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1دورية أكاديمية
المؤلفون: John R. P. Knight, Owen J. Sansom
المصدر: Molecular & Cellular Oncology, Vol 8, Iss 2 (2021)
مصطلحات موضوعية: protein synthesis, colorectal cancer, myc, kras mutation, eif4e, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
وصف الملف: electronic resource
Relation: https://doaj.org/toc/2372-3556
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2دورية أكاديمية
المؤلفون: John R. P. Knight, Gavin Garland, Tuija Pöyry, Emma Mead, Nikola Vlahov, Aristeidis Sfakianos, Stefano Grosso, Fabio De-Lima-Hedayioglu, Giovanna R. Mallucci, Tobias von der Haar, C. Mark Smales, Owen J. Sansom, Anne E. Willis
المصدر: Disease Models & Mechanisms, Vol 13, Iss 3 (2020)
مصطلحات موضوعية: elongation control, protein synthesis, mrna translation control, Medicine, Pathology, RB1-214
وصف الملف: electronic resource
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3دورية أكاديمية
المؤلفون: John R. P. Knight, Simon J. Allison, Jo Milner
المصدر: Open Biology, Vol 3, Iss 11 (2013)
مصطلحات موضوعية: active regulator of sirt1, regulation of sirt1, p53 acetylation, Biology (General), QH301-705.5
وصف الملف: electronic resource
Relation: https://doaj.org/toc/2046-2441
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المؤلفون: Mark Stoneley, John R. P. Knight, Anne E. Willis, Thomas Sbarrato
المصدر: Encyclopedia of Cell Biology ISBN: 9780128216248
مصطلحات موضوعية: Fight-or-flight response, Stress (mechanics), Genetics, Stress sensing, Translation (biology), Biology, Cell fate determination, Ribosome, Molecular machine, Biogenesis, Cell biology
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72b6f91ba6d575ba22a69361e808ecf6
https://doi.org/10.1016/b978-0-12-821618-7.00218-2 -
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المؤلفون: Owen J. Sansom, John R. P. Knight, Simon T. Barry, Rachel A. Ridgway, David Sumpton, Rory T. Steven, Giovanny Rodriguez-Blanco, Eyal Gottlieb, Gaurav Malviya, William C. Clark, Douglas Strathdee, Emma R. Johnson, Holly Hall, Alex Dexter, Teresa Murta, David Y. Lewis, Saverio Tardito, Gregory Hamm, Gavin Brown, Colin Nixon, Kathryn Gilroy, Zoltan Takats, Sudhir B Malla, Dmitry Solovyev, Sigrid K. Fey, Fatih Ceteci, Gillian M. Mackay, Susan E. Critchlow, Ann Hedley, Nikola Vlahov, Alan M. Race, Martin Bushell, Andrew D. Campbell, Arafath Kaja Najumudeen, Richard J. A. Goodwin, Josephine Bunch, Chelsea J. Nikula, Agata Mrowinska, Philip D Dunne, Rene Jackstadt, Joshua D.G. Leach
المصدر: Nature Genetics. 53:16-26
مصطلحات موضوعية: 0303 health sciences, Mutation, Mutant, mTORC1, Biology, medicine.disease_cause, digestive system diseases, Glutamine, 03 medical and health sciences, 0302 clinical medicine, Cancer cell, Genetics, medicine, Cancer research, Amino acid transporter, KRAS, Signal transduction, neoplasms, 030217 neurology & neurosurgery, 030304 developmental biology
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المؤلفون: Louise Mitchell, John R. P. Knight, Sara Zanivan, Sarah Slater, Chara Ntala, Janis Fleming, Joanne Edwards, Karen Blyth, Carl S. Goodyear, Ann Hedley, Kirsteen J. Campbell, Noor Akmar Nam, Mark Salji, Sheila Bryson, Hing Y. Leung, Craig N. Robson, Carolyn J. Loveridge, Rachana Patel, Imran Ahmad, Douglas Strathdee, Colin Nixon, Sergio Lilla, Matthew Neilson, Peter Repiscak
