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1
المؤلفون: Seungil Han, Martin E. Dowty, Ralph P. Robinson, Steven E. Heasley, Peter T. Symanowicz, Jason Jussif, Thomas M. Harris, Neelu Kaila, Lu Wang, Matthew Frank Brown, Jeffrey M. Casavant, Nicole Caspers, Sarah H. Griffin, Mark J. Mitton-Fry, Martin Hegen, Johnson Timothy Allan, Tenbrink Ruth E, Mary Ellen Banker, Jonathan Langille, Mihir D. Parikh, Tsung H. Lin, Arindrajit Basak, Jean-Baptiste Telliez, James D. Clark, Strohbach Joseph Walter, Eric P. Arnold, Ray Unwalla, Li Li, Brian A. Duclos, Xin Yang, Mark Edward Flanagan, John David Trzupek, Michael L. Vazquez, Soojin Kwon, Ashley Edward Fenwick
المصدر: Journal of Medicinal Chemistry. 61:1130-1152
مصطلحات موضوعية: Models, Molecular, 0301 basic medicine, Protein Conformation, Drug Evaluation, Preclinical, Arthritis, Inflammation, Pharmacology, Autoimmune Diseases, Substrate Specificity, Inhibitory Concentration 50, 03 medical and health sciences, Dogs, Immune system, Drug Discovery, medicine, Animals, Humans, Pyrroles, Tissue Distribution, Protein Kinase Inhibitors, Thrombopoietin, Sulfonamides, Tofacitinib, Chemistry, Janus Kinase 1, Janus Kinase 2, medicine.disease, Arthritis, Experimental, Rats, Pyrimidines, 030104 developmental biology, Tyrosine kinase 2, Molecular Medicine, medicine.symptom, Janus kinase, Tyrosine kinase, Cyclobutanes
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73b9d013c1aa57b2199cce24ad33fac0
https://doi.org/10.1021/acs.jmedchem.7b01598 -
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المؤلفون: Jotham Wadsworth Coe, Phillip J. Fiore, Ian Edmonds, Jeffrey B. Sperry, Wiglesworth Kristin, Eugene Lvovich Piatnitski Chekler, Jonathan Langille, David C. Boyles, Roberta Louise Dorow, David B. Damon
المصدر: Organic Process Research & Development. 18:1752-1758
مصطلحات موضوعية: Organic Chemistry, chemistry.chemical_element, Buchwald–Hartwig amination, Catalysis, chemistry.chemical_compound, chemistry, Yield (chemistry), Organic chemistry, Amine gas treating, Physical and Theoretical Chemistry, Amination, Stoichiometry, Palladium, BINAP
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::470ba14d178fb0c8d303c2bfa1cd4ece
https://doi.org/10.1021/op5002319 -
3
المؤلفون: Louis Leung, Jonathan Langille, John I. Trujillo, Paul B. Balbo, Jason Jussif, Jill Chrencik, Martin Hegen, Felix Vajdos, Atli Thorarensen, Sarah Soucy, Adam M. Gilbert, Jean-Baptiste Telliez, Tsung Lin, Ray Unwalla, Matthew Merrill Hayward, Justin I. Montgomery, Sidney Liang, Fabien Vincent, Robert M. Czerwinski, Ye Che, Martin E. Dowty, Mary Ellen Banker, Xin Yang, Matthew Frank Brown, Agustin Casimiro-Garcia, Jotham Wadsworth Coe, Brian Juba
المصدر: Journal of medicinal chemistry. 60(5)
مصطلحات موضوعية: 0301 basic medicine, Gene isoform, Administration, Oral, Pharmacology, 01 natural sciences, 03 medical and health sciences, In vivo, Drug Discovery, Humans, Pyrroles, Protein Kinase Inhibitors, chemistry.chemical_classification, 010405 organic chemistry, Janus kinase 3, Janus Kinase 3, 0104 chemical sciences, Safety profile, 030104 developmental biology, Orally active, Enzyme, Pyrimidines, Biochemistry, chemistry, Pharmacodynamics, Drug Design, Molecular Medicine, Janus kinase, Signal Transduction
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c5195e7072387df8494062118b596b7
https://pubmed.ncbi.nlm.nih.gov/28139931 -
4
