نتائج البحث - "John T. Lazzaro"

1

Striatal, Hippocampal, and Cortical Networks Are Differentially Responsive to the M4- and M1-Muscarinic Acetylcholine Receptor Mediated Effects of Xanomeline

المؤلفون: Christopher R Butter, Joshua Moon, John F. Harms, Stefanus J. Steyn, John T. Lazzaro, Rebecca E. O’Connor, Catherine A. Thorn, Clinton A Bourbonais, Eda Stark, Jeremy R. Edgerton, Michael Popiolek

المصدر: ACS Chemical Neuroscience. 10:1753-1764

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9025a7351ef105457c2ee5a26339b5c2
https://doi.org/10.1021/acschemneuro.8b00625

Find this issue from the American Chemical Society

2

The Discovery of a Novel Phosphodiesterase (PDE) 4B-Preferring Radioligand for Positron Emission Tomography (PET) Imaging

المصدر: Journal of Medicinal Chemistry. 60:8538-8551

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7f5ba940556ef8664e507811b6fb86d
https://doi.org/10.1021/acs.jmedchem.7b01050

Find this issue from the American Chemical Society

3

Discovery and Characterization of (R)-6-Neopentyl-2-(pyridin-2-ylmethoxy)-6,7-dihydropyrimido[2,1-c][1,4]oxazin-4(9H)-one (PF-06462894), an Alkyne-Lacking Metabotropic Glutamate Receptor 5 Negative Allosteric Modulator Profiled in both Rat and Nonhuman Primates

المؤلفون: Daniel P. Walker, Antonia F. Stepan, Mark A. Moen, Gregg D. Cappon, Christopher Houle, Annie C Won, Joshua R. Dunetz, Michael John Bohanon, Lei Zhang, Marc B. Skaddan, Patrick Robert Verhoest, Susan E. Drozda, Xinjun Hou, Kenneth R. Zasadny, Julie Cianfrogna, Deborah L. Smith, Ann S. Wright, John T. Lazzaro, Steven Victor O'neil, Patrick Trapa, Emily Miller, Somraj Ghosh, Gabriela Barreiro, John M. Marcek, Margaret M. Zaleska, Jason Barricklow, Michelle Marie Claffey, Lois K. Chenard, Jessica Mancuso, Christopher L. Shaffer, Jessica Whritenour, Gayatri Balan, Brian P. Boscoe, Vinod D. Parikh, Karen J. Coffman, Laigao Chen, Isao Sakurada, Jamison B. Tuttle, Matthew R. Reese, Karki Kapil Kumar

المصدر: Journal of Medicinal Chemistry. 60:7764-7780

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74f7bf401a8f31cb0664e65627c9432b
https://doi.org/10.1021/acs.jmedchem.7b00604

Find this issue from the American Chemical Society

4

Design and Synthesis of γ- and δ-Lactam M1 Positive Allosteric Modulators (PAMs): Convulsion and Cholinergic Toxicity of an M1-Selective PAM with Weak Agonist Activity

المصدر: Journal of Medicinal Chemistry. 60:6649-6663

مصطلحات موضوعية: 0301 basic medicine, Agonist, Allosteric modulator, medicine.drug_class, Chemistry, Allosteric regulation, Muscarinic acetylcholine receptor M1, Pharmacology, 03 medical and health sciences, 030104 developmental biology, Drug Discovery, Convulsion, medicine, Molecular Medicine, Cholinergic, Structure–activity relationship, medicine.symptom, Receptor

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::e16d6e6b4f8608876f69c7501545a8c8
https://doi.org/10.1021/acs.jmedchem.7b00597

Find this issue from the American Chemical Society

5

Discovery of Selective M4 Muscarinic Acetylcholine Receptor Agonists with Novel Carbamate Isosteres

المؤلفون: Christopher Ryan Butler, Qingyi Yang, Michael Popiolek, Natasha M. Kablaoui, Lei Zhang, Sarah Grimwood, John T. Lazzaro, Rouba Kozak, Damien Webb, Rebecca E. O’Connor, Erik Alphie Lachapelle

المصدر: ACS Med Chem Lett

مصطلحات موضوعية: Carbamate, 010405 organic chemistry, Chemistry, medicine.medical_treatment, Organic Chemistry, Key features, 01 natural sciences, Biochemistry, 0104 chemical sciences, Structural homology, 010404 medicinal & biomolecular chemistry, Drug Discovery, Muscarinic acetylcholine receptor, medicine, Cholinergic, Interaction mode, Binding site, Neuroscience

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8b7038f52a14a71fc93cf610efea16b
https://pubmed.ncbi.nlm.nih.gov/31223452

Find this issue from the American Chemical Society

6

Characterization of a Novel M1 Muscarinic Acetylcholine Receptor Positive Allosteric Modulator Radioligand, [3H]PT-1284