المصدر: Loveridge, C J, Slater, S, Campbell, K J, Nam, N A, Knight, J, Ahmad, I, Hedley, A, Lilla, S, Repiscak, P, Patel, R, Salji, M, Fleming, J, Mitchell, L, Nixon, C, Strathdee, D, Neilson, M, Ntala, C, Bryson, S, Zanivan, S, Edwards, J, Robson, C N, Goodyear, C S, Blyth, K & Leung, H Y 2020, ' BRF1 accelerates prostate tumourigenesis and perturbs immune infiltration ', Oncogene, vol. 39, no. 8, pp. 1797-1806 . https://doi.org/10.1038/s41388-019-1106-x
Oncogeneمصطلحات موضوعية: CD4-Positive T-Lymphocytes, Male, 0301 basic medicine, Cancer Research, Carcinogenesis, Urological cancer, Biology, medicine.disease_cause, Article, 03 medical and health sciences, Prostate cancer, 0302 clinical medicine, Immune system, Downregulation and upregulation, Prostate, Genetics, medicine, Humans, Molecular Biology, Aged, Cell Proliferation, Cancer, TATA-Binding Protein Associated Factors, Innate immune system, Manchester Cancer Research Centre, ResearchInstitutes_Networks_Beacons/mcrc, Cell Cycle, PTEN Phosphohydrolase, Prostatic Neoplasms, Correction, Middle Aged, Prognosis, Acquired immune system, medicine.disease, Complement system, 030104 developmental biology, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Cancer research
وصف الملف: application/pdf
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المؤلفون: Anne E. Willis, Laura McDonald, George Skalka, Andrew D. Campbell, Heather McKinnon, Kevin M. Haigis, John R. P. Knight, Sebastian May-Wilson, Kathryn Gilroy, William J. Faller, Emma Stanway, Leah Officer, Rachael C. L. Smith, Joshua D.G. Leach, Joseph A. Waldron, Rachel A. Ridgway, Nicola Valeri, Ewan M. Smith, Arafath Kaja Najumudeen, Nahum Sonenberg, Joanne Edwards, Rene Jackstadt, Ana Teodósio, John Le Quesne, Dustin J. Flanagan, Anne Cheasty, Georgios Kanellos, Kerri McArthur, Christopher G. Proud, Constantinos Alexandrou, Georgios Vlachogiannis, Neil P. Jones, Nikola Vlahov, Owen J. Sansom, Kathryn Af Pennel, Craig MacKay, Martin E. Swarbrick, Martin Bushell
المصدر: Knight, J R P, Alexandrou, C, Skalka, G L, Vlahov, N, Pennel, K, Officer, L, Teodosio, A, Kanellos, G, Gay, D M, May-Wilson, S, Smith, E M, Najumudeen, A K, Gilroy, K, Ridgway, R A, Flanagan, D J, Smith, R C L, McDonald, L, MacKay, C, Cheasty, A, McArthur, K, Stanway, E, Leach, J D, Jackstadt, R, Waldron, J A, Campbell, A D, Vlachogiannis, G, Valeri, N, Haigis, K M, Sonenberg, N, Proud, C G, Jones, N P, Swarbrick, M E, McKinnon, H J, Faller, W J, Quesne, J L, Edwards, J, Willis, A E, Bushell, M & Sansom, O J 2021, ' MNK Inhibition Sensitizes KRAS-Mutant Colorectal Cancer to mTORC1 Inhibition by Reducing eIF4E Phosphorylation and c-MYC Expression ', Cancer discovery, vol. 11, no. 5, pp. 1228-1247 . https://doi.org/10.1158/2159-8290.CD-20-0652
مصطلحات موضوعية: 0301 basic medicine, Eukaryotic Initiation Factor-4E/drug effects, Colorectal cancer, Mutant, mTORC1, Biology, medicine.disease_cause, 03 medical and health sciences, Mice, 0302 clinical medicine, medicine, Animals, Humans, Protein Serine-Threonine Kinases/drug effects, Phosphorylation, neoplasms, Intracellular Signaling Peptides and Proteins/drug effects, MTOR Inhibitors/pharmacology, Mutation, Manchester Cancer Research Centre, ResearchInstitutes_Networks_Beacons/mcrc, EIF4E, Translation (biology), medicine.disease, Colorectal Neoplasms/genetics, digestive system diseases, 3. Good health, Mice, Inbred C57BL, Disease Models, Animal, 030104 developmental biology, Oncology, 030220 oncology & carcinogenesis, Cancer research, KRAS
