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1
المؤلفون: Joel M. Harris, Xiaoping Zhou, John A. Morrow, Sue-Ing Lin, Marco A. S. Baptista, John M. Sanders, Xiaoping Zhang, Hong Mei, Mark W. Embrey, Sylvie M. Sur, Duane E. DeMong, Ravi P. Nargund, Alan Hruza, Heather E. Tiscia, Matthew J. Fell, Zhizhang Yin, Gautam Agnihotri, Honglu Zhang, Thomas J. Greshock, Jack D. Scott, Yinghui Lin, Zhi-Cai Shi, John A. Mccauley, Sarah W. Li, Ronald K. Chang, Mark T. Bilodeau, Michael W. Miller, Reshma Kuvelkar, Andrew Stamford, Marc Poirier, Hong Liu, Megan K. Macala, Kallol Basu, Li Xiao, Lynn A. Hyde, Jonathan T. Kern, Xing Dai, Christian Mirescu, Paul L. Walsh, Matthew E. Kennedy, John J. Renger, Zhiyong Hu, John Columbus, Robert E. Drolet, Eric M. Parker
المصدر: Journal of medicinal chemistry. 60(7)
مصطلحات موضوعية: 0301 basic medicine, Male, Indazoles, Leucine-rich repeat, Leucine-Rich Repeat Serine-Threonine Protein Kinase-2, 03 medical and health sciences, 0302 clinical medicine, Drug Discovery, Animals, Humans, c-Raf, Kinase activity, Enzyme Inhibitors, Rats, Wistar, biology, Cyclin-dependent kinase 4, Kinase, Chemistry, Cyclin-dependent kinase 2, Brain, Parkinson Disease, LRRK2, nervous system diseases, Rats, Molecular Docking Simulation, 030104 developmental biology, Protein kinase domain, Biochemistry, biology.protein, Molecular Medicine, 030217 neurology & neurosurgery
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2
المؤلفون: Mireya Rodriguez, Pei W. Thomas, Bodin Tuesuwan, Jing Li, Jonathan T. Kern, Wendi M. David, Sean M. Kerwin
مصطلحات موضوعية: Base Sequence, biology, DNA polymerase, Antigens, Polyomavirus Transforming, Circular bacterial chromosome, DNA Helicases, Helicase, DNA, Simian virus 40, Biochemistry, RNA Helicase A, Molecular biology, DNA helicase activity, Spectrometry, Fluorescence, Control of chromosome duplication, biology.protein, heterocyclic compounds, Primase, dnaB helicase, DNA Primers
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2316058063f5f237f79431c8137022fc
https://doi.org/10.1021/bi701747d -
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المؤلفون: John A. McCauley, Ronald K. Chang, Thomas J. Greshock, Ming-Tain Lai, John M. Sanders, Hemaka A. Rajapakse, Hua Su, Robert E. Drolet, Rosa I. Sanchez, Sylvie M. Sur, John J. Renger, Jonathan T. Kern, Heather E. Tiscia, Rada Vanessa L, Mark T. Bilodeau, Boyoung Kim
المصدر: Bioorganicmedicinal chemistry letters. 26(11)
مصطلحات موضوعية: 0301 basic medicine, Parkinson's disease, Clinical Biochemistry, Pharmaceutical Science, Administration, Oral, Biological Availability, Thiophenes, Leucine-rich repeat, Pharmacology, Leucine-Rich Repeat Serine-Threonine Protein Kinase-2, Biochemistry, 03 medical and health sciences, chemistry.chemical_compound, Structure-Activity Relationship, 0302 clinical medicine, Drug Discovery, medicine, Structure–activity relationship, Humans, Molecular Biology, Protein Kinase Inhibitors, Dose-Response Relationship, Drug, Molecular Structure, Chemistry, Kinase, Organic Chemistry, medicine.disease, LRRK2, Small molecule, nervous system diseases, Molecular Docking Simulation, 030104 developmental biology, Lactam, Molecular Medicine, Sample collection, 030217 neurology & neurosurgery
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المؤلفون: Sean M. Kerwin, Jonathan T. Kern
المصدر: Bioorganic & Medicinal Chemistry Letters. 12:3395-3398
مصطلحات موضوعية: Guanine, Base pair, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Imides, G-quadruplex, Biochemistry, Fluorescence spectroscopy, Substrate Specificity, chemistry.chemical_compound, Diimide, Drug Discovery, Polymer chemistry, Scattering, Radiation, heterocyclic compounds, Imide, Perylene, Molecular Biology, Base Composition, Base Sequence, Organic Chemistry, DNA, G-Quadruplexes, Spectrometry, Fluorescence, chemistry, Nucleic Acid Conformation, Molecular Medicine, Spectrophotometry, Ultraviolet, Selectivity
