نتائج البحث - "John R. P. Knight"

المصدر: Loveridge, C J, Slater, S, Campbell, K J, Nam, N A, Knight, J, Ahmad, I, Hedley, A, Lilla, S, Repiscak, P, Patel, R, Salji, M, Fleming, J, Mitchell, L, Nixon, C, Strathdee, D, Neilson, M, Ntala, C, Bryson, S, Zanivan, S, Edwards, J, Robson, C N, Goodyear, C S, Blyth, K & Leung, H Y 2020, ' BRF1 accelerates prostate tumourigenesis and perturbs immune infiltration ', Oncogene, vol. 39, no. 8, pp. 1797-1806 . https://doi.org/10.1038/s41388-019-1106-x
Oncogene

مصطلحات موضوعية: CD4-Positive T-Lymphocytes, Male, 0301 basic medicine, Cancer Research, Carcinogenesis, Urological cancer, Biology, medicine.disease_cause, Article, 03 medical and health sciences, Prostate cancer, 0302 clinical medicine, Immune system, Downregulation and upregulation, Prostate, Genetics, medicine, Humans, Molecular Biology, Aged, Cell Proliferation, Cancer, TATA-Binding Protein Associated Factors, Innate immune system, Manchester Cancer Research Centre, ResearchInstitutes_Networks_Beacons/mcrc, Cell Cycle, PTEN Phosphohydrolase, Prostatic Neoplasms, Correction, Middle Aged, Prognosis, Acquired immune system, medicine.disease, Complement system, 030104 developmental biology, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Cancer research

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https://doi.org/10.1038/s41388-019-1106-x

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7

MNK Inhibition Sensitizes KRAS-Mutant Colorectal Cancer to mTORC1 Inhibition by Reducing eIF4E Phosphorylation and c-MYC Expression

المصدر: Knight, J R P, Alexandrou, C, Skalka, G L, Vlahov, N, Pennel, K, Officer, L, Teodosio, A, Kanellos, G, Gay, D M, May-Wilson, S, Smith, E M, Najumudeen, A K, Gilroy, K, Ridgway, R A, Flanagan, D J, Smith, R C L, McDonald, L, MacKay, C, Cheasty, A, McArthur, K, Stanway, E, Leach, J D, Jackstadt, R, Waldron, J A, Campbell, A D, Vlachogiannis, G, Valeri, N, Haigis, K M, Sonenberg, N, Proud, C G, Jones, N P, Swarbrick, M E, McKinnon, H J, Faller, W J, Quesne, J L, Edwards, J, Willis, A E, Bushell, M & Sansom, O J 2021, ' MNK Inhibition Sensitizes KRAS-Mutant Colorectal Cancer to mTORC1 Inhibition by Reducing eIF4E Phosphorylation and c-MYC Expression ', Cancer discovery, vol. 11, no. 5, pp. 1228-1247 . https://doi.org/10.1158/2159-8290.CD-20-0652

مصطلحات موضوعية: 0301 basic medicine, Eukaryotic Initiation Factor-4E/drug effects, Colorectal cancer, Mutant, mTORC1, Biology, medicine.disease_cause, 03 medical and health sciences, Mice, 0302 clinical medicine, medicine, Animals, Humans, Protein Serine-Threonine Kinases/drug effects, Phosphorylation, neoplasms, Intracellular Signaling Peptides and Proteins/drug effects, MTOR Inhibitors/pharmacology, Mutation, Manchester Cancer Research Centre, ResearchInstitutes_Networks_Beacons/mcrc, EIF4E, Translation (biology), medicine.disease, Colorectal Neoplasms/genetics, digestive system diseases, 3. Good health, Mice, Inbred C57BL, Disease Models, Animal, 030104 developmental biology, Oncology, 030220 oncology & carcinogenesis, Cancer research, KRAS

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https://doi.org/10.1158/2159-8290.CD-20-0652

8

Brf1 loss and not overexpression disrupts tissues homeostasis in the intestine, liver and pancreas

المؤلفون: Owen J. Sansom, Carolyn J.P. Jones, John R. P. Knight, Kirsteen J. Campbell, Rachel A. Ridgway, Sheila Bryson, Karen Blyth, Thomas G. Bird, Kate Dudek, Ayala King, Douglas Strathdee, Dritan Liko, David A. Stevenson, Anne E. Willis, Louise Mitchell, Jennifer P. Morton

المصدر: Liko, D, Mitchell, L, Campbell, K J, Ridgway, R A, Jones, C, Dudek, K, King, A, Bryson, S, Stevenson, D, Blyth, K, Strathdee, D, Morton, J P, Bird, T G, Knight, J R P, Willis, A E & Sansom, O J 2019, ' Brf1 loss and not overexpression disrupts tissues homeostasis in the intestine, liver and pancreas ', Cell Death and Differentiation . https://doi.org/10.1038/s41418-019-0316-7
Cell death and differentiation
Liko, D, Mitchell, L, Campbell, K J, Ridgway, R A, Jones, C, Dudek, K, King, A, Bryson, S, Stevenson, D A, Blyth, K, Strathdee, D, Morton, J P, Bird, T G, Knight, J R P, Willis, A E & Sansom, O J 2019, ' Brf1 loss and not overexpression disrupts tissues homeostasis in the intestine, liver and pancreas ', Cell Death and Differentiation, vol. 26, no. 12, pp. 2535-2550 . https://doi.org/10.1038/s41418-019-0316-7