وصف الملف: application/pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4b093ca20383c7ab94bac414895dbf3
https://doi.org/10.1158/2159-8290.CD-20-0652 -
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المؤلفون: Owen J. Sansom, Carolyn J.P. Jones, John R. P. Knight, Kirsteen J. Campbell, Rachel A. Ridgway, Sheila Bryson, Karen Blyth, Thomas G. Bird, Kate Dudek, Ayala King, Douglas Strathdee, Dritan Liko, David A. Stevenson, Anne E. Willis, Louise Mitchell, Jennifer P. Morton
المصدر: Liko, D, Mitchell, L, Campbell, K J, Ridgway, R A, Jones, C, Dudek, K, King, A, Bryson, S, Stevenson, D, Blyth, K, Strathdee, D, Morton, J P, Bird, T G, Knight, J R P, Willis, A E & Sansom, O J 2019, ' Brf1 loss and not overexpression disrupts tissues homeostasis in the intestine, liver and pancreas ', Cell Death and Differentiation . https://doi.org/10.1038/s41418-019-0316-7
Cell death and differentiation
Liko, D, Mitchell, L, Campbell, K J, Ridgway, R A, Jones, C, Dudek, K, King, A, Bryson, S, Stevenson, D A, Blyth, K, Strathdee, D, Morton, J P, Bird, T G, Knight, J R P, Willis, A E & Sansom, O J 2019, ' Brf1 loss and not overexpression disrupts tissues homeostasis in the intestine, liver and pancreas ', Cell Death and Differentiation, vol. 26, no. 12, pp. 2535-2550 . https://doi.org/10.1038/s41418-019-0316-7مصطلحات موضوعية: 0301 basic medicine, Biology, medicine.disease_cause, Article, RNA polymerase III, Loss of heterozygosity, Mice, 03 medical and health sciences, 0302 clinical medicine, Protein biosynthesis, medicine, Animals, Homeostasis, Humans, Intestinal Mucosa, Pancreas, Molecular Biology, Transcription factor, TATA-Binding Protein Associated Factors, Manchester Cancer Research Centre, Cell growth, ResearchInstitutes_Networks_Beacons/mcrc, Cell Biology, Embryonic stem cell, Cell biology, 030104 developmental biology, medicine.anatomical_structure, Liver, 030220 oncology & carcinogenesis, Butyrate Response Factor 1, Carcinogenesis
وصف الملف: application/pdf
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المؤلفون: Susan M. Mason, John R. P. Knight, Arnaud Echard, Giuseppina Caligiuri, Dide Reijmer, Monika Calka, Flore Kruiswijk, David Sumpton, David Novo, Karen Blyth, Iain R. Macpherson, Karen H. Vousden, Peter Bailey, Sara Zanivan, Kerstin Klinkert, Jim C. Norman, Judith Secklehner, Amanda MacFarlane, Nikki Heath, Huabing Yin, Jennifer P. Morton, Leo M. Carlin, Louise Mitchell, Ewan J. McGhee, Laura Charlton, Emmanuel Dornier
المساهمون: The Beatson Institute for Cancer Research, University of Glasgow, Institute of Cancer Sciences [Glasgow, UK] (CR-UK Beatson Institute), James Watt School of Engineering [Univ Glasgow], Trafic membranaire et Division cellulaire - Membrane Traffic and Cell Division, Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), Inflammation, Repair and Development, National Heart & Lung Institute, Imperial College London, Wolfson Wohl Cancer Research Centre [Glasgow, UK], University of Glasgow-Institute of Cancer Sciences [Glasgow, UK], This work was funded by Cancer Research UK and Breast Cancer Now. We acknowledge the Cancer Research UK Glasgow Centre (C596/A18076) and the BSU facilities at the Cancer Research UK Beatson Institute (C596/A17196)., Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS)