المؤلفون: Deborah L. Smith, Sarah J. Neal, Lei Zhang, Jeremy R. Edgerton, Jennifer E. Davoren, Sarah Grimwood, John T. Lazzaro, Chewah Lee

المصدر: Molecular Pharmacology. 90:177-187

مصطلحات موضوعية: Male, 0301 basic medicine, Carbachol, Allosteric modulator, Pyridines, Stereochemistry, Allosteric regulation, CHO Cells, Isoindoles, Hippocampus, Rats, Sprague-Dawley, Radioligand Assay, 03 medical and health sciences, Cricetulus, 0302 clinical medicine, Allosteric Regulation, Cricetinae, Muscarinic acetylcholine receptor, medicine, Radioligand, Animals, Humans, Fluorometry, Pharmacology, Membranes, Chemistry, Ligand binding assay, Receptor, Muscarinic M1, N-Methylscopolamine, Acetylcholine, Electrophysiological Phenomena, Kinetics, HEK293 Cells, 030104 developmental biology, Positron-Emission Tomography, Autoradiography, Molecular Medicine, 030217 neurology & neurosurgery, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59a4cbb153c3abcd01cb4427f9543370
https://doi.org/10.1124/mol.116.104737

7

A role for the M1 muscarinic receptor in gastrointestinal motility

المؤلفون: Asser Bassyouni, Stephen Jenkinson, John T. Lazzaro, Lisa Nottebaum, Betty Pettersen, Jennifer Elizabeth Davoren

المصدر: Journal of Pharmacological and Toxicological Methods. 99:106595

مصطلحات موضوعية: Pharmacology, business.industry, Medicine, Motility, M1 muscarinic receptor, Toxicology, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::588b2a545f7396eabfc6951af6d1fb1e
https://doi.org/10.1016/j.vascn.2019.05.196

View record from ScienceDirect

8

Harnessing biosynthesis and quantitative NMR for late stage functionalization of lead molecules: Application to the M1 positive allosteric modulator (PAM) program

المؤلفون: Raman Sharma, Michael Aaron Brodney, Gregory S. Walker, R. Scott Obach, John T. Lazzaro

المصدر: Bioorganicmedicinal chemistry letters. 28(11)

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::550afcdd1c14b23dcb7abc8cddbdcadf
https://pubmed.ncbi.nlm.nih.gov/29716781

View record from ScienceDirect

9

Design and Synthesis of γ- and δ-Lactam M

المصدر: Journal of medicinal chemistry. 60(15)

مصطلحات موضوعية: Diarrhea, Male, Lactams, Vomiting, Scopolamine, Isoindoles, Structure-Activity Relationship, Dogs, Allosteric Regulation, Piperidines, Seizures, Thiadiazoles, Animals, Humans, Donepezil, Rats, Wistar, Oxazoles, Sulfonamides, Receptor, Muscarinic M1, Mice, Inbred C57BL, Amphetamine, Drug Design, Indans, Microsomes, Liver, Ataxia, Female

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::29248df43dd90a74489fbab479a9cfba
https://pubmed.ncbi.nlm.nih.gov/28598634

Find this issue from the American Chemical Society

10

Discovery and Preclinical Characterization of 1-Methyl-3-(4-methylpyridin-3-yl)-6-(pyridin-2-ylmethoxy)-1H-pyrazolo-[3,4-b]pyrazine (PF470): A Highly Potent, Selective, and Efficacious Metabotropic Glutamate Receptor 5 (mGluR5) Negative Allosteric Modulator

المصدر: Journal of Medicinal Chemistry. 57:861-877

مصطلحات موضوعية: Male, Models, Molecular, Dyskinesia, Drug-Induced, Cell Membrane Permeability, Allosteric modulator, Pyrazine, Stereochemistry, Receptor, Metabotropic Glutamate 5, Allosteric regulation, Administration, Oral, Biological Availability, Pharmacology, Madin Darby Canine Kidney Cells, Antiparkinson Agents, Levodopa, Rats, Sprague-Dawley, Radioligand Assay, Structure-Activity Relationship, chemistry.chemical_compound, Dogs, Allosteric Regulation, Pharmacokinetics, Drug Discovery, Animals, Humans, Potency, Hypersensitivity, Delayed, Metabotropic glutamate receptor 5, MPTP, Parkinson Disease, Rats, Macaca fascicularis, HEK293 Cells, chemistry, Regulatory toxicology, 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine, Pyrazines, Microsomes, Liver, Pyrazoles, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a87c83f67fb92d09c6e15f29a119306f
https://doi.org/10.1021/jm401622k

Find this issue from the American Chemical Society

تنقيح النتائج