المؤلفون: Simon R. Green, Susan H. Davis, Sebastian Damerow, Curtis A. Engelhart, Michael Mathieson, Beatriz Baragaña, David A. Robinson, Jevgenia Tamjar, Alice Dawson, Fabio K. Tamaki, Kirsteen I. Buchanan, John Post, Karen Dowers, Sharon M. Shepherd, Chimed Jansen, Fabio Zuccotto, Ian H. Gilbert, Ola Epemolu, Jennifer Riley, Laste Stojanovski, Maria Osuna-Cabello, Esther Pérez-Herrán, María José Rebollo, Laura Guijarro López, Patricia Casado Castro, Isabel Camino, Heather C. Kim, James M. Bean, Navid Nahiyaan, Kyu Y. Rhee, Qinglan Wang, Vee Y. Tan, Helena I. M. Boshoff, Paul J. Converse, Si-Yang Li, Yong S. Chang, Nader Fotouhi, Anna M. Upton, Eric L. Nuermberger, Dirk Schnappinger, Kevin D. Read, Lourdes Encinas, Robert H. Bates, Paul G. Wyatt, Laura A. T. Cleghorn

المصدر: Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)

مصطلحات موضوعية: Science

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2041-1723

URL الوصول: https://doaj.org/article/3aefb9dc25794e5b8cda7dfd998654ed

المؤلفون: Vitor Mendes, Simon R. Green, Joanna C. Evans, Jeannine Hess, Michal Blaszczyk, Christina Spry, Owain Bryant, James Cory-Wright, Daniel S-H. Chan, Pedro H. M. Torres, Zhe Wang, Navid Nahiyaan, Sandra O’Neill, Sebastian Damerow, John Post, Tracy Bayliss, Sasha L. Lynch, Anthony G. Coyne, Peter C. Ray, Chris Abell, Kyu Y. Rhee, Helena I. M. Boshoff, Clifton E. Barry, Valerie Mizrahi, Paul G. Wyatt, Tom L. Blundell

المصدر: Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)

مصطلحات موضوعية: Science

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2041-1723

URL الوصول: https://doaj.org/article/dfbd7ac1fa2f42d49910fcdc7940c42e

المؤلفون: Ohm Prakash, Jana Führing, John Post, Sharon M. Shepherd, Thomas C. Eadsforth, David Gray, Roman Fedorov, Françoise H. Routier

المصدر: Molecules, Vol 24, Iss 5, p 996 (2019)

مصطلحات موضوعية: UDP-sugar pyrophosphorylase, allosteric inhibitor, inhibitor scaffold, library screen, Organic chemistry, QD241-441

وصف الملف: electronic resource

Relation: http://www.mdpi.com/1420-3049/24/5/996; https://doaj.org/toc/1420-3049

URL الوصول: https://doaj.org/article/b37b76d672f440b78c8b8d1d93b9d946

المؤلفون: Myong Gyu, Kim, Trine, Gulholm, Kate, Lennard, Feras, Mirdad, Kristen, Overton, Michael, Maley, Pamela, Konecny, David, Andresen, Jeffrey John, Post

المصدر: Journal of medical virologyREFERENCES. 95(1)

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::25fc37df62fb4b0ab0c34ea8ea12bec7
https://pubmed.ncbi.nlm.nih.gov/36207770

المؤلفون: Paul G. Wyatt, Peter C. Ray, Kyu Y. Rhee, Sasha L. Lynch, Valerie Mizrahi, Clifton E. Barry, John Post, Helena I. Boshoff, Navid Nahiyaan, Anthony G. Coyne, Tom L. Blundell, Joanna C. Evans, Christina Spry, Dinakaran Murugesan, Vitor Mendes, Simon Green, Jeannine Hess, Stephen Thompson, Chris Abell, Zhe Wang

المساهمون: Evans, Joanna C [0000-0002-4139-9527], Mendes, Vitor [0000-0002-2734-2444], Green, Simon R [0000-0001-5054-4792], Spry, Christina [0000-0002-8156-7070], Coyne, Anthony G [0000-0003-0205-5630], Abell, Chris [0000-0001-9174-1987], Boshoff, Helena IM [0000-0002-4333-206X], Wyatt, Paul G [0000-0002-0397-245X], Mizrahi, Valerie [0000-0003-4824-9115], Apollo - University of Cambridge Repository

