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1دورية أكاديمية
المؤلفون: E Josue Ruiz, Adan Pinto-Fernandez, Andrew P Turnbull, Linxiang Lan, Thomas M Charlton, Hannah C Scott, Andreas Damianou, George Vere, Eva M Riising, Clive Da Costa, Wojciech W Krajewski, David Guerin, Jeffrey D Kearns, Stephanos Ioannidis, Marie Katz, Crystal McKinnon, Jonathan O'Connell, Natalia Moncaut, Ian Rosewell, Emma Nye, Neil Jones, Claire Heride, Malte Gersch, Min Wu, Christopher J Dinsmore, Tim R Hammonds, Sunkyu Kim, David Komander, Sylvie Urbe, Michael J Clague, Benedikt M Kessler, Axel Behrens
المصدر: eLife, Vol 10 (2021)
مصطلحات موضوعية: squamous cell lung cancer, USP28, c-MYC, Medicine, Science, Biology (General), QH301-705.5
وصف الملف: electronic resource
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المؤلفون: Axel Behrens, Clive Da Costa, Min Wu, David Joseph Guerin, Emma Nye, Jonathan O'Connell, Adan Pinto-Fernandez, Eva M. Riising, Jeffrey D Kearns, Tim Hammonds, Andrew P. Turnbull, Crystal McKinnon, E. Josue Ruiz, Claire Heride, Christopher J. Dinsmore, Malte Gersch, Ian Rosewell, Thomas M. Charlton, Linxiang Lan, Neil P. Jones, Andreas Damianou, Hannah C. Scott, Benedikt M. Kessler, Sylvie Urbé, Michael J. Clague, Natalia Moncaut, Wojciech W. Krajewski, Stephanos Ioannidis, David Komander, Marie Katz, Sunkyu Kim, George Vere
مصطلحات موضوعية: Chemistry, Cancer research, Small molecule, Squamous cell lung carcinoma
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::205d91672bd258cadd1c178b2544807d
https://doi.org/10.7554/elife.71596.sa2 -
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المؤلفون: Malte Gersch, Thomas M. Charlton, Michael J. Clague, Linxiang Lan, Hannah C. Scott, Sylvie Urbé, George Vere, Min Wu, Sunkyu Kim, Stephanos Ioannidis, Claire Heride, Jeffrey D Kearns, Jonathan O'Connell, David Komander, Adan Pinto-Fernandez, E. Josue Ruiz, Emma Nye, Axel Behrens, Benedikt M. Kessler, Andrew P. Turnbull, Marie Katz, Natalia Moncaut, Andreas Damianou, Wojciech W. Krajewski, Neil P. Jones, Christopher J. Dinsmore, Ian Rosewell, Tim Hammonds, David Joseph Guerin, Eva M. Riising, Crystal McKinnon, Clive Da Costa
المصدر: eLife, Vol 10 (2021)
eLifeمصطلحات موضوعية: Lung Neoplasms, Gene Expression, medicine.disease_cause, Imaging, Mice, 0302 clinical medicine, Biology (General), Cancer Biology, Human Biology & Physiology, 0303 health sciences, Chemistry, Stem Cells, General Neuroscience, Lung squamous cell carcinoma, Genome Integrity & Repair, Treatment options, General Medicine, Small molecule, 3. Good health, DNA-Binding Proteins, medicine.anatomical_structure, c-MYC, 030220 oncology & carcinogenesis, Medicine, Lung tumours, Ubiquitin Thiolesterase, Genetics & Genomics, Research Article, Human, Squamous cell lung carcinoma, Model organisms, QH301-705.5, Science, Chemical biology, USP28, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, squamous cell lung cancer, Biochemistry and Chemical Biology, medicine, Ubiquitin specific protease, Animals, Humans, Neoplasms, Squamous Cell, Survival rate, 030304 developmental biology, Lung, General Immunology and Microbiology, Tumour Biology, Disease Models, Animal, Cancer research, Carcinogenesis, Gene Deletion, Transcription Factors
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::beb8f4f7baf6b379b1145b3efa1b3fa6
https://elifesciences.org/articles/71596 -
