المؤلفون: Guanglin Luo, Ling Chen, Walter A. Kostich, Brian Hamman, Jason Allen, Amy Easton, Clotilde Bourin, Michael Gulianello, Jonathan Lippy, Susheel Nara, Sreenivasulu Naidu Pattipati, Kumaran Dandapani, Manoj Dokania, Pradeep Vattikundala, Vivek Sharma, Saravanan Elavazhagan, Manoj Kumar Verma, Manish Lal Das, Santosh Wagh, Anand Balakrishnan, Benjamin M. Johnson, Kenneth S. Santone, George Thalody, Rex Denton, Hariharan Saminathan, Vinay K. Holenarsipur, Anoop Kumar, Abhijith Rao, Siva Prasad Putlur, Sarat Kumar Sarvasiddhi, Ganesh Shankar, Justin V. Louis, Manjunath Ramarao, Charles M. Conway, Yu-Wen Li, Rick Pieschl, Yuan Tian, Yang Hong, Linda Bristow, Charles F. Albright, Joanne J. Bronson, John E. Macor, Carolyn D. Dzierba

المصدر: Journal of Medicinal Chemistry. 65:4534-4564

مصطلحات موضوعية: Mice, Structure-Activity Relationship, Spinal Cord, Anesthetics, General, Drug Discovery, Animals, Neuralgia, Molecular Medicine, Protein Kinase Inhibitors, Ethers, Rats

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbf11be6e3846cab6b37f029b5b93a8d
https://doi.org/10.1021/acs.jmedchem.1c02132

المؤلفون: Guanglin Luo, Ling Chen, Walter A. Kostich, Brian Hamman, Jason Allen, Amy Easton, Clotilde Bourin, Michael Gulianello, Jonathan Lippy, Susheel Nara, Tarun Kumar Maishal, Kamalraj Thiyagarajan, Prasadrao Jalagam, Sreenivasulu Naidu Pattipati, Kumaran Dandapani, Manoj Dokania, Pradeep Vattikundala, Vivek Sharma, Saravanan Elavazhagan, Manoj Kumar Verma, Manish Lal Das, Santosh Wagh, Anand Balakrishnan, Benjamin M. Johnson, Kenneth S. Santone, George Thalody, Rex Denton, Hariharan Saminathan, Vinay K. Holenarsipur, Anoop Kumar, Abhijith Rao, Siva Prasad Putlur, Sarat Kumar Sarvasiddhi, Ganesh Shankar, Justin V. Louis, Manjunath Ramarao, Charles M. Conway, Yu-Wen Li, Rick Pieschl, Yuan Tian, Yang Hong, Jonathan Ditta, Arvind Mathur, Jianqing Li, Daniel Smith, Joseph Pawluczyk, Dawn Sun, Shiuhang Yip, Dauh-Rurng Wu, Muthalagu Vetrichelvan, Anuradha Gupta, Alan Wilson, Suma Gopinathan, Suman Wason, Linda Bristow, Charles F. Albright, Joanne J. Bronson, John E. Macor, Carolyn D. Dzierba

المصدر: Journal of Medicinal Chemistry. 65:4457-4480

مصطلحات موضوعية: Drug Discovery, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::38224dcaf3d9ea2fabc4ac6df4a42a84
https://doi.org/10.1021/acs.jmedchem.1c02131

المؤلفون: Jonathan Lippy, Robert M. Borzilleri, Andrew J. Tebben, Litao Zhang, Charu Chaudhry, William J. Pitts, John S. Tokarski

المصدر: Drug Discovery Today. 26:1115-1125

مصطلحات موضوعية: 0301 basic medicine, Drug, Pharmaceutical drug, Computer science, media_common.quotation_subject, medicine.medical_treatment, Drug Resistance, Computational biology, Food and drug administration, 03 medical and health sciences, 0302 clinical medicine, Drug Discovery, medicine, Animals, Humans, Kinome, Drug Approval, Protein Kinase Inhibitors, media_common, Pharmacology, United States Food and Drug Administration, Drug discovery, Kinase, Small molecule, United States, 030104 developmental biology, 030220 oncology & carcinogenesis, Protein Kinases

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a1427877b39cb9b4aab8094dddf3cf4
https://doi.org/10.1016/j.drudis.2021.01.018