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المؤلفون: Jonathan T. Kern, Pei W. Thomas, Sean M. Kerwin
المصدر: Biochemistry. 41:11379-11389
مصطلحات موضوعية: Models, Molecular, Magnetic Resonance Spectroscopy, Stereochemistry, G-quadruplex, Biochemistry, chemistry.chemical_compound, Piperidines, Diimide, Humans, heterocyclic compounds, Perylene, Telomerase, Binding selectivity, Anthracenes, Base Sequence, biology, Ligand, Topoisomerase, DNA, Nuclear magnetic resonance spectroscopy, Oligodeoxyribonucleotides, chemistry, Spectrophotometry, biology.protein, Nucleic Acid Conformation, Selectivity
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المؤلفون: Jonathan T. Kern, John J. Renger
المصدر: Journal of Neurogenetics. 25:117-119
مصطلحات موضوعية: Cellular and Molecular Neuroscience, Modern medicine, Computer science, Genetics, Identification (biology), Engineering ethics, Drug industry, Neuroscience
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المؤلفون: Pei W. Thomas, Sean M. Kerwin, Anupama Rangan, Daekyu Sun, Jonathan T. Kern
المصدر: Bioorganic & Medicinal Chemistry Letters. 11:2411-2414
مصطلحات موضوعية: Stereochemistry, Clinical Biochemistry, Iodide, Drug Evaluation, Preclinical, Pharmaceutical Science, Biochemistry, Chemical synthesis, chemistry.chemical_compound, Drug Discovery, Humans, Taq Polymerase, Enzyme Inhibitors, Coloring Agents, Telomerase, Molecular Biology, chemistry.chemical_classification, Binding Sites, Bicyclic molecule, biology, Chemistry, Organic Chemistry, DNA, Carbocyanines, Ligand (biochemistry), Enzyme, Enzyme inhibitor, biology.protein, Nucleic Acid Conformation, Molecular Medicine, Taq polymerase, HeLa Cells
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المؤلفون: Sean M. Kerwin, Jonathan T. Kern, Ben C. Hoster, Mark M. McPhee
المصدر: Bioorganic Chemistry. 28:98-118
مصطلحات موضوعية: chemistry.chemical_classification, Stereochemistry, Sodium, Potassium, Picrate, Organic Chemistry, chemistry.chemical_element, Cleavage (embryo), Alkali metal, Biochemistry, chemistry.chemical_compound, Molecular recognition, chemistry, Drug Discovery, Polymer chemistry, DNA supercoil, Molecular Biology, Crown ether
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المؤلفون: John M. Sanders, Jonathan T. Kern, Robert E. Drolet
المصدر: Journal of neurogenetics. 25(4)
مصطلحات موضوعية: LRRK2 Gene, Neurons, Kinase, Parkinson Disease, MAP2K2, Biology, Leucine-rich repeat, Protein Serine-Threonine Kinases, MAP3K7, Leucine-Rich Repeat Serine-Threonine Protein Kinase-2, LRRK2, nervous system diseases, Cell biology, Substrate Specificity, Cellular and Molecular Neuroscience, Cytoskeletal Proteins, Protein kinase domain, Protein Biosynthesis, Genetics, Animals, Humans, Kinase activity, Protein Modification, Translational
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المؤلفون: Elena Nikonova, Ted M. Dawson, Eva M. Finney, Robert L. Vogel, David J. Stone, Yulan Xiong, Jonathan T. Kern, Valina L. Dawson, Keith Q. Tanis, Ian J. Reynolds
مصطلحات موضوعية: Genetically modified mouse, Male, Transcription, Genetic, Mice, Transgenic, Biology, Protein Serine-Threonine Kinases, Leucine-Rich Repeat Serine-Threonine Protein Kinase-2, Mice, Genetics, Animals, Humans, Kinase activity, Molecular Biology, Gene, Genetics (clinical), LRRK2 Gene, Mice, Knockout, Messenger RNA, Kinase, Brain, Parkinson Disease, General Medicine, Articles, LRRK2, Molecular biology, nervous system diseases, Reverse transcription polymerase chain reaction, Mice, Inbred C57BL, Female
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e4ee6da142e51999d799cf5064fde8d
https://europepmc.org/articles/PMC3235012/