-
1
المؤلفون: Gregory Hamm, Gareth Maglennon, Beth Williamson, Ruth Macdonald, Ann Doherty, Stewart Jones, Jayne Harris, James Blades, Alexander R. Harmer, Peter Barton, Philip B. Rawlins, Paul Smith, Jon Winter-Holt, Lindsay McMurray, Julia Johansson, Paul Fitzpatrick, William McCoull, Muireann Coen
المصدر: Archives of Toxicology. 96:613-624
مصطلحات موضوعية: Male, Mice, Knockout, c-Mer Tyrosine Kinase, Health, Toxicology and Mutagenesis, Retinal Degeneration, Retinal Pigment Epithelium, General Medicine, Toxicology, Multimodal Imaging, Mass Spectrometry, Cell Line, Rats, Mice, Inbred C57BL, Mice, Phagocytosis, Animals, Humans, Female, Rats, Long-Evans, Tissue Distribution, sense organs, Rats, Wistar, Photoreceptor Cells, Vertebrate
-
2
المؤلفون: Edward J. Hennessy, Marianne Schimpl, Emma Rivers, Paul D. Smith, Elizabeth Hardaker, Ann T. Doherty, Nichola L. Davies, Jon Travers, Qianxiu Zhu, Beth Williamson, Graham Smith, Lorraine Mooney, Helen Musgrove, Kristin Goldberg, Muireann Coen, Anne-Laure Lainé, Xiefeng Jiang, Philip Hopcroft, Yuting Zheng, Robert I Troup, George Hodgson, Nicola Lindsay, Lindsay McMurray, Olga Collingwood, Stephen D. Wilkinson, Sharon Tentarelli, Guang He, Philip B. Rawlins, Roshini Markandu, Jon Winter-Holt, Josephine Walton, Ankur Karmokar, J. Willem M. Nissink, Yumeng Mao, Dejian Yang, Alexander Pflug, Gary Fairley, Scott Boyd, Cheng Wang, Anne Jackson, Martin R. Brown, William McCoull, Neville McLean, Venkatesh Pilla Reddy
المصدر: Journal of Medicinal Chemistry. 64:13524-13539
مصطلحات موضوعية: chemistry.chemical_compound, Tumor microenvironment, Innate immune system, Chemistry, Kinase, In vivo, Drug Discovery, Pyridine, Lipophilicity, Cancer research, Molecular Medicine, Potency, Compound 32
-
3
المؤلفون: Beth Williamson, Lindsay McMurray, Scott Boyd, Olga Collingwood, Neville McLean, Jon Winter-Holt, Christina Chan, Aixiang Xue, William McCoull
المصدر: Molecular pharmaceutics. 19(7)
مصطلحات موضوعية: Benzylamines, c-Mer Tyrosine Kinase, Metabolic Clearance Rate, Drug Discovery, Biphenyl Compounds, Hepatocytes, Pharmaceutical Science, Molecular Medicine, Animals, Models, Biological, Rats
-
4
المؤلفون: William McCoull, Jon Winter-Holt, Marianne Schimpl, Elizabeth Underwood, Ross Overman, Juli Warwicker, Philip B. Rawlins, J. Willem M. Nissink, Alexander Pflug, Caroline Truman
المصدر: Biochemical Journal
مصطلحات موضوعية: Biophysics, Context (language use), Biochemistry, Protein Structure, Secondary, 03 medical and health sciences, Adenosine Triphosphate, MerTK, 0302 clinical medicine, Structural Biology, Humans, Kinome, Protein Kinase Inhibitors, Molecular Biology, Research Articles, Cancer, 030304 developmental biology, 0303 health sciences, c-Mer Tyrosine Kinase, Chemistry, Kinase, Pharmacology & Toxicology, Cell Biology, activation loop, MERTK, Receptor–ligand kinetics, activation segment, TAM, Protein kinase domain, 030220 oncology & carcinogenesis, Phosphorylation, Tyrosine kinase