المصدر: Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
Nature Communications
Nature Communications, Nature Publishing Group, 2018, 9 (1), pp.5069. ⟨10.1038/s41467-018-07339-y⟩
Nature Communications, 2018, 9 (1), pp.5069. ⟨10.1038/s41467-018-07339-y⟩
Novo, D, Heath, N, Mitchell, L, Caligiuri, G, MacFarlane, A, Reijmer, D, Charlton, L, Knight, J, Calka, M, McGhee, E, Dornier, E, Sumpton, D, Mason, S, Echard, A, Klinkert, K, Secklehner, J, Kruiswijk, F, Vousden, K, Macpherson, I R, Blyth, K, Bailey, P, Yin, H, Carlin, L M, Morton, J, Zanivan, S & Norman, J C 2018, ' Mutant p53s generate pro-invasive niches by influencing exosome podocalyxin levels ', Nature Communications, vol. 9, no. 1, 5069 . https://doi.org/10.1038/s41467-018-07339-yمصطلحات موضوعية: 0301 basic medicine, [SDV]Life Sciences [q-bio], Mutant, General Physics and Astronomy, Exosomes, Microscopy, Atomic Force, Extracellular matrix, Mice, chemistry.chemical_compound, MESH: Animals, MESH: Sialoglycoproteins, MESH: Tumor Suppressor Protein p53, lcsh:Science, MESH: Microscopy, Atomic Force, Multidisciplinary, Manchester Cancer Research Centre, biology, Chemistry, Cell biology, Podocalyxin, Female, MESH: Sialomucins, MESH: Mutation, Sialomucins, Endosome, Sialoglycoproteins, Science, Integrin, Mice, Nude, [SDV.CAN]Life Sciences [q-bio]/Cancer, [SDV.BC]Life Sciences [q-bio]/Cellular Biology, Exosome, Article, General Biochemistry, Genetics and Molecular Biology, Cell Line, 03 medical and health sciences, MESH: Mice, Nude, Animals, Humans, MESH: Exosomes, MESH: Mice, Diacylglycerol kinase, MESH: Humans, ResearchInstitutes_Networks_Beacons/mcrc, General Chemistry, Microvesicles, MESH: Cell Line, MESH: rab GTP-Binding Proteins, 030104 developmental biology, rab GTP-Binding Proteins, Mutation, biology.protein, lcsh:Q, Tumor Suppressor Protein p53, MESH: Female
وصف الملف: application/pdf
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المؤلفون: John R P, Knight, Constantinos, Alexandrou, George L, Skalka, Nikola, Vlahov, Kathryn, Pennel, Leah, Officer, Ana, Teodosio, Georgios, Kanellos, David M, Gay, Sebastian, May-Wilson, Ewan M, Smith, Arafath K, Najumudeen, Kathryn, Gilroy, Rachel A, Ridgway, Dustin J, Flanagan, Rachael C L, Smith, Laura, McDonald, Craig, MacKay, Anne, Cheasty, Kerri, McArthur, Emma, Stanway, Joshua D, Leach, Rene, Jackstadt, Joseph A, Waldron, Andrew D, Campbell, Georgios, Vlachogiannis, Nicola, Valeri, Kevin M, Haigis, Nahum, Sonenberg, Christopher G, Proud, Neil P, Jones, Martin E, Swarbrick, Heather J, McKinnon, William J, Faller, John, Le Quesne, Joanne, Edwards, Anne E, Willis, Martin, Bushell, Owen J, Sansom
المصدر: Cancer Discov
مصطلحات موضوعية: Intracellular Signaling Peptides and Proteins, MTOR Inhibitors, Protein Serine-Threonine Kinases, digestive system diseases, Article, Mice, Inbred C57BL, Disease Models, Animal, Mice, Eukaryotic Initiation Factor-4E, Animals, Humans, Phosphorylation, Colorectal Neoplasms, neoplasms
URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::c2f8097c7234ed04603f0d786b945e20
https://pubmed.ncbi.nlm.nih.gov/33328217