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https://doi.org/10.1038/s41418-019-0316-7

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9

Mutant p53s generate pro-invasive niches by influencing exosome podocalyxin levels

المساهمون: The Beatson Institute for Cancer Research, University of Glasgow, Institute of Cancer Sciences [Glasgow, UK] (CR-UK Beatson Institute), James Watt School of Engineering [Univ Glasgow], Trafic membranaire et Division cellulaire - Membrane Traffic and Cell Division, Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), Inflammation, Repair and Development, National Heart & Lung Institute, Imperial College London, Wolfson Wohl Cancer Research Centre [Glasgow, UK], University of Glasgow-Institute of Cancer Sciences [Glasgow, UK], This work was funded by Cancer Research UK and Breast Cancer Now. We acknowledge the Cancer Research UK Glasgow Centre (C596/A18076) and the BSU facilities at the Cancer Research UK Beatson Institute (C596/A17196)., Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS)

المصدر: Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
Nature Communications
Nature Communications, Nature Publishing Group, 2018, 9 (1), pp.5069. ⟨10.1038/s41467-018-07339-y⟩
Nature Communications, 2018, 9 (1), pp.5069. ⟨10.1038/s41467-018-07339-y⟩
Novo, D, Heath, N, Mitchell, L, Caligiuri, G, MacFarlane, A, Reijmer, D, Charlton, L, Knight, J, Calka, M, McGhee, E, Dornier, E, Sumpton, D, Mason, S, Echard, A, Klinkert, K, Secklehner, J, Kruiswijk, F, Vousden, K, Macpherson, I R, Blyth, K, Bailey, P, Yin, H, Carlin, L M, Morton, J, Zanivan, S & Norman, J C 2018, ' Mutant p53s generate pro-invasive niches by influencing exosome podocalyxin levels ', Nature Communications, vol. 9, no. 1, 5069 . https://doi.org/10.1038/s41467-018-07339-y

مصطلحات موضوعية: 0301 basic medicine, [SDV]Life Sciences [q-bio], Mutant, General Physics and Astronomy, Exosomes, Microscopy, Atomic Force, Extracellular matrix, Mice, chemistry.chemical_compound, MESH: Animals, MESH: Sialoglycoproteins, MESH: Tumor Suppressor Protein p53, lcsh:Science, MESH: Microscopy, Atomic Force, Multidisciplinary, Manchester Cancer Research Centre, biology, Chemistry, Cell biology, Podocalyxin, Female, MESH: Sialomucins, MESH: Mutation, Sialomucins, Endosome, Sialoglycoproteins, Science, Integrin, Mice, Nude, [SDV.CAN]Life Sciences [q-bio]/Cancer, [SDV.BC]Life Sciences [q-bio]/Cellular Biology, Exosome, Article, General Biochemistry, Genetics and Molecular Biology, Cell Line, 03 medical and health sciences, MESH: Mice, Nude, Animals, Humans, MESH: Exosomes, MESH: Mice, Diacylglycerol kinase, MESH: Humans, ResearchInstitutes_Networks_Beacons/mcrc, General Chemistry, Microvesicles, MESH: Cell Line, MESH: rab GTP-Binding Proteins, 030104 developmental biology, rab GTP-Binding Proteins, Mutation, biology.protein, lcsh:Q, Tumor Suppressor Protein p53, MESH: Female

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http://link.springer.com/article/10.1038/s41467-018-07339-y

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10

MNK Inhibition Sensitizes

المؤلفون: John R P, Knight, Constantinos, Alexandrou, George L, Skalka, Nikola, Vlahov, Kathryn, Pennel, Leah, Officer, Ana, Teodosio, Georgios, Kanellos, David M, Gay, Sebastian, May-Wilson, Ewan M, Smith, Arafath K, Najumudeen, Kathryn, Gilroy, Rachel A, Ridgway, Dustin J, Flanagan, Rachael C L, Smith, Laura, McDonald, Craig, MacKay, Anne, Cheasty, Kerri, McArthur, Emma, Stanway, Joshua D, Leach, Rene, Jackstadt, Joseph A, Waldron, Andrew D, Campbell, Georgios, Vlachogiannis, Nicola, Valeri, Kevin M, Haigis, Nahum, Sonenberg, Christopher G, Proud, Neil P, Jones, Martin E, Swarbrick, Heather J, McKinnon, William J, Faller, John, Le Quesne, Joanne, Edwards, Anne E, Willis, Martin, Bushell, Owen J, Sansom

المصدر: Cancer Discov

مصطلحات موضوعية: Intracellular Signaling Peptides and Proteins, MTOR Inhibitors, Protein Serine-Threonine Kinases, digestive system diseases, Article, Mice, Inbred C57BL, Disease Models, Animal, Mice, Eukaryotic Initiation Factor-4E, Animals, Humans, Phosphorylation, Colorectal Neoplasms, neoplasms

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::c2f8097c7234ed04603f0d786b945e20
https://pubmed.ncbi.nlm.nih.gov/33328217

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