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8d4c6e582a9e63dc834895d8a9b2dea
https://doi.org/10.1042/bcj20200735 -
5
المؤلفون: Nanhua Deng, Sameer Kawatkar, Haoyu Wang, Michael Zinda, Allan Wu, Neil P. Grimster, Scott Throner, Kirsten Bell, Claudio Chuaqui, Richard Woessner, Xian You Peng, Wenzhan Yang, Huawei Chen, Qibin Su, Xiaohui Pei, Jon Read, Erica Banks, Melissa Vasbinder, Andrew D. Ferguson, Paul Lyne, Zhanlei Tang, Linette Ruston, Jason Grant Kettle, Jon Winter-Holt, Geraldine Bebernitz, Stephen Fawell, Cassandra F. Borenstein
المصدر: Journal of Medicinal Chemistry. 63:4517-4527
مصطلحات موضوعية: 0303 health sciences, Janus Kinase 1 Inhibitor, Chemistry, Stereochemistry, medicine.medical_treatment, 01 natural sciences, stat, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, 03 medical and health sciences, Cytokine, Tyrosine kinase 2, Drug Discovery, medicine, Molecular Medicine, Janus kinase, 030304 developmental biology
-
6
المؤلفون: William, McCoull, Scott, Boyd, Martin R, Brown, Muireann, Coen, Olga, Collingwood, Nichola L, Davies, Ann, Doherty, Gary, Fairley, Kristin, Goldberg, Elizabeth, Hardaker, Guang, He, Edward J, Hennessy, Philip, Hopcroft, George, Hodgson, Anne, Jackson, Xiefeng, Jiang, Ankur, Karmokar, Anne-Laure, Lainé, Nicola, Lindsay, Yumeng, Mao, Roshini, Markandu, Lindsay, McMurray, Neville, McLean, Lorraine, Mooney, Helen, Musgrove, J Willem M, Nissink, Alexander, Pflug, Venkatesh Pilla, Reddy, Philip B, Rawlins, Emma, Rivers, Marianne, Schimpl, Graham F, Smith, Sharon, Tentarelli, Jon, Travers, Robert I, Troup, Josephine, Walton, Cheng, Wang, Stephen, Wilkinson, Beth, Williamson, Jon, Winter-Holt, Dejian, Yang, Yuting, Zheng, Qianxiu, Zhu, Paul D, Smith
المصدر: Journal of medicinal chemistry. 64(18)
مصطلحات موضوعية: Male, Molecular Structure, c-Mer Tyrosine Kinase, Pyridines, Imidazoles, Mice, Nude, Receptor Protein-Tyrosine Kinases, Antineoplastic Agents, Axl Receptor Tyrosine Kinase, Mice, Inbred C57BL, Structure-Activity Relationship, Cell Line, Tumor, Neoplasms, Proto-Oncogene Proteins, Animals, Female, Drug Screening Assays, Antitumor, Protein Kinase Inhibitors, Cell Proliferation
-
7
المؤلفون: Ross Overman, Juli Warwicker, Kristin Goldberg, Alexander Pflug, Jeremy S. Disch, Allison Olszewski, Philip B. Rawlins, John P. Guilinger, William McCoull, Rachael Jetson, Anthony D. Keefe, Simon A. Woodcock, Emma Rivers, Olga Collingwood, Elizabeth Hardaker, Sana Bazzaz, Elizabeth Underwood, Marianne Schimpl, J. Willem M. Nissink, Lindsay McMurray, Carolyn Blackett, Diana Gikunju, Jon Winter-Holt, Edward J. Hennessy, Paul D. Smith, Marian Preston, Caroline Truman, Matthew A. Clark, Ying Zhang
المصدر: Journal of medicinal chemistry. 64(6)
مصطلحات موضوعية: Models, Molecular, Computational biology, Crystallography, X-Ray, 01 natural sciences, Chemical library, 03 medical and health sciences, chemistry.chemical_compound, Drug Discovery, Animals, Data Mining, Humans, Immune homeostasis, Protein Kinase Inhibitors, 030304 developmental biology, 0303 health sciences, Tumor microenvironment, c-Mer Tyrosine Kinase, Chemistry, Kinase, Kinase Family, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Molecular Medicine, Kinase binding, Function (biology), TYRO3
