebben, Luisa Salter-Cid, Alaric J. Dyckman, Praveen Balimane, Paul Levesque, Anthony M. Marino, Percy H. Carter, Julia P. Li, Michael Galella, Kathleen M. Gillooly, Kim W. McIntyre, Virna Borowski, Joel C. Barrish, Bethanne M. Warrack, Celia D’Arienzo, William J. Pitts, Parag Mukhopadhyay, Scott H. Watterson, Ding Ren Shen, Melissa Yarde, James E. Sheppeck, Tracy L. Taylor

المصدر: Journal of Medicinal Chemistry. 59:6248-6264

مصطلحات موضوعية: Male, 0301 basic medicine, Encephalomyelitis, Autoimmune, Experimental, Lymphocyte, Metabolite, Carboxylic acid, Inflammation, Pharmacology, 01 natural sciences, Mice, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, Dogs, Ethanolamine, Drug Discovery, medicine, Animals, Humans, Structure–activity relationship, Lymphocyte Count, Lymphocytes, Sphingosine-1-phosphate, chemistry.chemical_classification, 010405 organic chemistry, Chemistry, Arthritis, Haplorhini, Sphingolipid, Rats, 0104 chemical sciences, Mice, Inbred C57BL, Receptors, Lysosphingolipid, 030104 developmental biology, medicine.anatomical_structure, Rats, Inbred Lew, Molecular Medicine, Female, medicine.symptom

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6850f73bf5ddc401ad2b63a00b09ac54
https://doi.org/10.1021/acs.jmedchem.6b00373

المؤلفون: Michael G, Yang, Zili, Xiao, T G Murali, Dhar, Hai-Yun, Xiao, John L, Gilmore, David, Marcoux, Jenny H, Xie, Kim W, McIntyre, Tracy L, Taylor, Virna, Borowski, Elizabeth, Heimrich, Yu-Wen, Li, Jianlin, Feng, Alda, Fernandes, Zheng, Yang, Praveen, Balimane, Anthony M, Marino, Georgia, Cornelius, Bethanne M, Warrack, Arvind, Mathur, Dauh-Rurng, Wu, Peng, Li, Anuradha, Gupta, Bala, Pragalathan, Ding Ren, Shen, Mary Ellen, Cvijic, Lois D, Lehman-McKeeman, Luisa, Salter-Cid, Joel C, Barrish, Percy H, Carter, Alaric J, Dyckman

المصدر: Journal of medicinal chemistry. 59(24)

مصطلحات موضوعية: Mice, Inbred BALB C, Encephalomyelitis, Autoimmune, Experimental, Dose-Response Relationship, Drug, Molecular Structure, Naphthalenes, Mice, Inbred C57BL, Disease Models, Animal, Mice, Receptors, Lysosphingolipid, Structure-Activity Relationship, HEK293 Cells, Animals, Humans, Female, Lymphocytes, Cells, Cultured

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::4b2e1d408c29f4ffe886d0c98ba38169
https://pubmed.ncbi.nlm.nih.gov/28002964

المؤلفون: Hai-Yun, Xiao, Scott H, Watterson, Charles M, Langevine, Anurag S, Srivastava, Soo S, Ko, Yanlei, Zhang, Robert J, Cherney, Wei-Wei, Guo, John L, Gilmore, James E, Sheppeck, Dauh-Rurng, Wu, Peng, Li, Duraisamy, Ramasamy, Piramanayagam, Arunachalam, Arvind, Mathur, Tracy L, Taylor, David J, Shuster, Kim W, McIntyre, Ding-Ren, Shen, Melissa, Yarde, Mary Ellen, Cvijic, Anthony M, Marino, Praveen V, Balimane, Zheng, Yang, Dana M, Banas, Georgia, Cornelius, Celia J, D'Arienzo, Bethanne M, Warrack, Lois, Lehman-McKeeman, Luisa M, Salter-Cid, Jenny, Xie, Joel C, Barrish, Percy H, Carter, Alaric J, Dyckman, T G Murali, Dhar

المصدر: Journal of medicinal chemistry. 59(21)

مصطلحات موضوعية: Male, Dose-Response Relationship, Drug, Molecular Structure, Fingolimod Hydrochloride, Freund's Adjuvant, Ligands, Arthritis, Experimental, Mycobacterium, Rats, Macaca fascicularis, Mice, Receptors, Lysosphingolipid, Structure-Activity Relationship, Dogs, Rats, Inbred Lew, Drug Design, Animals, Tissue Distribution, Lymphocytes, Heterocyclic Compounds, 3-Ring

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::f9eb88b5ba2b222a1d206be47d1ac90e
https://pubmed.ncbi.nlm.nih.gov/27726358