المصدر: ACS Infectious Diseases

مصطلحات موضوعية: 0301 basic medicine, Coenzyme A, 030106 microbiology, Druggability, Article, Cofactor, Pantothenic Acid, drug discovery, Mycobacterium tuberculosis, 03 medical and health sciences, chemistry.chemical_compound, In vivo, Cysteine, Peptide Synthases, biology, Drug discovery, Chemistry, biology.organism_classification, Small molecule, In vitro, 3. Good health, 030104 developmental biology, Infectious Diseases, Biochemistry, tuberculosis, biology.protein, CoaBC

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b118e20c165cc2ee3aa60e19f743440
https://www.repository.cam.ac.uk/handle/1810/322238

المؤلفون: Laifeng Ding, Robert L. Peach, Uwais Mufti, Leandro Castellano, Dan Leibovici, J. Mark Skehel, Francesco Mauri, Lucksamon Thamlikitkul, Joel Abrahams, Lucinda Billingham, Christopher I. Moore, David J. Pinato, Mauricio Barahona, Rajat Roy, Mathias Winkler, Michael J. Seckl, Julian Downward, Neil Steven, Michael Cullen, Georgios Giamas, Philip Cohen, Sophia N. Yaliraki, Olivier E. Pardo, Seth J. Salpeter, David C. Hancock, Miriam Molina-Arcas, Stelios Chrysostomou, Silvia Ottaviani, David Hrouda, Yulan Wang, Kathryn L. Chapman, Shay Golan, Devmini Moonamale, Adi Zundelevich, Romain Lara, Jennifer Pascoe, Maruf M.U. Ali, David R. Klug, Vered Bar, Filippo Prischi, Sarah Pirrie, Claire Gaunt, John Post

المساهمون: Cancer Treatment & Research Trust, IP2IPO Innovations Limited, Cancer Research UK, Engineering & Physical Science Research Council (EPSRC), Engineering and Physical Sciences Research Council

المصدر: Sci Transl Med

مصطلحات موضوعية: 0301 basic medicine, Lung Neoplasms, medicine.medical_treatment, Drug resistance, Ribosomal Protein S6 Kinases, 90-kDa, Article, Metastasis, 03 medical and health sciences, Mice, 0302 clinical medicine, In vivo, Cell Line, Tumor, medicine, Gene silencing, Animals, Humans, Lung cancer, Lung, 11 Medical and Health Sciences, Chemotherapy, Bladder cancer, business.industry, General Medicine, 06 Biological Sciences, medicine.disease, Gene Expression Regulation, Neoplastic, 030104 developmental biology, Urinary Bladder Neoplasms, Drug Resistance, Neoplasm, 030220 oncology & carcinogenesis, Cancer research, business, Ex vivo

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::652437ab75168eac8df4c7cdc12b7c5f
http://hdl.handle.net/10044/1/90380

المؤلفون: Clifton E. Barry, Paul G. Wyatt, Sasha L. Lynch, Pedro Henrique Monteiro Torres, Daniel Shiu-Hin Chan, Simon Green, Helena I. Boshoff, Joanna C. Evans, Vitor Mendes, Kyu Y. Rhee, James Cory-Wright, Michal Blaszczyk, Peter C. Ray, Valerie Mizrahi, Sebastian Damerow, Navid Nahiyaan, Anthony G. Coyne, John Post, Tom L. Blundell, Tracy Bayliss, Sandra O’Neill, Chris Abell, Jeannine Hess, Christina Spry, Zhe Wang, Owain J. Bryant

المساهمون: Mendes, Vitor [0000-0002-2734-2444], Hess, Jeannine [0000-0001-5916-0728], Spry, Christina [0000-0002-8156-7070], Coyne, Anthony G. [0000-0003-0205-5630], Abell, Chris [0000-0001-9174-1987], Rhee, Kyu Y. [0000-0003-4582-2895], Boshoff, Helena I. M. [0000-0002-4333-206X], Barry, Clifton E. [0000-0002-2927-270X], Blundell, Tom L. [0000-0002-2708-8992], Apollo - University of Cambridge Repository, Coyne, Anthony G [0000-0003-0205-5630], Rhee, Kyu Y [0000-0003-4582-2895], Boshoff, Helena IM [0000-0002-4333-206X], Barry, Clifton E [0000-0002-2927-270X], Blundell, Tom L [0000-0002-2708-8992]