-
8
المؤلفون: Qibin, Su, Erica, Banks, Geraldine, Bebernitz, Kirsten, Bell, Cassandra F, Borenstein, Huawei, Chen, Claudio E, Chuaqui, Nanhua, Deng, Andrew D, Ferguson, Sameer, Kawatkar, Neil P, Grimster, Linette, Ruston, Paul D, Lyne, Jon A, Read, Xianyou, Peng, Xiaohui, Pei, Stephen, Fawell, Zhanlei, Tang, Scott, Throner, Melissa M, Vasbinder, Haoyu, Wang, Jon, Winter-Holt, Richard, Woessner, Allan, Wu, Wenzhan, Yang, Michael, Zinda, Jason G, Kettle
المصدر: Journal of medicinal chemistry. 63(9)
مصطلحات موضوعية: Acrylamides, Aniline Compounds, Indoles, Molecular Structure, Mice, Nude, Drug Synergism, Janus Kinase 1, Xenograft Model Antitumor Assays, ErbB Receptors, Structure-Activity Relationship, Cell Line, Tumor, Drug Design, Drug Discovery, Animals, Humans, Female, Drug Screening Assays, Antitumor, Protein Kinase Inhibitors
-
9
المؤلفون: Magnus Gustafsson, David J. Drake, Sébastien L. Degorce, David M. Andrews, Kevin M. Higgins, Jon Winter
المصدر: Drug Discovery Today. 20:1250-1255
مصطلحات موضوعية: Pharmacology, Service (business), Drug Industry, Databases, Pharmaceutical, business.industry, Chemistry, Pharmaceutical, Ownership, Internet privacy, Control (management), Sample (statistics), Ownership rights, Dynamic database, Drug Discovery, Premise, Humans, Social media, Business, Cooperative Behavior, Social Media, Open innovation
-
10
المؤلفون: Ian M. Hardern, Jarrod Walsh, Ed Wheatley, Jon Winter-Holt, Sarita Maman, Judit E. Debreczeni, Graeme Walker, Susan E. Critchlow, Gareth M. Davies, Nicola J. Evans, Richard A. Ward, Neil P. Jones, Sheila B. McLoughlin, Andrew Peter Thomas, Neil Bennett, Geoff Holdgate, Nicola Curtis, Stephen A. St-Gallay, Lindsey Leach, Laurent Rigoreau, Andrew P. Turnbull, Marian Preston
المصدر: SLAS discovery : advancing life sciences RD. 23(1)
مصطلحات موضوعية: 0301 basic medicine, Phosphofructokinase-2, Chlorine atom, Quantitative Structure-Activity Relationship, Antineoplastic Agents, Crystal structure, Calorimetry, Molecular Dynamics Simulation, computer.software_genre, Ligands, 01 natural sciences, Biochemistry, Analytical Chemistry, Workflow, Small Molecule Libraries, 03 medical and health sciences, Inhibitory Concentration 50, Ic50 values, Humans, Enzyme Inhibitors, Throughput (business), Series (mathematics), Chemistry, Isothermal titration calorimetry, Combinatorial chemistry, 0104 chemical sciences, High-Throughput Screening Assays, Gene Expression Regulation, Neoplastic, Molecular Docking Simulation, 010404 medicinal & biomolecular chemistry, 030104 developmental biology, Molecular Medicine, Data mining, Drug Screening Assays, Antitumor, computer, Biotechnology
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbb293272e1c04a39e000a87f72a6166
https://pubmed.ncbi.nlm.nih.gov/28945981