المؤلفون: Shaoyi Sun, Ray Chui, Ivana Rajlic, Jonathan Langille, Qi Jia, Shifeng Liu, Jianyu Sun, Wendy Young, Sultan Chowdhury, Jianmin Fu, Jing Zhong, Mikhail Chafeev, Zaihui Zhang, Sazzad Hossain, Henry Verschoof, Mark Wood, Kuldip Khakh, Tom Hsieh, Serguei Sviridov, Audrey Wang, Xing Cheng, Rainbow Kwan, Cadieux Jean-Jacques
المصدر: Medicinal Chemistry Research. 22:1825-1836
مصطلحات موضوعية: chemistry.chemical_compound, Sodium channel blocker, Chemistry, In vivo, Organic Chemistry, Pharmacology toxicology, Mitsunobu reaction, General Pharmacology, Toxicology and Pharmaceutics, Pharmacology, Inflammatory pain, In vitro, Methylenedioxy, ADME
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::140743f6d89198f0c7f887c44e1f4632
https://doi.org/10.1007/s00044-012-0180-1 -
5
المؤلفون: Renato Skerlj, Tuya Ba, Ernest J. McEachern, Elyse Bourque, Ian Baird, Dominique Schols, Wilson Trevor R, Renee Mosi, Jonathan Langille, Yuanxi Zhou, Bryon Carpenter, Michael Bey, Simon P. Fricker, Dana Huskens, Duane Veale, Rebecca S.Y. Wong, Gary Bridger, Curtis Harwig, Veronique Bodart, Ron MacFarland, Markus Metz, Sanjay Danthi
المصدر: ACS Medicinal Chemistry Letters. 3:216-221
مصطلحات موضوعية: congenital, hereditary, and neonatal diseases and abnormalities, biology, business.industry, Purkinje fibers, Organic Chemistry, hERG, Human immunodeficiency virus (HIV), Pharmacology, medicine.disease_cause, Biochemistry, Bioavailability, Chemokine receptor, medicine.anatomical_structure, Drug Discovery, Lipophilicity, biology.protein, Medicine, Action potential duration, cardiovascular diseases, business, Ion channel
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9674269a09a599b87e9e9ed8edb34dc
https://doi.org/10.1021/ml2002604 -
6
المؤلفون: Renato Skerlj, Gary Bridger, Yuanxi Zhou, Elyse Bourque, Ernest McEachern, Jonathan Langille, Curtis Harwig, Duane Veale, Wen Yang, Tongshong Li, Yongbao Zhu, Michael Bey, Ian Baird, Michael Sartori, Markus Metz, Renee Mosi, Kim Nelson, Veronique Bodart, Rebecca Wong, Simon Fricker, Ron Mac Farland, Dana Huskens, Dominique Schols
المصدر: Bioorganic & Medicinal Chemistry Letters. 21:6950-6954
مصطلحات موضوعية: Tertiary amine, Anti-HIV Agents, Pyridines, medicine.drug_class, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Carboxamide, CCR5 receptor antagonist, Pharmacology, Virus Replication, Biochemistry, Peripheral blood mononuclear cell, Chemical synthesis, Inhibitory Concentration 50, Dogs, Piperidines, Drug Discovery, medicine, Animals, Humans, Structure–activity relationship, Molecular Biology, Molecular Structure, Chemistry, Organic Chemistry, virus diseases, Amides, In vitro, Rats, Viral replication, Drug Design, CCR5 Receptor Antagonists, HIV-1, Leukocytes, Mononuclear, Molecular Medicine
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe8c7c65ea6806cdd761d65d01e7a8e4
https://doi.org/10.1016/j.bmcl.2011.09.133 -
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المؤلفون: Zefferino Santucci, Gary Bridger, Gloria Lau, Dominique Schols, Elyse Bourque, Wen Yang, Simon P. Fricker, Markus Metz, Curtis Harwig, Marilyn C. Darkes, Renato T. Skerlj, Jonathan Langille, Jean Labrecque, Sanjay Danthi
المصدر: Journal of the American Chemical Society. 133:16477-16485
مصطلحات موضوعية: Models, Molecular, Anti-HIV Agents, Stereochemistry, hERG, Allosteric regulation, Mutagenesis (molecular biology technique), Microbial Sensitivity Tests, Computational biology, CCR5 receptor antagonist, Biochemistry, Catalysis, Structure-Activity Relationship, Colloid and Surface Chemistry, medicine, Humans, Urea, Structure–activity relationship, Dose-Response Relationship, Drug, Molecular Structure, biology, Chemistry, Stereoisomerism, General Chemistry, Small molecule, Ether-A-Go-Go Potassium Channels, Entry inhibitor, Molecular Weight, Mutagenesis, Drug Design, CCR5 Receptor Antagonists, HIV-1, Leukocytes, Mononuclear, biology.protein, Pharmacophore, medicine.drug