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المؤلفون: Reiner Meyer, Heribert Arnhof, Daniela Haering, Rachel L Mendes, David J. Richard, Irene Weiner, Norbert Kraut, Wolfgang Hela, Christian Salamon, Klaus Rumpel, Gerd Bader, Michael Gmachl, Andreas Dr. Zöphel, Renate Schnitzer, Peter Ettmayer, Jark Böttcher, Matthew D Kennedy, Juergen Ramharter, Michael P. Sanderson, Darryl B. McConnell, Nikolai Pototschnig, Dirk Kessler, Silvia Munico-Martinez, Tobias Wunberg, Marco H. Hofmann, Katja Hauer, Thomas Gerstberger, Lyne Lamarre, Patrick Werni, Christiane Kofink, Jonathan O’Connell, Bernhard Wolkerstorfer
المصدر: Journal of medicinal chemistry. 64(10)
مصطلحات موضوعية: Afatinib, Mutagenesis (molecular biology technique), Molecular Dynamics Simulation, medicine.disease_cause, 01 natural sciences, Proto-Oncogene Proteins p21(ras), 03 medical and health sciences, Allosteric Regulation, Catalytic Domain, Drug Discovery, medicine, Humans, Protein Interaction Maps, Colorectal tumor, 030304 developmental biology, EGFR inhibitors, 0303 health sciences, Binding Sites, Chemistry, 0104 chemical sciences, ErbB Receptors, 010404 medicinal & biomolecular chemistry, Cancer research, SOS1, Mutagenesis, Site-Directed, Quinazolines, Molecular Medicine, KRAS, Colorectal Neoplasms, SOS1 Protein, medicine.drug, Foot-in-the-door technique
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المؤلفون: Weiping Wang, Adan Pinto-Fernandez, Caravella Justin Andrew, Stephanos Ioannidis, Claire Heride, Benedikt M. Kessler, David Komander, Michael J. Clague, Simon J. Davis, Marie Katz, Victoria Smith, Hannah Elcocks, Tim Hammonds, Andreas Kallinos, Sylvie Urbé, Bruce Follows, Christopher J. Dinsmore, Sunkyu Kim, Katherine J. Kayser-Bricker, Steven Mischke, Shawn Fessler, Anne Clancy, Neil P. Jones, Axel Behrens, Jonathan O'Connell, Crystal McKinnon
المصدر: The Journal of Cell Biology
مصطلحات موضوعية: Protein Stability, Ubiquitination, Correction, Reproducibility of Results, Cell Biology, Computational biology, Biology, Ribosomal RNA, Ribosome, Antibodies, HEK293 Cells, Ribonucleoproteins, Cell Line, Tumor, Biocatalysis, Humans, Carrier Proteins, Ribosomes, Ubiquitin Thiolesterase
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e018963cdf960a0fdc0658ee368510ab
http://europepmc.org/articles/PMC7888347 -
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المؤلفون: Weiping Wang, Adan Pinto-Fernandez, Simon J. Davis, Katherine J. Kayser-Bricker, Victoria Smith, Jonathan O'Connell, Christopher J. Dinsmore, Crystal McKinnon, Neil P. Jones, Bruce Follows, Marie Katz, Claire Heride, Sylvie Urbé, Anne Clancy, Benedikt M. Kessler, Andreas Kallinos, Sunkyu Kim, Axel Behrens, Steven Mischke, Stephanos Ioannidis, Shawn Fessler, David Komander, Caravella Justin Andrew, Tim Hammonds, Hannah Elcocks, Michael J. Clague
المصدر: The Journal of Cell Biology
Bioxrivمصطلحات موضوعية: chemistry.chemical_classification, 0303 health sciences, DNA ligase, Protein Homeostasis, biology, Translation (biology), Cell Biology, Ribosomal RNA, Proteomics, Small molecule, Biochemistry, Ribosome, Cell biology, 03 medical and health sciences, 0302 clinical medicine, USP9X, chemistry, Ubiquitin, Centrosome, Report, Proteome, biology.protein, 030217 neurology & neurosurgery, 030304 developmental biology
وصف الملف: application/pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be84b6d5732fc90b5778aeba316a4c43
https://doi.org/10.1083/jcb.202004211 -
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المؤلفون: Szu-Chin Fu, Norbert Kraut, Rachel L Mendes, Marco H. Hofmann, Michael Gmachl, Peter Ettmayer, Katharina Schipany, Juergen Ramharter, Joseph R. Marszalek, Michael P. Sanderson, Tobias Wunberg, Fabio Savarese, Mark Petronczki, Timothy P. Heffernan, Thomas Gerstberger, Jark Böttcher, Mark Pearson, Dana-Adriana Botesteanu, Daniel Gerlach, Dirk Kessler, Franziska Schachinger, Klaus Rumpel, Jessica Teh, Jonathan O’Connell, Christiane Kofink, Heribert Arnhof, Simone Lieb, Jürgen Moll, Christopher P. Vellano, Nikolai Pototschnig, Andreas Zoephel, Darryl B. McConnell, Francesca Trapani
