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المؤلفون: Senuri Pathiranage, Iwao Ojima, Maurizio Del Poeta, Julia Zambito, Yi Sun, John P. Mallamo, Cristina Lazzarini, J. Brian McCarthy, Krupanandan Haranahalli
المصدر: J Med Chem
مصطلحات موضوعية: Antifungal, Drug, Antifungal Agents, medicine.drug_class, media_common.quotation_subject, Microbial Sensitivity Tests, 01 natural sciences, Article, Structure-Activity Relationship, 03 medical and health sciences, Drug Discovery, medicine, Structure–activity relationship, Candida, 030304 developmental biology, media_common, Voriconazole, Sphingolipids, 0303 health sciences, Dose-Response Relationship, Drug, Molecular Structure, Drug discovery, Chemistry, Aspergillus fumigatus, Hydrazones, Sphingolipid, 0104 chemical sciences, Sphingolipid synthesis, Fungicide, 010404 medicinal & biomolecular chemistry, Biochemistry, Molecular Medicine, medicine.drug
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المؤلفون: Caroline Mota Fernandes, Iwao Ojima, Maurizio Del Poeta, J. Brian McCarthy, John P. Mallamo, Krupanandan Haranahalli, Deveney Dasilva
المصدر: Antimicrob Agents Chemother
مصطلحات موضوعية: Antifungal Agents, Antifungal drug, Drug resistance, Bioinformatics, 03 medical and health sciences, High morbidity, chemistry.chemical_compound, Pharmacotherapy, Ergosterol, Drug Discovery, Medicine, Humans, Pharmacology (medical), 030304 developmental biology, Fungal pathogenesis, Pharmacology, 0303 health sciences, 030306 microbiology, business.industry, Fungi, Infectious Diseases, Drug development, chemistry, Mycoses, Molecular targets, Minireview, business
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b30625e3bc366ab7619e982e2bd61b2
https://europepmc.org/articles/PMC7848987/ -
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المؤلفون: Maurizio Del Poeta, Iwao Ojima, John P. Mallamo, Cristina Lazzarini, J. Brian McCarthy, Krupanandan Haranahalli
المصدر: Antimicrob Agents Chemother
مصطلحات موضوعية: Antifungal Agents, Cryptococcus, Pharmacology, Aspergillosis, Mice, 03 medical and health sciences, Pharmacokinetics, In vivo, Animals, Medicine, Experimental Therapeutics, Pharmacology (medical), 030304 developmental biology, 0303 health sciences, Aspergillus, biology, 030306 microbiology, business.industry, Candidiasis, biology.organism_classification, medicine.disease, Infectious Diseases, Mycoses, Mechanism of action, Cryptococcosis, Toxicity, medicine.symptom, business, Invasive Fungal Infections
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bc405e4ba5c56e9f21e2215c2c2c4c5
https://doi.org/10.1128/aac.00946-20 -
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المصدر: ACS Chemical Neuroscience
مصطلحات موضوعية: Drug, Physiology, Research areas, Cognitive Neuroscience, media_common.quotation_subject, Central nervous system, Disease, chemoinformatics, Biochemistry, Brain cancer, chemical substructures, Medicine, solvent accessible surface area, media_common, molecular volume, Drug discovery, business.industry, non-CNS drugs, Cell Biology, General Medicine, physicochemical property profile, aliphatic amine, medicine.anatomical_structure, linear chains, Aliphatic amine, polar hydrogen, CNS, polar surface area, business, CNS drugs, Neuroscience, Research Article
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المؤلفون: Emir Duzic, Edward R. Bacon, Joanne R. Mathiasen, Michael J. Marino, Donna Bozyczko-Coyne, John A. Gruner, John P. Mallamo, Rita Raddatz, Dorothy G. Flood, Lisa D. Aimone, Hervé Schaffhauser, Siyuan Le, Maciej Gasior, Michael Williams, Mark A. Ator, Robert L. Hudkins
المصدر: Journal of Pharmacology and Experimental Therapeutics. 340:124-133
مصطلحات موضوعية: Pharmacology, Agonist, Chemistry, medicine.drug_class, Antagonist, Receptor antagonist, Dose–response relationship, chemistry.chemical_compound, medicine, Molecular Medicine, Inverse agonist, Receptor, Ex vivo, Histamine
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::d821744703207b55845570e2612fea8e
https://doi.org/10.1124/jpet.111.186585 -