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f068a451bbd2e2f3c06180565814c9f6
https://doi.org/10.1021/ja2043722 -
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المؤلفون: Renato Skerlj, Gary Bridger, Yuanxi Zhou, Elyse Bourque, Jonathan Langille, Maria Di Fluri, David Bogucki, Wen Yang, Tongshuang Li, Letian Wang, Susan Nan, Ian Baird, Markus Metz, Marilyn Darkes, Jean Labrecque, Gloria Lau, Simon Fricker, Dana Huskens, Dominique Schols
المصدر: Bioorganic & Medicinal Chemistry Letters. 21:2450-2455
مصطلحات موضوعية: Receptors, CCR5, Pyridines, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, Virus Replication, Amides, Biochemistry, Rats, Cyclic N-Oxides, Structure-Activity Relationship, Dogs, Piperidines, Drug Design, CCR5 Receptor Antagonists, Oximes, Drug Discovery, HIV-1, Animals, Humans, Molecular Medicine, Molecular Biology
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db65c2f32206af093539db4b4c1cf2c1
https://doi.org/10.1016/j.bmcl.2011.02.058 -
9
المؤلفون: Patricia S. Doyle, Zefferino Santucci, Gloria Lau, Ling Qin, Elizabeth Hansell, Jonathan Langille, Youngbao Zhu, Simon P. Fricker, Virginia Anastassov, Renato Skerlj, Beth R. Cameron, Micki Olsen, Jennifer H. Cox, Ian Baird, James H. McKerrow, Rebecca S.Y. Wong, Renee Mosi
المصدر: Journal of Inorganic Biochemistry. 102:1839-1845
مصطلحات موضوعية: Trypanosoma, Proteases, Stereochemistry, chemistry.chemical_element, Cysteine Proteinase Inhibitors, Biochemistry, Cathepsin B, Rhodium, Inorganic Chemistry, Metal, Animals, Humans, Chagas Disease, Osmium, Leishmaniasis, Leishmania, Chemistry, Trypanocidal Agents, Cysteine protease, Cysteine Endopeptidases, Inorganic Chemicals, Metals, visual_art, visual_art.visual_art_medium, Cysteine, Palladium
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a5eaf8e8b9f6ade96977408fd187275
https://doi.org/10.1016/j.jinorgbio.2008.05.010 -
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المؤلفون: Curtis Harwig, Dominique Schols, Gang Chen, Wen Yang, Duane Veale, Susan Nan, Simon P. Fricker, Alan Kaller, Danielle Guay, Jason M. Crawford, Michael Satori, Markus Metz, Yongbao Zhu, Helen Yee, Maria Krumpak, Elyse Bourque, Wilson Trevor R, David Bogucki, Bryon Carpenter, Michael Bey, David C. Leitch, Ron MacFarland, David Gauthier, Ian Baird, Rebecca Wong, Renato T. Skerlj, Jonathan Langille, Yuanxi Zhou, Gary Bridger, Renee Mosi, Ernest J. McEachern, Tuya Ba, Tong-Shuang Li, Krystyna Vocadlo, Veronique Bodart
المصدر: Journal of medicinal chemistry. 56(20)
مصطلحات موضوعية: Receptors, CCR5, Anti-HIV Agents, Cell Survival, hERG, Human immunodeficiency virus (HIV), CHO Cells, Pharmacology, medicine.disease_cause, Imidazolidines, Virus Replication, Benzoates, Chemokine receptor, Structure-Activity Relationship, Cricetulus, Piperidines, In vivo, Cricetinae, Drug Discovery, medicine, Animals, Humans, Cells, Cultured, Cardiotoxicity, biology, Molecular Structure, Chemistry, Imidazoles, In vitro, Receptor selectivity, HEK293 Cells, Biochemistry, Models, Chemical, Drug Design, Lipophilicity, CCR5 Receptor Antagonists, Host-Pathogen Interactions, biology.protein, HIV-1, Leukocytes, Mononuclear, Molecular Medicine
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63349d2f129c824dd1d79fd4e3bd1bc8
https://pubmed.ncbi.nlm.nih.gov/24090135