المصدر: Cancer discovery. 11(1)
مصطلحات موضوعية: 0301 basic medicine, Lung Neoplasms, Cell, Mitogen-activated protein kinase kinase, medicine.disease_cause, Proto-Oncogene Proteins p21(ras), 03 medical and health sciences, 0302 clinical medicine, Cell Line, Tumor, medicine, Humans, neoplasms, Protein Kinase Inhibitors, Mitogen-Activated Protein Kinase Kinases, Mutation, Chemistry, Activator (genetics), Effector, Nucleotides, digestive system diseases, respiratory tract diseases, Blockade, 030104 developmental biology, medicine.anatomical_structure, Oncology, 030220 oncology & carcinogenesis, SOS1, Cancer research, KRAS
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbecb23494b6ef4a8ee31ed4191d443e
https://pubmed.ncbi.nlm.nih.gov/34003780 -
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المؤلفون: Michael Gmachl, Thomas Gerstberger, Heinz Stadtmueller, Heribert Arnhof, Christiane Kofink, Marco H. Hofmann, Juergen Moll, David Richard, Adrian Saldanha, Rachel L Mendes, Mark Pearson, Peter Ettmayer, Darryl B. McConnell, Norbert Kraut, Michael P. Sanderson, Fabio Savarese, Dana-Adriana Botesteanu, Tobias Wunberg, Daniel Gerlach, Francesca Trapani, Renate Schnitzer, Dirk Kessler, Jonathan O’Connell, Jürgen Ramharter
المصدر: Molecular Cancer Therapeutics. 18:C133-C133
مصطلحات موضوعية: MAPK/ERK pathway, Cancer Research, Oncogene, business.industry, MEK inhibitor, Cancer, Context (language use), medicine.disease_cause, medicine.disease, Oncology, medicine, Cancer research, SOS1, Guanine nucleotide exchange factor, KRAS, business
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::c8c81524c075dbcf336518c2b41d6bc4
https://doi.org/10.1158/1535-7163.targ-19-c133 -
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المؤلفون: Szu-Chin Fu, Christiane Kofink, Jonathan O’Connell, Thomas Gerstberger, Mark Pearson, Marco H. Hofmann, Juergen Moll, Heribert Arnhof, Jürgen Ramharter, Fabio Savarese, Daniel Gerlach, Jessica Teh, Dana-Adriana Botesteanu, Joseph R. Marszalek, Michael Gmachl, Timothy P. Heffernan, Rachel L Mendes, Michael P. Sanderson, Peter Ettmayer, Dirk Kessler, Klaus Rumpel, Tobias Wunberg, Norbert Kraut, Francesca Trapani, Darryl B. McConnell, Christopher P. Vellano
المصدر: Molecular Cancer Therapeutics. 18:PL06-01
مصطلحات موضوعية: 0301 basic medicine, MAPK/ERK pathway, Cancer Research, Oncogene, Cell growth, business.industry, MEK inhibitor, Cancer, Context (language use), medicine.disease, medicine.disease_cause, digestive system diseases, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Oncology, 030220 oncology & carcinogenesis, SOS1, medicine, Cancer research, KRAS, business
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::3fe6b025e13debe76ee5133e06441c15
https://doi.org/10.1158/1535-7163.targ-19-pl06-01 -
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المؤلفون: Debra, Nickischer, Lisa, Elkin, Normand, Cloutier, Jonathan, O'Connell, Martyn, Banks, Andrea, Weston
المصدر: Methods in molecular biology (Clifton, N.J.). 1683
مصطلحات موضوعية: Microscopy, Data Interpretation, Statistical, Drug Discovery, Image Processing, Computer-Assisted, Cluster Analysis, Humans, Reproducibility of Results, Hep G2 Cells, High-Throughput Screening Assays, Molecular Imaging
URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::d027fbc415718506ef93b476f0f615b4
https://pubmed.ncbi.nlm.nih.gov/29082493
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