المؤلفون: Guanglin, Luo, Ling, Chen, Walter A, Kostich, Brian, Hamman, Jason, Allen, Amy, Easton, Clotilde, Bourin, Michael, Gulianello, Jonathan, Lippy, Susheel, Nara, Tarun Kumar, Maishal, Kamalraj, Thiyagarajan, Prasadrao, Jalagam, Sreenivasulu Naidu, Pattipati, Kumaran, Dandapani, Manoj, Dokania, Pradeep, Vattikundala, Vivek, Sharma, Saravanan, Elavazhagan, Manoj Kumar, Verma, Manish Lal, Das, Santosh, Wagh, Anand, Balakrishnan, Benjamin M, Johnson, Kenneth S, Santone, George, Thalody, Rex, Denton, Hariharan, Saminathan, Vinay K, Holenarsipur, Anoop, Kumar, Abhijith, Rao, Siva Prasad, Putlur, Sarat Kumar, Sarvasiddhi, Ganesh, Shankar, Justin V, Louis, Manjunath, Ramarao, Charles M, Conway, Yu-Wen, Li, Rick, Pieschl, Yuan, Tian, Yang, Hong, Jonathan, Ditta, Arvind, Mathur, Jianqing, Li, Daniel, Smith, Joseph, Pawluczyk, Dawn, Sun, Shiuhang, Yip, Dauh-Rurng, Wu, Muthalagu, Vetrichelvan, Anuradha, Gupta, Alan, Wilson, Suma, Gopinathan, Suman, Wason, Linda, Bristow, Charles F, Albright, Joanne J, Bronson, John E, Macor, Carolyn D, Dzierba

المصدر: Journal of medicinal chemistry. 65(6)

مصطلحات موضوعية: Mice, Spinal Cord, Animals, Brain, Neuralgia, Amines, Protein Kinase Inhibitors, Rats

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::1e41976413f9c4afd18a0630ac9bd2a0
https://pubmed.ncbi.nlm.nih.gov/35257579

المؤلفون: Jennifer Brown, Karen E. Parrish, Andrew J. Tebben, Jonathan Lippy, Kamalavenkatesh Palanisamy, Todd Kinsella, Chetan Padmakar Darne, Vinay K. Holenarsipur, Anwar Murtaza, Muthalagu Vetrichelvan, Chunhong Yan, Karen Augustine-Rauch, Max Ruzanov, Mark Fereshteh, Upender Velaparthi, Gopal Dhar, Gregory D. Vite, Peiying Liu, Steven Sheriff, Jayakumar Sankara Warrier, Aravind Anandam, Marina Gelman, Arvind Mathur, Barri Wautlet, Robert M. Borzilleri, Hasibur Rahaman, Zheng Yang, Anuradha Gupta, Arun Kumar Gupta, Rajinder Singh, Joseph Fargnoli, Jesse Swanson

المصدر: ACS Med Chem Lett

مصطلحات موضوعية: biology, 010405 organic chemistry, business.industry, Organic Chemistry, Pharmacology, 01 natural sciences, Biochemistry, 0104 chemical sciences, Bioavailability, 010404 medicinal & biomolecular chemistry, Regimen, Pharmacokinetics, In vivo, Drug Discovery, biology.protein, Medicine, Potency, Kinome, Dosing, Antibody, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57c0a6b7db9a564a606d22c0c365bdb7
https://doi.org/10.1021/acsmedchemlett.9b00552

المؤلفون: Jodi K. Muckelbauer, Ramkumar Rajamani, Jeffrey M. Brown, C M Vijaya Kumar, Kumaran Dandapani, Jonathan Lippy, Saravanan Elavazhagan, Vijay T. Ahuja, John E. Macor, Carolyn Diane Dzierba, Brian D. Hamman, Walter Kostich, Michael Gulianello, Manoj Dokania, Susan E. Kiefer, Susheel J. Nara, Joanne J. Bronson, Amy Easton, Richard A. Hartz, Linda J. Bristow, Martin A. Lewis, Jason Allen, Sreenivasulu N Pattipati, Neha Surti, Lisa Hunihan, Daniel M. Camac

المصدر: Journal of medicinal chemistry. 64(15)

مصطلحات موضوعية: Male, Phenotypic screening, Pharmacology, Protein Serine-Threonine Kinases, chemistry.chemical_compound, Mice, Structure-Activity Relationship, In vivo, Drug Discovery, medicine, Animals, Humans, Dose-Response Relationship, Drug, Molecular Structure, Kinase, Chemistry, Anti-Inflammatory Agents, Non-Steroidal, Chronic pain, AAK1, Signal transducing adaptor protein, Brain, medicine.disease, Amides, Mice, Inbred C57BL, HEK293 Cells, Neuropathic pain, Microsomes, Liver, Molecular Medicine, Neuralgia, Caco-2 Cells, Penetrant (biochemical), Protein Kinases

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a874893d7c1ec730ba639d989c3f7ccd
https://pubmed.ncbi.nlm.nih.gov/34270254

المؤلفون: Joe Baldick, Jonathan Lippy, Peter Chase, Austin Crithary, Sha Li, Jing Chen, Alan Futran, Brian J. Arey, Alex Wolicki, Kylie Fogarty

المصدر: SLAS discovery : advancing life sciences RD. 26(3)

