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المؤلفون: Richard A. Hartz, Vijay T. Ahuja, Guanglin Luo, Ling Chen, Prasanna Sivaprakasam, Hong Xiao, Carol M. Krause, Wendy J. Clarke, Songmei Xu, John S. Tokarski, Kevin Kish, Hal Lewis, Nicolas Szapiel, Ramu Ravirala, Sayali Mutalik, Deepa Nakmode, Devang Shah, Catherine R. Burton, John E. Macor, Gene M. Dubowchik
المصدر: Journal of Medicinal Chemistry.
مصطلحات موضوعية: Drug Discovery, Molecular Medicine
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المؤلفون: Matthew D. Hill, Haiquan Fang, Derek Norris, George V. Delucca, Hong Huang, Mikkel DeBenedetto, Claude Quesnelle, William D. Schmitz, John S. Tokarski, Steven Sheriff, Chunhong Yan, Caroline Fanslau, Zuzana Haarhoff, Christine Huang, Melissa Kramer, Shilpa Madari, Krista Menard, Laura Monereau, John Morrison, Nirmala Raghavan, Eric E. Shields, Jean Simmermacher-Mayer, Michael Sinz, Ching Kim Tye, Richard Westhouse, Chunshan Xie, Haiying Zhang, Lisa Zhang, Tatyana Zvyaga, Francis Lee, Ashvinikumar V. Gavai, Andrew P. Degnan
المصدر: ACS Medicinal Chemistry Letters. 13:1165-1171
مصطلحات موضوعية: Organic Chemistry, Drug Discovery, Biochemistry
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المؤلفون: Ching Kim Tye, Chunhong Yan, Sarah C. Traeger, Wayne Vaccaro, Yingru Zhang, Gerry Everlof, Jianqing Li, Henry Yip, Peng Li, John T. Hunt, Michael A. Poss, Gregory D. Vite, Mussari Christopher P, Steven Sheriff, Asoka Ranasinghe, Haiying Zhang, Richard A. Westhouse, Dharmpal S. Dodd, Richard Rampulla, Zheng Yang, Frank Marsilio, Derek J. Norris, Wen-Ching Han, Tram N. Huynh, Yufen Zhao, Patrice Gill, Nirmala Raghavan, Lalgudi S. Harikrishnan, Ashvinikumar V. Gavai, Susan Wee, John S. Tokarski, Dauh-Rurng Wu, Arvind Mathur, Mei-Li Wen, Huiping Zhang, David R. Tortolani, George V. Delucca, Krista Menard, Francis Y. Lee, Claude A. Quesnelle, Dawn Sun, Vijay T. Ahuja, Daniel O'malley, Christine Huang, Muthoni G. Kamau
المصدر: Journal of Medicinal Chemistry. 64:14247-14265
مصطلحات موضوعية: Drug, Proline, Phenylalanine, media_common.quotation_subject, Carbazoles, Administration, Oral, Antineoplastic Agents, Cell Cycle Proteins, Computational biology, BET inhibitor, Structure-Activity Relationship, Pharmacokinetics, In vivo, Drug Discovery, Transcriptional regulation, Humans, Potency, media_common, Dose-Response Relationship, Drug, Molecular Structure, Chemistry, Tryptophan, Signal transducing adaptor protein, Bromodomain, Molecular Medicine, Transcription Factors
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المؤلفون: Jonathan Lippy, Robert M. Borzilleri, Andrew J. Tebben, Litao Zhang, Charu Chaudhry, William J. Pitts, John S. Tokarski
المصدر: Drug Discovery Today. 26:1115-1125
مصطلحات موضوعية: 0301 basic medicine, Drug, Pharmaceutical drug, Computer science, media_common.quotation_subject, medicine.medical_treatment, Drug Resistance, Computational biology, Food and drug administration, 03 medical and health sciences, 0302 clinical medicine, Drug Discovery, medicine, Animals, Humans, Kinome, Drug Approval, Protein Kinase Inhibitors, media_common, Pharmacology, United States Food and Drug Administration, Drug discovery, Kinase, Small molecule, United States, 030104 developmental biology, 030220 oncology & carcinogenesis, Protein Kinases
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المؤلفون: Gregory A, Locke, Jodi, Muckelbauer, John S, Tokarski, Christopher M, Barbieri, Stefan, Belić, Bradley, Falk, Jeffrey, Tredup, Ying-Kai, Wang
المصدر: Methods in enzymology. 667
مصطلحات موضوعية: TYK2 Kinase, Allosteric Regulation, Janus Kinases, Signal Transduction
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المؤلفون: Jianqing Li, Daniel Smith, John S. Tokarski, Lihong Cheng, John E. Macor, Javed Khan, Adriana Zupa-Fernandez, Anil Thankappan, Chunjian Liu, Charu Chaudhry, David S. Weinstein, Percy H. Carter, Kathleen M. Gillooly, Kim W. McIntyre, Yifan Zhang, Anjaneya Chimalakonda, Joann Strnad, James Lin, James R. Burke, David J. Shuster, Manoj Chiney, Paul A. Elzinga, Max Ruzanov, Louis J. Lombardo, Charles M. Langevine