المصدر: Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)

مصطلحات موضوعية: 0301 basic medicine, Carboxy-Lyases, 45/41, ved/biology.organism_classification_rank.species, Antitubercular Agents, General Physics and Astronomy, Crystallography, X-Ray, 01 natural sciences, chemistry.chemical_compound, Peptide Synthases, Multidisciplinary, biology, Drug discovery, Mycobacterium smegmatis, 3. Good health, Enzymes, Biochemistry, Gene Knockdown Techniques, Allosteric Site, Tuberculosis, 145, Science, Coenzyme A, Allosteric regulation, Microbial Sensitivity Tests, General Biochemistry, Genetics and Molecular Biology, Article, Mycobacterium tuberculosis, 03 medical and health sciences, Biosynthesis, Allosteric Regulation, Bacterial Proteins, medicine, Humans, Model organism, 82/83, X-ray crystallography, Enzyme Assays, 49/98, 010405 organic chemistry, ved/biology, 631/154, General Chemistry, biology.organism_classification, medicine.disease, 0104 chemical sciences, High-Throughput Screening Assays, Metabolic pathway, 030104 developmental biology, chemistry, 631/535/1266, 631/45/607

وصف الملف: application/pdf; application/zip; text/xml

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e93480516255c2e8d7aeba39be349059
http://europepmc.org/articles/PMC7794376

المؤلفون: John Post, Dennis Silage

المصدر: 2018 ASEE Annual Conference & Exposition Proceedings.

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::fd75498f402f6929b663154a4ee5e36e
https://doi.org/10.18260/1-2--30647

المؤلفون: David W. Gray, David A. Robinson, Sharon M. Shepherd, Darren Edwards, Claire J. MacKenzie, Michael G. Thomas, Ian H. Gilbert, Judith V. Hobrath, Leah S. Torrie, Rafael Ferreira, Alan H. Fairlamb, Manu De Rycker, Eun-Jung Ko, John Post, Karolina Wrobel

المصدر: ACS Infectious Diseases

مصطلحات موضوعية: 0301 basic medicine, 030106 microbiology, Allosteric regulation, Trypanosoma brucei brucei, Protozoan Proteins, Methionine-tRNA Ligase, Trypanosoma brucei, Article, drug discovery, allosteric, 03 medical and health sciences, Methionine, parasitic diseases, Homology modeling, Binding site, Trypanosoma cruzi, chemistry.chemical_classification, Leishmania, biology, Chemistry, Drug discovery, methionyl-tRNA synthetase, biology.organism_classification, 3. Good health, inhibitor, 030104 developmental biology, Infectious Diseases, Enzyme, Biochemistry, kinetoplastid, Allosteric Site

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd271fc0b17de969f9ccf108761ec897
https://pubmed.ncbi.nlm.nih.gov/32275825

المؤلفون: Zhe Wang, Valerie Mizrahi, Christina Spry, Kyu Y. Rhee, Sebastian Damerow, John Post, Owain J. Bryant, James Cory-Wright, Sasha L. Lynch, Sandra O’Neill, Tracy Bayliss, Michal Blaszczyk, Paul G. Wyatt, Clifton E. Barry, Pedro Henrique Monteiro Torres, Jeannine Hess, Peter C. Ray, Vitor Mendes, Tom L. Blundell, Simon Green, Chris Abell, Joanna C. Evans, Helena I. Boshoff, Daniel S-H. Chan, Anthony G. Coyne

مصطلحات موضوعية: 0303 health sciences, Tuberculosis, biology, Chemistry, ved/biology, Coenzyme A, Mycobacterium smegmatis, 030302 biochemistry & molecular biology, Allosteric regulation, ved/biology.organism_classification_rank.species, biology.organism_classification, medicine.disease, 3. Good health, Mycobacterium tuberculosis, 03 medical and health sciences, Metabolic pathway, chemistry.chemical_compound, Biochemistry, Biosynthesis, medicine, Model organism, 030304 developmental biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad01cb6cb3beb75dc60f063a9f3eaf83