مصطلحات موضوعية: 0301 basic medicine, Ribosomal Proteins, T-Lymphocytes, Primary Cell Culture, Computational biology, Biology, Real-Time Polymerase Chain Reaction, Biochemistry, Analytical Chemistry, 03 medical and health sciences, 0302 clinical medicine, Antigens, Neoplasm, Cell Line, Tumor, Gene expression, Drug Discovery, Humans, Throughput (business), Chemokine CCL3, Automation, Laboratory, Osteoblasts, business.industry, Drug discovery, Gene Expression Profiling, Membrane Proteins, HCT116 Cells, Automation, Baculoviral IAP Repeat-Containing 3 Protein, High-Throughput Screening Assays, Neoplasm Proteins, Gene expression profiling, 030104 developmental biology, Gene Expression Regulation, 030220 oncology & carcinogenesis, Molecular Medicine, business, Biotechnology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e97359b5502f738d67330317e2fe02ce
https://pubmed.ncbi.nlm.nih.gov/32935608

المؤلفون: Neha Surti, Jonathan Lippy, Samuel Gerritz, David G. Harden, Peter Chase, Jefferson Chin, Julia M. Nielsen, Harold N. Weller, R. Michael Lawrence, Wilson Z. Shou, Darshani Weerakoon

المصدر: SLAS discovery : advancing life sciences RD. 26(2)

مصطلحات موضوعية: 0303 health sciences, Computer science, High-throughput screening, Computational biology, Integrity assessment, 01 natural sciences, Biochemistry, Mass Spectrometry, 0104 chemical sciences, Analytical Chemistry, High-Throughput Screening Assays, Small Molecule Libraries, 010404 medicinal & biomolecular chemistry, 03 medical and health sciences, Cheminformatics, Drug Discovery, Molecular Medicine, 030304 developmental biology, Biotechnology, Chromatography, Liquid

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c60028ac212de1108d34666138b183b
https://pubmed.ncbi.nlm.nih.gov/32400264

المؤلفون: James R. Burke, Matthew B. Robers, James D Vasta, H. Ribeiro, B. Arey, G. Locke, Jonathan Lippy, Charu Chaudhry, Joseph A. Tino, Mark A. Pattoli, Stacey Skala, Andrew J. Tebben, Lixia Zhang, L. L. Ong, Scott H. Watterson, L. Monereau, Poncho Meisenheimer

المصدر: SLAS discovery : advancing life sciences RD. 25(2)

مصطلحات موضوعية: 0301 basic medicine, Cell signaling, 01 natural sciences, Biochemistry, Analytical Chemistry, 03 medical and health sciences, Agammaglobulinaemia Tyrosine Kinase, Fluorescence Resonance Energy Transfer, Bruton's tyrosine kinase, Structure–activity relationship, Humans, Kinase activity, Phosphorylation, Protein Kinase Inhibitors, biology, 010405 organic chemistry, Chemistry, Kinase, Phenotype, 0104 chemical sciences, Cell biology, High-Throughput Screening Assays, Kinetics, 030104 developmental biology, biology.protein, Molecular Medicine, Tyrosine kinase, Intracellular, Biotechnology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bce774a861c747b37f478bb8945a972
https://pubmed.ncbi.nlm.nih.gov/31709883

المؤلفون: Barri Wautlet, Lalgudi S. Harikrishnan, Jonathan Lippy, Andrew J. Tebben, Amol G. Dikundwar, P.N. Arunachalam, Raju Mannoori, Max Ruzanov, Yi Fan, Gopikishan Tonukunuru, Vishweshwaraiah Baligar, Mark Fereshteh, Balaji Seshadri, Jayakumar Warrier, Sudhakara R. Madduri, Joseph Fargnoli, Robert M. Borzilleri, Ching-Ping Ho, Brian E. Fink, Steven Sheriff, Hasibur Rahaman

المصدر: Bioorganic & Medicinal Chemistry. 26:1026-1034

مصطلحات موضوعية: 0301 basic medicine, Epithelial-Mesenchymal Transition, T-Lymphocytes, Clinical Biochemistry, Receptor, Transforming Growth Factor-beta Type I, Thiazines, Pharmaceutical Science, Smad Proteins, SMAD, Molecular Dynamics Simulation, Protein Serine-Threonine Kinases, Crystallography, X-Ray, Biochemistry, Bridged Bicyclo Compounds, Structure-Activity Relationship, 03 medical and health sciences, 0302 clinical medicine, In vivo, Drug Discovery, TGF beta signaling pathway, Humans, Pyrroles, Epithelial–mesenchymal transition, Phosphorylation, Molecular Biology, Cells, Cultured, Binding Sites, Chemistry, Organic Chemistry, In vitro, Protein Structure, Tertiary, 030104 developmental biology, Drug Design, 030220 oncology & carcinogenesis, Cancer research, Molecular Medicine, Signal transduction, Receptors, Transforming Growth Factor beta, Protein Binding, Transforming growth factor

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27a455e12641eb310526027a244db0ac
https://doi.org/10.1016/j.bmc.2018.01.014