المصدر: Journal of Medicinal Chemistry. 64:677-694
مصطلحات موضوعية: Cyclopropanes, TYK2 Kinase, Chemistry, Hydrogen bond, Drug discovery, Ligand, Stereochemistry, Plasma protein binding, Crystallography, X-Ray, Catalysis, Pyridazine, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Amide, Drug Discovery, Animals, Humans, Psoriasis, Molecular Medicine, Structure–activity relationship, Moiety, Oxazoles, Protein Kinase Inhibitors, Protein Binding
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المؤلفون: Gregory A. Locke, Jodi Muckelbauer, John S. Tokarski, Christopher M. Barbieri, Stefan Belić, Bradley Falk, Jeffrey Tredup, Ying-Kai Wang
المصدر: Methods in Enzymology ISBN: 9780323915410
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::0f1fcafaa9f16795bca7c80dddcc9f17
https://doi.org/10.1016/bs.mie.2022.03.051 -
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المؤلفون: Ashvinikumar V. Gavai, Brian E. Fink, Dianlin Xie, Susan Wee, David A Critton, Jesse Swanson, Carolyn Cao, John S. Tokarski, Vijay T. Ahuja, Daniel O'malley, Nicolas Szapiel, Benjamin M. Johnson, Cindy Wang, Anthony A. Paiva
المصدر: ACS Medicinal Chemistry Letters. 10:1486-1491
مصطلحات موضوعية: 010405 organic chemistry, Chemistry, T cell, Organic Chemistry, Inhibitory postsynaptic potential, 01 natural sciences, Biochemistry, 0104 chemical sciences, Negative regulator, Cell biology, 010404 medicinal & biomolecular chemistry, chemistry.chemical_compound, medicine.anatomical_structure, C-terminal Src kinase, Drug Discovery, Pyridine, medicine, Phosphorylation, Proto-oncogene tyrosine-protein kinase Src
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المؤلفون: Andrew P. Degnan, Haiquan Fang, Tatyana Zvyaga, Zuzana Haarhoff, Claude A. Quesnelle, Melissa Kramer, Frank Marsilio, Richard A. Westhouse, John S. Tokarski, Shilpa Madari, Jiuqiao Zhao, Amy Wiebesiek, Chunhong Yan, Francis Y. Lee, Michael Sinz, John Morrison, Jean Simmermacher-Mayer, Carolynn Fanslau, Steven Sheriff, Lisa Huang, Ashvinikumar V. Gavai, Chunshan Xie, Matthew D. Hill, Gerry Everlof
المصدر: Bioorganicmedicinal chemistry letters. 51
مصطلحات موضوعية: Stereochemistry, Cell Survival, Clinical Biochemistry, Pharmaceutical Science, Structural diversity, Administration, Oral, Antineoplastic Agents, Triple Negative Breast Neoplasms, Biochemistry, Polar surface area, BET inhibitor, Mice, Structure-Activity Relationship, Drug Development, Drug Discovery, medicine, Animals, Humans, Molecular Biology, Chemotype, Dose-Response Relationship, Drug, Molecular Structure, Chemistry, Organic Chemistry, Cancer, Mammary Neoplasms, Experimental, Proteins, medicine.disease, In vitro, Bromodomain, Molecular Medicine, Drug Screening Assays, Antitumor, Carbolines
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المؤلفون: Charu Chaudhry, Percy H. Carter, Moslin Ryan M, Celia D’Arienzo, James Lin, Jodi K. Muckelbauer, Luisa Salter-Cid, Tracy L. Taylor, Kim W. McIntyre, Chunjian Liu, James R. Burke, Paul A. Elzinga, Hyunsoo Park, Kathleen M. Gillooly, Chiehying Chang, Dianlin Xie, Jing Chen, Lihong Cheng, David S. Weinstein, Cliff Chen, Jeffrey Tredup, Huadong Sun, Peng Li, Louis J. Lombardo, Adriana Zupa-Fernandez, Joann Strnad, John S. Tokarski, Dauh-Rurng Wu, Nelly Aranibar
المصدر: ACS Medicinal Chemistry Letters. 10:383-388
مصطلحات موضوعية: chemistry.chemical_classification, 010405 organic chemistry, Hydrogen bond, Stereochemistry, Aryl, Organic Chemistry, Ring (chemistry), 01 natural sciences, Biochemistry, 0104 chemical sciences, Pyridazine, 010404 medicinal & biomolecular chemistry, chemistry.chemical_compound, chemistry, Tyrosine kinase 2, Pharmacodynamics, Intramolecular force, Drug Discovery, Alkyl
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