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المؤلفون: Gilbert Moachon, Lars J. S. Knutsen, Nadine C. Becknell, Mark A. Ator, Joanne R. Mathiasen, Lisa D. Aimone, Rita Raddatz, Michael J. Marino, Robert L. Hudkins, Michael Williams, Mehran Yazdanian, Edward R. Bacon, John P. Mallamo, Prouty Catherine P, Ming Tao
المصدر: Journal of Medicinal Chemistry. 54:4781-4792
مصطلحات موضوعية: Male, Pyrrolidines, Drug Inverse Agonism, Stereochemistry, Histamine Antagonists, Biological Availability, In Vitro Techniques, Pharmacology, Crystallography, X-Ray, Permeability, Rats, Sprague-Dawley, Mice, Structure-Activity Relationship, Histamine receptor, Dogs, Pharmacokinetics, Drug Discovery, Animals, Humans, Receptors, Histamine H3, Inverse agonist, Tissue Distribution, Receptor, biology, Chemistry, Brain, Cytochrome P450, Stereoisomerism, Rats, Pyridazines, Macaca fascicularis, Solubility, Lipophilicity, Microsomes, Liver, biology.protein, Molecular Medicine, Histamine H3 receptor
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المؤلفون: Donna Bozyczko-Coyne, Steven C. Almo, Jean Husten, Michael S. Saporito, Richard W. Scott, Alexander A. Fedorov, Mark A. Ator, Chung Ho Park, Diebold James L, Ming Tao, Thelma S. Angeles, Sheryl L. Meyer, John P. Mallamo, Lisa D. Aimone, Elena V. Fedorov, Kurt A. Josef, Beverly P. Holskin, Robert L. Hudkins, Joanne R. Mathiasen, John T. Durkin
المصدر: Journal of Medicinal Chemistry. 51:5680-5689
مصطلحات موضوعية: Models, Molecular, Magnetic Resonance Spectroscopy, Molecular model, Stereochemistry, Carbazoles, Administration, Oral, In Vitro Techniques, Crystallography, X-Ray, Mice, In vivo, Cell Line, Tumor, Drug Discovery, Animals, Humans, Transferase, Protein Kinase Inhibitors, chemistry.chemical_classification, Molecular Structure, MAP kinase kinase kinase, biology, Chemistry, MAP Kinase Kinase Kinases, Pyrrolidinones, Rats, Enzyme, Enzyme inhibitor, Mitogen-activated protein kinase, biology.protein, Molecular Medicine, Signal transduction
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المصدر: Journal of Medicinal Chemistry. 51:5149-5171
مصطلحات موضوعية: Drug, media_common.quotation_subject, Quantitative Structure-Activity Relationship, Pharmacology, Ligands, chemistry.chemical_compound, Drug Discovery, medicine, Humans, Databases, Protein, Benzamide, Phosphorylase kinase, Protein Kinase Inhibitors, media_common, Binding Sites, biology, Chemistry, Drug discovery, Kinase, Imatinib, Biochemistry, Drug Design, Mitogen-activated protein kinase, biology.protein, Molecular Medicine, Signal transduction, medicine.drug
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المؤلفون: John P. Mallamo, Shi X. Yang, Thelma S. Angeles, Rabindranath Tripathy
المصدر: Bioorganic & Medicinal Chemistry Letters. 18:3551-3555
مصطلحات موضوعية: Male, Isostere, Stereochemistry, Clinical Biochemistry, Carbazoles, Molecular Conformation, Pharmaceutical Science, Antineoplastic Agents, Stereoisomerism, Biochemistry, Rats, Sprague-Dawley, Small Molecule Libraries, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, Animals, Structure–activity relationship, Pyrroles, Receptor, trkA, Protein Kinase Inhibitors, Molecular Biology, Indole test, biology, Organic Chemistry, Diastereomer, Neoplasms, Experimental, Staurosporine, Xenograft Model Antitumor Assays, Rats, Aglycone, nervous system, chemistry, Enzyme inhibitor, biology.protein, Molecular Medicine, Bioisostere
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10Synthesis and Mixed Lineage Kinase Activity of Pyrrolocarbazole and Isoindolone Analogs of (+)K-252a
المصدر: Journal of Medicinal Chemistry. 50:433-441
مصطلحات موضوعية: Models, Molecular, Indoles, Stereochemistry, Carbazoles, Stereoisomerism, CHO Cells, Heterocyclic Compounds, 4 or More Rings, Chemical synthesis, Indole Alkaloids, Structure-Activity Relationship, chemistry.chemical_compound, Cricetulus, Polycyclic compound, Cricetinae, Drug Discovery, Animals, Structure–activity relationship, Pyrroles, Indole test, chemistry.chemical_classification, Aryl, MAP Kinase Kinase Kinases, Aglycone, chemistry, Lactam, Molecular Medicine